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11. 发明申请

US20130344510A1 IDENTIFICATION OF CANCER PATIENTS LIKELY TO BENEFIT FROM RADIATION THERAPY 审中-公开
标题翻译：癌症患者的鉴定有利于从辐射治疗中获益
公开(公告)号：US20130344510A1
公开(公告)日：2013-12-26
申请号：US13990727
申请日：2011-12-02
申请人： Mark Gustavson , Jason Christiansen , Anthony Martin Magliocco
发明人： Mark Gustavson , Jason Christiansen , Anthony Martin Magliocco
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N33/57415 , G01N2333/723 , G01N2800/52
摘要： Disclosed herein are methods of identifying suitable patients for postoperative radiotherapy based on the discovery that the quantification of ER, beyond simple positive/negative characterization, can provide valuable predictive information for the treatment of cancer, specifically breast cancer, and more particularly may predict a group more likely to respond to RT and spare patients from a potentially harmful treatment. Furthermore, the true quantification of ER expression provides a continuous recurrence risk assessment for patients being treated with tamoxifen, and therefore the standardization of the data across sites and imaging platforms significantly reduces the misclassification of patients when compared to the current standard by which ER expression is determined.
摘要翻译：本文公开了基于以下发现来鉴定合适的患者的方法：基于以下发现：除了简单的阳性/阴性表征之外，ER的定量可以提供用于治疗癌症，特别是乳腺癌的有价值的预测信息，更具体地，可以预测组更有可能对RT和备用患者进行有潜在的有害治疗。此外，ER表达的真实定量为接受他莫昔芬治疗的患者提供了连续的复发风险评估，因此与现有标准相比，跨站点和成像平台的数据标准化显着降低了患者的错误分类，决心。

12. 发明申请

US20120270233A1 ASSOCIATION OF BIOMARKERS WITH PATIENT OUTCOME 审中-公开
标题翻译：生物标志物与患者结果的协调
公开(公告)号：US20120270233A1
公开(公告)日：2012-10-25
申请号：US12866836
申请日：2009-02-10
申请人： Donald E. Waldron , Alpana Waldron , Robert Pinard , Mark Gustavson
发明人： Donald E. Waldron , Alpana Waldron , Robert Pinard , Mark Gustavson
IPC分类号： G01N21/64 , C12Q1/02 , C12Q1/48 , G01N21/17
CPC分类号： G01N33/57407 , A61K45/06 , A61N5/00 , G01N2800/56
摘要： The present method relates to quantification of prognostic and predictive biomarkers of the PDK/AKT/mTOR pathway, such as GSK3β, S6, CREB, PTEN, AKT and mTOR, using AQUA® analysis to estimate both patient risk and benefit of treatment to patients diagnosed with glioblastoma. Unlike traditional IHC, the AQUA® system is objective and produces quantitative in situ protein expression data on a continuous scale. Taking advantage of the power of the AQUA system, the present method provides a highly robust and standardized diagnostic assays that can be used in the clinical setting to provide physicians with reliable prognostic and predictive information. Glioblastoma multiform (GBM) remains one of the most aggressive human cancers, and biomarkers that provide prognostic and predictive information would be extremely valuable to both the physician and the patient. A patient's risk may be determined using the prognostic biomarkers of the present method. Such a prognostic determination will allow physicians to identify patients with a relatively ‘good’ or a relatively ‘poor’ prognosis. The benefit of treating specific patients with a specific therapy, may be determined usin̂ the predictive markers of the present method. Treatment with the AGC-family kinase inhibitor enzastaurin, for example, identifies patients that will likely benefit from treatment or not.
摘要翻译：本方法涉及使用AQUA®分析来估计PDK / AKT / mTOR途径的预后和预测生物标志物如GSK3和bgr，S6，CREB，PTEN，AKT和mTOR，以评估患者的风险和治疗对患者的益处诊断为胶质母细胞瘤。与传统IHC不同，AQUA®系统是客观的，可以连续量产定量的原位蛋白表达数据。利用AQUA系统的优势，本方法提供了一种高度鲁棒和标准化的诊断测定，可用于临床环境，为医师提供可靠的预后和预测信息。多形性成胶质细胞瘤（GBM）仍然是最具侵袭性的人类癌症之一，提供预后和预测信息的生物标志物对于医师和患者都是非常有价值的。可以使用本方法的预后生物标志物确定患者的风险。这样的预后测定将允许医师鉴定具有相对较好或较差预后的患者。用特定疗法治疗特定患者的益处可以通过本方法的预测标记来确定。例如，用AGC-家族激酶抑制剂恩斯特劳林治疗可以确定可能从治疗中获益的患者。

13. 发明授权

US08367351B2 Methods for determining signal transduction activity in tumors 有权
标题翻译：确定肿瘤信号转导活性的方法
公开(公告)号：US08367351B2
公开(公告)日：2013-02-05
申请号：US12299699
申请日：2007-05-07
申请人： Mark Gustavson , Jennifer Giltnane , Marisa P. Dolled-Filhart , Robert L. Camp , David L. Rimm
发明人： Mark Gustavson , Jennifer Giltnane , Marisa P. Dolled-Filhart , Robert L. Camp , David L. Rimm
IPC分类号： G01N33/53 , G01N31/00
CPC分类号： G01N33/6893 , G01N33/5035 , G01N33/5041 , G01N33/5082 , G01N33/566 , G01N33/574 , Y10T436/10
摘要： The method of the invention pertains to determining the signal transduction activity in a tissue section by immunohistochemistry techniques. The expression level of the receptor of interest is determined as well as the expression levels of one or more effector molecules of the receptor signal transduction pathway. Furthermore a combined ratio of expression levels of effector molecules in subcellular compartments with the receptor expression was found to have prognostic significance.
摘要翻译：本发明的方法涉及通过免疫组织化学技术测定组织切片中的信号转导活性。确定感兴趣受体的表达水平以及受体信号转导途径的一个或多个效应分子的表达水平。此外，发现亚细胞区室中效应分子与受体表达的表达水平的组合比具有预后意义。

14. 发明授权

US11347817B2 Optimized artificial intelligence search system and method for providing content in response to search queries 有权
公开(公告)号：US11347817B2
公开(公告)日：2022-05-31
申请号：US16748279
申请日：2020-01-21
申请人： Mark Gustavson , Garnet R. Chaney
发明人： Mark Gustavson , Garnet R. Chaney
IPC分类号： G06F16/9535 , G06F16/9538 , G06F16/907 , G06F16/957 , G06F16/9536
摘要： An optimized artificial intelligence search system for providing content in response to search queries, comprising: a computing device configured to allow a user to input search queries into a content extraction module that is in communication with an optimized search engine; an optimized search engine configured to receive search queries from the content extraction module and execute search queries to generate or render a list of search results to the content extraction module, and a database comprising templates associated with topics and the optimized search engine configured to interact with the database to choose templates in response to search queries, the content extraction module configured to highlight relevant content of web pages from the list of search results and display highlighted relevant content of web pages from the list of search results by filtering out irrelevant content on the computing device.

15. 发明申请

US20110081665A1 Methods for making cancer prognoses based on subcellular localization of biomarkers 审中-公开
标题翻译：基于生物标志物亚细胞定位的癌症预后的方法
公开(公告)号：US20110081665A1
公开(公告)日：2011-04-07
申请号：US12661141
申请日：2010-03-10
申请人： David L. Rimm , Gregory Tedeschi , Robert L. Camp , Mark Gustavson
发明人： David L. Rimm , Gregory Tedeschi , Robert L. Camp , Mark Gustavson
IPC分类号： G01N33/574 , G01N33/50
CPC分类号： G01N1/30 , G01N33/57419 , G01N33/57496 , G01N2333/91011 , G01N2800/52
摘要： This invention provides a method of making a prognosis for a patient afflicted with a type of cancer such as colon cancer, based upon quantification of biomarkers such as thymidylate synthase in subcellular compartments.
摘要翻译：本发明提供了一种基于对亚细胞区室中的胸苷酸合酶的生物标志物的定量，为患有诸如结肠癌类型的患者预后的方法。

16. 发明授权

US07709222B2 Methods for making cancer prognoses based on subcellular localization of biomarkers 有权
标题翻译：基于生物标志物亚细胞定位的癌症预后的方法
公开(公告)号：US07709222B2
公开(公告)日：2010-05-04
申请号：US11827694
申请日：2007-07-13
申请人： David L. Rimm , Gregory Tedeschi , Robert L. Camp , Mark Gustavson
发明人： David L. Rimm , Gregory Tedeschi , Robert L. Camp , Mark Gustavson
IPC分类号： C12Q1/48
CPC分类号： G01N1/30 , G01N33/57419 , G01N33/57496 , G01N2333/91011 , G01N2800/52
摘要： This invention provides a method of making a prognosis for a patient afflicted with a type of cancer such as colon cancer, based upon quantification of biomarkers such as thymidylate synthase in subcellular compartments.
摘要翻译：本发明提供了一种基于对亚细胞区室中的胸苷酸合酶的生物标志物的定量，为患有诸如结肠癌类型的患者预后的方法。

17. 发明授权

US12045300B2 Optimized artificial intelligence search system and method for providing content in response to search queries 有权
公开(公告)号：US12045300B2
公开(公告)日：2024-07-23
申请号：US17824358
申请日：2022-05-25
申请人： Mark Gustavson , Garnet R. Chaney
发明人： Mark Gustavson , Garnet R. Chaney
IPC分类号： G06F16/9538
CPC分类号： G06F16/9538
摘要： An optimized artificial intelligence search system may comprise a pinch zoomable 3D representation of an outline providing content in response to search queries. Search results may include a emoticon system using emotions to sentiment to further describe search results. A user interface may comprise means and methods of allowing a user to delete search results and then be presented with queries to indicate why the deleted results were not relevant to the user. Disclosed systems may further comprise a computing device configured to allow a user to input search queries into a content extraction module that is in communication with an optimized search engine; an optimized search engine configured to receive search queries from the content extraction module and execute search queries to generate or render a list of search results to the content extraction module.

18. 发明申请

US20080026415A1 Methods for making cancer prognoses based on subcellular localization of biomarkers 有权
标题翻译：基于生物标志物亚细胞定位的癌症预后的方法
公开(公告)号：US20080026415A1
公开(公告)日：2008-01-31
申请号：US11827694
申请日：2007-07-13
申请人： David Rimm , Gregory Tedeschi , Robert Camp , Mark Gustavson
发明人： David Rimm , Gregory Tedeschi , Robert Camp , Mark Gustavson
IPC分类号： C12Q1/48 , C12Q1/00 , G01N1/30
CPC分类号： G01N1/30 , G01N33/57419 , G01N33/57496 , G01N2333/91011 , G01N2800/52
摘要： This invention provides a method of making a prognosis for a patient afflicted with a type of cancer such as colon cancer, based upon quantification of biomarkers such as thymidylate synthase in subcellular compartments.
摘要翻译：本发明提供了一种基于对亚细胞区室中的胸苷酸合酶的生物标志物的定量，为患有诸如结肠癌类型的患者预后的方法。

19. 发明申请

US20220292156A1 OPTIMIZED ARTIFICIAL INTELLIGENCE SEARCH SYSTEM AND METHOD FOR PROVIDING CONTENT IN RESPONSE TO SEARCH QUERIES 有权
公开(公告)号：US20220292156A1
公开(公告)日：2022-09-15
申请号：US17824358
申请日：2022-05-25
申请人： Mark Gustavson , Garnet R. Chaney
发明人： Mark Gustavson , Garnet R. Chaney
IPC分类号： G06F16/9538
摘要： An optimized artificial intelligence search system may comprise a pinch zoomable 3D representation of an outline providing content in response to search queries. Search results may include a emoticon system using emotions to sentiment to further describe search results. A user interface may comprise means and methods of allowing a user to delete search results and then be presented with queries to indicate why the deleted results were not relevant to the user. Disclosed systems may further comprise a computing device configured to allow a user to input search queries into a content extraction module that is in communication with an optimized search engine; an optimized search engine configured to receive search queries from the content extraction module and execute search queries to generate or render a list of search results to the content extraction module.

20. 发明申请

US20200159798A1 OPTIMIZED ARTIFICIAL INTELLIGENCE SEARCH SYSTEM AND METHOD FOR PROVIDING CONTENT IN RESPONSE TO SEARCH QUERIES 审中-公开
公开(公告)号：US20200159798A1
公开(公告)日：2020-05-21
申请号：US16748279
申请日：2020-01-21
申请人： Mark Gustavson , Garnet R. Chaney , Jonathan Fried
发明人： Mark Gustavson , Garnet R. Chaney , Jonathan Fried
IPC分类号： G06F16/9535 , G06F16/9538 , G06F16/9536 , G06F16/957 , G06F16/907
摘要： An optimized artificial intelligence search system for providing content in response to search queries, comprising: a computing device configured to allow a user to input search queries into a content extraction module that is in communication with an optimized search engine; an optimized search engine configured to receive search queries from the content extraction module and execute search queries to generate or render a list of search results to the content extraction module, and a database comprising templates associated with topics and the optimized search engine configured to interact with the database to choose templates in response to search queries, the content extraction module configured to highlight relevant content of web pages from the list of search results and display highlighted relevant content of web pages from the list of search results by filtering out irrelevant content on the computing device.

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