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11. 发明申请

US20100267059A1 IMMUNODEFICIENCY SCREENING AT POINT OF CARE 审中-公开
标题翻译：保健点免疫屏蔽
公开(公告)号：US20100267059A1
公开(公告)日：2010-10-21
申请号：US12763865
申请日：2010-04-20
申请人： James W. Jacobson
发明人： James W. Jacobson
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2333/70514 , G01N2333/70517 , G01N2333/70596 , G01N2800/24 , G01N2800/38
摘要： Embodiments of the invention utilizes advanced detection methodologies as a cost-effective, efficient, ultra-sensitive rapid method for diagnosing severe combined immunodeficiency (SCID) in infants. In certain aspects, multiple markers of SCID are concurrently detected and measured to provide a more efficient, sensitive and accurate diagnosis of SCID.
摘要翻译：本发明的实施例利用先进的检测方法作为诊断婴儿严重联合免疫缺陷（SCID）的成本效益高，超灵敏的快速方法。在某些方面，SCID的多个标记物被同时检测和测量，以提供对SCID的更有效，灵敏和准确的诊断。

12. 发明授权

US4013219A Manually actuated, self-expiring, temporary override apparatus and method for thermostatic system 失效
标题翻译：手动启动，自动过载，临时超控装置和恒温系统的方法
公开(公告)号：US4013219A
公开(公告)日：1977-03-22
申请号：US666666
申请日：1976-03-15
申请人： James W. Jacobson
发明人： James W. Jacobson
IPC分类号： H01H43/02 , H01H37/62 , F23N5/20
CPC分类号： H01H43/022
摘要： A standard thermostat control unit, such as used in residential heating systems, is modified to include a manually actuated, electro-mechanical timer that includes a switch connected across the unit's thermostatically operated contacts, such that actuation of the timer produces a temporary, self-expiring, operating mode in which the normal thermostatic regulation of the furnace is overridden and the furnace is held "on" for the brief duration of the timer interval. The modified unit may be used in lieu of the standard unit as an energy and cost saving device in places such as in a vacant house, waiting to be sold or rented, with the unit preset at a minimum, thermostatically regulated temperature level. To briefly increase the temperature in the house to a comfort level, for such temporary occupancy as a realtor showing the house to prospective purchasers, the timer is manually actuated to commence a short timing interval, such as five minutes, during which the furnace is turned on and maintained so for the timing interval, and at the expiration thereof the unit automatically reverts to the energy saving, thermostatically regulated mode at the lower temperature.
摘要翻译：标准恒温控制单元（例如用于住宅供暖系统）被修改为包括手动致动的机电计时器，其包括连接在设备的恒温操作的触点上的开关，使得定时器的致动产生临时的，在炉子的正常恒温调节被覆盖并且炉子在定时器间隔的短暂持续时间内保持“接通”的过期操作模式。修改后的单元可以代替标准单元，作为能量和成本节约设备，在诸如空房子等待出售或租赁的地方，单元预设在最低温度调节温度水平。为了将房屋的温度简单地提高到一个舒适的水平，对于这样的临时占用，作为向预期购买者显示房屋的房地产经纪人，定时器被手动地启动以开始一个短的时间间隔，例如五分钟，在此期间炉转动在定时间隔内保持并保持，并且在其到期时，该单元在较低温度下自动恢复到节能，恒温调节模式。

13. 发明授权

US07795040B2 Methods, particles, and kits for determining activity of a kinase 失效
标题翻译：测定激酶活性的方法，粒子和试剂盒
公开(公告)号：US07795040B2
公开(公告)日：2010-09-14
申请号：US11736254
申请日：2007-04-17
申请人： James W. Jacobson , Ananda G. Lugade , Michaela R. Hoffmeyer
发明人： James W. Jacobson , Ananda G. Lugade , Michaela R. Hoffmeyer
IPC分类号： G01N33/543
CPC分类号： C12Q1/485
摘要： Methods, particles and kits for determining kinase activity within a sample are provided. An embodiment of a method includes exposing a fluorescent particle to an assay, wherein the fluorescent particle includes a support substrate having one or more fluorescent materials and a peptide substrate coupled to the support substrate via a functional group of the support substrate. The method further includes phosphorylating the peptide substrate during exposure of the fluorescent particle to the assay and processing the fluorescent particle such that the peptide substrate is dephosphorylated and a polarized double bond is generated at a dephosphorylated site. In addition, the method includes coupling a fluorescent reporter having a nucleophilic terminal group to the fluorescent particle via the polarized double bond.
摘要翻译：提供了用于确定样品中激酶活性的方法，颗粒和试剂盒。一种方法的实施方案包括将荧光颗粒暴露于测定中，其中荧光颗粒包括具有一种或多种荧光材料的支撑衬底和通过支撑衬底的官能团与支撑衬底耦合的肽底物。该方法还包括在将荧光颗粒暴露于测定期间磷酸化底物，并处理荧光颗粒，使得肽底物脱磷酸化，并在去磷酸化位点产生偏振双键。此外，该方法包括通过偏振双键将具有亲核末端基团的荧光报告物偶联到荧光颗粒上。

14. 发明授权

US07465540B2 Multiple reporter read-out for bioassays 有权
标题翻译：多位记者阅读生物检测
公开(公告)号：US07465540B2
公开(公告)日：2008-12-16
申请号：US09956857
申请日：2001-09-21
申请人： James W. Jacobson , Jennifer L. Burroughs , Kerry G. Oliver
发明人： James W. Jacobson , Jennifer L. Burroughs , Kerry G. Oliver
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： G01N33/54313 , C12Q1/6827 , Y02A50/59 , C12Q2565/501 , C12Q2563/107 , C12Q2537/143
摘要： A method for detecting a plurality of reactive sites on an analyte, comprising allowing reactants on an addressable microsphere and the reactive sites to react, forming reactant-reactive site pairs distinguishable by fluorescence intensity. The invention also provides a method for detecting a plurality of analytes in a sample using addressable microspheres in combination with one or more reporter reagents. Also provided are a method for determining allele zygosity of a genetic locus having two alleles or more alleles using microparticles, and a method for detecting a plurality of SNPs in nucleic acid molecules. The instant invention also provides a composition comprising an addressable microsphere carrying at least two fluorescent reactants capable of forming reactant-analyte pairs distinguishable by their fluorescence intensity, and kits comprising the inventive composition and a plurality of reporter reagents.
摘要翻译：一种用于检测分析物上的多个反应位点的方法，包括使可寻址微球上的反应物和反应位点反应，形成由荧光强度可区分的反应物反应性位点对。本发明还提供了一种使用可寻址的微球与一种或多种报道试剂组合来检测样品中多种分析物的方法。还提供了使用微粒来确定具有两个等位基因或更多等位基因的遗传基因座的等位基因接合度的方法，以及用于检测核酸分子中多个SNP的方法。本发明还提供一种组合物，其包含携带至少两种能够形成可通过其荧光强度区分的反应物 - 分析物对的荧光反应物的可寻址微球，以及包含本发明组合物和多种报道试剂的试剂盒。

15. 发明授权

US07455980B2 Method for characterizing autoimmune disorders 有权
标题翻译：表征自身免疫性疾病的方法
公开(公告)号：US07455980B2
公开(公告)日：2008-11-25
申请号：US11674365
申请日：2007-02-13
申请人： James P. Mapes , James W. Jacobson , Harold N. Baker , Michael D. Spain
发明人： James P. Mapes , James W. Jacobson , Harold N. Baker , Michael D. Spain
IPC分类号： G01N33/53
CPC分类号： G01N33/54313 , G01N33/564 , G01N2800/24 , Y10S435/973 , Y10S436/811
摘要： The invention relates to methods of characterizing autoimmune diseases by detecting and measuring at least one analyte using multiplexed assay systems. According to one embodiment, a target is detected and measured by different bead sets having different reactants. According to another approach the ratio of self-antigen to autoantibody is measured by exposing a sample suspected of containing self-antigen and autoantibody to a bead set associated with monoclonal antibody specific for the self-antigen and a bead set associated with the self-antigen.
摘要翻译：本发明涉及通过使用多重测定系统检测和测量至少一种分析物来表征自身免疫性疾病的方法。根据一个实施例，通过具有不同反应物的不同珠组检测和测量靶。根据另一种方法，通过将怀疑含有自身抗原和自身抗体的样品暴露于与自身抗原特异性的单克隆抗体相关联的珠粒组和与自身抗原相关的珠粒组来测量自身抗原与自身抗体的比例。

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