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11. 发明授权

US07879022B2 Rapid exchange fluid jet thrombectomy device and method 有权
标题翻译：快速交换液喷射血栓切除装置及方法
公开(公告)号：US07879022B2
公开(公告)日：2011-02-01
申请号：US11096592
申请日：2005-04-01
申请人： Michael J. Bonnette , Michael P. Schrom , Hieu V. Le
发明人： Michael J. Bonnette , Michael P. Schrom , Hieu V. Le
IPC分类号： A61M3/00 , A61M25/00
CPC分类号： A61B17/32037 , A61B17/22 , A61B17/3203 , A61B2017/00292 , A61B2017/00778 , A61B2017/22041 , A61B2090/034
摘要： A rapid exchange fluid jet thrombectomy device having a streamlined manifold and a catheter having multiple tubular segments where each tubular segment increases in flexibility in a distal direction. Torque response and pushability is enhanced by the arrangement of a proximally located tubular segment composed of a polymer-jacketed spiral metal tube in combination with an intermediate tubular section and a distal tubular section each having different degrees of flexibility. A guidewire tube exit region is provided where the intermediate tubular section joins the distal tubular section for over-the-wire guidewire usage. The polymer-jacketed spiral metal tube can extend along a partial or full length of the catheter and can include a basic continuous spiral cut which has regions of constant pitch or which has progressively increasing pitch, or in the alternative, can include an interlocking spiral cut having constant pitch regions or progressively decreasing pitch.
摘要翻译：具有流线型歧管的快速交换流体喷射血栓切除装置和具有多个管状区段的导管，其中每个管状区段在远端方向上的柔性增加。通过由聚合物夹套的螺旋金属管组成的近端定位的管状部分与中间管状部分和每个具有不同柔性程度的远端管状部分的组合来增强扭矩响应和推动性。提供导丝管出口区域，其中中间管状部分连接远端管状部分用于线上导丝使用。聚合物套管的螺旋金属管可以沿着导管的部分或全长延伸，并且可以包括具有恒定节距或具有逐渐增加的间距的区域的基本连续螺旋切口，或者替代地，可以包括互锁螺旋切口具有恒定的音调区域或逐渐减小音调。

12. 发明申请

US20080312671A1 Infusion flow guidewire system 有权
标题翻译：输液流导丝系统
公开(公告)号：US20080312671A1
公开(公告)日：2008-12-18
申请号：US11980164
申请日：2007-10-30
申请人： John C. Riles , Douglas J. Ball , Michael J. Bonnette , Eric J. Thor , John L. Teschendorf , Hieu V. Le
发明人： John C. Riles , Douglas J. Ball , Michael J. Bonnette , Eric J. Thor , John L. Teschendorf , Hieu V. Le
IPC分类号： A61B17/22
CPC分类号： A61B17/32037 , A61B2017/22038 , A61B2017/22049 , A61M2025/09083
摘要： An infusion flow guidewire system including a delivery sheath and an infusion flow guidewire. The minimal cross section flexible infusion flow guidewire includes a nitinol hypotube, a flexible tip and distally located rearwardly directed orifices for infusion of fibrinolytics and for introduction of high pressure fluids for maceration and rearwardly directed flow of thrombus debris located in tortuous small sized vessels. Apparatus, some of which is removably attachable, is provided for grasping members of the invention for rotational torquing and for longitudinal actuation along and within the vasculature.
摘要翻译：一种输液流导丝系统，包括输送鞘和输注流导丝。最小横截面柔性输注流导丝包括镍钛诺海波管，柔性尖端和向远侧定位的用于输注纤维蛋白溶解剂的向后的孔，并引入高压流体用于位于曲折的小尺寸血管中的浸渍和向后定向的血栓碎屑流。提供其中一些可移除地附接的装置用于抓握本发明的构件用于旋转扭矩并沿着和在脉管系统内沿纵向致动。

13. 发明申请

US20080275393A1 Isolation thrombectomy catheter system 审中-公开
标题翻译：隔离血栓切除术导管系统
公开(公告)号：US20080275393A1
公开(公告)日：2008-11-06
申请号：US10925113
申请日：2004-08-24
申请人： Michael J. Bonnette , Hieu V. Le
发明人： Michael J. Bonnette , Hieu V. Le
IPC分类号： A61M1/00 , A61M25/10
CPC分类号： A61B17/22 , A61B17/32037 , A61B2017/22054 , A61B2017/22067 , A61B2017/22084
摘要： An isolation thrombectomy catheter system where thrombus, clotted material, or the like is isolated by distally and proximally placed inflated occlusive balloons sealing a portion of the vasculature for subsequent removal of thrombus by cross stream jets. An isolation catheter accommodates either a jet assembly for ablation of thrombus and for drug or medication delivery, or accommodates a drug delivery device for introduction of lysing fluids, drugs or medications to a thrombus site. Alternating of lysing fluid delivery and ablation can be incorporated for a combined thrombectomy effort.
摘要翻译：隔离血栓切除术导管系统，其中血栓，凝块材料等通过远侧和近端放置的充气闭塞球隔离，密封一部分脉管系统，以便随后通过流动射流除去血栓。隔离导管容纳用于消融血栓和用于药物或药物输送的射流组件，或者容纳用于将裂解液，药物或药物引入血栓部位的药物递送装置。可以并入裂解液输送和消融的交替用于组合的血栓切除术。

14. 发明授权

US07608063B2 Dual lumen aspiration catheter system 有权
标题翻译：双腔吸气导管系统
公开(公告)号：US07608063B2
公开(公告)日：2009-10-27
申请号：US11360148
申请日：2006-02-23
申请人： Hieu V. Le , Michael P. Schrom , Diana L. Dutcher , Kyle R. Matson , Dean A. Swanson , Kathleen C. Grant , James T. Klee
发明人： Hieu V. Le , Michael P. Schrom , Diana L. Dutcher , Kyle R. Matson , Dean A. Swanson , Kathleen C. Grant , James T. Klee
IPC分类号： A61M25/00
CPC分类号： A61M25/008 , A61B17/22 , A61M25/0032 , A61M25/0068 , A61M2025/0081
摘要： A dual lumen aspiration catheter system with an aspiration catheter, a hub and a flexible strain relief, and a suction assembly. The aspiration catheter includes multiple successively connected flexible tubular components each increasing in relative flexibility in the distal direction, the most proximal tubular component connectingly extending from the hub and through the flexible strain relief. The tubular components of the aspiration catheter include, in order proximally to distally, a composite tube, an intermediate tube, a dual lumen tube, and a flexible tip tube. The dual lumen tube includes eccentrically co-located large and small tubular portions forming eccentrically co-located large and small lumens to provide a minimum cross section. The distal end of the dual lumen tube includes a convex beveled edge. The convex beveled edge and the flexible tip tube singly or jointly inflict minimal traumatic contact with a vessel wall when urged along a tortuous vascular path.
摘要翻译：具有抽吸导管，轮毂和柔性应变消除装置的双腔抽吸导管系统和抽吸组件。抽吸导管包括多个连续连接的柔性管状部件，每个柔性管状部件在远端方向上相对柔性增加，最近端的管状部件从轮毂连接延伸并穿过柔性应变消除部。抽吸导管的管状部件按照向远端方向依次包括复合管，中间管，双腔管和柔性末端管。双腔管包括偏心地共同定位的大和小管状部分，形成偏心共同定位的大小腔，以提供最小横截面。双腔管的远端包括凸出的斜边缘。当沿着曲折的血管路径被推动时，凸出的斜边缘和柔性尖端管单独或联合地与血管壁产生最小的创伤性接触。

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