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11. 发明申请

US20110008421A1 Liposome for delivery to posterior segment of eye and pharmaceutical composition for disease in posterior segment of eye 有权
标题翻译：用于输送到眼后段的脂质体和眼后部疾病的药物组合物
公开(公告)号：US20110008421A1
公开(公告)日：2011-01-13
申请号：US12919807
申请日：2009-02-26
申请人： Hideaki Hara , Hirofumi Takeuchi
发明人： Hideaki Hara , Hirofumi Takeuchi
IPC分类号： A61K9/127 , A61P27/02
CPC分类号： A61K9/0048 , A61K9/1272 , A61K31/00
摘要： The invention provides a liposome for delivery to the posterior segment of the eye, comprising (A) a phospholipid, (B) a charged substance, and/or (C) a membrane-reinforcing substance; the liposome having a rigidity that provides the liposome with cell membrane permeability, and having a mean particle diameter of 1 μm or less; and a pharmaceutical composition for a disease in the posterior segment of an eye, comprising a drug encapsulated in the liposome. The liposome is delivered to the posterior segment of the eye by instillation, and is non-cytotoxic; and the pharmaceutical composition for a disease in the posterior segment of the eye comprises the liposome.
摘要翻译：本发明提供一种用于输送到眼后段的脂质体，包括（A）磷脂，（B）带电物质和/或（C）膜增强物质; 所述脂质体具有赋予所述脂质体细胞膜通透性并且平均粒径为1μm以下的刚性; 和用于眼后段疾病的药物组合物，其包含包封在脂质体中的药物。通过滴注将脂质体递送至眼后段，是非细胞毒性的; 并且眼睛后段中疾病的药物组合物包含脂质体。

12. 发明申请

US20070128273A1 Composition containing medicine extremely slightly soluble in water and method for preparation thereof 失效
标题翻译：含有极微溶于水的药物的组合物及其制备方法
公开(公告)号：US20070128273A1
公开(公告)日：2007-06-07
申请号：US10551901
申请日：2004-04-28
申请人： Hiroshi Miura , Makoto Kanebako , Masayuki Kanishi , Yasuo Shinoda , Toshio Inagi , Hirofumi Takeuchi
发明人： Hiroshi Miura , Makoto Kanebako , Masayuki Kanishi , Yasuo Shinoda , Toshio Inagi , Hirofumi Takeuchi
IPC分类号： A61K9/20
CPC分类号： A61K31/50 , A61K9/1611 , A61K9/1694 , A61K9/2009 , A61K9/2095
摘要： A composition containing a very low water-soluble drug, which composition is produced by treating, with a supercritical or subcritical carbon dioxide fluid, a mixture containing a very low water-soluble drug and a porous material (exclusive of a porous silica material characterized in that the material has an average pore diameter of 1 to 20 nm, the total pore volume of the material that have a diameter falling within a range of ±40% of the average pore diameter account for 60% or more the volume of all the pores of the material, and, when subjected to X-ray diffractometry, the material exhibits one or more peaks at a diffraction angle (2θ) corresponding to d of 1 nm or more); and a method for producing the composition. The very-low-water-soluble-drug-containing composition of the present invention ensures improved dissolution of the very low water-soluble drug.
摘要翻译：含有非常低水溶性药物的组合物，该组合物通过用超临界或亚临界二氧化碳流体处理含有非常低水溶性药物和多孔材料的混合物（不包括多孔二氧化硅材料该材料的平均孔径为1〜20nm，直径在平均孔径的±40％范围内的材料的总孔体积占所有孔的体积的60％以上的材料，并且当进行X射线衍射测定时，该材料在对应于d为1nm以上的衍射角（2θ）处表现出一个或多个峰）; 以及该组合物的制造方法。本发明的非常低水溶性药物的组合物确保极低水溶性药物的溶出度得到改善。

13. 发明授权

US5806761A Combination faucet device 失效
标题翻译：组合龙头装置
公开(公告)号：US5806761A
公开(公告)日：1998-09-15
申请号：US746644
申请日：1996-11-12
申请人： Masatoshi Enoki , Osamu Tokunaga , Setsuo Ito , Masaaki Itoh , Hirofumi Takeuchi
发明人： Masatoshi Enoki , Osamu Tokunaga , Setsuo Ito , Masaaki Itoh , Hirofumi Takeuchi
IPC分类号： F16K31/00 , F16K31/70 , G05D23/02 , G05D23/13
CPC分类号： G05D23/025 , F16K31/002 , G05D23/1346 , G05D23/1353
摘要： In a combination faucet device (10) according to the invention, a movable valve member (160) slidingly moves relative to a main casing (30) to change a mixing ratio of high-temperature water supplied from a hot water port (116) to low-temperature water supplied from a cold water port (106). The movable valve member (160) is pressed by a temperature sensitive spring (130) in a first direction while being pressed by a bias spring (150) in a second direction opposite to the first direction. The temperature sensitive spring (130) is exposed to a water mixture and varies its spring constant according to the temperature of the water mixture. The temperature sensitive spring (130) accordingly moves the movable valve member (160) in a direction for decreasing the ratio of the high-temperature water to a certain position where the spring force of the temperature sensitive spring (130) balances with the spring force of the bias spring (150), thus allowing a water mixture adjusted to a target temperature.
摘要翻译：在根据本发明的组合龙头装置（10）中，可移动阀构件（160）相对于主壳体（30）滑动移动，以将从热水口（116）供应的高温水的混合比改变为从冷水口（106）供应的低温水。可移动阀构件（160）在温度敏感弹簧（130）的第一方向上被按压在与第一方向相反的第二方向的偏置弹簧（150）上。温度敏感弹簧（130）暴露于水混合物，并根据水混合物的温度改变其弹簧常数。因此，温度敏感弹簧130相应地使可移动阀构件160沿着使温度高的水比与温度敏感弹簧130的弹簧力与弹簧力平衡的特定位置的方向移动的偏压弹簧（150），从而允许将水混合物调节到目标温度。

14. 发明授权

US5738275A Combination faucet device 失效
标题翻译：组合龙头装置
公开(公告)号：US5738275A
公开(公告)日：1998-04-14
申请号：US699486
申请日：1996-08-19
申请人： Masatoshi Enoki , Osamu Tokunaga , Setsuo Ito , Masaaki Itoh , Hirofumi Takeuchi
发明人： Masatoshi Enoki , Osamu Tokunaga , Setsuo Ito , Masaaki Itoh , Hirofumi Takeuchi
IPC分类号： F16K31/00 , F16K31/70 , G05D23/02 , G05D23/13
CPC分类号： G05D23/025 , F16K31/002 , G05D23/1346 , G05D23/1353
摘要： In a combination faucet device (10) according to the invention, a movable valve member (160) slidingly moves relative to a main casing (30) to change a mixing ratio of high-temperature water supplied from a hot water port (116) to low-temperature water supplied from a cold water port (106). The movable valve member (160) is pressed by a temperature sensitive spring (130) in a first direction while being pressed by a bias spring (150) in a second direction opposite to the first direction. The temperature sensitive spring (130) is exposed to water mixture and varies its spring constant according to the temperature of the water mixture. The temperature sensitive spring (130) accordingly moves the movable valve member (160) in a direction for decreasing the ratio of the high-temperature water to a certain position where the spring force of the temperature sensitive spring (130) balances with the spring force of the bias spring (150), thus allowing water mixture adjusted to a target.
摘要翻译：在根据本发明的组合龙头装置（10）中，可动阀构件（160）相对于主壳体（30）滑动移动，以将从热水口（116）供应的高温水的混合比改变为从冷水口（106）供应的低温水。可移动阀构件（160）在温度敏感弹簧（130）的第一方向上被按压在与第一方向相反的第二方向的偏置弹簧（150）上。温度敏感弹簧（130）暴露于水混合物，并根据水混合物的温度改变其弹簧常数。因此，温度敏感弹簧130相应地使可移动阀构件160沿着使温度高的水比与温度敏感弹簧130的弹簧力与弹簧力平衡的特定位置的方向移动的偏置弹簧（150），从而允许将水混合物调节到目标。

15. 发明授权

US08568787B2 Hydroxyalkylcellulose microparticles 有权
标题翻译：羟烷基纤维素微粒
公开(公告)号：US08568787B2
公开(公告)日：2013-10-29
申请号：US13510096
申请日：2010-11-24
申请人： Hirofumi Takeuchi , Satoru Abe , Takeshi Shimotori , Gentaro Nemoto
发明人： Hirofumi Takeuchi , Satoru Abe , Takeshi Shimotori , Gentaro Nemoto
IPC分类号： A61K9/50
CPC分类号： C08B15/02 , A61K9/0056 , A61K9/1652 , A61K9/2054 , C08B11/08 , C08J3/12 , C08J2301/28 , C08L1/284 , C08L2205/18 , Y10T428/2982
摘要： Provided is a method of producing hydroxyalkylcellulose microparticles, the method including generating a pulse shock wave, and supplying a hydroxyalkylcellulose aqueous solution to the pulse shock wave generation region, thereby crushing and drying the hydroxyalkylcellulose aqueous solution. According to the production method, hydroxyalkylcellulose microparticles having a volume-average particle size of at least 0.1 μm but less than 15 μm are obtained. By mixing the hydroxyalkylcellulose microparticles with a principal agent and subjecting the resulting mixture to a tablet compression, a solid preparation having excellent tensile strength and disintegration properties can be obtained.
摘要翻译：提供一种生产羟烷基纤维素微粒的方法，该方法包括产生脉冲冲击波，并将脉冲冲击波产生区域的羟烷基纤维素水溶液供应，从而破碎和干燥羟烷基纤维素水溶液。根据制造方法，得到体积平均粒径为0.1μm以上且小于15μm的羟烷基纤维素微粒。通过将羟烷基纤维素微粒与主剂混合并将所得混合物进行片剂压片，可以获得具有优异拉伸强度和崩解性能的固体制剂。

16. 发明授权

US08101207B2 Composition containing medicine extremely slightly soluble in water and method for preparation thereof 失效
标题翻译：含有极微溶于水的药物的组合物及其制备方法
公开(公告)号：US08101207B2
公开(公告)日：2012-01-24
申请号：US10551901
申请日：2004-04-28
申请人： Hiroshi Miura , Makoto Kanebako , Masayuki Kanishi , Yasuo Shinoda , Toshio Inagi , Hirofumi Takeuchi
发明人： Hiroshi Miura , Makoto Kanebako , Masayuki Kanishi , Yasuo Shinoda , Toshio Inagi , Hirofumi Takeuchi
IPC分类号： A61K9/20 , A61K47/02 , A61K47/04 , A61K31/50
CPC分类号： A61K31/50 , A61K9/1611 , A61K9/1694 , A61K9/2009 , A61K9/2095
摘要： A composition containing a very low water-soluble drug, which composition is produced by treating, with a supercritical or subcritical carbon dioxide fluid, a mixture containing a very low water-soluble drug and a porous material (exclusive of a porous silica material characterized in that the material has an average pore diameter of 1 to 20 nm, the total pore volume of the material that have a diameter falling within a range of ±40% of the average pore diameter account for 60% or more the volume of all the pores of the material, and, when subjected to X-ray diffractometry, the material exhibits one or more peaks at a diffraction angle (2θ) corresponding to d of 1 nm or more); and a method for producing the composition.The very-low-water-soluble-drug-containing composition of the present invention ensures improved dissolution of the very low water-soluble drug.
摘要翻译：含有非常低水溶性药物的组合物，该组合物通过用超临界或亚临界二氧化碳流体处理含有非常低水溶性药物和多孔材料的混合物（不包括多孔二氧化硅材料该材料的平均孔径为1〜20nm，直径在平均孔径的±40％范围内的材料的总孔体积占所有孔的体积的60％以上的材料，当进行X射线衍射测定时，该材料在对应于d的衍射角（2θ）为1nm以上）表现出一个以上的峰值。以及该组合物的制造方法。本发明的非常低水溶性药物的组合物确保极低水溶性药物的溶出度得到改善。

17. 发明授权

US5259073A Water closet flushing apparatus 失效
标题翻译：水厕冲洗装置
公开(公告)号：US5259073A
公开(公告)日：1993-11-09
申请号：US923372
申请日：1992-07-31
申请人： Osamu Tsutsui , Atsuo Makita , Hirofumi Takeuchi , Shinji Shibata , Noboru Shinbara
发明人： Osamu Tsutsui , Atsuo Makita , Hirofumi Takeuchi , Shinji Shibata , Noboru Shinbara
IPC分类号： E03D5/10 , E03D1/00
CPC分类号： E03D5/10
摘要： A water closet flushing apparatus provided with a pressure detector mounted along a water supply pipe, an opening and closing apparatus to open and close a water supply passage provided along the water supply pipe and a control apparatus that uses the pressure detected by the pressure detector to control the opening and closing operation of the opening and closing apparatus so that a predetermined amount of water is supplied to the water closet.
摘要翻译：一种设置有沿着供水管安装的压力检测器的洗手间冲洗装置，用于打开和关闭沿着供水管设置的供水通道的打开和关闭装置，以及使用由压力检测器检测的压力的控制装置控制打开和关闭装置的打开和关闭操作，使得预定量的水被供应到水厕。

18. 发明授权

US5155870A Water closet flushing apparatus 失效
标题翻译：水龙头冲洗装置
公开(公告)号：US5155870A
公开(公告)日：1992-10-20
申请号：US576261
申请日：1990-08-31
申请人： Osamu Tsutsui , Atsuo Makita , Hirofumi Takeuchi , Shinji Shibata , Noboru Shinbara
发明人： Osamu Tsutsui , Atsuo Makita , Hirofumi Takeuchi , Shinji Shibata , Noboru Shinbara
IPC分类号： E03D5/10
CPC分类号： E03D5/10 , E03D2201/30 , Y10S4/03
摘要： A water closet flushing apparatus provided with a pressure detector mounted along a water supply pipe, an opening and closing apparatus to open and close a water supply passage provided along the water supply pipe and a control apparatus that uses the pressure detected by the pressure detector to control the opening and closing operation of the opening and closing apparatus so that a predetermined amount of water is supplied to the water closet.

19. 发明授权

US5109550A Flush water supply system for toilet stool 失效
标题翻译：用于洗手间的冲洗水供应系统
公开(公告)号：US5109550A
公开(公告)日：1992-05-05
申请号：US713120
申请日：1991-06-10
申请人： Atsuo Makita , Hirofumi Takeuchi , Shinji Shibata , Noboru Shimbara
发明人： Atsuo Makita , Hirofumi Takeuchi , Shinji Shibata , Noboru Shimbara
IPC分类号： E03D5/10 , E03D9/16
CPC分类号： E03D5/10 , E03D9/16 , E03D2201/30
摘要： A flush water supply system comprising a passageway valve mounted in a pipeline for supplying flush water to a toilet stool, and a control circuit for controlling the closing and opening of the passageway valve. A constant flow valve is mounted in the pipeline for keeping a predetermined amount of discharge flow, irrespective of water supply pressure.

20. 发明授权

US5052060A Flush water supply system for toilet stool 失效
标题翻译：厕所水冲洗供水系统
公开(公告)号：US5052060A
公开(公告)日：1991-10-01
申请号：US502063
申请日：1990-03-29
申请人： Atsuo Makita , Hirofumi Takeuchi , Shinji Shibata , Noboru Shimbara
发明人： Atsuo Makita , Hirofumi Takeuchi , Shinji Shibata , Noboru Shimbara
IPC分类号： E03D5/00 , E03D5/10
CPC分类号： E03D5/10 , E03D5/00 , E03D2201/30 , Y10S4/03 , Y10T137/7848
摘要： A flush water supply system comprising a passageway valve mounted in a pipeline for supplying flush water to a toilet stool, and a control circuit for controlling the closing and opening of the passageway valve. A constant flow valve is mounted in the pipeline for keeping a predetermined amount of discharge flow, irrespective of water supply pressure.
摘要翻译：一种冲洗水供应系统，包括安装在用于向马桶便器提供冲洗水的管道中的通道阀，以及用于控制通道阀的关闭和打开的控制电路。不管供水压力如何，恒流阀安装在管道中以保持预定量的排放流量。

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