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11. 发明申请

US20070179173A1 Carbostyril compound 有权
标题翻译：碳青霉烯化合物
公开(公告)号：US20070179173A1
公开(公告)日：2007-08-02
申请号：US10582014
申请日：2005-09-26
申请人： Takeshi Kuroda , Takahito Yamauchi , Tomoichi Shinohara , Kunio Oshima , Chiharu Kitajima , Hitoshi Nagao , Tae Fukushima , Takahiro Tomoyasu , Hironobu Ishiyama , Kazuhide Ohta , Masaaki Takano , Takumi Sumida
发明人： Takeshi Kuroda , Takahito Yamauchi , Tomoichi Shinohara , Kunio Oshima , Chiharu Kitajima , Hitoshi Nagao , Tae Fukushima , Takahiro Tomoyasu , Hironobu Ishiyama , Kazuhide Ohta , Masaaki Takano , Takumi Sumida
IPC分类号： A61K31/473 , A61K31/4709 , C07D417/14
CPC分类号： C07D471/08 , C07D417/04 , C07D417/06 , C07D417/14 , C07D487/04 , C07D495/04
摘要： The present invention provides a carbostyril compound represented by General Formula (1) or a salt thereof, wherein A is a direct bond, a lower alkylene group, or a lower alkylidene group; X is an oxygen atom or a sulfur atom; R4 and R5 each represent a hydrogen atom; the bond between the 3 and 4 positions of the carbostyril skeleton is a single bond or a double bond; R1 is a hydrogen atom, etc; R2 is a hydrogen atom, etc; and R3 is a hydrogen atom, etc. The carbostyril compound or salt thereof of the present invention induces the production of TFF, and thus is usable for the treatment and/or prevention of disorders such as alimentary tract diseases, oral diseases, upper respiratory tract diseases, respiratory tract diseases, eye diseases, cancers, and wounds.
摘要翻译：本发明提供由通式（1）表示的喹诺酮化合物或其盐，其中A为直接键，低级亚烷基或低级亚烷基; X是氧原子或硫原子; R 4和R 5各自表示氢原子; 喹诺酮骨架的3和4位之间的键是单键或双键; R 1是氢原子等; R 2是氢原子等; 和R 3是氢原子等。本发明的喹诺酮化合物或其盐诱导TFF的产生，因此可用于治疗和/或预防诸如消化道疾病，口腔疾病，上呼吸道疾病，呼吸道疾病，眼睛疾病，癌症和伤口。

12. 发明授权

US08362252B2 Carbostyril compound 失效
标题翻译：碳青霉烯化合物
公开(公告)号：US08362252B2
公开(公告)日：2013-01-29
申请号：US12611921
申请日：2009-11-03
申请人： Takeshi Kuroda , Takahito Yamauchi , Tomoichi Shinohara , Kunio Oshima , Chiharu Kitajima , Hitoshi Nagao , Tae Fukushima , Takahiro Tomoyasu , Hironobu Ishiyama , Kazuhide Ohta , Masaaki Takano , Takumi Sumida
发明人： Takeshi Kuroda , Takahito Yamauchi , Tomoichi Shinohara , Kunio Oshima , Chiharu Kitajima , Hitoshi Nagao , Tae Fukushima , Takahiro Tomoyasu , Hironobu Ishiyama , Kazuhide Ohta , Masaaki Takano , Takumi Sumida
IPC分类号： C07D215/38
CPC分类号： C07D471/08 , C07D417/04 , C07D417/06 , C07D417/14 , C07D487/04 , C07D495/04
摘要： The present invention provides a carbostyril compound represented by General Formula (1) or a salt thereof, wherein A is a direct bond, a lower alkylene group, or a lower alkylidene group; X is an oxygen atom or a sulfur atom; R4 and R5 each represent a hydrogen atom; the bond between the 3 and 4 positions of the carbostyril skeleton is a single bond or a double bond; R1 is a hydrogen atom, etc; R2 is a hydrogen atom, etc; and R3 is a hydrogen atom, etc. The carbostyril compound or salt thereof of the present invention induces the production of TFF, and thus is usable for the treatment and/or prevention of disorders such as alimentary tract diseases, oral diseases, upper respiratory tract diseases, respiratory tract diseases, eye diseases, cancers, and wounds.
摘要翻译：本发明提供由通式（1）表示的喹诺酮化合物或其盐，其中A为直接键，低级亚烷基或低级亚烷基; X是氧原子或硫原子; R4和R5各自表示氢原子; 喹诺酮骨架的3和4位之间的键是单键或双键; R1是氢原子等; R2是氢原子等; R3是氢原子等。本发明的喹诺酮化合物或其盐诱导TFF的产生，因此可用于治疗和/或预防诸如消化道疾病，口腔疾病，上呼吸道疾病疾病，呼吸道疾病，眼睛疾病，癌症和伤口。

13. 发明申请

US20100261705A1 CARBOSTYRIL COMPOUND 失效
标题翻译：卡波西汀化合物
公开(公告)号：US20100261705A1
公开(公告)日：2010-10-14
申请号：US12611921
申请日：2009-11-03
申请人： Takeshi Kuroda , Takahito Yamauchi , Tomoichi Shinohara , Kunio Oshima , Chiharu Kitajima , Hitoshi Nagao , Tae Fukushima , Takahiro Tomoyasu , Hironobu Ishiyama , Ohta Kazuhide , Masaaki Takano , Takumi Sumida
发明人： Takeshi Kuroda , Takahito Yamauchi , Tomoichi Shinohara , Kunio Oshima , Chiharu Kitajima , Hitoshi Nagao , Tae Fukushima , Takahiro Tomoyasu , Hironobu Ishiyama , Ohta Kazuhide , Masaaki Takano , Takumi Sumida
IPC分类号： A61K31/4709 , C07D417/10 , C07D417/14 , A61K31/5377 , A61K31/496 , A61K31/506 , A61K31/473 , A61K31/498 , A61K31/55 , A61P1/00 , A61P11/00 , A61P27/02 , A61P35/00 , A61P17/02
CPC分类号： C07D471/08 , C07D417/04 , C07D417/06 , C07D417/14 , C07D487/04 , C07D495/04
摘要： The present invention provides a carbostyril compound represented by General Formula (1) or a salt thereof, wherein A is a direct bond, a lower alkylene group, or a lower alkylidene group; X is an oxygen atom or a sulfur atom; R4 and R5 each represent a hydrogen atom; the bond between the 3 and 4 positions of the carbostyril skeleton is a single bond or a double bond; R1 is a hydrogen atom, etc; R2 is a hydrogen atom, etc; and R3 is a hydrogen atom, etc. The carbostyril compound or salt thereof of the present invention induces the production of TFF, and thus is usable for the treatment and/or prevention of disorders such as alimentary tract diseases, oral diseases, upper respiratory tract diseases, respiratory tract diseases, eye diseases, cancers, and wounds.
摘要翻译：本发明提供由通式（1）表示的喹诺酮化合物或其盐，其中A为直接键，低级亚烷基或低级亚烷基; X是氧原子或硫原子; R4和R5各自表示氢原子; 喹诺酮骨架的3和4位之间的键是单键或双键; R1是氢原子等; R2是氢原子等; R3是氢原子等。本发明的喹诺酮化合物或其盐诱导TFF的产生，因此可用于治疗和/或预防诸如消化道疾病，口腔疾病，上呼吸道疾病疾病，呼吸道疾病，眼睛疾病，癌症和伤口。

14. 发明授权

US09005378B2 Spring steel wire rod excellent in decarburization resistance and wire drawing workability and method for producing same 有权
标题翻译：耐脱碳性和拉丝加工性优异的弹簧钢线材及其制造方法
公开(公告)号：US09005378B2
公开(公告)日：2015-04-14
申请号：US12192437
申请日：2008-08-15
申请人： Takuya Kochi , Shogo Murakami , Takeshi Kuroda , Hiromichi Tsuchiya
发明人： Takuya Kochi , Shogo Murakami , Takeshi Kuroda , Hiromichi Tsuchiya
IPC分类号： C22C38/18
CPC分类号： C22C38/18
摘要： Disclosed is a spring steel wire rod that comprises C in a range of 0.35 to 0.65% (mass %, the same applies to respective elements described hereinafter), Si in a range of 1.4 to 2.2%, Mn in a range of 0.10 to 1.0%, Cr in a range of 0.1 to 2.0%, P not more than 0.025% (0% excluded), and S not more than 0.025% (0% excluded), balance comprising iron, and unavoidable impurities, wherein an average grain size Dc of a central part of the steel wire rod is not more than 80 μm while an average grain size Ds of a surface layer part of the steel wire rod is not less than 3.0 μm.
摘要翻译：公开了一种弹簧钢线材，其包含在0.35至0.65％范围内的C（质量％，同样适用于下文所述的元素），Si在1.4至2.2％的范围内，Mn在0.10至1.0的范围内％，Cr为0.1〜2.0％，P为0.025％以下（不包括0％），S为0.025％以下（0％除外），余量为铁和不可避免的杂质，平均粒径钢线材的中心部的Dc为80μm以下，钢线材的表层部的平均粒径Ds为3.0μm以上。

15. 发明授权

US08382916B2 Method for production of steel product with outstanding descalability; and steel wire with outstanding descalability 有权
标题翻译：具有优异的除鳞性能的钢制品生产方法; 钢丝具有优异的除鳞性能
公开(公告)号：US08382916B2
公开(公告)日：2013-02-26
申请号：US12795109
申请日：2010-06-07
申请人： Takeshi Kuroda , Hidenori Sakai , Mikako Takeda , Takuya Kochi , Takashi Onishi , Tomotada Maruo , Takaaki Minamida
发明人： Takeshi Kuroda , Hidenori Sakai , Mikako Takeda , Takuya Kochi , Takashi Onishi , Tomotada Maruo , Takaaki Minamida
IPC分类号： C23C8/18
CPC分类号： B21B45/00 , C21D8/06 , C21D9/52 , C22C38/02 , C22C38/04
摘要： The present invention aims at providing a method for production of a steel product which surely retains scale during cooling, storage, and transportation and permits scale to scale off easily at the time of mechanical descaling and pickling that precede the secondary fabrication. The steel product is produced by heating and hot rolling a steel billet and spraying the hot-rolled steel product with steam and/or water mist having a particle diameter no larger than 100 μm, for surface oxidation.
摘要翻译：本发明的目的在于提供一种钢制品的生产方法，其在冷却，储存和运输过程中确保保持垢，并且允许在二次加工之前的机械除锈和酸洗时容易地缩放垢。钢产品通过对钢坯进行加热和热轧而制造，并且对具有不大于100μm的粒径的蒸汽和/或水雾喷射热轧钢产品进行表面氧化。

16. 发明授权

US07300089B2 Fixing member and a fixing structure for vehicle part 有权
标题翻译：固定件和车辆部件固定结构
公开(公告)号：US07300089B2
公开(公告)日：2007-11-27
申请号：US10957741
申请日：2004-10-05
申请人： Takeshi Kuroda
发明人： Takeshi Kuroda
IPC分类号： B60R13/01 , F16B13/04
CPC分类号： B60R13/0206 , Y10T24/309
摘要： A fixing member includes a base portion having an opening portion at side surfaces thereof, a pair of flange portions protruding from a free end portion of the base portion, at least one elastic portion perpendicularly extending from a lower surface of each flange portion toward within the opening portion of the base portion, and at least one pair of engagement portions protruding from inner surfaces of the base portion. The inner surfaces of the base portion are opposed to each other. When the fixing member for fixing car interior material to a vehicle body is engaged with a boss member, the elastic portion presses against both sides of the boss portion by its distal end portion of the elastic portion.
摘要翻译：固定构件包括在其侧表面具有开口部的基部，从基部的自由端部突出的一对凸缘部，从每个凸缘部的下表面垂直延伸的至少一个弹性部，基部的开口部，以及从基部的内表面突出的至少一对接合部。基部的内表面彼此相对。当用于将车辆内部材料固定到车身的固定构件与凸起构件接合时，弹性部分通过其弹性部分的远端部分压靠凸台部分的两侧。

17. 发明申请

US20060048864A1 Hot milled wire rod excelling in wire drawability and enabling avoiding heat treatment before wire drawing 有权
标题翻译：热拔丝线材具有优良的拉丝性能，能够避免拉丝前的热处理
公开(公告)号：US20060048864A1
公开(公告)日：2006-03-09
申请号：US10528263
申请日：2003-09-24
申请人： Mamoru Nagao , Takeshi Kuroda , Takaaki Minamida
发明人： Mamoru Nagao , Takeshi Kuroda , Takaaki Minamida
IPC分类号： C22C38/00
CPC分类号： C22C38/02 , C21D8/06 , C21D9/5732 , C21D2211/009 , C22C38/04 , C22C38/40
摘要： A hot-rolled wire rod: the wire rod being a hot-rolled wire rod 5.0 mm or more in diameter, containing in mass C: 0.6 to 1.0%, Si: 0.1 to 1.5%, Mn: 0.3 to 1.0%, P: 0.02% or less, and S: 0.02% or less; not less than 90% of the wire rod in area percentage being composed of a pearlite structure; and the mechanical properties of the wire rod 4 m in length satisfying the following expressions (1) to (4), (1) TS*−30≦Average value of tensile strength (TSAV in MPa)≦TS*+30, where, TS*=400×{[C]+([Mn]+[Si])/5}+670 and the elements in square brackets [ ] in the equality mean the contents of relevant elements in percentage, (2) Standard deviation of tensile strength (TSσ)≦30 MPa, (3) Average value of reduction of area (RAAV)>35%, (4) Standard deviation of reduction of area (RAσ) ≦4%. A hot-rolled wire rod according to the present invention is incomparably excellent in wire drawability and brakes less frequently than a conventional wire rod even when it is processed as hot-rolled with heat treatment such as patenting treatment omitted.
摘要翻译：热轧线材：线材为直径5.0mm以上的热轧线材，质量C：0.6〜1.0％，Si：0.1〜1.5％，Mn：0.3〜1.0％，P： 0.02％以下，S：0.02％以下。不少于90％的线材面积百分比由珠光体组织构成; 以及长度满足下述式（1）〜（

18. 发明申请

US20050116485A1 Fixing member and a fixing structure for vehicle part 有权
标题翻译：固定件和车辆部件固定结构
公开(公告)号：US20050116485A1
公开(公告)日：2005-06-02
申请号：US10957741
申请日：2004-10-05
申请人： Takeshi Kuroda
发明人： Takeshi Kuroda
IPC分类号： B60R13/02 , B60R13/00
CPC分类号： B60R13/0206 , Y10T24/309
摘要： A fixing member includes a base portion having an opening portion at side surfaces thereof, a pair of flange portions protruding from a free end portion of the base portion, at least one elastic portion perpendicularly extending from a lower surface of each flange portion toward within the opening portion of the base portion, and at least one pair of engagement portions protruding from inner surfaces of the base portion. The inner surfaces of the base portion are opposed to each other. When the fixing member for fixing car interior material to a vehicle body is engaged with a boss member, the elastic portion presses against both sides of the boss portion by its distal end portion of the elastic portion.
摘要翻译：固定构件包括在其侧表面具有开口部的基部，从基部的自由端部突出的一对凸缘部，从每个凸缘部的下表面垂直延伸的至少一个弹性部，基部的开口部，以及从基部的内表面突出的至少一对接合部。基部的内表面彼此相对。当用于将车辆内部材料固定到车身的固定构件与凸起构件接合时，弹性部分通过其弹性部分的远端部分压靠凸台部分的两侧。

19. 发明申请

US20050087270A1 Very thin, high carbon steel wire and method of producing same 有权
标题翻译：非常薄的高碳钢丝及其制造方法
公开(公告)号：US20050087270A1
公开(公告)日：2005-04-28
申请号：US10968253
申请日：2004-10-20
申请人： Mamoru Nagao , Takeshi Kuroda , Takaaki Minamida
发明人： Mamoru Nagao , Takeshi Kuroda , Takaaki Minamida
IPC分类号： B21C1/00 , B21C1/04 , B21C9/00 , B21C37/04 , C21D8/06 , C21D9/52 , C22C38/00 , C22C38/02 , C22C38/04 , C22C38/54
CPC分类号： C22C38/04 , B21C1/04 , B21C9/005 , B21C37/047 , C21D8/06 , C21D9/525 , C21D2211/009 , C22C38/02
摘要： The very thin, high carbon wire is 0.05 to 0.50 mm in diameter and comprises, in mass %, 0.90-1.20% of C, 0.05-1.2% of Si, 0.2-1.0% of Mn, and 0.0050% or less of N, with the balance being iron and impurities. In a differential scanning thermal analysis curve A of the steel wire, the steel wire has an exothermic peak X in the temperature range of 60° to 130° C., and a maximum height h of the exothermic peak X relative to a reference line Y joining the point of 60° C. and the point of 130° C. in the differential scanning thermal analysis curve is set at 5 μW/mg or more. The very thin, high carbon steel wire is free of delamination in high-speed stranding and superior in both strength and ductility.
摘要翻译：非常薄的高碳丝的直径为0.05-0.50mm，以质量％计含有C：0.90-1.20％，Si：0.05-1.2％，Mn：0.2-1.0％，N：0.0050％余量为铁和杂质。在钢丝的差示扫描热分析曲线A中，钢线在60〜130℃的温度范围内具有放热峰X，相对于基准线Y的放热峰X的最大高度h 将差示扫描热分析曲线中的60℃的点和130℃的点连接设定为5μW/ mg以上。非常薄的高碳钢丝在高速绞合中没有分层，并且在强度和延展性方面都是优异的。

20. 发明授权

US06372056B1 Spring steel superior in workability 有权
标题翻译：弹钢优越的可加工性
公开(公告)号：US06372056B1
公开(公告)日：2002-04-16
申请号：US09466930
申请日：1999-12-20
申请人： Takeshi Kuroda , Nobuhiko Ibaraki , Nao Yoshihara
发明人： Takeshi Kuroda , Nobuhiko Ibaraki , Nao Yoshihara
IPC分类号： C22C3802
CPC分类号： C21D8/06 , C21D9/02 , C21D9/525
摘要： A spring steel which is superior in both shaving properties and green drawing properties, which are important in spring production. A process for making the spring steel into wire rods for good springs. A rolled spring steel superior in workability characterized in that it has the following mechanical properties. Tensile strength≦1200 MPa 30%≦reduction of area≦70% A process for producing a steel wire rod for springs from said spring steel, said process comprising drawing, shaving, and oil tempering, which are carried out sequentially, said drawing being optionally followed by prescribed treatment.
摘要翻译：在春季生产中重要的是在剃须性和绿色拉伸性上均优异的弹簧钢。将弹簧钢制成用于良好弹簧的线材的方法。一种加工性优异的轧制弹簧钢，其特征在于其具有以下机械性能。抗拉强度<= 1200MPa 30％<=面积减小<= 70％一种用于从所述弹簧钢制造用于弹簧的钢线材的方法，所述方法包括依次进行的拉拔，刮削和回火，所述图纸任选地进行规定的处理。

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