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11. 发明授权

US08500775B2 Protection device and method against embolization agent reflux 有权
标题翻译：栓塞剂回流保护装置及方法
公开(公告)号：US08500775B2
公开(公告)日：2013-08-06
申请号：US12829565
申请日：2010-07-02
申请人： James E. Chomas , Leonard Pinchuk , John Martin , Aravind Arepally
发明人： James E. Chomas , Leonard Pinchuk , John Martin , Aravind Arepally
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61B17/12172 , A61B17/12186 , A61F2002/018 , A61F2230/0006 , A61F2230/008
摘要： An apparatus is provided that is useful in an embolization procedure and enables substantially unrestricted forward flow of blood in a vessel and reduces or stops reflux (regurgitation or backward flow) of embolization agents which are introduced into the blood. A method of using the apparatus is also provided.
摘要翻译：提供了一种在栓塞过程中有用的装置，并且使血管中的血液能够基本上不受限制的向前流动并且减少或阻止引入血液中的栓塞剂的反流（反流或逆流）。还提供了使用该装置的方法。

12. 发明申请

US20130079731A1 Flow Directional Infusion Device 有权
标题翻译：流向定向灌注装置
公开(公告)号：US20130079731A1
公开(公告)日：2013-03-28
申请号：US13611080
申请日：2012-09-12
申请人： James E. Chomas , Norman R. Weldon , Leonard Pinchuk
发明人： James E. Chomas , Norman R. Weldon , Leonard Pinchuk
IPC分类号： A61M25/00
CPC分类号： A61M25/0043 , A61B17/12113 , A61B17/12186 , A61B2017/1205 , A61F2/01 , A61M25/0097 , A61M2039/2406 , A61M2039/2433 , A61M2205/75 , A61M2205/7545 , A61M2205/7554
摘要： A flow directional infusion device includes a filter valve located at the distal end of a catheter. The filter valve constrains delivery of an embolic agent through the catheter to the locus of the aneurysm. In order to provide such delivery, the valve includes a longitudinal opening, radial opening or is otherwise partially permeable in a direction of the aneurysm so that the embolic agent or a delivery element for such agent is limited toward the aneurysm. In addition, the filter valve permits and directs blood flow within the blood vessel about the aneurysm during the treatment without obstructing the vessel and without allowing retrograde flow of the embolic agent in the vessel upstream of the aneurysm.
摘要翻译：流动定向输注装置包括位于导管远端的过滤阀。过滤阀限制栓塞剂通过导管向动脉瘤的位置输送。为了提供这种输送，阀包括纵向开口，径向开口，或者在动脉瘤的方向上部分地是可渗透的，使得用于这种药剂的栓塞剂或递送元件限于动脉瘤。此外，过滤阀允许并引导在治疗期间在动脉瘤周围的血管内的血液流动，而不会阻塞血管，并且不允许栓塞剂在动脉瘤上游的血管中逆行流动。

13. 发明授权

US08177719B2 Contrast agent imaging with agent specific ultrasound detection 有权
标题翻译：对比剂成像与特异性超声检测
公开(公告)号：US08177719B2
公开(公告)日：2012-05-15
申请号：US11152521
申请日：2005-06-14
申请人： Ismayil M. Guracar , James E. Chomas , Patrick J. Phillips
发明人： Ismayil M. Guracar , James E. Chomas , Patrick J. Phillips
IPC分类号： A61B8/14
CPC分类号： A61B8/481 , A61B8/483
摘要： Highly specific measurements of flow in vessels, such as the coronary artery, can be obtained by processing cubic fundamental information. By showing flow in vessels with a high degree of contrast-to-tissue specificity, ultrasound based 3D contrast agent based coronary artery angiograms may be possible. Measurement and display of the velocity of agent from the cubic fundamental signal is provided simultaneously with display of cubic fundamental energy, such as providing a display map indexed by both energy and velocity. High pulse repetition frequency (PRF) for cubic fundamental detection in conjunction with long velocity measurement intervals may increase low velocity sensitivity and measurement precision. Pulsed wave (PW) Doppler may be improved by using a cubic fundamental sensitive pulse sequence. Using cubic fundamental sensitive techniques with other motion estimation techniques, such as two-dimensional velocity estimation or speckle tracking, may operate better than using other contrast agent detection techniques because of substantially reduced clutter.
摘要翻译：可以通过处理立方基本信息来获得容器中诸如冠状动脉之间的流动的高度特异性测量。通过显示具有高度对比组织特异性的血管中的流动，基于超声的基于3D造影剂的冠状动脉血管造影可能是可能的。与三次基本能量的显示同时提供来自三次基本信号的试剂速度的测量和显示，例如提供由能量和速度两者分度的显示图。结合长速度测量间隔的三次基波检测的高脉冲重复频率（PRF）可以提高低速度灵敏度和测量精度。脉冲波（PW）多普勒可以通过使用立方基本敏感脉冲序列来改善。使用三维基本敏感技术与其他运动估计技术（如二维速度估计或斑点跟踪）相比，使用其他造影剂检测技术的操作可能比实际上减少的杂波更好。

14. 发明申请

US20120089102A1 Microvalve Protection Device and Method of Use for Protection Against Embolization Agent Reflux 有权
标题翻译：微阀保护装置及其防止栓塞剂回流的使用方法
公开(公告)号：US20120089102A1
公开(公告)日：2012-04-12
申请号：US13280608
申请日：2011-10-25
申请人： James E. Chomas , Leonard Pinchuk , John Martin , Aravind Arepally , Brett E. Naglreiter , Norman R. Weldon , Bryan M. Pinchuk
发明人： James E. Chomas , Leonard Pinchuk , John Martin , Aravind Arepally , Brett E. Naglreiter , Norman R. Weldon , Bryan M. Pinchuk
IPC分类号： A61M25/00
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0076 , A61F2230/008 , A61M25/005 , A61M25/0075 , A61M2025/0004 , A61M2025/0042 , A61M2025/0076 , A61M2025/0681
摘要： An endovascular valve device for use in a vessel during a therapy procedure includes a catheter having at its distal end a valve. The valve is constructed of a braid of elongate first filaments coupled together at their proximal ends in a manner that the first filaments are movable relative to each other along their lengths. The first filaments have a spring bias that radially expands the valve. A filter is provided to the braid formed by electrostatically depositing or spinning polymeric second filaments onto the braided first filaments. The lumen of the catheter is in communication with the center of the valve.
摘要翻译：在治疗过程中在血管中使用的血管内瓣膜装置包括在其远端具有阀的导管。该阀由细长的第一丝的编织物构成，该编织物在其近端处以这样的方式联接在一起，使得第一细丝沿其长度相对于彼此可移动。第一个细丝具有径向扩张阀的弹簧偏压。向通过静电沉积或将聚合物第二长丝纺丝到编织的第一丝上形成的编织物提供过滤器。导管的内腔与阀的中心连通。

15. 发明授权

US08043219B2 Automated power level for contrast agent imaging 有权
标题翻译：造影剂成像自动功率水平
公开(公告)号：US08043219B2
公开(公告)日：2011-10-25
申请号：US10944072
申请日：2004-09-17
申请人： James E. Chomas
发明人： James E. Chomas
IPC分类号： A61B8/14
CPC分类号： A61B8/481 , A61B8/14
摘要： Automated determination and setting of an ultrasound system transmit power level is provided for contrast agent imaging. Low mechanical index imaging of contrast agents allows substantially continuous imaging of contrast agents without destruction. By comparing data associated with different transmit power levels and spatial locations, different delays between acquisition or different acquisition sequences, a contrast agent imaging transmit power generally minimizing destruction of contrast agents and maximizing signal-to-noise ratio is automatically determined. By using contrast agent specificity for setting the transmit power in addition or alternative to destruction of contrast agents, harmonic imaging may be improved.
摘要翻译：提供超声系统发射功率水平的自动确定和设置用于造影剂成像。造影剂的低机械指数成像允许对比剂的基本连续成像而不破坏。通过比较与不同发射功率电平和空间位置相关联的数据，可以自动确定采集或不同采集序列之间的不同延迟，通常最小化造影剂破坏和最大化信噪比的造影剂成像发射功率。通过使用造影剂特异性来设置发射功率或替代造影剂的破坏，可以提高谐波成像。

16. 发明申请

US20090082671A1 Contrast Agent Imaging With Agent Specific Ultrasound Detection 有权
公开(公告)号：US20090082671A1
公开(公告)日：2009-03-26
申请号：US12233940
申请日：2008-09-19
申请人： Ismayil M. Guracar , James E. Chomas , Patrick J. Phillips
发明人： Ismayil M. Guracar , James E. Chomas , Patrick J. Phillips
IPC分类号： A61B8/14
CPC分类号： A61B8/481 , A61B8/483
摘要： Highly specific measurements of flow in vessels, such as the coronary artery, can be obtained by processing cubic fundamental information. By showing flow in vessels with a high degree of contrast-to-tissue specificity, ultrasound based 3D contrast agent based coronary artery angiograms may be possible. Measurement and display of the velocity of agent from the cubic fundamental signal is provided simultaneously with display of cubic fundamental energy, such as providing a display map indexed by both energy and velocity. High pulse repetition frequency (PRF) for cubic fundamental detection in conjunction with long velocity measurement intervals may increase low velocity sensitivity and measurement precision. Pulsed wave (PW) Doppler may be improved by using a cubic fundamental sensitive pulse sequence. Using cubic fundamental sensitive techniques with other motion estimation techniques, such as two-dimensional velocity estimation or speckle tracking, may operate better than using other contrast agent detection techniques because of substantially reduced clutter.

17. 发明申请

US20090030316A1 IMAGE PLANE STABILIZATION FOR MEDICAL IMAGING 审中-公开
标题翻译：用于医学成像的图像平面稳定
公开(公告)号：US20090030316A1
公开(公告)日：2009-01-29
申请号：US12240153
申请日：2008-09-29
申请人： James E. Chomas , Kutay F. Ustuner , Thilaka S. Sumanaweera
发明人： James E. Chomas , Kutay F. Ustuner , Thilaka S. Sumanaweera
IPC分类号： A61B8/00
CPC分类号： A61B8/14 , A61B8/469 , A61B8/483 , A61B8/5276 , A61B8/5284 , A61B8/543 , G01S7/52077 , G01S7/52085 , G01S7/52088 , G01S15/8925 , G01S15/8979 , G01S15/8993
摘要： A medical imaging system automatically acquires two-dimensional images representing a user-defined region of interest despite motion. The plane of acquisition is updated or altered adaptively as a function of detected motion. The user-designated region of interest is then continually scanned due to the alteration in scan plane position. A multi-dimensional array is used to stabilize imaging of a region of interest in a three-dimensional volume. The user defines a region of interest for two-dimensional imaging. Motion is then detected. The position of a scan plane used to generate a subsequent two-dimensional image is then oriented as a function of the detected motion within the three-dimensional volume. By repeating the motion determination and adaptive alteration of the scan plane position, real time imaging of a same region of interest is provided while minimizing the region of interest fading into or out of the sequence of images.
摘要翻译：医疗成像系统自动获取表示用户定义的兴趣区域的二维图像，尽管运动。作为检测到的运动的函数，采集平面被自适应地更新或改变。然后由于扫描平面位置的变化，用户指定的感兴趣区域被连续地扫描。多维阵列用于稳定三维体积中感兴趣区域的成像。用户定义用于二维成像的感兴趣区域。然后检测到运动。然后将用于产生后续二维图像的扫描平面的位置定义为三维体积内检测到的运动的函数。通过重复扫描平面位置的运动确定和自适应改变，提供了相同感兴趣区域的实时成像，同时将感兴趣的区域最小化到图像序列中或退出图像序列。

18. 发明授权

US08518069B2 Dissection handpiece and method for reducing the appearance of cellulite 有权
公开(公告)号：US08518069B2
公开(公告)日：2013-08-27
申请号：US12787382
申请日：2010-05-25
申请人： Robert L. Clark, III , James E. Chomas , Adnan I. Merchant , Ben F. Brian, III
发明人： Robert L. Clark, III , James E. Chomas , Adnan I. Merchant , Ben F. Brian, III
IPC分类号： A61B17/32
CPC分类号： A61B17/32093 , A61B17/00 , A61B17/32 , A61B17/320016 , A61B17/32002 , A61B17/3201 , A61B18/1402 , A61B18/1477 , A61B18/18 , A61B18/20 , A61B2017/00119 , A61B2017/00747 , A61B2017/00761 , A61B2017/308 , A61B2017/320028 , A61B2017/32004 , A61B2017/320052 , A61B2017/320056 , A61B2017/32006 , A61B2017/3405 , A61B2017/3407 , A61B2018/0016 , A61B2018/00291 , A61B2018/00452 , A61B2018/00702 , A61B2018/00791 , A61B2018/00875 , A61B2018/143 , A61B2018/1432 , A61B2090/0811 , A61B2090/0815 , A61B2217/005 , A61B2217/007 , A61B2218/002 , A61H23/0245 , A61H2201/0207 , A61H2201/10 , A61H2201/105 , A61H2207/00 , A61N1/306 , A61N1/327 , A61N1/328 , A61N1/403 , A61N7/02 , A61N2007/0008
摘要： A dermatological skin treatment device is provided. The device comprises a handpiece and a cutting tool, wherein the tool is inserted through the conduit and percutaneously inserted into a tissue disposed within a recessed area of the handpiece. The device and method cut the fibrous structures under the skin that cause cellulite at an angle substantially parallel to the surface of the skin and replace these structures with a non-cellulite forming structure by deploying a highly fibrous mesh through a single needle hole to create a highly fibrous layer directly or through wound healing processes.

19. 发明申请

US20120165725A1 DISSECTION HANDPIECE WITH ASPIRATION MEANS FOR REDUCING THE APPEARANCE OF CELLULITE 有权
标题翻译：用于减少细胞膜外观的消除手段
公开(公告)号：US20120165725A1
公开(公告)日：2012-06-28
申请号：US12975966
申请日：2010-12-22
申请人： James E. Chomas , Adnan I. Merchant , Robert L. Clark, III , Ben F. Brian, III
发明人： James E. Chomas , Adnan I. Merchant , Robert L. Clark, III , Ben F. Brian, III
IPC分类号： A61M5/00
CPC分类号： A61M1/0039 , A61B17/00234 , A61B17/30 , A61B17/320016 , A61B17/320725 , A61B17/32075 , A61B18/14 , A61B2017/00747 , A61B2017/308 , A61B2018/0022 , A61B2018/00464 , A61B2018/00589 , A61B2018/00601 , A61B2018/1425 , A61B2018/1467 , A61B2217/005 , A61B2218/002 , A61B2218/007 , A61M1/008
摘要： A dermatological skin treatment device is provided. The device comprises a handpiece and a cutting tool, wherein the tool is inserted through the conduit and percutaneously inserted into a tissue disposed within a recessed area of the handpiece. The device and method cut the fibrous structures under the skin that cause cellulite at an angle substantially parallel to the surface of the skin and replace these structures with a non-cellulite forming structure by deploying a highly fibrous mesh through a single needle hole to create a highly fibrous layer directly or through wound healing processes. A tool is provided to aspirate excess fluid and tissue from the treatment area.
摘要翻译：提供皮肤病治疗装置。该装置包括一个手持件和一个切割工具，其中工具插入通过导管并经皮地插入设置在手持件的凹进区域内的组织中。该装置和方法切割皮肤下的纤维结构，其以基本上平行于皮肤表面的角度引起脂肪团，并通过将高度纤维状网状物通过单个针孔部署来形成非脂肪团形成结构来代替这些结构，以产生高度纤维层直接或通过伤口愈合过程。提供了一种工具，用于从治疗区域吸出多余的液体和组织。

20. 发明申请

US20110130657A1 Protection Device and Method Against Embolization Agent Reflux 有权
标题翻译：栓塞剂回流保护装置及方法
公开(公告)号：US20110130657A1
公开(公告)日：2011-06-02
申请号：US12829565
申请日：2010-07-02
申请人： James E. Chomas , Leonard Pinchuk , John Martin , Aravind Arepally
发明人： James E. Chomas , Leonard Pinchuk , John Martin , Aravind Arepally
IPC分类号： A61B17/22 , A61M25/14 , A61B6/00
CPC分类号： A61F2/013 , A61B17/12172 , A61B17/12186 , A61F2002/018 , A61F2230/0006 , A61F2230/008
摘要： An apparatus is provided that is useful in an embolization procedure and enables substantially unrestricted forward flow of blood in a vessel and reduces or stops reflux (regurgitation or backward flow) of embolization agents which are introduced into the blood. A method of using the apparatus is also provided.
摘要翻译：提供了一种在栓塞过程中有用的装置，并且使血管中的血液能够基本上不受限制的向前流动并且减少或阻止引入血液中的栓塞剂的回流（反流或逆流）。还提供了使用该装置的方法。

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