专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明申请

US20090137041A1 3-HYDROXYISOTHIAZOLE-4-CARBOXAMIDINE DERIVATIVES AS CHK2 INHIBITORS 有权
标题翻译：作为CHK2抑制剂的3-羟基异噻唑-4-羧酰胺衍生物
公开(公告)号：US20090137041A1
公开(公告)日：2009-05-28
申请号：US12143672
申请日：2008-06-20
申请人： Jim Zhen Wu , Huanming Chen
发明人： Jim Zhen Wu , Huanming Chen
IPC分类号： C07D275/03 , C12N5/00
CPC分类号： C07D275/03
摘要： This invention provides compounds of Formula I which are inhibitors of Chk2 and are useful as a radiation protection agents in anticancer radiotherapy. A method of modulating Chk2 in vitro includes treating a substrate with Chk2 in the presence of compounds of formula I. A method of making a compound of formula I includes: a) forming a biaryl amine having an amino (NH2) group; b) converting the amino group to an isothiocyanate group; c) adding a cyanoacetamide to said isothiocyanate group to form a thioamide adduct; d) cyclizing said thioamide adduct to form an isothiazole having a cyano group; and e) adding an amine to said cyano group to form a carboxamidine group.
摘要翻译：本发明提供了作为Chk2抑制剂的式I化合物，可用作抗癌放射治疗中的放射防护剂。在体外调节Chk2的方法包括在式I化合物存在下用Chk2处理底物。制备式I化合物的方法包括：a）形成具有氨基（NH 2）基团的联芳基胺; b）将氨基转化为异硫氰酸酯基团; c）向所述异硫氰酸酯基团加入氰基乙酰胺以形成硫代酰胺加合物; d）环化所述硫代酰胺加合物以形成具有氰基的异噻唑; 和e）向所述氰基中加入胺形成甲脒基。

12. 发明授权

US08344137B2 3,3-dimethyl tetrahydroquinoline derivatives 有权
标题翻译： 3,3-二甲基四氢喹啉衍生物
公开(公告)号：US08344137B2
公开(公告)日：2013-01-01
申请号：US13081527
申请日：2011-04-07
申请人： Li Chen , Lichun Feng , Mengwei Huang , Yongfu Liu , Guolong Wu , Jim Zhen Wu , Mingwei Zhou
发明人： Li Chen , Lichun Feng , Mengwei Huang , Yongfu Liu , Guolong Wu , Jim Zhen Wu , Mingwei Zhou
IPC分类号： C07D215/48 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D471/04
CPC分类号： C07D215/48 , C07D215/12 , C07D215/18 , C07D215/36 , C07D401/04 , C07D401/10 , C07D401/12 , C07D405/12 , C07D413/10 , C07D471/04
摘要： A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R5 have the significance given in claim 1, can be used as a medicament.
摘要翻译：式（I）化合物及其药学上可接受的盐，其中R 1至R 5具有权利要求1中给出的含义，可用作药物。

13. 发明申请

US20130196974A1 COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS DISEASE 有权
标题翻译：用于治疗和预防呼吸道感染病毒性疾病的化合物
公开(公告)号：US20130196974A1
公开(公告)日：2013-08-01
申请号：US13561366
申请日：2012-07-30
申请人： Li Chen , Lichun Feng , Song Feng , Lu Gao , Tao Guo , Mengwei Huang , Chungen Liang , Yongfu Liu , Lisha Wang , Jason Christopher Wong , Jim Zhen Wu , Xihan Wu , Hongying Yun , Xiufang Zheng
发明人： Li Chen , Lichun Feng , Song Feng , Lu Gao , Tao Guo , Mengwei Huang , Chungen Liang , Yongfu Liu , Lisha Wang , Jason Christopher Wong , Jim Zhen Wu , Xihan Wu , Hongying Yun , Xiufang Zheng
IPC分类号： C07D493/10 , C07D487/04 , C07D413/04 , C07D407/14 , C07D401/04 , C07D417/14 , C07D417/04
CPC分类号： C07D493/10 , C07D401/04 , C07D401/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D487/04 , C07D491/107
摘要： A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R10, A, Q, X and Y are as defined in the specification and claims, and their use as a pharmaceutical for the treatment or prophylaxis of respiratory syncytial virus disease.
摘要翻译：式（I）化合物及其药学上可接受的盐，其中R 1至R 10，A，Q，X和Y如说明书和权利要求中所定义，及其作为治疗或预防呼吸道合胞体药物的用途病毒病。

14. 发明申请

US20110257151A1 NOVEL 3,3-DIMETHYL TETRAHYDROQUINOLINE DERIVATIVES 有权
标题翻译：新的3,3-二甲基四氢喹啉衍生物
公开(公告)号：US20110257151A1
公开(公告)日：2011-10-20
申请号：US13081527
申请日：2011-04-07
申请人： Li Chen , Lichun Feng , Mengwei Huang , Yongfu Liu , Guolong Wu , Jim Zhen Wu , Mingwei Zhou
发明人： Li Chen , Lichun Feng , Mengwei Huang , Yongfu Liu , Guolong Wu , Jim Zhen Wu , Mingwei Zhou
IPC分类号： A61K31/4709 , A61K31/47 , C07D401/12 , A61K31/497 , C07D413/12 , A61K31/5377 , A61K31/496 , C07D413/14 , C07D401/04 , C07D413/10 , C07D401/10 , C07D401/06 , C07D471/04 , A61K31/519 , A61P3/06 , A61P3/04 , A61P3/10 , A61P35/00 , C07D215/48
CPC分类号： C07D215/48 , C07D215/12 , C07D215/18 , C07D215/36 , C07D401/04 , C07D401/10 , C07D401/12 , C07D405/12 , C07D413/10 , C07D471/04
摘要： A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R5 have the significance given in claim 1, can be used as a medicament.
摘要翻译：式（I）化合物及其药学上可接受的盐，其中R 1至R 5具有权利要求1中给出的含义，可用作药物。

15. 发明授权

US08871756B2 Compounds for the treatment and prophylaxis of Respiratory Syncytial Virus disease 有权
标题翻译：用于治疗和预防呼吸道合胞病毒疾病的化合物
公开(公告)号：US08871756B2
公开(公告)日：2014-10-28
申请号：US13561366
申请日：2012-07-30
申请人： Li Chen , Lichun Feng , Song Feng , Lu Gao , Tao Guo , Mengwei Huang , Chungen Liang , Yongfu Liu , Lisha Wang , Jason Christopher Wong , Jim Zhen Wu , Xihan Wu , Hongying Yun , Xiufang Zheng
发明人： Li Chen , Lichun Feng , Song Feng , Lu Gao , Tao Guo , Mengwei Huang , Chungen Liang , Yongfu Liu , Lisha Wang , Jason Christopher Wong , Jim Zhen Wu , Xihan Wu , Hongying Yun , Xiufang Zheng
IPC分类号： C07D493/10 , C07D487/04 , C07D413/04 , C07D407/14 , C07D401/04 , C07D417/14 , C07D417/04 , C07D409/14 , C07D491/107 , C07D413/14 , C07D405/14 , C07D401/14
CPC分类号： C07D493/10 , C07D401/04 , C07D401/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D487/04 , C07D491/107
摘要： A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R10, A, Q, X and Y are as defined in the specification and claims, and their use as a pharmaceutical for the treatment or prophylaxis of respiratory syncytial virus disease.
摘要翻译：式（I）化合物及其药学上可接受的盐，其中R 1至R 10，A，Q，X和Y如说明书和权利要求中所定义，及其作为治疗或预防呼吸道合胞体药物的用途病毒病。

16. 发明申请

US20110195979A1 COMPOUNDS FOR THE TREATMENT AND PREVENTION OF INFLUENZA 审中-公开
标题翻译：用于治疗和预防流感的化合物
公开(公告)号：US20110195979A1
公开(公告)日：2011-08-11
申请号：US13021793
申请日：2011-02-07
申请人： Li Chen , Xianfeng Lin , Zongxing Qiu , Guozhi Tang , Lisha Wang , Jim Zhen Wu , Wengang Yang
发明人： Li Chen , Xianfeng Lin , Zongxing Qiu , Guozhi Tang , Lisha Wang , Jim Zhen Wu , Wengang Yang
IPC分类号： A61K31/4965 , C07C215/70 , C07C255/58 , C07C237/30 , C07C311/39 , C07C69/157 , C07D213/74 , C07D239/42 , C07D239/47 , C07D239/84 , A61K31/136 , A61K31/166 , A61K31/18 , A61K31/277 , A61K31/222 , A61K31/4402 , A61K31/44 , A61K31/505 , A61P31/16
CPC分类号： C07C215/42 , C07C211/52 , C07C217/52 , C07C217/84 , C07C219/24 , C07C235/40 , C07C237/24 , C07C237/30 , C07C255/58 , C07C255/60 , C07C2601/14 , C07D213/74 , C07D217/22 , C07D231/56 , C07D239/42 , C07D239/47 , C07D239/84 , C07D263/58
摘要： A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R4 and Ar are as defined in description and in claims, can be used as a medicament.
摘要翻译：式（I）化合物及其药学上可接受的盐，其中R 1至R 4和Ar如描述和权利要求中所定义，可用作药物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式