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11. 发明申请

US20100298324A1 Prolyl Hydroxylase Inhibitors 审中-公开
标题翻译：脯氨酰羟化酶抑制剂
公开(公告)号：US20100298324A1
公开(公告)日：2010-11-25
申请号：US12808195
申请日：2008-12-19
申请人： Dimitar B. Gotchev , Jian Jin , Yonghui Wang
发明人： Dimitar B. Gotchev , Jian Jin , Yonghui Wang
IPC分类号： A61K31/517 , C07D401/04 , C07D413/14 , A61K31/5377 , A61P7/06
CPC分类号： C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D413/06 , C07D417/04 , C07D417/06
摘要： The invention described herein relates to certain 4-oxo-2-thioxo-1,2,3,4-tetrahydro-7-quinazolinecarboxamide derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
摘要翻译：本文描述的本发明涉及作为HIF脯氨酰羟化酶的拮抗剂的式（I）的某些4-氧代-2-硫代-1,2,3,4-四氢-7-喹唑啉羧酰胺衍生物，并且可用于治疗受益于抑制这种酶，贫血就是一个例子。

12. 发明申请

US20090149447A1 Novel M3 Muscarinic Acetylcholine Receptor Antagonists 失效
标题翻译：新型M3毒蕈碱乙酰胆碱受体拮抗剂
公开(公告)号：US20090149447A1
公开(公告)日：2009-06-11
申请号：US11719336
申请日：2005-11-15
申请人： Brian W. Budzik , Anthony W.J. Cooper , Jian Jin , Dramane I. Laine , Brent W. McCleland , Michael R. Palovich , Ralph A. Rivero , Yonghui Wang , Haibo Xie , Chongjie Zhu
发明人： Brian W. Budzik , Anthony W.J. Cooper , Jian Jin , Dramane I. Laine , Brent W. McCleland , Michael R. Palovich , Ralph A. Rivero , Yonghui Wang , Haibo Xie , Chongjie Zhu
IPC分类号： C07D413/12 , C07D403/12 , A61K31/496 , A61K31/551 , A61K31/5377 , A61P11/00 , A61P37/08
CPC分类号： C07D487/08 , C07D241/04 , C07D295/135 , C07D295/155 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/14 , C07D417/14 , C07D487/10
摘要： Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.
摘要翻译：提供毒蕈碱性乙酰胆碱受体拮抗剂及其使用方法。

13. 发明申请

US20080306112A1 Benzimidazolones Which Have Activity at M1 Receptor 失效
标题翻译：在M1受体上具有活性的苯并咪唑酮
公开(公告)号：US20080306112A1
公开(公告)日：2008-12-11
申请号：US12088489
申请日：2006-09-27
申请人： Brian Budzik , David Gwyn Cooper , Ian Thomson Forbes , Jian Jin , Dongchuan Shi , Paul William Smith , Graham Walker
发明人： Brian Budzik , David Gwyn Cooper , Ian Thomson Forbes , Jian Jin , Dongchuan Shi , Paul William Smith , Graham Walker
IPC分类号： A61K31/454 , C07D211/06 , A61P25/00
CPC分类号： C07D401/04 , C07D405/04 , C07D405/14
摘要： Compounds of formula (I) and salts are provided: wherein R6 is selected from hydrogen, halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano, and Q is hydrogen or C1-6alkyl. The compounds are M1 agonists and are useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.
摘要翻译：提供式（I）和盐的化合物：其中R 6选自氢，卤素，C 1-6烷基，被一个或多个氟原子取代的C 1-6烷基，C 3-6环烷基，被一个或多个氟原子取代的C 3-6环烷基， C 1-6烷氧基，被一个或多个氟原子取代的C 1-6烷氧基和氰基，Q是氢或C 1-6烷基。化合物是M1激动剂，可用于治疗，例如治疗精神病和认知障碍。

14. 发明申请

US20050222215A1 Broadspectrum heterocyclic substituted phenyl containing sulfonamide hiv protease inhibitors 失效
标题翻译：支链杂环取代苯基含磺酰胺hiv蛋白酶抑制剂
公开(公告)号：US20050222215A1
公开(公告)日：2005-10-06
申请号：US10499221
申请日：2002-12-20
申请人： Steven Coulton , Michael Hadley , Hugh Herdon , Jian Jin , Graham Joiner , Roderick Porter , Shahzad Rahman
发明人： Steven Coulton , Michael Hadley , Hugh Herdon , Jian Jin , Graham Joiner , Roderick Porter , Shahzad Rahman
IPC分类号： C07D233/64 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4178 , A61K31/4188 , A61K31/421 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/429 , A61K31/443 , A61K31/497 , A61K31/506 , A61K31/53 , A61K45/00 , A61P31/12 , A61P31/18 , A61P43/00 , C07C311/18 , C07D231/12 , C07D233/54 , C07D233/88 , C07D263/32 , C07D277/20 , C07D277/40 , C07D277/42 , C07D277/46 , C07D417/04 , C07D417/12 , C07D417/14 , C07D493/04 , C07D513/04 , C07D519/00 , A61K31/44 , A61K31/16 , A61K31/277 , A61K31/40
CPC分类号： C07D231/12 , C07C311/18 , C07C2603/18 , C07D233/64 , C07D233/88 , C07D263/32 , C07D277/40 , C07D277/42 , C07D277/46 , C07D417/04 , C07D417/12 , C07D417/14 , C07D493/04 , C07D513/04
摘要： The present invention concerns the compounds having the formula (I), N-oxides, salt, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein Haryl is an aromatic monocyclic, bicyclic or tricyclic heterocycle having 3 to 14 ring members which contains one or more heteroatom ring members selected from nitrogen, oxygen and sulfur and which may optionally be substituted on (i) one or more carbon atoms by C1-6alkyl, halogen, hydroxy, optionally mono- or disubstituted amino, nitro, cyano, haloC1-6alkyl, carboxyl, C3-7cycloalkyl, optionally mono- or disubstituted aminocarbonyl, methylthio, methylsulfonyl, aryl, (R7a)n-M-R7b, Het1 and Het2; whereby the optional substituents on any amino function are independently selected from R5 and -A-R6; and on (ii) a nitrogen atom if present by hydroxy or -A-R6. It further relates to their use as broadspectrum HIV protease inhibitors, processes for their preparation as well as pharmaceutical compositions and diagnostic kits comprising them. It also concerns combinations thereof with another anti-retroviral agent, and to their use in assays as reference compounds or as reagents.
摘要翻译：本发明涉及具有式（I），N-氧化物，盐，立体异构形式，外消旋混合物，前药，酯和代谢物的化合物，其中Haryl是具有3至14个环成员的芳族单环，双环或三环杂环，含有一个或多个选自氮，氧和硫的杂原子环成员，并且其可任选地在（i）一个或多个碳原子上被C 1-6烷基取代，卤素，羟基，或二取代的氨基，硝基，氰基，卤代C 1-6烷基，羧基，C 3-7环烷基，任选的单或二取代的氨基羰基，甲硫基，甲基磺酰基，芳基，（ H＆lt; 1＆gt;和＆lt; 2＆gt;;＆lt; 2＆gt; 其中任何氨基官能团上的任选取代基独立地选自R 5和-A-R 6; 和（ii）如果存在羟基或-A-R 6的氮原子。它还涉及它们作为广谱的HIV蛋白酶抑制剂，其制备方法以及药物组合物和包含它们的诊断试剂盒的用途。它还涉及与另一种抗逆转录病毒剂的组合，以及它们在测定中用作参考化合物或作为试剂。

15. 发明授权

US5880680A Apparatus and method for determining boring direction when boring underground 失效
标题翻译：在地下钻孔时确定钻孔方向的装置和方法
公开(公告)号：US5880680A
公开(公告)日：1999-03-09
申请号：US759656
申请日：1996-12-06
申请人： John C. Wisehart , Austin L. Widener , Jian Jin
发明人： John C. Wisehart , Austin L. Widener , Jian Jin
IPC分类号： E21B47/024 , G01V3/00
CPC分类号： E21B47/024
摘要： A guidance module for an underground horizontal boring assembly. The module determines the pitch angle of the boring tool independent of roll using a single accelerometer sensor. The accelerometer sensor has a single sensitive axis which is aligned parallel to, and preferably coaxial with, the longitudinal axis of the boring tool. The accelerometer sensor is calibrated to obtain a temperature offset and a gain compensating gain factor. Data samples are read from the accelerometer sensor while the boring tool is rotating. The temperature is read from the temperature sensor. The data samples from the accelerometer sensor and the temperature from the temperature sensor are transmitted to a processor. The processor applies simple average filtering to the accelerometer data samples to get an average result, and adjusts the average result for gain. The average result is adjusted for the temperature offset and for the gain compensating gain factor. The average result then can be adjusted for an optional roll angle offset. The pitch angle is determined either from a lookup table or from the arcsin value of the quantity of the average result minus the temperature offset divided by the gain compensating gain factor.
摘要翻译：地下水平镗孔总成的引导模块。该模块使用单个加速度传感器确定镗刀独立于滚子的俯仰角。加速度计传感器具有与镗孔工具的纵向轴线平行并且优选与轴向对准的单个敏感轴。校准加速度计传感器以获得温度偏移和增益补偿增益因子。钻孔工具旋转时，从加速度传感器读取数据样本。从温度传感器读取温度。来自加速度计传感器的数据样本和来自温度传感器的温度被传送到处理器。处理器对加速度计数据样本应用简单的平均滤波以获得平均结果，并调整增益的平均结果。对于温度偏移和增益补偿增益因子调整平均结果。然后可以对可选的滚动角偏移量调整平均结果。俯仰角由查找表或平均值结果的arcsin值减去温度偏移除以增益补偿增益因子来确定。

16. 发明授权

US5850624A Electronic compass 失效
标题翻译：电子指南针
公开(公告)号：US5850624A
公开(公告)日：1998-12-15
申请号：US544940
申请日：1995-10-18
申请人： Michael F. Gard , Jian Jin , John C. Wisehart
发明人： Michael F. Gard , Jian Jin , John C. Wisehart
IPC分类号： E21B47/022 , G01R33/02 , G01C17/38
CPC分类号： G01R33/0206 , E21B47/022
摘要： An electronic compass (10) for use in a boring tool (12) which will provide an orientation of the boring tool relative to the earth's magnetic field. In addition, a more straightforward left or right deviation from an initial bearing can be determined. The invention can correct for pitch angle and roll angle variation as well. The magnetic field is sensed by an axial magnetic field (12), a radial magnetic field sensor (18) and a plane-normal magnetic sensor (24) which are preferably magnetoresistive sensors.
摘要翻译：一种用于钻孔工具（12）中的电子罗盘（10），其将提供钻孔工具相对于地球磁场的取向。此外，可以确定与初始方位的更直接的左或右偏差。本发明也可以矫正桨距角和侧倾角变化。磁场由优选磁阻传感器的轴向磁场（12），径向磁场传感器（18）和平面正常磁传感器（24）感测。

17. 发明申请

US20140140636A1 Anisotropic Gradient Regularization for Image Denoising, Compression, and Interpolation 审中-公开
标题翻译：图像去噪，压缩和插值的各向异性梯度正则化
公开(公告)号：US20140140636A1
公开(公告)日：2014-05-22
申请号：US14131534
申请日：2011-08-30
申请人： Wenfei Jiang , Jian Jin , Zhi Bo Chen
发明人： Wenfei Jiang , Jian Jin , Zhi Bo Chen
IPC分类号： G06T5/00
CPC分类号： G06T5/002 , G06T5/20 , G06T2207/20021 , G06T2207/20192
摘要： De-noising an image by Anisotropic Gradient Regulation commences by first choosing edge directions for the image. Thereafter, an anisotropic gradient norm is established for the image from anisotropic gradient norms along the selected edge directions. The image pixels undergo adjustment to minimize the anisotropic gradient norm for the image, thereby removing image noise.
摘要翻译：首先选择图像的边缘方向，通过各向异性梯度调节来消除图像。此后，沿着所选择的边缘方向从各向异性梯度范数的图像建立各向异性梯度范数。图像像素经过调整以最小化图像的各向异性梯度范数，从而消除图像噪声。

18. 发明申请

US20140126834A1 METHOD AND DEVICE FOR PROCESSING OF AN IMAGE 有权
标题翻译：用于处理图像的方法和装置
公开(公告)号：US20140126834A1
公开(公告)日：2014-05-08
申请号：US14128626
申请日：2012-06-19
申请人： Wen Fei Jiang , Jian Jin , Zhibo Chen
发明人： Wen Fei Jiang , Jian Jin , Zhibo Chen
IPC分类号： G06T5/00
CPC分类号： G06T5/00 , G06T5/002 , G06T2207/20192 , H04N1/4092
摘要： The invention addresses the problem that traditional Total Variation only enforces the horizontal and vertical intensity continuity and thus fails to reconstruct oblique edges well. In an embodiment, Directional Total Variation is defined which supports multiple gradient directions. It first pre-processes the image and determines the direction of edges/texture; Directional TV is calculated based on the gradients along the determined direction and its orthogonal direction. By utilizing adaptive weights to different directions in the regularization, Directional TV is capable of preserving edges independent from their orientation nicely. Thus, Directional TV regularization based image denoising, compression or super resolution tend to obtain better quality.
摘要翻译：本发明解决了传统的总变化仅强制水平和垂直强度连续性并因此不能很好地重建倾斜边缘的问题。在一个实施例中，定义了方向总变化，其支持多个梯度方向。它首先预处理图像并确定边缘/纹理的方向; 定向电视是根据沿着确定方向及其正交方向的梯度计算的。通过在正规化中利用不同方向的自适应权重，定向电视能够很好地保持与其方向无关的边缘。因此，基于定向电视正则化的图像去噪，压缩或超分辨率往往获得更好的质量。

19. 发明授权

US08324208B2 Prolyl hydroxylase inhibitors 有权
标题翻译：脯氨酰羟化酶抑制剂
公开(公告)号：US08324208B2
公开(公告)日：2012-12-04
申请号：US12305675
申请日：2007-06-22
申请人： Kevin J. Duffy , Duke M. Fitch , Jian Jin , Ronggang Liu , Antony N. Shaw , Kenneth Wiggall
发明人： Kevin J. Duffy , Duke M. Fitch , Jian Jin , Ronggang Liu , Antony N. Shaw , Kenneth Wiggall
IPC分类号： C07D239/54 , A61K31/515
CPC分类号： C07D239/60 , A61K31/515 , C07D239/22 , C07D239/54 , C07D239/62 , C07D401/04 , C07D405/04 , C07D405/10 , C07D409/04 , C07D409/10 , C07D413/06 , C07D413/10 , C07D417/10
摘要： The invention described herein relates to certain pyrimidinetrione N-substituted glycine derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
摘要翻译：本文描述的本发明涉及作为HIF脯氨酰羟化酶的拮抗剂的式（I）的某些嘧啶四酮N-取代的甘氨酸衍生物，并且可用于治疗受益于该酶的抑制的疾病，贫血是一个示例。

20. 发明授权

US08288412B2 Compounds which have activity at M1 receptor and their uses in medicine 失效
标题翻译：具有M1受体活性的化合物及其在药物中的用途
公开(公告)号：US08288412B2
公开(公告)日：2012-10-16
申请号：US12088451
申请日：2006-09-27
申请人： Brian Budzik , David Gwyn Cooper , Ian Thomson Forbes , Vincenzo Garzya , Jian Jin , Dongchuan Shi , Paul William Smith , Graham Walker
发明人： Brian Budzik , David Gwyn Cooper , Ian Thomson Forbes , Vincenzo Garzya , Jian Jin , Dongchuan Shi , Paul William Smith , Graham Walker
IPC分类号： A61K31/454 , C07D405/04
CPC分类号： C07D401/14
摘要： Compounds of formula (I) and salts are provided: wherein R5 is selected from halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano; R6 is selected from halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano; and Q is hydrogen or C1-6alkyl. The compounds are M1 agonists and are useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.
摘要翻译：提供式（I）和盐的化合物：其中R 5选自卤素，C 1-6烷基，被一个或多个氟原子取代的C 1-6烷基，C 1-6烷氧基，被一个或多个氟原子取代的C 1-6烷氧基，和氰基; R 6选自卤素，C 1-6烷基，被一个或多个氟原子取代的C 1-6烷基，C 3-6环烷基，被一个或多个氟原子取代的C 3-6环烷基，C 1-6烷氧基，被一个或多个氟原子和氰基; Q是氢或C 1-6烷基。化合物是M1激动剂，可用于治疗，例如治疗精神病和认知障碍。

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