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    • 11. 发明授权
    • On-vehicle vehicle guide apparatus, communication server system, and substitute vehicle guide system
    • 车载导航装置,通信服务器系统和替代车辆引导系统
    • US06484091B2
    • 2002-11-19
    • US09875920
    • 2001-06-08
    • Makoto ShibataNobuyuki MoribeTomonari Yamaguchi
    • Makoto ShibataNobuyuki MoribeTomonari Yamaguchi
    • G01K2124
    • G08G1/202G08G1/123G08G1/127G08G1/205
    • There is provided an alternative vehicle guiding system wherein a communication sever system receives a fault condition information from vehicles and also transmits the necessary information to the navigation system of an alternative vehicle in order to prevent the damage of loads by quickly guiding the alternative vehicle to the fault generating vehicle position and then realizing smooth transfer of remaining work to the alternative vehicle. The navigation system, fault monitoring means and vehicle communication means are respectively provided in the vehicles for transportation work and the center server system is also provided to transmit the vehicle distribution information to the vehicles. When a fault is generated in the vehicle, the communication server system receives the information from this vehicle and the navigation system of the alternative vehicle displays the transmitted information. Thereby, the alternative vehicle can always be distributed smoothly without any manual operation, the time required until the alternative vehicle arrives and the work transfer time can be shortened and adverse effect on the loads and successive load distribution work can be prevented.
    • 提供了替代的车辆引导系统,其中通信服务器系统从车辆接收故障状况信息,并且还将必要的信息发送到替代车辆的导航系统,以便通过快速地将替代车辆引导到 故障发生车辆位置,然后实现剩余作业平稳转移到替代车辆。 导航系统,故障监测装置和车辆通信装置分别设置在用于运输工作的车辆中,并且还提供中央服务器系统以将车辆分配信息传送到车辆。 当在车辆中产生故障时,通信服务器系统从该车辆接收信息,并且替代车辆的导航系统显示所发送的信息。 因此,替代车辆总是可以顺利地分配,而无需任何手动操作,直到替代车辆到达所需的时间和工件传送时间可以缩短,并且可以防止对负载和连续的负载分配工作的不利影响。
    • 13. 发明授权
    • Pyrroloazepine derivatives
    • 吡咯并氮衍生物
    • US06258805B1
    • 2001-07-10
    • US09312713
    • 1999-05-17
    • Akira MizunoMakoto ShibataTomoe IwamoriTetsuo ShimamotoKyoko NakanishiNorio Inomata
    • Akira MizunoMakoto ShibataTomoe IwamoriTetsuo ShimamotoKyoko NakanishiNorio Inomata
    • A61K3155
    • C07D487/04C07D207/34
    • A method for treating a circulatory disease or condition in a mammal, which entails administering to the mammal an effective amount of a compound of the formula (I) or a pharmaceutically acceptable salt thereof: wherein the ring P represented by  is a pyrrole ring having the following structure: wherein R1 represents C1-C8 alkyl, C3-C8 cycloalkyl, C4-C8 cycloalkyl-alkyl, C6-C14 aryl or C7-C22 aralkyl, which are optionally substituted; and R2 represents H or C1-C8 alkyl, which is optionally substituted; the dashed line indicates the presence or absence of a bond; and, when the bond is present, Z2 is not present and Z1 represents H, but, when the bond is absent, Z1 and Z2 are both H; Z1 represents H and Z2 represents a group OR3, in which R3 represents H, C1-C8 alkyl, or C7-C22 aralkyl, which are optionally substituted; Z1 and Z2 both represent groups SR4, in which R4 represents C1-C8 alkyl or C7-C22 aralkyl, which are optionally substituted; or Z1 and Z2 are combined together to represent O, a group NOR5, in which R5 represents H, or C1-C8 alkyl or C2-C3 alkylenedithio, which are optionally substituted; A represents alkylene, alkenylene or alkynylene; and Y represents a group in which W is CH, C═ or N, m is for 0 or 1, n is for 1, 2 or 3, G is O, S, C═O, sulfinyl, sulfonyl, alkylene, alkenylene or acetal; E1 and E2 is H or C1-C8 alkyl; and D represents an aromatic hydrocarbon or an aromatic heterocyclic ring. The compound (I) has strong serotonin-2 receptor antagonistic action and low toxicity and less side effects, and is therapeutically useful in the treatment of circulatory diseases and/or conditions related thereto.
    • 一种用于治疗哺乳动物的循环系统疾病或病症的方法,其需要向哺乳动物施用有效量的式(I)化合物或其药学上可接受的盐:其中由表示的环P是具有以下基团的吡咯环 结构:其中R 1表示任选取代的C 1 -C 8烷基,C 3 -C 8环烷基,C 4 -C 8环烷基 - 烷基,C 6 -C 14芳基或C 7 -C 22芳烷基; 并且R 2表示H或被任选取代的C 1 -C 8烷基; 虚线表示存在或不存在键; 当存在键时,Z 2不存在,Z1表示H,但不存在键时,Z 1和Z 2均为H; Z1表示H,Z2表示OR3,其中R3表示H,任选取代的C 1 -C 8烷基或C 7 -C 22芳烷基; Z 1和Z 2均表示SR 4,其中R 4表示任选取代的C 1 -C 8烷基或C 7 -C 22芳烷基; 或Z 1和Z 2组合在一起表示O,其中R 5表示H的基团NOR 5或任选被取代的C 1 -C 8烷基或C 2 -C 3亚烷基二硫基; A表示亚烷基,亚烯基或亚炔基; 并且Y表示W为CH,C =或N的基团,m为0或1,n为1,2或3,G为O,S,C = O,亚磺酰基,磺酰基,亚烷基,亚烯基或亚磺酰基 乙缩醛 E1和E2是H或C1-C8烷基; D表示芳族烃或芳香族杂环。 化合物(I)具有强的5-羟色胺-2受体拮抗作用和低毒性和较少的副作用,并且在治疗循环系统疾病和/或与之有关的病症中是治疗上有用的。
    • 16. 发明授权
    • Non-contact type seal device for turbocharger
    • 用于涡轮增压器的非接触式密封装置
    • US4645213A
    • 1987-02-24
    • US749967
    • 1985-06-28
    • Kouichi WashimiMakoto ShibataMitsuyuki Ugajin
    • Kouichi WashimiMakoto ShibataMitsuyuki Ugajin
    • F01D11/00F01D25/18F02B39/00F16J15/40F16J15/44F16J15/447
    • F01D25/183F16J15/406
    • A non-contact type seal device for a turbocharger in which lubricating oil is prevented from leaking into the compression chamber of the turbocharger over the entire range of rotational speeds thereof. The seal device of the invention includes a retainer mounted in a compression chamber of a housing of the turbocharger, a collar attached to a compressor wheel mounting portion of the rotor shaft of the turbocharger, and a ring provided on an inner peripheral surface of the retainer. An annular groove receiving the ring is formed in the outer peripheral surface of the collar. A first gap is formed between the outer peripheral surface of the collar and the inner peripheral surface of the retainer, while a second gap is formed between the inner surface of the annular groove and each of the inner and outer end surfaces of the ring. A threaded groove is formed in the inner peripheral surface of the retainer in opposition to the outer peripheral surface of the collar.
    • 一种用于涡轮增压器的非接触式密封装置,其中防止润滑油在其旋转速度的整个范围内泄漏到涡轮增压器的压缩室中。 本发明的密封装置包括安装在涡轮增压器的壳体的压缩室中的保持器,附接到涡轮增压器的转子轴的压缩机叶轮安装部分的轴环和设置在保持器的内周面上的环 。 在轴环的外周面上形成有环状的环形槽。 在环的外周面和保持器的内周面之间形成有第一间隙,同时在环的内表面与环的内外表面之间形成第二间隙。 相对于套环的外周面,在保持器的内周面形成螺纹槽。
    • 18. 发明授权
    • Pyrrolothiazine and pyrrolothiazepine compounds having serotonin-2 receptor antagonistic and &agr;-1-blocking action
    • 具有5-羟色胺受体拮抗作用和α-1-阻断作用的吡罗噻嗪和吡咯并噻吩类化合物
    • US06583296B2
    • 2003-06-24
    • US09939829
    • 2001-08-28
    • Akira MizunoMakoto ShibataTomoe KameiHarukazu FukamiNorio Inomata
    • Akira MizunoMakoto ShibataTomoe KameiHarukazu FukamiNorio Inomata
    • C07D20736
    • C07D513/04C07D207/36
    • A pyrrolesulfonamide compound having the following formula (I): wherein the ring P represented by is a pyrrole ring having the following structure: wherein A represents alkylene, alkenylene or alkynylene; and Y represents a group in which W represents CH, C═ or N; m stands for 0 or 1 when W is CH or N, or m stands for 1 when W is C═; B represents a specific divalent group; E1 and E2 each independently represents H or lower alkyl; and D represents an aromatic hydrocarbon group or heterocyclic group; l stands for 0 or 1; the dashed line indicates the presence or absence of a bond; and, when the bond is present, Z2 is not present and Z1 represents H but, when the bond is absent, Z1 represents H and Z2 represents OH or Z1 and Z2 are combined together to represent O or a group NOR5, in which R5 represents H, or alkyl, aralkyl or aryl; and R represents H, alkyl, cycloalkyl, cycloalkyl-alkyl or aralkyl. The compound (1) has been improved in potency, selectivity to receptors other than serotonin-2 receptors, toxicity, side effects and/or the like over medicines reported to date and equipped with &agr;1-blocking action and serotonin-2 receptor antagonistic action in combination.
    • 具有下式(I)的吡咯磺酰胺化合物:其中由具有以下结构的吡咯环表示的环P:其中A表示亚烷基,亚烯基或亚炔基; Y表示W表示CH,C =或N的基团; 当W为CH或N时,m代表0或1,当W为C =时,m代表1; B表示特定的二价基团; E1和E2各自独立地表示H或低级烷基; D表示芳族烃基或杂环基; l代表0或1; 虚线表示存在或不存在键; 当存在键时,Z 2不存在,Z1表示H,但当不存在键时,Z1表示H,Z2表示OH或Z1,Z2组合在一起表示O或NOR5基团,其中R5表示 H或烷基,芳烷基或芳基; R代表H,烷基,环烷基,环烷基 - 烷基或芳烷基。 化合物(1)对迄今为止报道的并且具有α1-阻断作用和5-羟色胺-2受体拮抗作用的药物的效力,对5-羟色胺2受体以外的受体的选择性,毒性,副作用等改善 组合。