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11. 发明申请

US20060194844A1 2-Acylaminothiazole derivative or salt thereof 失效
标题翻译： 2-酰基氨基噻唑衍生物或其盐
公开(公告)号：US20060194844A1
公开(公告)日：2006-08-31
申请号：US10564520
申请日：2004-07-15
申请人： Keizo Sugasawa , Yuji Koga , Kazuyoshi Obitsu , Takao Okuda , Koichiro Harada , Hideki Kubota , Fukushi Hirayama , Masaki Abe , Ken-ichi Suzuki
发明人： Keizo Sugasawa , Yuji Koga , Kazuyoshi Obitsu , Takao Okuda , Koichiro Harada , Hideki Kubota , Fukushi Hirayama , Masaki Abe , Ken-ichi Suzuki
IPC分类号： C07D417/02 , A61K31/4439 , A61K31/426
CPC分类号： C07D417/14 , C07D417/04
摘要： 2-Acylaminothiazole derivatives or salts thereof which have a platelet increasing activity based on an excellent human c-mpl-Ba/F3 cell growth function and a function of accelerating formation of megakaryocytic colonies and which are useful for treating thrombocytopenia are provided.
摘要翻译：提供了基于优异的人c-mpl-Ba / F3细胞生长功能具有血小板增加活性的2-酰基氨基噻唑衍生物或其盐，并且具有促进巨核细胞集落形成并且可用于治疗血小板减少症的功能。

12. 发明授权

US4165344A Cyclopentadiene resin and isocyanate cured epoxy resin compositions 失效
标题翻译：环戊二烯树脂和异氰酸酯固化的环氧树脂组合物
公开(公告)号：US4165344A
公开(公告)日：1979-08-21
申请号：US795370
申请日：1977-05-09
申请人： Takao Okuda , Akira Wada
发明人： Takao Okuda , Akira Wada
IPC分类号： C08G18/00 , C08G18/58 , C08G18/62 , C08G18/67 , C08G18/69 , C08G59/40 , C08G59/64 , C08L63/00 , C09D163/00 , C09D175/00
CPC分类号： C08L63/00 , C08G18/58 , C08G18/584 , C08G18/6204 , C08G18/6705 , C08G59/4028 , C08G59/64 , C09D163/00
摘要： An epoxy resin composition comprising (a) a cyclopentadiene-type hydrocarbon resin having a hydroxyl value of 100 to 300 obtained by copolymerizing a cyclopentadiene-type monomer and a hydroxyl-containing monolefinic monomer at elevated temperatures, (b) a polyol selected from the group consisting of epoxy resins containing at least two hydroxyl groups in the molecule and epoxy resin derivatives containing at least two hydroxyl groups in the molecule and obtained by the reaction of epoxy resins with alkanolamines, and (c) an isocyanate-type curing agent. The compositions have improved low temperature curability, acid resistance and water resistance while retaining the various desirable properties of epoxy resins such as chemical resistance and oil resistance, and which when used as paints, exhibit improved adhesion to an adherend and improved re-coating adhesion to the film formed thereon.
摘要翻译：一种环氧树脂组合物，其包含（a）通过在升高的温度下使环戊二烯型单体和含羟基的单烯属单体共聚获得的羟值为100〜300的环戊二烯型烃树脂，（b）选自由分子中含有至少两个羟基的环氧树脂和分子中含有至少两个羟基并通过环氧树脂与链烷醇胺的反应获得的环氧树脂衍生物和（c）异氰酸酯型固化剂组成。该组合物具有改善的低温固化性，耐酸性和耐水性，同时保持环氧树脂的各种所需性能如耐化学性和耐油性，并且当用作涂料时，显示出对被粘物的改善的粘附性和改善的涂覆粘附性在其上形成膜。

13. 发明授权

US08144991B2 Apparatus, method, and computer program for processing information 有权
标题翻译：用于处理信息的装置，方法和计算机程序
公开(公告)号：US08144991B2
公开(公告)日：2012-03-27
申请号：US11240512
申请日：2005-10-03
申请人： Tatsuo Nagamatsu , Kunitoshi Shimizu , Tsutomu Teranishi , Takao Okuda , Hiroshi Kawaguchi , Atsushi Mitsuzawa
发明人： Tatsuo Nagamatsu , Kunitoshi Shimizu , Tsutomu Teranishi , Takao Okuda , Hiroshi Kawaguchi , Atsushi Mitsuzawa
IPC分类号： G06K9/46
CPC分类号： H04H60/48 , G06K9/00711
摘要： An information processing apparatus includes a selecting unit for selecting extraction information concerning contents to be extracted from among a plurality of contents organized in time sequence, the extraction information prepared on a per content basis for the contents to be extracted and including a feature contained in the content to be extracted, and an extraction range that is represented with respect to the position of the feature, a detecting unit for detecting, from the contents, the same feature as the feature contained in the extraction information selected by the selecting unit, and an extracting unit for extracting a predetermined content in accordance with the extraction range contained in the extraction information selected by the selecting unit if the detecting unit detects the same feature as the feature contained in the extraction information.
摘要翻译：一种信息处理装置，包括：选择单元，用于从按时间顺序组织的多个内容中选择关于要提取的内容的提取信息;对于要提取的内容，以每个内容为基础准备的提取信息，并且包括在要提取的内容以及关于特征位置表示的提取范围，检测单元，用于从内容中检测与由选择单元选择的提取信息中包含的特征相同的特征，以及提取单元，用于如果检测单元检测到与提取信息中包含的特征相同的特征，则根据由选择单元选择的提取信息中包含的提取范围来提取预定内容。

14. 发明申请

US20090197834A1 QUINOLONE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF 失效
标题翻译：喹诺酮衍生物或药物可接受的盐
公开(公告)号：US20090197834A1
公开(公告)日：2009-08-06
申请号：US12293055
申请日：2007-03-14
申请人： Yuji Koga , Takao Okuda , Susumu Watanuki , Takashi Kamikubo , Fukushi Hirayama , Hiroyuki Moritomo , Jiro Fujiyasu , Michihito Kageyama , Toshio Uemura , Jun Takasaki
发明人： Yuji Koga , Takao Okuda , Susumu Watanuki , Takashi Kamikubo , Fukushi Hirayama , Hiroyuki Moritomo , Jiro Fujiyasu , Michihito Kageyama , Toshio Uemura , Jun Takasaki
IPC分类号： A61K31/675 , C07D215/22 , A61K31/47 , C07F9/60
CPC分类号： C07D513/04 , C07D215/22 , C07D215/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/14 , C07D487/04 , C07F7/1804 , C07F9/60
摘要： [Problem] To provide a compound having excellent platelet aggregation inhibitory activity.[Means for Resolution] It was found that quinolone derivatives characterized in that these have lower alkyl, cycloalkyl or the like at the 1-position; —N(R0)C(O)-lower alkylene-CO2R0, lower alkylene-CO2R0, lower alkenylene-CO2R0, —O-lower alkylene-CO2R0, —O-(lower alkylene which may be substituted with —CO2R0)-aryl or —O-lower alkenylene-CO2R0 (wherein R0 is H or lower alkyl) at the 3-position; halogen at the 6-position; and amino group substituted with a substituent group having a ring structure at the 7-position, respectively, or pharmaceutically acceptable salts thereof, has excellent P2Y12 inhibitory activity. In addition, it was confirmed that these quinolone derivatives also have excellent platelet aggregation inhibitory activity. Based on the above, these quinolone derivatives or pharmaceutically acceptable salts thereof are useful as platelet aggregation inhibitors.
摘要翻译：提供具有优异血小板聚集抑制活性的化合物。 [解决方法]发现喹诺酮衍生物的特征在于它们在1-位具有低级烷基，环烷基等; -N（R 0）C（O） - 低级亚烷基-CO 2 R 0，低级亚烷基-CO 2 R 0，低级亚烯基-CO 2 R O，-O-低级亚烷基-CO 2 R O，-O-（可被-CO 2 R 0取代的低级亚烷基） - 芳基或 O-低级亚烯基-CO 2 R 0（其中R 0是H或低级烷基）在3-位; 6位卤素; 分别被具有7位具有环结构的取代基取代的氨基或其药学上可接受的盐具有优异的P2Y12抑制活性。此外，证实这些喹诺酮衍生物也具有优异的血小板聚集抑制活性。基于上述，这些喹诺酮衍生物或其药学上可接受的盐可用作血小板聚集抑制剂。

15. 发明授权

US4119596A Thermosetting coating compositions 失效
标题翻译：热固性涂料组合物
公开(公告)号：US4119596A
公开(公告)日：1978-10-10
申请号：US795369
申请日：1977-05-09
申请人： Takao Okuda , Akira Wada
发明人： Takao Okuda , Akira Wada
IPC分类号： C09D7/00 , C08L33/00 , C08L33/02 , C08L67/00 , C08L67/08 , C09D133/04 , C09D161/20 , C09D167/00 , C09D167/08 , C08L91/00 , C08L61/24 , C08L61/28
CPC分类号： C09D167/08
摘要： In a thermosetting coating composition comprising at least one thermosetting resin selected from aminoalkyd resins and aminoacrylic resins as a main ingredient of a vehicle, the improvement wherein the composition contains 100 parts by weight of the thermosetting resin and 5 to 50 parts by weight of a cyclopentadiene-derived hydrocarbon resin having a softening point of 50.degree. to 160.degree. C. and obtained by heat polymerizing a mixture of 85 to 55% by weight of a cyclopentadiene-type monomer with 15 to 45% by weight of a polar monolefinic monomer copolymerizable therewith.The compositions have improved flexibility, impact strength and adhesion and are useful as vehicles for thermosetting oil-base paints.
摘要翻译：在包含至少一种选自氨基醇酸树脂和氨基丙烯酸树脂的热固性树脂作为载体的主要成分的热固性涂料组合物中，其组合物包含100重量份的热固性树脂和5至50重量份的环戊二烯软化点为50〜160℃，通过将85〜55重量％的环戊二烯型单体与15〜45重量％的可与其共聚的极性单烯属单体的混合物进行热聚合得到。。

16. 发明申请

US20110082133A1 PYRIDONE COMPOUNDS 审中-公开
标题翻译：吡咯烷酮化合物
公开(公告)号：US20110082133A1
公开(公告)日：2011-04-07
申请号：US12999379
申请日：2009-06-16
申请人： Takashi Kamikubo , Masanori Miura , Takao Okuda , Keisuke Maki , Fukushi Hirayama , Ayako Moritomo , Yuriko Komiya , Keisuke Matsuura , Ryotaro Ibuka
发明人： Takashi Kamikubo , Masanori Miura , Takao Okuda , Keisuke Maki , Fukushi Hirayama , Ayako Moritomo , Yuriko Komiya , Keisuke Matsuura , Ryotaro Ibuka
IPC分类号： A61K31/5415 , A61K31/4725 , A61K31/4439 , A61K31/4412 , C07D417/06 , A61P9/10 , A61K31/444 , C07D417/12 , C07D401/06 , C07D211/72
CPC分类号： C07D401/06 , A61K31/13 , A61K31/4412 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/538 , A61K31/5415 , C07D213/64 , C07D213/69 , C07D213/79 , C07D409/12 , C07D413/06 , C07D413/10 , C07D413/14 , C07D417/06 , C07D417/12
摘要： [Problems] A useful compound which can be used as a pharmaceutical, in particular, an agent for treating peripheral arterial occlusive disease is provided.[Means for Solution] The present inventors have conducted extensive studies on EP4 receptor agonists, and as a result, have found that a novel pyridone compound, in which a group having an acidic group is substituted at the 1-position of the pyridone ring, the 6-position is bonded with an aromatic ring group via a linking part, and the linking part contains a nitrogen atom, has an excellent EP4 receptor agonistic action, thereby completing the present invention. Since the compound of the present invention has an excellent EP4 receptor agonistic action, it is useful as a pharmaceutical, in particular, as an agent for treating peripheral arterial occlusive disease.
摘要翻译： [问题]提供了可用作药物，特别是用于治疗外周动脉闭塞性疾病的药剂的有用化合物。 [解决方案]本发明人对EP4受体激动剂进行了广泛的研究，结果发现，其中具有酸性基团的基团在吡啶酮环的1位被取代的新的吡啶酮化合物， 6-位通过连接部分与芳环基团键合，并且连接部分含有氮原子，具有优异的EP4受体激动作用，从而完成了本发明。由于本发明的化合物具有优异的EP4受体激动作用，所以作为药物，特别是作为治疗外周动脉闭塞性疾病的药剂是有用的。

17. 发明申请

US20100113391A1 BICYCLIC HETEROCYCLIC COMPOUND 审中-公开
标题翻译：双相杂环化合物
公开(公告)号：US20100113391A1
公开(公告)日：2010-05-06
申请号：US12596643
申请日：2008-04-17
申请人： Yuji Koga , Takao Okuda , Takashi Kamikubo , Michihito Kageyama , Hiroyuki Moritomo
发明人： Yuji Koga , Takao Okuda , Takashi Kamikubo , Michihito Kageyama , Hiroyuki Moritomo
IPC分类号： A61K31/695 , C07D215/22 , C07D239/80 , C07F7/02 , C07D243/14 , A61K31/47 , A61K31/517 , A61K31/5513 , A61P7/02
CPC分类号： C07D217/24 , C07D239/96 , C07D243/14 , C07D401/06 , C07D403/12 , C07D405/04 , C07D405/06 , C07D413/06 , C07D417/06
摘要： [Problem]Provided is a compound, which exhibits a P2Y12 inhibitory action and is useful as a medical drug, particularly, as a platelet aggregation inhibitor.[Means for Solution]The inventors have eagerly investigated P2Y12 inhibitors. As a result, the inventors have found that a bicyclic heterocyclic compound such as quinazolinedione, isoquinolone, and the like having an amino group substituted with lower alkyl, cycloalkyl, or lower alkylene-cycloalkyl at the specific position exhibits an excellent platelet aggregation inhibitory action, thereby completing the present invention. Since the compound of the invention exhibits excellent P2Y12 inhibitory action and platelet aggregation inhibitory action, it is useful as a platelet aggregation inhibitor.
摘要翻译： [问题]提供了表现出P2Y12抑制作用的化合物，可用作医药，特别是作为血小板聚集抑制剂。解决方法本发明人急切地研究P2Y12抑制剂。结果发现，在具体位置具有被低级烷基，环烷基或低级亚烷基 - 环烷基取代的氨基的喹唑啉二酮，异喹诺酮等双环杂环化合物显示优异的血小板聚集抑制作用，从而完成了本发明。由于本发明化合物表现出优异的P2Y12抑制作用和血小板聚集抑制作用，因此作为血小板聚集抑制剂是有用的。

18. 发明申请

US20060148806A1 Quinolone derivative or salt thereof 失效
公开(公告)号：US20060148806A1
公开(公告)日：2006-07-06
申请号：US10562128
申请日：2004-07-22
申请人： Susumu Watanuki , Yuji Koga , Hiroyuki Moritomo , Issei Tsukamoto , Daisuke Kaga , Takao Okuda , Fukushi Hirayama , Yumiko Moritani , Jun Takasaki
发明人： Susumu Watanuki , Yuji Koga , Hiroyuki Moritomo , Issei Tsukamoto , Daisuke Kaga , Takao Okuda , Fukushi Hirayama , Yumiko Moritani , Jun Takasaki
IPC分类号： A61K31/503 , C07D471/02 , C07D487/02 , A61K31/4745
CPC分类号： C07D237/28 , A61K31/4709 , A61K31/4725 , C07D215/56 , C07D405/04 , C07F9/5765 , C07F9/60 , C07F9/650947
摘要： A platelet aggregation inhibitor comprising a quinolone derivative or a pharmaceutically acceptable salt thereof as an active ingredient, and a novel quinolone derivative or a pharmaceutically acceptable salt thereof useful as a platelet aggregation inhibitor.

19. 发明申请

US20060072827A1 Apparatus, method, and computer program for processing information 有权
标题翻译：用于处理信息的装置，方法和计算机程序
公开(公告)号：US20060072827A1
公开(公告)日：2006-04-06
申请号：US11240512
申请日：2005-10-03
申请人： Tatsuo Nagamatsu , Kunitoshi Shimizu , Tsutomu Teranishi , Takao Okuda , Hiroshi Kawaguchi , Atsushi Mitsuzawa
发明人： Tatsuo Nagamatsu , Kunitoshi Shimizu , Tsutomu Teranishi , Takao Okuda , Hiroshi Kawaguchi , Atsushi Mitsuzawa
IPC分类号： G06K9/46
CPC分类号： H04H60/48 , G06K9/00711
摘要： An information processing apparatus includes a selecting unit for selecting extraction information concerning contents to be extracted from among a plurality of contents organized in time sequence, the extraction information prepared on a per content basis for the contents to be extracted and including a feature contained in the content to be extracted, and an extraction range that is represented with respect to the position of the feature, a detecting unit for detecting, from the contents, the same feature as the feature contained in the extraction information selected by the selecting unit, and an extracting unit for extracting a predetermined content in accordance with the extraction range contained in the extraction information selected by the selecting unit if the detecting unit detects the same feature as the feature contained in the extraction information.
摘要翻译：一种信息处理装置，包括：选择单元，用于从按时间顺序组织的多个内容中选择关于要提取的内容的提取信息;对于要提取的内容，以每个内容为基础准备的提取信息，并且包括在要提取的内容以及关于特征位置表示的提取范围，检测单元，用于从内容中检测与由选择单元选择的提取信息中包含的特征相同的特征，以及提取单元，用于如果检测单元检测到与提取信息中包含的特征相同的特征，则根据由选择单元选择的提取信息中包含的提取范围来提取预定内容。

20. 发明授权

US4761409A Cephem derivatives 失效
标题翻译： Cephem衍生物
公开(公告)号：US4761409A
公开(公告)日：1988-08-02
申请号：US762560
申请日：1985-08-05
申请人： Hirotada Yamada , Naruhito Masai , Shinji Ueda , Takao Okuda , Masuhiro Kato , Masatomo Fukasawa , Masataka Fukumura
发明人： Hirotada Yamada , Naruhito Masai , Shinji Ueda , Takao Okuda , Masuhiro Kato , Masatomo Fukasawa , Masataka Fukumura
IPC分类号： A61K31/545 , C07D277/22 , C07D279/08 , C07D285/04 , C07D417/14 , C07D501/18 , C07D501/36
CPC分类号： C07D501/36
摘要： A cephem derivative represented by the general formula ##STR1## wherein R.sup.1 represents hydrogen or methyl, R.sup.2 represents carboxyl or esterified carboxyl, and n represents 0 or 1, or a pharmaceutically acceptable salt thereof; intermediates for the cephem derivative or salt thereof; processes for producing these compounds; and a pharmaceutical composition and method for preventing or treating bacterial infectious diseases, wherein the cephem derivative or the salt thereof is used.
摘要翻译：由通式表示的头孢烯衍生物，其中R1表示氢或甲基，R2表示羧基或酯化的羧基，n表示0或1，或其药学上可接受的盐; 头孢烯衍生物或其盐的中间体; 制备这些化合物的方法; 以及使用头孢衍生物或其盐的预防或治疗细菌感染性疾病的药物组合物和方法。

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