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11. 发明授权

US08790236B2 Axial flow-pump with multi-grooved rotor 有权
标题翻译：带多槽转子的轴流泵
公开(公告)号：US08790236B2
公开(公告)日：2014-07-29
申请号：US11992997
申请日：2006-06-02
申请人： Jeffrey A. LaRose , Charles R. Shambaugh, Jr. , Richard A. Marquis , Daniel G. White , Palanivelu Thyagarajan
发明人： Jeffrey A. LaRose , Charles R. Shambaugh, Jr. , Richard A. Marquis , Daniel G. White , Kartikeyan Trichi
IPC分类号： A61M1/12
CPC分类号： A61M1/1036 , A61M1/1008 , A61M1/101 , A61M1/1012 , A61M1/1015 , A61M1/1017 , A61M1/1029 , A61M1/1031 , A61M1/1086 , A61M1/122 , A61M1/125 , F04D3/02 , F04D29/0476
摘要： An axial-flow blood pump for pumping blood includes a substantially cylindrical outer enclosure. A tubular housing concentric with and located within the outer enclosure has at one end an inlet and at an opposite end an outlet. A motor stator is concentric with and located between the outer enclosure and the tubular housing. An impeller is concentric with and located within the tubular housing. The impeller is suspended in operation by a combination of passive magnetic forces between magnets within the impeller or magnetized regions of the impeller and the motor stator and hydrodynamic thrust forces generated as blood flows between the tubular housing and a plurality of hydrodynamic thrust bearing surfaces located on the impeller. A volute may be in fluid-tight connection with the outlet of the tubular housing for receiving blood in the axial direction and directing blood in a direction normal to the axial direction. The volute has a flow-improving member extending axially from the volute and into and coaxially with the tubular housing.
摘要翻译：用于泵送血液的轴流血泵包括基本上圆柱形的外壳。与外壳同心并且位于外壳内的管状壳体在一端具有入口，在相对端具有出口。电动机定子与外壳和管状壳体同心并位于外壳和管壳之间。叶轮与管状壳体同心且位于管状壳体内。叶轮悬挂在操作中，通过叶轮内的磁体或叶轮的磁化区域和电动机定子之间的无源磁力的组合以及当管状壳体和位于管状壳体之间的多个流体动力推力轴承表面时产生的流体动力推力叶轮。蜗壳可以与管状壳体的出口流体密封连接，用于在轴向方向上接收血液并且在垂直于轴向的方向上引导血液。蜗壳具有从蜗壳轴向延伸并与管状壳体同轴的流动改进构件。

12. 发明申请

US20140148638A1 INTRAVASCULAR VENTRICULAR ASSIST DEVICE 有权
标题翻译：静脉血管辅助装置
公开(公告)号：US20140148638A1
公开(公告)日：2014-05-29
申请号：US14171615
申请日：2014-02-03
申请人： Jeffrey A. LaRose , Charles R. Shambaugh, Jr. , Daniel G. White , Richard A. Marquis , Steven A. White
发明人： Jeffrey A. LaRose , Charles R. Shambaugh, Jr. , Daniel G. White , Richard A. Marquis , Steven A. White , Kartikeyan Trichi
IPC分类号： A61M1/10
CPC分类号： A61M1/125 , A61M1/1008 , A61M1/101 , A61M1/1017 , A61M1/1031 , A61M1/1036 , A61M1/122 , A61M2205/0211 , A61M2205/0272 , A61M2205/8206 , A61M2210/127
摘要： One aspect of an intravascular ventricular assist device is an implantable blood pump where the pump includes a housing defining a bore having an axis, one or more rotors disposed within the bore, each rotor including a plurality of magnetic poles, and one or more stators surrounding the bore for providing a magnetic field within the bore to induce rotation of each of the one or more rotors. Another aspect of the invention includes methods of providing cardiac assistance to a mammalian subject as, for example, a human. Further aspects of the invention include rotor bodies having helical channels formed longitudinally along the length of the body of the rotor where each helical channel is formed between peripheral support surface areas facing radially outwardly and extending generally in circumferential directions around the rotational axis of the rotor.
摘要翻译：血管内心室辅助装置的一个方面是可植入血液泵，其中泵包括限定具有轴的孔的壳体，设置在孔内的一个或多个转子，每个转子包括多个磁极，以及一个或多个围绕所述孔用于在所述孔内提供磁场以引起所述一个或多个转子中的每一个的旋转。本发明的另一方面包括向例如人类的哺乳动物受试者提供心脏辅助的方法。本发明的其它方面包括具有沿着转子主体的长度纵向形成的螺旋通道的转子体，其中每个螺旋通道形成在围绕转子的旋转轴线的径向向外并沿圆周方向延伸的周向支撑表面区域之间。

13. 发明授权

US08419609B2 Impeller for a rotary ventricular assist device 有权
标题翻译：用于旋转心室辅助装置的叶轮
公开(公告)号：US08419609B2
公开(公告)日：2013-04-16
申请号：US11243722
申请日：2005-10-05
申请人： Charles R. Shambaugh, Jr. , Kartikeyan Trichi , Jeffrey A. LaRose
发明人： Charles R. Shambaugh, Jr. , Kartikeyan Trichi , Jeffrey A. LaRose
IPC分类号： A61M1/12
CPC分类号： A61M1/1036 , A61M1/1008 , A61M1/101 , A61M1/1012 , A61M1/1015 , A61M1/1017 , A61M1/1029 , A61M1/1031 , A61M1/1086 , A61M1/122 , A61M1/125 , F04D3/02 , F04D29/0476
摘要： An impeller for a blood pump such as a magnetically driven, rotary ventricular assist device for pumping blood of a patient, the impeller being substantially entirely made of an alloy which consists essentially of about 70-80 weight percent of platinum and 20-30 weight percent of cobalt.
摘要翻译：一种用于血液泵的叶轮，例如用于泵送患者血液的磁驱动的旋转心室辅助装置，叶轮基本上完全由合金制成，该合金基本上由约70-80重量％的铂和20-30重量％的钴。

14. 发明申请

US20140322022A9 PLATINUM-COBALT-BORON BLOOD PUMP ELEMENT 审中-公开
公开(公告)号：US20140322022A9
公开(公告)日：2014-10-30
申请号：US13621551
申请日：2012-09-17
申请人： Jeffrey A. LaRose , Charles R. Shambaugh, JR.
发明人： Jeffrey A. LaRose , Charles R. Shambaugh, JR.
IPC分类号： F03B3/12
CPC分类号： A61M1/1015 , A61M1/101 , A61M1/1012 , A61M1/1017 , A61M1/1029 , A61M1/1031 , A61M1/122 , A61M1/125 , A61M2205/02 , F04D29/026 , F04D29/181 , F05D2300/11 , F05D2300/143 , F05D2300/17 , F05D2300/507
摘要： A magnetic impeller for a blood pump such as a magnetically driven, rotary ventricular assist device for pumping blood of a patient, the impeller comprising a magnetic alloy including platinum, cobalt, and boron.

15. 发明申请

US20090203957A1 Ventricular assist device for intraventricular placement 有权
标题翻译：心室辅助装置用于心室内放置
公开(公告)号：US20090203957A1
公开(公告)日：2009-08-13
申请号：US12322746
申请日：2009-02-06
申请人： Jeffrey A. LaRose , Charles R. Shambaugh, JR. , Steve A. White
发明人： Jeffrey A. LaRose , Charles R. Shambaugh, JR. , Steve A. White
IPC分类号： A61M1/10
CPC分类号： A61M1/122 , A61M1/1008 , A61M1/101 , A61M1/1012 , A61M1/1031 , A61M1/1036 , A61M1/125 , A61M2205/04 , A61M2205/103 , A61M2210/125
摘要： A ventricular assist device includes a pump such as an axial flow pump, an outflow cannula connected to the outlet of the pump, and an anchor element. The anchor element is physically connected to the pump, as by an elongate element. The pump is implanted within the left ventricle with the outflow cannula projecting through the aortic valve but desirably terminating short of the aortic arch. The anchor element is fixed to the wall of the heart near the apex of the heart so that the anchor element holds the pump and outflow cannula in position.
摘要翻译：心室辅助装置包括泵，例如轴流泵，连接到泵的出口的流出套管和锚固元件。锚元件通过细长元件物理连接到泵。将泵植入左心室内，其中流出套管突出通过主动脉瓣，但期望终止于主动脉弓。锚固元件固定在心脏顶点附近的心脏壁上，使得锚固元件将泵和流出套管保持在适当位置。

16. 发明授权

US07972122B2 Multiple rotor, wide blade, axial flow pump 有权
标题翻译：多转子，宽叶片，轴流泵
公开(公告)号：US07972122B2
公开(公告)日：2011-07-05
申请号：US11118551
申请日：2005-04-29
申请人： Jeffrey A. LaRose , Charles R. Shambaugh, Jr.
发明人： Jeffrey A. LaRose , Charles R. Shambaugh, Jr.
IPC分类号： F04B35/04
CPC分类号： F04D3/02 , A61M1/101 , A61M1/1012 , A61M1/1013 , A61M1/1015 , A61M1/1017 , A61M1/1031 , A61M1/122 , F04D13/0633 , F04D13/064 , F04D29/181 , F04D29/669
摘要： A blood pump comprises a pump housing; a plurality of rotors positioned in said housing, each rotor comprising an impeller having a hydrodynamic surface for pumping blood; and a motor including a plurality of magnetic poles carried by each impeller, having motor stators, each including electrically conductive coils located adjacent to or within the housing. At least one of the rotors is adopted to rotate clockwise, and at least one of rotors is adopted to rotate counterclockwise. By this means, stator or stationary blades between the rotors may not be needed.
摘要翻译：血泵包括泵壳体; 定位在所述壳体中的多个转子，每个转子包括具有用于泵送血液的流体动力表面的叶轮; 以及电动机，其包括由每个叶轮承载的多个磁极，具有电动机定子，每个电极包括位于壳体附近或壳体内的导电线圈。采用至少一个转子顺时针旋转，并且使用至少一个转子逆时针旋转。通过这种方式，转子之间的定子或固定叶片可能不需要。

17. 发明授权

US07699586B2 Wide blade, axial flow pump 有权
标题翻译：宽叶片，轴流泵
公开(公告)号：US07699586B2
公开(公告)日：2010-04-20
申请号：US11003810
申请日：2004-12-03
申请人： Jeffrey A. LaRose , Charles R. Shambaugh, Jr.
发明人： Jeffrey A. LaRose , Charles R. Shambaugh, Jr.
IPC分类号： F04B35/04 , A61N1/362 , A61M1/10
CPC分类号： A61M1/1017 , A61M1/101 , A61M1/1012 , A61M1/1015 , A61M1/1031 , A61M1/122
摘要： A blood pump comprises a pump housing; a rotor positioned in the housing and comprising an impeller having a hydrodynamic surface for pumping blood; and a motor including a plurality of magnets carried by the impeller, plus a rotor stator, including an electrically conductive coil located adjacent to or within the housing. The impeller comprises radially outwardly extending, bladelike projections that define generally longitudinally extending spaces between the projections. The shape of the projections and the spaces therebetween tend to drive blood in the spaces in an axial direction as the impeller is rotated. The spaces collectively have a total width along most of their lengths at the radial periphery of the rotor, that is substantially equal to or less than the collective width of the projections along most of their lengths at the radial periphery. Thus, the bladelike projections are thicker, achieving significant advantages.
摘要翻译：血泵包括泵壳体; 转子，其定位在壳体中并且包括具有用于泵送血液的流体动力表面的叶轮; 以及包括由叶轮承载的多个磁体的马达，加上转子定子，其包括位于壳体附近或壳体内的导电线圈。叶轮包括径向向外延伸的扁平凸起，其在凸起之间限定大致纵向延伸的空间。当叶轮旋转时，突起的形状和它们之间的空间容易沿轴向驱动空间中的血液。这些空间在转子的径向周边处共同具有沿其大部分长度的总宽度，其大体上等于或小于在径向周边沿其大部分长度的突起的总体宽度。因此，扁平状突起较厚，具有显着的优点。

18. 发明申请

US20090204205A1 Platinum-cobalt-boron blood pump element 审中-公开
标题翻译：铂 - 钴硼血液泵元件
公开(公告)号：US20090204205A1
公开(公告)日：2009-08-13
申请号：US12322821
申请日：2009-02-06
申请人： Jeffrey A. LaRose , Charles R. Shambaugh, JR.
发明人： Jeffrey A. LaRose , Charles R. Shambaugh, JR.
IPC分类号： A61M1/10 , F04D29/38 , F04B17/00
CPC分类号： F04D29/181 , A61M1/101 , A61M1/1012 , A61M1/1015 , A61M1/1017 , A61M1/1031 , A61M1/122 , A61M1/125 , F04D3/00 , F04D13/0606 , F04D29/026 , F04D29/048 , F05D2300/17 , F05D2300/507
摘要： A magnetic impeller for a blood pump such as a magnetically driven, rotary ventricular assist device for pumping blood of a patient, the impeller comprising a magnetic alloy including platinum, cobalt, and boron.
摘要翻译：一种用于血泵的磁性叶轮，例如用于泵送患者血液的磁驱动的旋转心室辅助装置，所述叶轮包括包含铂，钴和硼的磁性合金。

19. 发明申请

US20160015880A1 VENTRICULAR ASSIST DEVICE FOR INTRAVENTRICULAR PLACEMENT 有权
标题翻译：用于室内放置的心室辅助装置
公开(公告)号：US20160015880A1
公开(公告)日：2016-01-21
申请号：US14867696
申请日：2015-09-28
申请人： Jeffrey A. LaRose , Charles R. Shambaugh, JR. , Steve A. White , Daniel Tamez
发明人： Jeffrey A. LaRose , Charles R. Shambaugh, JR. , Steve A. White , Daniel Tamez
IPC分类号： A61M1/12 , A61M1/10
CPC分类号： A61M1/122 , A61M1/1008 , A61M1/101 , A61M1/1012 , A61M1/1031 , A61M1/1036 , A61M1/125 , A61M2205/04 , A61M2205/103 , A61M2210/125
摘要： The present invention, in one embodiment, is a blood pump for intraventricular placement inside a heart of a mammalian subject including a rigid elongate member having a length between proximal and distal ends and a bore extending along the length, an anchor element connected towards the proximal end of the rigid elongate member and mounted to the subject's heart, a pump having an inlet and an outlet, a rotor and at least one electric drive coil for magnetically driving the rotor, the pump connected at or adjacent to the distal end of the rigid elongate member remote from the anchor element and wiring extending through the bore to the pump, wherein the proximal end of the rigid elongate member extends past the anchor element to a position outside of the subject's heart. Additional embodiments of a blood pump, and various methods of intraventricular placement inside a heart of a mammalian subject are also considered.
摘要翻译：在一个实施例中，本发明是用于心室内放置在哺乳动物对象的心脏内的血泵，包括刚性细长构件，其具有在近端和远端之间的长度以及沿着长度延伸的孔，锚固元件连接到近端刚性细长构件的端部并且安装到被检者的心脏，具有入口和出口的泵，转子和用于磁驱动转子的至少一个电驱动线圈，泵连接在刚性的远端处或邻近刚性的远端远离锚固元件的细长构件和延伸穿过孔到泵的布线，其中刚性细长构件的近端延伸穿过锚固元件到受试者心脏外部的位置。还考虑了血液泵的另外的实施方案以及哺乳动物受试者的心脏内的心室内放置的各种方法。

20. 发明授权

US08852072B2 Ventricular assist device for intraventricular placement 有权
标题翻译：心室辅助装置用于心室内放置
公开(公告)号：US08852072B2
公开(公告)日：2014-10-07
申请号：US12322746
申请日：2009-02-06
申请人： Jeffrey A. LaRose , Charles R. Shambaugh, Jr. , Steve A. White , Daniel Tamez
发明人： Jeffrey A. LaRose , Charles R. Shambaugh, Jr. , Steve A. White , Daniel Tamez
IPC分类号： A61N1/362 , A61M1/12 , A61M1/10
CPC分类号： A61M1/122 , A61M1/1008 , A61M1/101 , A61M1/1012 , A61M1/1031 , A61M1/1036 , A61M1/125 , A61M2205/04 , A61M2205/103 , A61M2210/125
摘要： A ventricular assist device includes a pump such as an axial flow pump, an outflow cannula connected to the outlet of the pump, and an anchor element. The anchor element is physically connected to the pump, as by an elongate element. The pump is implanted within the left ventricle with the outflow cannula projecting through the aortic valve but desirably terminating short of the aortic arch. The anchor element is fixed to the wall of the heart near the apex of the heart so that the anchor element holds the pump and outflow cannula in position.
摘要翻译：心室辅助装置包括泵，例如轴流泵，连接到泵的出口的流出套管和锚固元件。锚元件通过细长元件物理连接到泵。将泵植入左心室内，其中流出套管突出通过主动脉瓣，但期望终止于主动脉弓。锚固元件固定在心脏顶点附近的心脏壁上，使得锚固元件将泵和流出套管保持在适当位置。

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