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11. 发明申请

US20090069382A1 Bicyclic Angiotensin II Agonists 有权
标题翻译：双相血管紧张素II激动剂
公开(公告)号：US20090069382A1
公开(公告)日：2009-03-12
申请号：US11918241
申请日：2006-04-12
申请人： Mathias Alterman , Anders Hallberg , Murugaiah Andappan Murugaiah Subbaiah
发明人： Mathias Alterman , Anders Hallberg , Murugaiah Andappan Murugaiah Subbaiah
IPC分类号： A61K31/381 , C07D409/00 , C07D333/34 , A61P9/00 , A61P25/00 , A61P11/00 , A61P1/00 , A61K31/4436
CPC分类号： C07D409/12 , C07D333/34 , C07D333/40
摘要： There is provided a compound of formula I, wherein R1a, R1b, X, Y1, Y2, Y3, Y4, Z1, Z2, R2 and R3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful as selective agonists of the AT2 receptor, and thus, in particular, in the treatment of inter alia gastrointestinal conditions, such as dyspepsia, IBS and MOF, and cardiovascular disorders.
摘要翻译：提供了式I化合物，其中R 1a，R 1b，X，Y 1，Y 2，Y 3，Y 4，Z 1，Z 2，R 2和R 3具有本说明书中给出的含义及其药学上可接受的盐， AT2受体的选择性激动剂，特别是治疗胃肠道疾病如消化不良，IBS和MOF以及心血管疾病。

12. 发明授权

US4715528A Reclosable opening arrangement on a packing container 失效
标题翻译：包装容器上的可重新开启的开口布置
公开(公告)号：US4715528A
公开(公告)日：1987-12-29
申请号：US905157
申请日：1986-09-09
申请人： Tom Kjelgaard , Anders Hallberg , Kenth Jacobsson
发明人： Tom Kjelgaard , Anders Hallberg , Kenth Jacobsson
IPC分类号： B65D5/74 , B65D5/70 , B65D77/30 , B65D5/72
CPC分类号： B65D5/708
摘要： An opening arrangement on a packing container of the type which comprises a pouring opening 6 formed in the upper side of the container. The opening arrangement comprises a cover strip 8 and a pouring edge strip 7 arranged between the cover strip 8 and the packing container. To make possible the reclosure of the pouring opening 6 the cover strip 8 is provided with a gripping strip 9' sealed to its underside which preferably has a free gripping edge 9" facilitating the hooking of the cover strip 8 to the pouring tab 7.
摘要翻译：在包装容器上的开口装置，该包装容器包括形成在容器上侧的倾倒开口6。开口装置包括盖带8和布置在盖带8和包装容器之间的倾倒边缘条7。为了使倾倒开口6的重新闭合，盖带8设置有密封到其下侧的夹紧条9'，其优选地具有自由的夹紧边缘9“，其有助于将盖带8钩挂到浇注突片7。

13. 发明申请

US20090042931A1 Tricyclic Angiotensin II Agonists 有权
标题翻译：三环血管紧张素II激动剂
公开(公告)号：US20090042931A1
公开(公告)日：2009-02-12
申请号：US11918240
申请日：2006-04-12
申请人： Mathias Alterman , Anders Hallberg , Xiongyu Wu
发明人： Mathias Alterman , Anders Hallberg , Xiongyu Wu
IPC分类号： A61K31/4178 , A61P1/00 , A61P9/00 , C07D409/10 , A61K31/4155 , A61K31/437 , C07D471/04 , A61K31/4184 , A61P11/00 , A61P25/00
CPC分类号： C07D409/10
摘要： There is provided compounds of formula I, wherein A, X1, X2, X3, X4, Y1, Y2, Y3, Y4, Z1, Z2, R4 and R5 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful as selective agonists of the AT2 receptor, and thus, in particular, in the treatment of inter alia gastrointestinal conditions, such as dyspepsia, IBS and MOF, and cardiovascular disorders.
摘要翻译：提供式I化合物，其中A，X 1，X 2，X 3，X 4，Y 1，Y 2，Y 3，Y 4，Z 1，Z 2，R 4和R 5具有说明书中给出的含义及其药学上可接受的盐，作为AT2受体的选择性激动剂是有用的，因此特别是用于治疗尤其是消化不良，IBS和MOF以及心血管疾病的胃肠道疾病。

14. 发明申请

US20060183780A1 Pyrazole compounds useful in the treatment of inflammation 审中-公开
标题翻译：吡唑类化合物可用于治疗炎症
公开(公告)号：US20060183780A1
公开(公告)日：2006-08-17
申请号：US10547996
申请日：2004-03-12
申请人： Anders Hallberg , Wesley Schaal , Mats Larhed , Kristofer Olofsson , Benjamin Pelcman , Andrei Sanin
发明人： Anders Hallberg , Wesley Schaal , Mats Larhed , Kristofer Olofsson , Benjamin Pelcman , Andrei Sanin
IPC分类号： A61K31/4439 , A61K31/427 , A61K31/4152 , C07D417/02 , C07D403/02
CPC分类号： C07D231/14 , C07D231/18 , C07D231/40 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要： There is provided a compound of formula (I), wherein R1, R2, R3, X and Y have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a lipoxygenase (e.g. 15-lipoxygenase) is desired and/or required, and particularly in the treatment of inflammation.
摘要翻译：提供式（I）的化合物，其中R 1，R 2，R 3，X和Y具有在描述及其药学上可接受的盐，该化合物可用于治疗期望和/或需要抑制脂氧合酶（例如，15-脂肪氧合酶）的活性，特别是治疗炎症的疾病。

15. 发明申请

US20060111376A1 2,4-Diamino quinazoline and pyridopyrimidine ester derivatives as dihydrofolate reductase inhibitors 审中-公开
标题翻译： 2,4-二氨基喹唑啉和吡啶并嘧啶酯衍生物作为二氢叶酸还原酶抑制剂
公开(公告)号：US20060111376A1
公开(公告)日：2006-05-25
申请号：US10525906
申请日：2003-08-27
申请人： Anders Hallberg , Malin Graffner-Nordberg , Arne Boman , Elisabeth Seifert
发明人： Anders Hallberg , Malin Graffner-Nordberg , Arne Boman , Elisabeth Seifert
IPC分类号： A61K31/517 , C07D239/95
CPC分类号： C07D239/95
摘要： The invention provides novel compounds or the formula II: wherein R1, R2, R3 and R4 are independently hydrogen of a group that liberates the free amine in vivo, for example —CO-alkyl, preferably —CO—C1-C3 alkyl or pivalate; or —COhaloalkyl, preferably —CO—C1-C3 haloalkyl, most preferably —CO—C1-C3 chloroalkyl; wherein W is: and @ denotes the points of attachment and wherein the ester can be located in either direction; wherein n and m are independently 0-5; wherein one but not both or X and Y can be nitrogen, or X is C-A and/or Y is C—B; wherein A and B are independently selected from hydrogen, alkyl optionally substituted with a halogen, an electron donor group such as amino, alkylamino, dialkylamino or hydroxy, or an electron acceptor group such as nitro, cyano. trihaloalkyl or amido, alkoxy or halogen; and pharmacologically acceptable salts thereof. Provided that when R1 to R4 are hydrogen, both X and Y are C—H, n is 1 and —(CH2)n— is attached to the bridging oxygen of the ester group W, then m cannot be 0 or 1.
摘要翻译：本发明提供了新的化合物或式II：其中R 1，R 2，R 3和R 4，独立地是在体内释放游离胺的基团的氢，例如-CO-烷基，优选-CO-C 1 -C 3烷基或特戊酸酯; 或-CO卤代烷基，优选-CO-C 1 -C 3卤代烷基，最优选-CO-C 1 -C 3 - / SUB-氯烷基; 其中W是：和@表示连接点，并且其中酯可以位于任一方向上; 其中n和m独立地为0-5; 其中一个但不是两个或X和Y可以是氮，或X是C-A和/或Y是C-B; 其中A和B独立地选自氢，任选被卤素取代的烷基，电子给体基团如氨基，烷基氨基，二烷基氨基或羟基，或电子受体基团如硝基，氰基。三卤代烷基或酰氨基，烷氧基或卤素; 及其药理学上可接受的盐。假设当R 1至R 4为氢时，X和Y都是CH，n是1和 - （CH 2 CH 2）_{n 连接到酯基W的桥连氧上，则m不能为0或1。}

16. 发明授权

US06551467B1 Microwave facilitated allyllic substitution 失效
标题翻译：微波促进了allyllic取代
公开(公告)号：US06551467B1
公开(公告)日：2003-04-22
申请号：US09786199
申请日：2001-04-16
申请人： Ulf Bremberg , Anders Hallberg , Mats Larhed , Christina Moberg , Nils-Fredrik Kaiser
发明人： Ulf Bremberg , Anders Hallberg , Mats Larhed , Christina Moberg , Nils-Fredrik Kaiser
IPC分类号： C07F500
CPC分类号： C07B53/00 , C07B37/04 , C07C67/343 , C07C69/618
摘要： The present invention is draw to microwave heating of a transition metal-catalysed organic reaction, in which a catalyst complex between a transition metal and an auxiliary ligand or ligands, the ligand being asymmetric or symmetric, monodentate or bidentate, results in highly chemoselective, regioselective, and stereoselective allylic substitution reactions. Molybdenum or palladium complexes form suitable catalytic systems with a plethora of ligands in a variety of solvents for such microwave facilitated nucleophilic substitution reactions.
摘要翻译：本发明涉及过渡金属催化的有机反应的微波加热，其中过渡金属和辅助配体或配体之间的催化剂络合物，不对称或对称的单齿或双齿配体导致高度化学选择性的区域选择性，和立体选择性烯丙基取代反应。钼或钯络合物形成合适的催化体系，在各种溶剂中具有多种配体，用于这种微波促进的亲核取代反应。

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