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11. 发明授权

US08222024B2 Apparatus and methods for analyte measurement and immunoassay 有权
标题翻译：用于分析物测量和免疫测定的装置和方法
公开(公告)号：US08222024B2
公开(公告)日：2012-07-17
申请号：US13198253
申请日：2011-08-04
申请人： Graham Davis , Imants Lauks , Chao Lin , Cary James Miller
发明人： Graham Davis , Imants Lauks , Chao Lin , Cary James Miller
IPC分类号： C12M3/00
CPC分类号： G01N33/543 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L2200/10 , B01L2300/0663 , B01L2300/0816 , B01L2300/087 , B01L2400/0421 , B01L2400/046 , B01L2400/0481 , B01L2400/0683 , G01N33/54366 , G01N35/08 , G01N2035/0436
摘要： The present invention relates to an apparatus for conducting a variety of assays for the determination of analytes in liquid samples, and relates to the methods for such assays. In particular, the invention relates to a single-use cartridge designed to be adaptable to a variety of real-time assay protocols, preferably assays for the determination of analytes in biological samples using immunosensors or other ligand/ligand receptor-based biosensor embodiments. The cartridge provides novel features for processing a metered portion of a sample, for precise and flexible control of the movement of a sample or second fluid within the cartridge, for the amending of solutions with additional compounds during an assay, and for the construction of immunosensors capable of adaptation to diverse analyte measurements. The disclosed device and methods of use enjoy substantial benefits over the prior art, including simplicity of use by an operator, rapid in situ determinations of one or more analytes, and single-use methodology that minimizes the risk of contamination of both operator and patient. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.
摘要翻译：本发明涉及一种用于进行各种测定液体样品中分析物测定的装置，并涉及这种测定方法。特别地，本发明涉及一种设计成能够适用于各种实时测定方案的单次使用的盒，优选使用免疫传感器或其他基于配体/配体受体的生物传感器实施方案来测定生物样品中分析物的测定。该盒提供用于处理样品的计量部分的新颖特征，用于精确和灵活地控制盒内样品或第二流体的运动，用于在测定过程中用附加化合物修饰溶液以及用于构建免疫传感器能够适应不同的分析物测量。所公开的装置和使用方法相对于现有技术具有实质性的益处，包括操作者的简单使用，一种或多种分析物的快速原位测定，以及使操作者和患者的污染风险最小化的一次性方法。所公开的发明适用于临床诊断领域，包括在事故现场，急诊室，手术室，疗养院，重症监护室和非医疗环境中的使用。

12. 发明申请

US20050150761A1 Electrode module 有权
标题翻译：电极模块
公开(公告)号：US20050150761A1
公开(公告)日：2005-07-14
申请号：US11041453
申请日：2005-01-25
申请人： Imants Lauks
发明人： Imants Lauks
IPC分类号： G01N27/27 , G01N27/30 , G01N27/327 , G01N27/403 , G01N27/414 , G01N27/447 , G01N27/26
CPC分类号： G01N27/307 , G01N27/403 , H01L2224/48091 , H01L2924/3011 , H01L2924/00014 , H01L2924/00
摘要： A chip-carrier module known from smart card technology is adapted as an electrode array for use in disposable sensing or separation devices containing electrodes. The electrodes are manufactured directly onto chip-carrier module. The preferred electrode module includes a chip-carrier module and at least one electrode formed thereon, the chip-carrier module being a laminate of a metal foil and an insulator foil, which metal foil is divided into at least two conductor regions, the insulator foil having a perforation over each conductor region, and the at least one electrode being formed by a membrane layer applied to the insulating foil to extend through one of the perforations for electrical contact with the conductor region associated therewith, the membrane layer imparting chemical sensitivity to the electrode. The result is an electrode module for use in disposable sensing or separation devices containing electrodes, whose unit cost of manufacture is low even at modest manufacturing volume.
摘要翻译：从智能卡技术已知的芯片载体模块被适配为用于包含电极的一次性感测或分离装置中的电极阵列。电极直接制造到芯片载体模块上。优选的电极模块包括芯片载体模块和形成在其上的至少一个电极，芯片载体模块是金属箔和绝缘体箔的叠层，该金属箔被分成至少两个导体区域，绝缘体箔在每个导体区域上具有穿孔，并且所述至少一个电极由施加到绝缘箔上的膜层形成，以延伸通过其中一个穿孔以与与其相关联的导体区域电接触，所述膜层对化学敏感性电极。结果是用于包含电极的一次性感测或分离装置的电极模块，即使在适度的制造体积下，制造的单位成本也低。

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