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11. 发明申请

US20120141526A1 Nanoemulsion vaccines 审中-公开
标题翻译：纳米乳剂疫苗
公开(公告)号：US20120141526A1
公开(公告)日：2012-06-07
申请号：US11929275
申请日：2007-10-30
申请人： James R. Baker , Anna Bielinska , Andrzej Myc
发明人： James R. Baker , Anna Bielinska , Andrzej Myc
IPC分类号： A61K39/21 , A61K39/12 , A61K39/02 , A61K39/07 , A61K39/145 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/16 , A61P31/18 , A61K39/00 , A61P37/04 , B82Y5/00
CPC分类号： A61K39/39 , A01N25/04 , A61K9/0043 , A61K9/1075 , A61K39/07 , A61K2039/521 , A61K2039/55566 , C12N2760/16134 , Y02A50/394 , Y02A50/403 , Y02A50/469 , Y02A50/489
摘要： The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides methods and compositions for the use of nanoemulsion compounds as mucosal adjuvants to induce immunity against environmental pathogens. Accordingly, in some embodiments, the present invention provides nanoemulsion vaccines comprising a nanoemulsion and an inactivated pathogen or protein derived from the pathogen. The present invention thus provides improved vaccines against a variety of environmental and human-released pathogens.
摘要翻译：本发明提供了用于刺激免疫应答的方法和组合物。具体地，本发明提供了使用纳米乳液化合物作为粘膜佐剂以诱导对环境病原体免疫的方法和组合物。因此，在一些实施方案中，本发明提供了包含纳米乳剂和衍生自病原体的灭活病原体或蛋白质的纳米乳剂疫苗。因此，本发明提供了针对各种环境和人释放的病原体的改进的疫苗。

12. 发明申请

US20110200657A1 METHODS OF USING NANOEMULSION COMPOSITIONS HAVING ANTI-INFLAMMATORY ACTIVITY 审中-公开
标题翻译：使用具有抗炎活性的纳米组合物的方法
公开(公告)号：US20110200657A1
公开(公告)日：2011-08-18
申请号：US13096836
申请日：2011-04-28
申请人： James R. Baker
发明人： James R. Baker
IPC分类号： A61K9/107 , A01N25/00 , A01P3/00 , A01P1/00 , A61P31/00 , A61P33/00 , A61P29/00 , B82Y5/00
CPC分类号： A61K9/1075 , A61K31/573
摘要： Nanoemulsion compositions with low toxicity that demonstrate broad spectrum inactivation of microorganisms or prevention of diseases are described. The nanoemulsions contain an aqueous phase, an oil phase comprising an oil and an organic solvent, at least one anti-inflammatory agent, and one or more surfactants. Methods of making nanoemulsions and inactivating pathogenic microorganisms are also provided.
摘要翻译：描述了显示出微生物的广谱灭活或预防疾病的低毒性的纳米乳剂组合物。纳米乳剂含有水相，包含油和有机溶剂的油相，至少一种抗炎剂和一种或多种表面活性剂。还提供了制备纳米乳剂和灭活病原微生物的方法。

13. 发明申请

US20080292555A1 Quantitative Two-Photon Flow Cytometry 有权
标题翻译：定量双光子流式细胞术
公开(公告)号：US20080292555A1
公开(公告)日：2008-11-27
申请号：US11662835
申请日：2005-09-16
申请人： Jing Yong Ye , Theodore B. Norris , Cheng F. Zhong , James R. Baker
发明人： Jing Yong Ye , Theodore B. Norris , Cheng F. Zhong , James R. Baker
IPC分类号： A61K49/00 , C12Q1/02 , A61B5/00
CPC分类号： G01N15/1459 , G01N15/1404 , G01N15/1484 , G01N2015/1075 , G01N2015/145 , G01N2015/1472 , G01N2015/1493
摘要： A method and apparatus of multi-dye analysis of particles using flow cytometer. The method includes dying particles to be detected using two or more dyes; urging the particles through a capillary in a non-uniform flow; exciting a first of the particles within the capillary using a multiphoton excitation laser beam causing the two or more dyes each to fluoresce thereby producing a first output signal and a second output signal respectively; and detecting the first output signal and the second output signal. A second of the particles within the capillary being excited using the multiphoton excitation laser beam causing the two or more dyes each to fluoresce thereby producing a third output signal and a forth output signal respectively. The method finally includes comparing a ratio of the first output signal and the second output signal to a ratio of the third output signal and the forth output signal to detect a desired change in the particles.
摘要翻译：使用流式细胞仪对颗粒进行多染色分析的方法和装置。该方法包括使用两种或更多种染料染色待检测的颗粒; 以不均匀的流动促使颗粒通过毛细管; 使用多光子激发激光束激发毛细管内的第一颗粒，使得两种或更多种染料各自发荧光，从而分别产生第一输出信号和第二输出信号; 以及检测第一输出信号和第二输出信号。使用多光子激发激光束激发毛细管内的第二颗粒，使得两种或更多种染料各自发出荧光，从而分别产生第三输出信号和第四输出信号。该方法最后包括将第一输出信号和第二输出信号的比率与第三输出信号和第四输出信号的比率进行比较，以检测颗粒中期望的变化。

14. 发明申请

US20080254777A1 SYSTEMS AND METHODS FOR FACILITATING AUTOMATIC GENERATION OF METADATA ABOUT DATA THAT IS COLLECTED BY A MOBILE DEVICE 审中-公开
标题翻译：关于移动设备收集的关于数据的自动生成的系统和方法
公开(公告)号：US20080254777A1
公开(公告)日：2008-10-16
申请号：US11733653
申请日：2007-04-10
申请人： Kenneth A. Arneson , Sy Prestwich , James R. Baker
发明人： Kenneth A. Arneson , Sy Prestwich , James R. Baker
IPC分类号： H04M3/42
CPC分类号： H04N1/00307 , H04M1/72572 , H04N2201/3205 , H04N2201/3214 , H04N2201/3215 , H04N2201/3233 , H04N2201/3253
摘要： A mobile device that facilitates automatic generation of metadata about data that is collected by the mobile device may include a processor and memory in electronic communication with the processor. Instructions may be stored in the memory. The instructions may be executable to collect data and to create an identifier that corresponds to the data that is collected. The instructions may also be executable to transmit a wireless communication signal that comprises the identifier. Transmitting the wireless communication signal may facilitate communication of the identifier to a location and telemetry system and may facilitate determination of metadata about the data by the location and telemetry system.
摘要翻译：促进关于由移动设备收集的数据的元数据的自动生成的移动设备可以包括与处理器电子通信的处理器和存储器。指令可能存储在存储器中。该指令可以执行以收集数据并创建与所收集的数据相对应的标识符。所述指令还可以被执行以发送包括所述标识符的无线通信信号。发送无线通信信号可以促进标识符到位置和遥测系统的通信，并且可以有助于通过位置和遥测系统确定关于数据的元数据。

15. 发明申请

US20080181949A1 Nanoemulsion Vaccines 审中-公开
公开(公告)号：US20080181949A1
公开(公告)日：2008-07-31
申请号：US11929295
申请日：2007-10-30
申请人： James R. Baker , Anna Bielinska , Andrzej Myc
发明人： James R. Baker , Anna Bielinska , Andrzej Myc
IPC分类号： A61K9/14 , A61P37/00 , A61K39/00
CPC分类号： A61K39/39 , A01N25/04 , A61K9/0043 , A61K9/1075 , A61K39/07 , A61K2039/521 , A61K2039/55566 , C12N2760/16134 , Y02A50/394 , Y02A50/403 , Y02A50/469 , Y02A50/489
摘要： The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides methods and compositions for the use of nanoemulsion compounds as mucosal adjuvants to induce immunity against environmental pathogens. Accordingly, in some embodiments, the present invention provides nanoemulsion vaccines comprising a nanoemulsion and an inactivated pathogen or protein derived from the pathogen. The present invention thus provides improved vaccines against a variety of environmental and human-released pathogens.

16. 发明申请

US20130168536A1 PHOTONIC CRYSTAL-METALLIC STRUCTURES AND APPLICATIONS 有权
标题翻译：光子晶体金属结构与应用
公开(公告)号：US20130168536A1
公开(公告)日：2013-07-04
申请号：US13700378
申请日：2011-05-26
申请人： Yunbo Guo , Theodore B. Norris , James R. Baker , Lingjie Jay Guo , Nils G. Walter
发明人： Yunbo Guo , Theodore B. Norris , James R. Baker , Lingjie Jay Guo , Nils G. Walter
IPC分类号： G02B5/00
CPC分类号： G02B5/008 , B82Y20/00 , G02B1/005 , Y10S977/70
摘要： A photonic crystal-metallic (PCM) structure receives an input light signal from a light source. The PCM structure includes a metal structure and a photonic crystal structure disposed adjacent the metal structure. The photonic crystal structure is configured to receive the input light signal such that the input light signal excites surface plasmons of the metallic structure and such that the input light signal is internally reflected within the photonic crystal structure.
摘要翻译：光子晶体金属（PCM）结构接收来自光源的输入光信号。 PCM结构包括邻近金属结构设置的金属结构和光子晶体结构。光子晶体结构被配置为接收输入光信号，使得输入光信号激发金属结构的表面等离子体，并且使得输入光信号在光子晶体结构内部被反射。

17. 发明申请

US20080254066A1 Nanoemulsion Vaccines 审中-公开
公开(公告)号：US20080254066A1
公开(公告)日：2008-10-16
申请号：US11966770
申请日：2007-12-28
申请人： James R. Baker , Tarek Hamouda
发明人： James R. Baker , Tarek Hamouda
IPC分类号： A61K39/00 , A61P37/00
CPC分类号： A61K39/39 , A01N25/04 , A61K9/0043 , A61K9/1075 , A61K39/07 , A61K2039/521 , A61K2039/55566 , C12N2760/16134 , Y02A50/394 , Y02A50/403 , Y02A50/469 , Y02A50/489
摘要： The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides methods and compositions for the use of nanoemulsion compounds as mucosal adjuvants to induce immunity against environmental pathogens. Accordingly, in some embodiments, the present invention provides nanoemulsion vaccines comprising a nanoemulsion and an inactivated pathogen or protein derived from the pathogen. The present invention thus provides improved vaccines against a variety of environmental and human-released pathogens.

18. 发明申请

US20080225293A1 Photonic crystal sensor 失效
标题翻译：光子晶体传感器
公开(公告)号：US20080225293A1
公开(公告)日：2008-09-18
申请号：US11881040
申请日：2007-07-25
申请人： Jing Yong Ye , Yunbo Guo , Theodore B. Norris , James R. Baker
发明人： Jing Yong Ye , Yunbo Guo , Theodore B. Norris , James R. Baker
IPC分类号： G01J4/00 , G01N21/41
CPC分类号： G01N21/648 , B82Y20/00 , G01N21/6408 , G01N21/7743 , G02B1/005
摘要： A photonic crystal sensor for outputting an output signal using a light source. The photonic crystal sensor includes a photonic crystal structure and a defect member disposed adjacent the photonic crystal structure. The defect member defines an operative surface. An input light signal from the light source is inputted to the photonic crystal structure and defect member and is internally reflected to thereby output the output signal. Also, the output signal relates to a condition at the operative surface.
摘要翻译：一种用于使用光源输出输出信号的光子晶体传感器。光子晶体传感器包括光子晶体结构和邻近光子晶体结构设置的缺陷部件。缺陷构件限定了操作表面。来自光源的输入光信号被输入到光子晶体结构和缺陷部件，并被内反射，从而输出输出信号。另外，输出信号与操作面的状态有关。

19. 发明授权

US06459024B1 Structural torsion brace for an acoustic musical instrument 失效
标题翻译：声乐乐器的结构扭力支架
公开(公告)号：US06459024B1
公开(公告)日：2002-10-01
申请号：US08933542
申请日：1997-09-19
申请人： James R. Baker
发明人： James R. Baker
IPC分类号： G10D300
CPC分类号： G10D3/02
摘要： An acoustic instrument is provided with a torsion brace which contacts the upper and lower plates in only three locations. The first location is at the head of the body, the second is at the heel of the body, and the third is where the bridge connects to the upper plate. This arrangement provides structural support to the guitar body because it braces the head and heel of the body and also supports the upper plate where the bridge is attached. However, because the brace contacts the plates at its neck and heel and at the bridge the plates may vibrate freely. This structure has been shown to resist feedback, yet does not dampen the vibration of the plates. As a result, the sound, projection, and sustain of the guitar are not adversely affected.
摘要翻译：声学仪器设置有扭力支架，其仅在三个位置接触上板和下板。第一个位置在身体的头部，第二个位于身体的后跟，第三个是桥连接到上板的位置。这种布置为吉他身体提供结构支撑，因为它支撑身体的头部和脚跟，并且还支撑连接桥的上板。然而，由于支架在其颈部和脚跟处以及桥接处接触板，所以板可以自由地振动。已经显示出这种结构抵抗反馈，但不会抑制板的振动。结果，吉他的声音，投影和持续不会受到不利影响。

20. 发明授权

US07969348B2 Systems and methods for obtaining and using data from a localized location and telemetry system in a wide area location and telemetry system 有权
标题翻译：用于在广域位置和遥测系统中获取和使用来自本地化位置和遥测系统的数据的系统和方法
公开(公告)号：US07969348B2
公开(公告)日：2011-06-28
申请号：US11934629
申请日：2007-11-02
申请人： James R. Baker , Sy Prestwich , Scott Bevan
发明人： James R. Baker , Sy Prestwich , Scott Bevan
IPC分类号： G01S13/74 , G01S13/75
CPC分类号： H04Q9/00 , G01S5/0009 , G01S5/0263 , G06Q10/08 , H04Q2209/43 , H04Q2209/47
摘要： A wide area location and telemetry system may include a wide area location and telemetry system server that is configured to determine wide area location and telemetry system data about an object when the object is located within the coverage area of the wide area location and telemetry system. The wide area location and telemetry system server may also be configured to receive localized location and telemetry system data about the object when the object is located within the coverage area of a localized location and telemetry system. The wide area location and telemetry system may also include a database and a database manager. The database manager may be configured to store the wide area location and telemetry system data and the localized location and telemetry system data in the database.
摘要翻译：广域位置和遥测系统可以包括广域位置和遥测系统服务器，其被配置为当对象位于广域位置和遥测系统的覆盖区域内时，确定关于对象的广域位置和遥测系统数据。广域位置和遥测系统服务器还可以被配置为当对象位于本地化位置和遥测系统的覆盖区域内时接收关于对象的本地化位置和遥测系统数据。广域位置和遥测系统还可以包括数据库和数据库管理器。数据库管理器可以被配置为将广域位置和遥测系统数据以及本地化位置和遥测系统数据存储在数据库中。

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