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11. 发明申请

US20130078216A1 LIVER TARGETING MOLECULES 审中-公开
标题翻译：肝脏靶向分子
公开(公告)号：US20130078216A1
公开(公告)日：2013-03-28
申请号：US13522407
申请日：2011-01-13
申请人： Grainne Dunlevy , Steven Holmes , Zhi Hong , Armin Sepp , Adam Walker
发明人： Grainne Dunlevy , Steven Holmes , Zhi Hong , Armin Sepp , Adam Walker
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： A61K39/39541 , A61K39/395 , C07K16/28 , C07K16/2851 , C07K2317/569
摘要： The present invention relates to molecules that can be targeted to the liver. These liver targeting molecules (e.g.fusions and conjugates) comprise proteins, antibodies or antibody fragments such as immunoglobulin (antibody) single variable domains (dAbs) and also one or more additional molecules which it is desired to deliver to the liver such as interferons. The invention further relates to uses, formulations, compositions and devices comprising such liver targeting molecules. The invention also relates to immunoglobulin (antibody) single variable domains which bind to hepatocytes.
摘要翻译：本发明涉及可靶向肝脏的分子。这些肝靶向分子（例如融合物和缀合物）包含蛋白质，抗体或抗体片段，例如免疫球蛋白（抗体）单可变结构域（dAb）以及希望递送至肝脏如干扰素的一种或多种另外的分子。本发明还涉及包含这种肝靶向分子的用途，制剂，组合物和装置。本发明还涉及结合肝细胞的免疫球蛋白（抗体）单可变结构域。

12. 发明申请

US20050164239A1 Optical sorting method 审中-公开
标题翻译：光学分选方法
公开(公告)号：US20050164239A1
公开(公告)日：2005-07-28
申请号：US10956242
申请日：2004-10-01
申请人： Andrew Griffiths , Dan Tawfik , Armin Sepp
发明人： Andrew Griffiths , Dan Tawfik , Armin Sepp
IPC分类号： G01N21/78 , C07K2/00 , C12N9/00 , C12N15/09 , C12N15/10 , C12P1/00 , C12P21/00 , C12P21/02 , C12Q1/00 , C12Q1/26 , C12Q1/68 , C12Q1/6811 , G01N21/64 , G01N33/15 , G01N33/50 , C12N15/85
CPC分类号： C12N15/1075 , C12N15/1062 , C12N15/113 , C12Q1/6811
摘要： The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements which produce the gene product having the desired activity using a change in the optical properties of the genetic elements. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention.
摘要翻译：本发明描述了一种用于分离编码具有所需活性的基因产物的一种或多种遗传元件的方法，包括以下步骤：（a）将遗传元件分隔成微胶囊; （b）表达遗传元件以在微胶囊内产生它们各自的基因产物; （c）使用遗传元件的光学性质的变化来分选产生具有所需活性的基因产物的遗传元件。本发明能够通过本发明方法的重复诱变和迭代应用来体外进化核酸和蛋白质。

13. 发明授权

US08084213B2 Selection 失效
标题翻译：选择
公开(公告)号：US08084213B2
公开(公告)日：2011-12-27
申请号：US11654820
申请日：2007-01-17
申请人： Armin Sepp , Andrew Griffiths
发明人： Armin Sepp , Andrew Griffiths
IPC分类号： C12Q1/68 , C12P21/08 , C12P21/00 , C12N15/00 , C12N5/00 , A61K38/16 , C07K14/00 , C07H21/04
CPC分类号： C12N15/1075 , C07K2319/41 , C07K2319/43 , C07K2319/50
摘要： The present invention to a nucleotide sequence encoding one or more Arc DNA binding domains, one or more Arc DNA binding sites and at least one polypeptide domain.
摘要翻译：本发明涉及编码一个或多个Arc DNA结合结构域，一个或多个Arc DNA结合位点和至少一个多肽结构域的核苷酸序列。

14. 发明申请

US20090053700A1 Optical sorting method 有权
公开(公告)号：US20090053700A1
公开(公告)日：2009-02-26
申请号：US11820165
申请日：2007-06-18
申请人： Andrew Griffiths , Dan Tawfik , Armin Sepp
发明人： Andrew Griffiths , Dan Tawfik , Armin Sepp
IPC分类号： C12Q1/68 , C07H21/00 , C12P21/04
CPC分类号： C12N15/1075 , C12N15/1062 , C12N15/113 , C12Q1/6811
摘要： The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements which produce the gene product having the desired activity using a change in the optical properties of the genetic elements. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention.

15. 发明申请

US20110301335A1 ANTI-TNFR1 POLYPEPTIDES, ANTIBODY VARIABLE DOMAINS & ANTAGONISTS 审中-公开
标题翻译：抗TNFR1多肽，抗体可变域和拮抗剂
公开(公告)号：US20110301335A1
公开(公告)日：2011-12-08
申请号：US13202349
申请日：2010-02-17
申请人： Stephen Duffield , Carolyn Enever , Haiqun Liu , Oliver Schon , Armin Sepp , Adriaan Allart Stoop
发明人： Stephen Duffield , Carolyn Enever , Haiqun Liu , Oliver Schon , Armin Sepp , Adriaan Allart Stoop
IPC分类号： C07K16/28
CPC分类号： C07K16/2878 , A61K2039/505 , C07K16/18 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/40 , C07K2317/569 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94 , C07K2319/31
摘要： The invention relates to anti-TNFR1 polypeptides, antibody single variable domains (dAbs), antagonists and multispecific ligands, as well as methods and uses of these. The anti-TNFR1 polypeptides, antibody single variable domains (dAbs), antagonists and multispecific ligands are useful for treating and/or preventing inflammatory disease, such as arthritis or COPD, as well as for pulmonary administration, oral administration, delivery to the lung and delivery to the GI tract of a patient.
摘要翻译：本发明涉及抗TNFR1多肽，抗体单可变结构域（dAb），拮抗剂和多特异性配体，以及它们的方法和用途。抗TNFR1多肽，抗体单可变结构域（dAb），拮抗剂和多特异性配体可用于治疗和/或预防炎性疾病如关节炎或COPD，以及用于肺部给药，口服给药，递送至肺和输送到患者的胃肠道。

16. 发明申请

US20090176209A1 Selection 失效
标题翻译：选择
公开(公告)号：US20090176209A1
公开(公告)日：2009-07-09
申请号：US11654820
申请日：2007-01-17
申请人： Armin Sepp , Andrew Griffiths
发明人： Armin Sepp , Andrew Griffiths
IPC分类号： C12Q1/68 , C12N15/11 , C12N15/00 , C12N5/06 , C07K14/00 , C07K16/18 , C12P21/00 , C12P21/08
CPC分类号： C12N15/1075 , C07K2319/41 , C07K2319/43 , C07K2319/50
摘要： The present invention to a nucleotide sequence encoding one or more Arc DNA binding domains, one or more Arc DNA binding sites and at least one polypeptide domain.
摘要翻译：本发明涉及编码一个或多个Arc DNA结合结构域，一个或多个Arc DNA结合位点和至少一个多肽结构域的核苷酸序列。

17. 发明申请

US20080038735A1 Tus DNA binding domains 审中-公开
标题翻译： Tus DNA结合结构域
公开(公告)号：US20080038735A1
公开(公告)日：2008-02-14
申请号：US11728574
申请日：2007-03-26
申请人： Armin Sepp , Albert Stoop
发明人： Armin Sepp , Albert Stoop
IPC分类号： C12P21/04 , C07K14/00 , C12N15/00 , C12Q1/68 , C12N15/11 , C12N5/06
CPC分类号： C07K16/241 , C07K16/24 , C07K16/40 , C07K2317/34 , C07K2317/569 , C07K2317/92 , C07K2319/00 , C12N15/1075
摘要： The present invention relates to a nucleic sequence encoding one or more Tus DNA binding domains, one or more DNA binding sites and at least one polypeptide domain.
摘要翻译：本发明涉及编码一种或多种TUS DNA结合结构域，一个或多个DNA结合位点和至少一个多肽结构域的核酸序列。

18. 发明授权

US06808882B2 Optical sorting method 有权
标题翻译：光学分选方法
公开(公告)号：US06808882B2
公开(公告)日：2004-10-26
申请号：US09896915
申请日：2001-06-29
申请人： Andrew Griffiths , Dan Tawfik , Armin Sepp
发明人： Andrew Griffiths , Dan Tawfik , Armin Sepp
IPC分类号： C12Q168
CPC分类号： C12N15/1075 , C12N15/1062 , C12N15/113 , C12Q1/6811
摘要： The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements which produce the gene product having the desired activity using a change in the optical properties of the genetic elements. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention.
摘要翻译：本发明描述了一种用于分离编码具有所需活性的基因产物的一种或多种遗传元件的方法，包括以下步骤：（a）将遗传元件分隔成微胶囊; （b）表达遗传元件以在微胶囊内产生它们各自的基因产物; （c）使用遗传元件的光学性质的变化来分选产生具有所需活性的基因产物的遗传元件。本发明能够通过本发明方法的重复诱变和迭代应用来体外进化核酸和蛋白质。

19. 发明申请

US20140187762A1 Optical Sorting Method 审中-公开
标题翻译：光学分选方法
公开(公告)号：US20140187762A1
公开(公告)日：2014-07-03
申请号：US14086787
申请日：2013-11-21
申请人： Andrew Griffiths , Dan Tawfik , Armin Sepp
发明人： Andrew Griffiths , Dan Tawfik , Armin Sepp
IPC分类号： C12N15/10 , C12N15/113
CPC分类号： C12N15/1075 , C12N15/1062 , C12N15/113 , C12Q1/6811
摘要： The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements which produce the gene product having the desired activity using a change in the optical properties of the genetic elements. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention.
摘要翻译：本发明描述了一种用于分离编码具有所需活性的基因产物的一种或多种遗传元件的方法，包括以下步骤：（a）将遗传元件分隔成微胶囊; （b）表达遗传元件以在微胶囊内产生它们各自的基因产物; （c）使用遗传元件的光学性质的变化来分选产生具有所需活性的基因产物的遗传元件。本发明能够通过本发明方法的重复诱变和迭代应用来体外进化核酸和蛋白质。

20. 发明申请

US20050037392A1 Optical sorting method 审中-公开
公开(公告)号：US20050037392A1
公开(公告)日：2005-02-17
申请号：US10866237
申请日：2004-06-11
申请人： Andrew Griffiths , Dan Tawfik , Armin Sepp
发明人： Andrew Griffiths , Dan Tawfik , Armin Sepp
IPC分类号： G01N21/78 , C07K2/00 , C12N9/00 , C12N15/09 , C12N15/10 , C12P1/00 , C12P21/00 , C12P21/02 , C12Q1/00 , C12Q1/26 , C12Q1/68 , C12Q1/6811 , G01N21/64 , G01N33/15 , G01N33/50 , C12P19/34
CPC分类号： C12N15/1075 , C12N15/1062 , C12N15/113 , C12Q1/6811
摘要： The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements which produce the gene product having the desired activity using a change in the optical properties of the genetic elements. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention.

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