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11. 发明申请

US20090047655A1 Method Of Screening Candidate Drug 审中-公开
标题翻译：筛选候选药物的方法
公开(公告)号：US20090047655A1
公开(公告)日：2009-02-19
申请号：US11667855
申请日：2005-11-16
申请人： Chise Mukaidani , Katsutoshi Yoshizato , Yasufumi Nishikura , Toru Horie , Hiroshi Nakazawa , Hiroshi Kanamaru , Chiaki Ueda , Chiemi Hine
发明人： Chise Mukaidani , Katsutoshi Yoshizato , Yasufumi Nishikura , Toru Horie , Hiroshi Nakazawa , Hiroshi Kanamaru , Chiaki Ueda , Chiemi Hine
IPC分类号： C12Q1/00
CPC分类号： G01N33/5088 , G01N33/5067 , G01N2333/80
摘要： It is intended to provide a method of screening a candidate drug mainly metabolized by a drug metabolizing enzyme, CYP2D6, CYP2C9 or CYP2C19 with the use of a chimeric mouse carrying human hepatocytes transplanted thereinto, whereby it is determined whether or not the candidate drug is metabolized in a subject deficient in CYP2D6, CYP2C9 or CYP2C19. It is also intended to provide a method of determining whether or not a candidate drug induces or inhibits the activity of any of drug metabolizing enzymes, CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 with the use of a chimeric mouse carrying human hepatocytes transplanted thereinto.
摘要翻译：本发明提供一种使用携带人肝细胞的嵌合小鼠筛选主要由药物代谢酶CYP2D6，CYP2C9或CYP2C19代谢的候选药物的方法，由此确定候选药物是否被代谢在CYP2D6，CYP2C9或CYP2C19缺乏的受试者中。还旨在提供一种使用携带人肝细胞的嵌合小鼠来确定候选药物是否诱导或抑制任何药物代谢酶CYP1A2，CYP2C9，CYP2C19，CYP2D6和CYP3A4的活性的方法。

12. 发明申请

US20070278750A1 Fuel Injection Valve 审中-公开
标题翻译：燃油喷射阀
公开(公告)号：US20070278750A1
公开(公告)日：2007-12-06
申请号：US10586058
申请日：2005-01-14
申请人： Shinji Okuhara , Toru Horie , Kiyoshi Matsuzaki , Kenichi Neki , Kazuo Koshizuka
发明人： Shinji Okuhara , Toru Horie , Kiyoshi Matsuzaki , Kenichi Neki , Kazuo Koshizuka
IPC分类号： F02F11/00
CPC分类号： F02M61/166 , F02M47/027 , F02M61/18 , F02M2200/90 , F02M2200/9038 , F02M2547/003 , F02M2547/006
摘要： In a fuel injection valve (1) having a nozzle body (31) with a nozzle hole (35) at its tip that is opened and closed by a nozzle needle (32) housed in the nozzle body (31), the area of contact between the nozzle needle (32) and a seat (31A) on the nozzle body (31) is provided with a coating layer (Y) to reduce the frictional resistance with the nozzle body (31). When the nozzle needle (32) seats on the seat (31A), between the time from when the tip of the nozzle needle (32) contacts the seat (31A) to when it is pressed against the seat (31A), the nozzle needle (32) slides on the surface of the nozzle body (31) with low frictional resistance. As a result, wear on the seat (31A) when the nozzle needle (32) is seated to open the valve can be kept down.
摘要翻译：在具有喷嘴孔（31）的燃料喷射阀（1）的喷嘴孔（35）的顶端处，其被容纳在喷嘴体（31）内的喷嘴针（32）开闭，在喷嘴体（31）上的喷嘴针（32）和座（31A）之间设置有涂层（Y），以减少与喷嘴体（31）的摩擦阻力。当喷嘴针（32）位于座椅（31a）上时，在从喷嘴针（32）的尖端与座（31A）接触到压靠在座椅（21A）之间的时间之间，喷嘴针（32）以低摩擦阻力在喷嘴体（31）的表面上滑动。结果，当喷嘴针（32）就座以打开阀时，座椅（31A）上的磨损可以保持下降。

13. 发明申请

US20050091419A1 Method for switching node and an information processing system 审中-公开
标题翻译：交换节点和信息处理系统的方法
公开(公告)号：US20050091419A1
公开(公告)日：2005-04-28
申请号：US10806338
申请日：2004-03-23
申请人： Yusuke Ohashi , Toru Horie , Akio Tatsumi
发明人： Yusuke Ohashi , Toru Horie , Akio Tatsumi
IPC分类号： G06F12/14 , G06F3/00 , G06F3/06 , G06F11/20
CPC分类号： G06F3/0637 , G06F3/0626 , G06F3/0635 , G06F3/0674
摘要： In an information processing system including host computers and disk devices, each of an execution-node host and a standby-node host includes an I/O request unit and an access-right change command unit. The I/O request unit issues an I/O request. The access-right change command unit transmits an access-right change command. The access-right change command results from causing I/O-enable/disable information and the host identification information to correspond to each other. The disk device includes an access control table, an access control unit, and an access-right change unit. The access control table stores information of the access-right change commands from the hosts. The access control unit judges the execution enablement/disablement for the I/O requests from the host identification information and the access control table. The access-right change unit, in accordance with the access-right change commands from the hosts, changes in batch the I/O-enable/disable information on each host basis within the access control table.
摘要翻译：在包括主计算机和磁盘设备的信息处理系统中，执行节点主机和备用节点主机中的每一个包括I / O请求单元和访问权限改变命令单元。 I / O请求单元发出I / O请求。访问权限改变命令单元发送访问权限改变命令。访问权限改变命令是由于导致I / O使能/禁止信息和主机标识信息彼此对应而产生的。磁盘装置包括访问控制表，访问控制单元和访问权限改变单元。访问控制表存储来自主机的访问权限改变命令的信息。访问控制单元从主机识别信息和访问控制表判断对I / O请求的执行启用/禁止。访问权限改变单元根据来自主机的访问权限改变命令，在访问控制表内基于每个主机批量地改变I / O启用/禁用信息。

14. 发明授权

US07765545B2 Method for automatically imparting reserve resource to logical partition and logical partitioned computer system 失效
标题翻译：自动赋予逻辑分区和逻辑分区计算机系统的预留资源的方法
公开(公告)号：US07765545B2
公开(公告)日：2010-07-27
申请号：US11221814
申请日：2005-09-09
申请人： Michihiro Uchishiba , Toru Horie
发明人： Michihiro Uchishiba , Toru Horie
IPC分类号： G06F9/46 , G06F9/455
CPC分类号： G06F9/5077
摘要： A logical partitioned computer system. A hypervisor includes a resource management table for managing resources assigned to the hypervisor and an assigning/collecting unit for assigning and collecting resources to logical partitions. Each logical partiion has a guest resource monitoring unit for monitoring the amount of the resource being used out of the amount of the resource assigned to the logical partiion and an adding/separating unit for requesting addition and separation of a resource to the assigning/collecting unit based on results of monitoring. In response to the request, assigning/collecting unit searches resource management table, assigns a resource to logical partition when a reserve resource exists in case of an assignment request, and collects a resource as a reserve resource in the resource management table in case of a collection request.
摘要翻译：逻辑分区计算机系统。管理程序包括用于管理分配给管理程序的资源的资源管理表和用于向逻辑分区分配和收集资源的分配/收集单元。每个逻辑单元具有一个来宾资源监视单元，用于监视分配给该逻辑单元的资源量的正在使用的资源量;以及添加/分离单元，用于请求向分配/收集单元添加和分离资源基于监测结果。响应于该请求，分配/收集单元搜索资源管理表，当在分配请求的情况下存在预留资源时，将资源分配给逻辑分区，并且在资源管理表中将资源作为备用资源收集在资源管理表中收集请求。

15. 发明申请

US20090157915A1 METHOD FOR SWITCHING NODE AND AN INFORMATION PROCESSING SYSTEM 失效
标题翻译：用于切换节点和信息处理系统的方法
公开(公告)号：US20090157915A1
公开(公告)日：2009-06-18
申请号：US12369994
申请日：2009-02-12
申请人： Yusuke OHASHI , Toru Horie , Akio Tatsumi
发明人： Yusuke OHASHI , Toru Horie , Akio Tatsumi
IPC分类号： G06F3/00
CPC分类号： G06F3/0637 , G06F3/0626 , G06F3/0635 , G06F3/0674
摘要： In an information processing system including host computers and disk devices, each of an execution-node host and a standby-node host includes an I/O request unit and an access-right change command unit. The I/O request unit issues an I/O request. The access-right change command unit transmits an access-right change command. The access-right change command results from causing I/O-enable/disable information and the host identification information to correspond to each other. The disk device includes an access control table, an access control unit, and an access-right change unit. The access control table stores information of the access-right change commands from the hosts. The access control unit judges the execution enablement/disablement for the I/O requests from the host identification information and the access control table. The access-right change unit, in accordance with the access-right change commands from the hosts, changes in batch the I/O-enable/disable information on each host basis within the access control table.
摘要翻译：在包括主计算机和磁盘设备的信息处理系统中，执行节点主机和备用节点主机中的每一个包括I / O请求单元和访问权限改变命令单元。 I / O请求单元发出I / O请求。访问权限改变命令单元发送访问权限改变命令。访问权限改变命令是由于导致I / O使能/禁止信息和主机标识信息彼此对应而产生的。磁盘装置包括访问控制表，访问控制单元和访问权限改变单元。访问控制表存储来自主机的访问权限改变命令的信息。访问控制单元从主机识别信息和访问控制表判断对I / O请求的执行启用/禁止。访问权限改变单元根据来自主机的访问权限改变命令，在访问控制表内基于每个主机批量地改变I / O启用/禁用信息。

16. 发明申请

US20080199847A1 Method for Predicting the Metabolism of Drug in Human Liver and Liver Function 审中-公开
标题翻译：预测人肝脏和肝功能中药物代谢的方法
公开(公告)号：US20080199847A1
公开(公告)日：2008-08-21
申请号：US11660592
申请日：2005-08-19
申请人： Shin-ichi Ninomiya , Yoshihiro Ohzone , Yasuhisa Adachi , Toru Horie , Yoshinori Soeno , Tae Inoue
发明人： Shin-ichi Ninomiya , Yoshihiro Ohzone , Yasuhisa Adachi , Toru Horie , Yoshinori Soeno , Tae Inoue
IPC分类号： C12Q1/00
CPC分类号： G01N33/5038 , G01N33/5088
摘要： The invention provides a method for precisely predicting the metabolism of a drug in human liver and the effect of the drug on liver function. The invention provides a method for predicting a metabolite of a test substance produced in human liver and functions of the liver, wherein the method includes administering a test substance to a nonhuman chimeric animal and a non-chimeric animal of the same species, wherein the chimeric animal intracorporeally carries a population of human-origin hepatocytes having proliferation potential and in which the hepatocyte, population substantially functions as the liver of the chimeric animal, and wherein these animals are protected from the attack by a human complement produced by the hepatocytes; and analyzing and comparing metabolites from the chimeric animal and the non-chimeric animal.
摘要翻译：本发明提供了一种精确预测人肝脏药物代谢及肝功能的作用的方法。本发明提供一种用于预测在人肝脏中产生的测试物质和肝脏功能的代谢物的方法，其中所述方法包括向非人类嵌合动物和相同物种的非嵌合动物施用测试物质，其中嵌合动物体内携带具有增殖潜力的人源肝细胞群体，其中肝细胞群体基本上起嵌合动物的肝脏的作用，并且其中这些动物被免于由肝细胞产生的人补体的攻击; 并分析和比较来自嵌合动物和非嵌合动物的代谢物。

17. 发明授权

US5462958A Benzene derivatives and method of treating arteriosclerosis with benzene derivatives 失效
标题翻译：苯衍生物和苯衍生物治疗动脉硬化的方法
公开(公告)号：US5462958A
公开(公告)日：1995-10-31
申请号：US182061
申请日：1994-05-19
申请人： Kenji Hayashi , Nobuhisa Watanabe , Koichi Nose , Hiroshi Tanaka , Issei Ohtsuka , Motoji Kokushi , Hironobu Hiyoshi , Hiroko Kobayashi , Toshie Yamada , Toru Horie
发明人： Kenji Hayashi , Nobuhisa Watanabe , Koichi Nose , Hiroshi Tanaka , Issei Ohtsuka , Motoji Kokushi , Hironobu Hiyoshi , Hiroko Kobayashi , Toshie Yamada , Toru Horie
IPC分类号： C07C275/34 , C07D233/54 , C07D233/60 , C07D233/64 , A61K31/415 , A61K31/195
CPC分类号： C07D233/64 , C07C275/34
摘要： The present invention provides a novel benzene derivative useful as a preventive and medically treating medicine for arteriosclerosis, and a cholesterol O-acyl transferase inhibitor comprising the benzene derivative as an active ingredient.The benzene derivative according to the present invention is represented by the following general formula (I): ##STR1## wherein R.sup.1 represents a carboxyl group which may be protected or a group represented by the formula: ##STR2## wherein R.sup.5 represents a lower alkyl group or a hydroxyalkyl group and R.sup.6 represents a hydrogen atom or a hydroxyl group; R.sup.2 represents a hydrogen atom, a lower alkyl group or the like; R.sup.3 and R.sup.4 each represent a hydrogen atom or a hydroxyl group; and p is an integer of 1 to 6.
摘要翻译： PCT No.PCT / JP93 / 00961 Sec。 371日期1994年5月19日 102（e）日期1994年5月19日PCT提交1993年7月12日PCT公布。出版物WO94 / 02452 日本1993年3月2日。本发明提供了可用作预防和医学治疗动脉硬化药物的苯衍生物，以及含有苯衍生物作为活性成分的胆固醇O-酰基转移酶抑制剂。根据本发明的苯衍生物由以下通式（I）表示：其中R 1表示可被保护的羧基或由下式表示的基团：其中R5表示低级烷基或羟烷基，R6表示氢原子或羟基; R2表示氢原子，低级烷基等; R3和R4各自表示氢原子或羟基; p为1〜6的整数。

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