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11. 发明授权

US5792756A Prodrugs of phosphonates 失效
标题翻译：膦酸盐的前药
公开(公告)号：US5792756A
公开(公告)日：1998-08-11
申请号：US481715
申请日：1995-06-07
申请人： John E. Starrett, Jr. , Muzammil M. Mansuri , John C. Martin , David R. Tortolani , Joanne J. Bronson
发明人： John E. Starrett, Jr. , Muzammil M. Mansuri , John C. Martin , David R. Tortolani , Joanne J. Bronson
IPC分类号： A61K31/675 , A61K31/66 , A61K31/70 , A61P31/12 , A61P35/00 , C07F9/6512 , C07F9/6561 , C07F9/6571 , C07F9/6574 , C07F9/6584 , C07H13/10 , C07H19/10 , C07H19/20 , C07F9/02
CPC分类号： C07F9/65742 , C07F9/65121 , C07F9/65616 , C07F9/657181 , C07F9/6584
摘要： There are disclosed novel oral prodrugs of phosphonate nucleotide analogs which are hydrolyzable under physiological conditions to yield compounds which are useful as antiviral agents, especially as agents effective against RNA and DNA viruses. They may also find use as antitumor agents.
摘要翻译：公开了在生理条件下可水解的新型口服前药的膦酸酯核苷酸类似物，以产生可用作抗病毒剂的化合物，特别是作为对RNA和DNA病毒有效的试剂。它们也可以用作抗肿瘤剂。

12. 发明授权

US5738161A Roll up door 失效
标题翻译：卷起门
公开(公告)号：US5738161A
公开(公告)日：1998-04-14
申请号：US711205
申请日：1996-09-09
申请人： John C. Martin
发明人： John C. Martin
IPC分类号： E05F15/16 , E06B9/11 , E05D15/06
CPC分类号： E05F15/684 , E05Y2800/00 , E05Y2900/106 , E06B2009/1555
摘要： A roll up door which may be used in the back of a van body has a plurality of panels arranged edge-to-edge with a thin flexible sheet glued to the outside face of the panels and a flexible belt attached to each pair of adjacent panels at the rear face of these panels. A roller extends from each end of each panel and is received by a generally inverted L-shaped guide track. With this arrangement, the panels may cant while moving from the vertical to the horizontal leg of the guide channels by virtue of the belts which hinge and collapse allowing the outer sheet to bend as well.
摘要翻译：可以用于厢式车身后部的卷起门具有多个面板，其边缘到边缘布置有多个薄片，该薄板粘合到面板的外表面，并且柔性带附接到每对相邻面板在这些面板的后面。辊从每个面板的每个端部延伸并且被大致倒置的L形导轨容纳。利用这种布置，由于可以使外部片材弯曲的铰链和折叠的带子，这些面板可能会从引导通道的垂直方向移动到水平支腿而倾斜。

13. 发明授权

US5696265A Vinyl ethers of nucleoside analogs 失效
标题翻译：核苷类似物的乙烯基醚
公开(公告)号：US5696265A
公开(公告)日：1997-12-09
申请号：US488340
申请日：1995-06-07
申请人： Choung Un Kim , John C. Martin , Bing Uh Luh , Peter F. Misco
发明人： Choung Un Kim , John C. Martin , Bing Uh Luh , Peter F. Misco
IPC分类号： C07D239/54 , C07D405/04 , C07D473/00 , C07D473/32 , C07D473/40 , C07F9/6512 , C07F9/6558 , C07F9/6561 , C07F9/6571 , C07H19/04 , C07H19/10 , C07H19/20 , A61K31/52 , C07D473/18 , C07D473/34 , C07D473/30
CPC分类号： C07D239/54 , C07D405/04 , C07D473/00 , C07D473/32 , C07D473/40 , C07F9/65121 , C07F9/65586 , C07F9/65616 , C07F9/657181 , C07H19/04 , C07H19/10 , C07H19/20
摘要： Provided are compounds of the following formulae: A phosphonomethoxymethyoxymethyl purine/pyrimidine derivative of the formula ##STR1## wherein X and X' are the same or different and are hydrogen or alkyl. R and R' are the same or different and are hydrogen, alkyl, hydroxyalkyl or alkanoyl and B is a purine or pyrimidine base. A 4'-phosphonomethoxytetrahydrofuranyl-1'-purine-pyrimidine of the formula ##STR2## wherein X and X' are the same or different and are hydrogen or alkyl, Y and Z are the same or different and are hydrogen, hydroxyl or alkyl or Y+Z is an alkenyl, an epoxide or cyclopropyl, and B is a purine or pyrimidine base. A compound of the formula (V) ##STR3## wherein B is cytosine, 5-ethylcytosine, 5-methylcytosine, thymine, uracil, 5-chlorouracil, 5-bromouracil, 5-ethyluracil, 5-iodouracil, 5-propyluracil, 5-vinyluracil, hypoxanthine, xanthine, guanine, 8-bromoguanine, 8-chloroguanine, 8-methylguanine, 8-thioguanine, 3-deazaguanine, purine, 2-aminopurine, 2,6-diaminopurine, adenine, 3-deazaadenine, 8-aminoguanine, 8-hydrazinoguanine, 8-hydroxyguanine, or 2-acetamido-6-diphenylcarbamoylpurine; and the pharmaceutically acceptable salts thereof.
摘要翻译：本发明提供下式的化合物：下式的膦酰甲氧基甲氧基甲氧基甲基嘌呤/嘧啶衍生物，其中X和X'相同或不同，为氢或烷基。 R和R'相同或不同，为氢，烷基，羟基烷基或烷酰基，B为嘌呤或嘧啶碱基。其中X和X'相同或不同且为氢或烷基，Y和Z相同或不同，为氢，羟基或烷基的4'-膦基甲氧基四氢呋喃基-1'-嘌呤嘧啶， Y + Z是烯基，环氧化物或环丙基，B是嘌呤或嘧啶碱基。式（V）化合物其中B为胞嘧啶，5-乙基胞嘧啶，5-甲基胞嘧啶，胸腺嘧啶，尿嘧啶，5-氯尿嘧啶，5-溴尿嘧啶，5-乙基尿嘧啶，5-碘尿嘧啶，5-丙基尿嘧啶， 5-乙酰尿嘧啶，次黄嘌呤，黄嘌呤，鸟嘌呤，8-溴鸟嘌呤，8-氯鸟嘌呤，8-甲基鸟嘌呤，8-硫鸟嘌呤，3-脱氮鸟嘌呤，嘌呤，2-氨基嘌呤，2,6-二氨基嘌呤，腺嘌呤，3-脱氮腺嘌呤，8-氨基鸟嘌呤， 8-肼基鸟嘌呤，8-羟基鸟嘌呤或2-乙酰氨基-6-二苯基氨基甲酰基嘌呤; 及其药学上可接受的盐。

14. 发明授权

US5130421A Production of 2',3'-dideoxy-2',3'-didehydronucleosides 失效
标题翻译： 2'，3'-二脱氧-2'，3'-二脱氢核苷的生产
公开(公告)号：US5130421A
公开(公告)日：1992-07-14
申请号：US697512
申请日：1991-04-29
申请人： John E. Starrett, Jr. , Muzammil M. Mansuri , John C. Martin , Carl E. Fuller , Henry G. Howell
发明人： John E. Starrett, Jr. , Muzammil M. Mansuri , John C. Martin , Carl E. Fuller , Henry G. Howell
IPC分类号： C07D405/04 , C07H19/04
CPC分类号： C07D405/04 , C07H19/04
摘要： There are disclosed novel processes for producing 2',3'-dideoxy-2'3'-didehydronucleosides, for example, 2',3'-dideoxy-2',3'-didehydrothymidine in high yields and on a large scale. The compounds so-produced are useful as antiviral agents, especially as agents effective against the human immunodeficiency viruses (HIV).
摘要翻译：公开了以高产率和大规模生产2'，3'-二脱氧-2'3'-二脱氢核苷，例如2'，3'-二脱氧-2'，3'-二脱氢胸苷的新方法。如此制备的化合物可用作抗病毒剂，特别是作为有效抵抗人类免疫缺陷病毒（HIV）的药剂。

15. 发明授权

US5126506A 2',3'-Dideoxy-2'-fluoronucleosides 失效
标题翻译： 2'，3'-二脱氧-2'-氟核苷
公开(公告)号：US5126506A
公开(公告)日：1992-06-30
申请号：US581941
申请日：1990-09-13
申请人： Roman Z. Sterzycki , Muzammil M. Mansuri , John C. Martin
发明人： Roman Z. Sterzycki , Muzammil M. Mansuri , John C. Martin
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7056 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61P31/12 , C07H19/04 , C07H19/056 , C07H19/06 , C07H19/16 , C07H19/19
CPC分类号： C07H19/06 , C07H19/04 , Y02P20/55
摘要： There are disclosed novel 2',3'-dideoxy-2'-fluoronucleosides and 2'-3'-dideoxy-2',3'-didehydro-2'-fluoronucleosides and processes for their preparation. The compounds so produced exhibit therapeutically useful antiviral and, more particularly, anti-HIV effects.
摘要翻译：公开了新的2'，3'-二脱氧-2'-氟核苷和2'- 3'-二脱氧-2'，3'-二脱氢-2'-氟核苷及其制备方法。如此制备的化合物显示出治疗有用的抗病毒，更具体地，抗HIV作用。

16. 发明授权

US4704392A Tricyclic derivatives of substituted pyrimidines 失效
标题翻译：取代嘧啶的三环衍生物
公开(公告)号：US4704392A
公开(公告)日：1987-11-03
申请号：US851591
申请日：1986-04-14
申请人： Julien P. H. Verheyden , John C. Martin , G. V. Bindu Madhavan , Daniel P. C. McGee , Ernest J. Prisbe
发明人： Julien P. H. Verheyden , John C. Martin , G. V. Bindu Madhavan , Daniel P. C. McGee , Ernest J. Prisbe
IPC分类号： C07D239/54 , C07D239/553 , C07D473/00 , C07D473/34 , A61K31/42 , C07D239/80
CPC分类号： C07D239/54 , C07D239/553 , C07D473/00 , C07D473/34
摘要： Compounds useful as antiviral agents are depicted in the formula: ##STR1## wherein: X is oxygen or NH, Y is hydrogen, iodo, fluoro, methyl or trifluoromethyl, Z is hydrogen or fluoro and Z' is fluoro; and the wavy line indicates that the group may be above or below the plane of the ring; and the pharmaceutically acceptable acid addition salts thereof.
摘要翻译：用作抗病毒剂的化合物如下式所示：其中：X为氧或NH，Y为氢，碘，氟，甲基或三氟甲基，Z为氢或氟，Z'为氟; 并且波浪线表示该组可以在环的平面之上或之下; 及其药学上可接受的酸加成盐。

17. 发明授权

US4523898A Hydraulic wobble pumps 失效
标题翻译：液压摆动泵
公开(公告)号：US4523898A
公开(公告)日：1985-06-18
申请号：US569616
申请日：1984-01-10
申请人： Paul H. Martin , John C. Martin
发明人： Paul H. Martin , John C. Martin
IPC分类号： F04B1/12 , F04B1/14 , F01B31/00
CPC分类号： F04B1/128 , F04B1/145
摘要： An hydraulic wobble pump having an inlet passage extending inwardly from one end thereof through the central portion of said housing and opening into said wobble chamber. The inlet passage being arranged to admit hydraulic fluid to said wobble chamber substantially centrally between said cylinders so as to be substantially uniformly distributed to each cylinder in use.
摘要翻译：一种液压摆动泵，具有从其一端通过所述壳体的中心部分向内延伸并进入所述摆动室的入口通道。入口通道被布置成基本上在所述气缸之间的中心处将液压流体接纳到所述摆动室，以便在使用中基本均匀地分配到每个气缸。

18. 发明申请

US20130014826A1 Ultrasonic Analyte Concentration and Application in Flow Cytometry 有权
公开(公告)号：US20130014826A1
公开(公告)日：2013-01-17
申请号：US13618237
申请日：2012-09-14
申请人： Gregory Kaduchak , Greg Goddard , Gary Salzman , Dipen Sinha , John C. Martin , Christopher Kwiatkowski , Steven Graves
发明人： Gregory Kaduchak , Greg Goddard , Gary Salzman , Dipen Sinha , John C. Martin , Christopher Kwiatkowski , Steven Graves
IPC分类号： F17D3/00
CPC分类号： B01D21/28 , G01N15/1459 , G01N2001/4094 , G01N2015/1413 , G01N2015/142 , Y10T137/0324 , Y10T137/206
摘要： The present invention includes an apparatus and corresponding method for concentrating analytes within a fluid flowing through a tube using acoustic radiation pressure. The apparatus includes a function generator that outputs a radio frequency electrical signal to a transducer that transforms the radio frequency electric signal to an acoustic signal and couples the acoustic signal to the tube. The acoustic signal is converted within the tube to acoustic pressure that concentrates the analytes within the fluid.

19. 发明申请

US20100197430A1 PROJECTILE LAUNCHED MEDIA RESERVOIR 审中-公开
标题翻译：项目启动媒体储备
公开(公告)号：US20100197430A1
公开(公告)日：2010-08-05
申请号：US12705194
申请日：2010-02-12
申请人： John C. Martin
发明人： John C. Martin
IPC分类号： F42B6/08 , F42B12/40
CPC分类号： F42B6/08 , F41J3/0004 , F42B6/02 , F42B12/362 , F42B12/40
摘要： A projectile having a launching assembly attached thereto is provided for marking a remote location with a marking media. The marking media is preferably in the form of a paint ball or a scent ball. The launching assembly includes a media reservoir defining a cavity and a plurality of supports extending outward from the media reservoir along a longitudinal axis. The supports secure the marking media within the cavity in a press-fit connection. In one embodiment, a cap and a resilient nose cone are attached to the media reservoir, surrounding the marking media, to prevent damage to a target upon impacting the target.
摘要翻译：提供具有连接到其上的发射组件的射弹，用于用标记介质标记远程位置。标记介质优选为油漆球或气味球的形式。发射组件包括限定空腔的介质储存器和沿着纵向轴线从介质储存器向外延伸的多个支撑件。支撑件将压痕连接中的标记介质固定在空腔内。在一个实施例中，盖和弹性鼻锥连接到介质储存器，围绕标记介质，以防止在撞击目标时损坏目标物。

20. 外观设计

USD394153S Oil change reminder for key rings 失效
公开(公告)号：USD394153S
公开(公告)日：1998-05-12
申请号：US56180
申请日：1996-06-25
申请人： John C. Martin
设计人： John C. Martin

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