专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US5436254A Carbostyril derivatives 失效
标题翻译：卡波他汀衍生物
公开(公告)号：US5436254A
公开(公告)日：1995-07-25
申请号：US125667
申请日：1993-11-02
申请人： Hidenori Ogawa , Hisashi Miyamoto , Kazumi Kondo , Hiroshi Yamashita , Kenji Nakaya , Michiaki Tominaga , Yoichi Yabuuchi
发明人： Hidenori Ogawa , Hisashi Miyamoto , Kazumi Kondo , Hiroshi Yamashita , Kenji Nakaya , Michiaki Tominaga , Yoichi Yabuuchi
IPC分类号： C07D215/22 , C07D215/227 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D493/04 , C07D521/00 , C07H15/26 , A61K31/47 , C07D217/00
CPC分类号： C07D215/227 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D493/04 , C07H15/26
摘要： Novel carbostyril derivatives of the formula: ##STR1## wherein R.sup.1 is H, NO.sub.2, alkoxy, alkoxycarbonyl, alkyl, halogen, optionally substituted amino, OH, CN, COOH, alkanoyloxy, hydrazinocarbonyl; q is 1 to 3, and R is a group of the formula: ##STR2## [wherein R.sup.2 is H, alkoxycarbonyl, optionally substituted phenoxycarbonyl, phenylalkenyl--CO--, optionally substituted phenylalkanoyl, alkanoyl, alkenyl--CO--, optionally substituted phenyl--SO.sub.2 --, --CONR.sup.8 R.sup.9, optionally substituted heterocyclic group--CO--, naphthyl--CO--, thienylalkanoyl, tricyclo[3.3.1.1]alkanoyl, ##STR3## (R.sup.13 is OH, optionally substituted alkoxy, --NR.sup.32 R.sup.33, --O--A--(E).sub.l --NR.sup.4 R.sup.5, --(B).sub.l --NR.sup.6 R.sup.7, etc.), n is 1 or 2, m is 0 or 1 to 3, R.sup.3 is alkyl, R.sup.10 is --(CO).sub.l --NR.sup.11 R.sup.12 ], and the bond between 3- and 4-position of carbostyril nucleus is single or double bond, which have excellent vasopressin antagonistic activities and are useful as vasodilator, hypotensive agent, water diuretics, platelet agglutination inhibitor, and a vasopressin antagonistic composition containing the compound as the active ingredient.
摘要翻译：其中R1是H，NO2，烷氧基，烷氧基羰基，烷基，卤素，任选取代的氨基，OH，CN，COOH，烷酰氧基，肼基羰基; q为1至3，并且R为下式的基团：其中R 2为H，烷氧基羰基，任选取代的苯氧基羰基，苯基烯基-CO-，任选取代的苯基烷酰基，烷酰基，烯基-CO-，任选取代的苯基-SO 2 - ，-CONR 8 R 9，任选取代的杂环基-CO-，萘基-CO-，噻吩基烷酰基，三环[3.3.1.1]烷酰基，（R 13是OH，任选取代的烷氧基，-NR 32 R 33，-OA - （E）1-NR4R5， - （B）1-NR6R7等），n为1或2，m为0或1至3，R3为烷基，R10为 - （CO）1-NR11R12] 喹诺酮核的3-和4-位之间的键是单键或双键，其具有优异的加压素拮抗活性，并且可用作血管扩张剂，降血压剂，水利尿剂，血小板凝集抑制剂和含有该化合物的血管加压素拮抗剂组合物有效成分。

12. 发明授权

US5753677A Benzoheterocyclic compounds 失效
标题翻译：苯并杂环化合物
公开(公告)号：US5753677A
公开(公告)日：1998-05-19
申请号：US474544
申请日：1995-06-07
申请人： Hidenori Ogawa , Hisashi Miyamoto , Kazumi Kondo , Hiroshi Yamashita , Kenji Nakaya , Hajime Komatsu , Michinori Tanaka , Shinya Kora , Michiaki Tominaga , Yoichi Yabuuchi
发明人： Hidenori Ogawa , Hisashi Miyamoto , Kazumi Kondo , Hiroshi Yamashita , Kenji Nakaya , Hajime Komatsu , Michinori Tanaka , Shinya Kora , Michiaki Tominaga , Yoichi Yabuuchi
IPC分类号： A61K31/55 , A61K31/551 , A61K31/47
CPC分类号： A61K31/551 , A61K31/55
摘要： Novel benzoheterocyclic compounds of the formula: ##STR1## which have excellent vasopressin antagonistic activities and are useful as vasodilator, hypotensive agent, water diuretics, platelet agglutination inhibitor, and a vasopressin antagonistic composition containing the compound as the active ingredient.
摘要翻译：具有优异的加压素拮抗活性并可用作血管扩张剂，降血压药，水利尿剂，血小板凝集抑制剂和含有该化合物作为活性成分的血管加压素拮抗剂组合物的新颖的苯并杂环化合物。

13. 发明授权

US5559230A Benzoheterocyclic compounds 失效
标题翻译：苯并杂环化合物
公开(公告)号：US5559230A
公开(公告)日：1996-09-24
申请号：US76804
申请日：1993-06-10
申请人： Hidenori Ogawa , Hisashi Miyamoto , Kazumi Kondo , Hiroshi Yamashita , Kenji Nakaya , Hajime Komatsu , Michinori Tanaka , Shinya Kora , Michiaki Tominaga , Yoichi Yabuuchi
发明人： Hidenori Ogawa , Hisashi Miyamoto , Kazumi Kondo , Hiroshi Yamashita , Kenji Nakaya , Hajime Komatsu , Michinori Tanaka , Shinya Kora , Michiaki Tominaga , Yoichi Yabuuchi
IPC分类号： A61K31/551 , C07D215/08 , C07D215/12 , C07D215/14 , C07D215/20 , C07D215/22 , C07D215/233 , C07D215/38 , C07D215/42 , C07D215/54 , C07D223/16 , C07D225/06 , C07D241/42 , C07D243/12 , C07D243/14 , C07D265/36 , C07D267/14 , C07D279/16 , C07D281/10 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D491/04 , C07D491/10 , C07D498/04 , A61K31/55
CPC分类号： C07D215/233 , A61K31/551 , C07D215/08 , C07D215/12 , C07D215/14 , C07D215/20 , C07D215/38 , C07D215/42 , C07D215/54 , C07D223/16 , C07D225/06 , C07D241/42 , C07D243/12 , C07D243/14 , C07D265/36 , C07D267/14 , C07D279/16 , C07D281/10 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D491/04 , C07D491/10
摘要： Novel benzoheterocyclic compounds of the formula: ##STR1## wherein R.sup.1 is H, halogen, alkyl, optionally substituted amino, alkoxy; R.sup.2 is H, halogen, alkoxy, phenyialkoxy, OH, alkyl, optionally substituted amino, carbamoyl-alkoxy, optionally substituted amino-alkoxy, optionally substituted benzoyloxy; R.sup.3 is a group: --NR.sup.4 R.sup.5 or --CO--NR.sup.11 R.sup.12 ; R.sup.4 is H, optionally substituted benzoyl, alkyl; R.sup.5 is a group: ##STR2## [R.sup.16 is halogen, optionally substituted alkyl, OH, alkoxy, alkanoyloxy, alkylthio, alkanoyl, carboxy, alkoxycarbonyl, CN, NO.sub.2, optionally substituted amino, phenyl, cycloalkyl, etc., or a group: --O--A--NR.sup.6 R.sup.7 ; m is 0 to 3], phenyl-alkoxycarbonyl, alkanoyl, phenylalkanoyl, etc.; R.sup.11 is H or alkyl; R.sup.12 is cycloalkyl or optionally substituted phenyl; and W is a group: --(CH.sub.2).sub.p (p is 3 to 5) or --CH.dbd.CH--(CH.sub.2).sub.q (q is 1 to 3), the carbon atom of these groups being optionally replaced by O, S, SO, SO.sub.2 or a group: --N(R).sup.12 and further these groups having optionally 1 to 3 substituents of alkyl, alkoxycarbonyl, carboxy, OH, O, alkanoyloxy, etc., which have excellent vasopressin antagonistic activities and are useful as vasodilator, hypotensive agent, water diuretics, platelet agglutination inhibitor, and a vasopressin antagonistic composition containing the compound as the active ingredient.
摘要翻译：新颖的下式的苯并杂环化合物：其中R 1是H，卤素，烷基，任选取代的氨基，烷氧基; R 2是H，卤素，烷氧基，苯基烷氧基，OH，烷基，任选取代的氨基，氨基甲酰基 - 烷氧基，任选取代的氨基 - 烷氧基，任选取代的苯甲酰氧基; R3是基团：-NR4R5或-CO-NR11R12; R 4是H，任选取代的苯甲酰基，烷基; R5是一个基团：[R 16是卤素，任选取代的烷基，OH，烷氧基，烷酰氧基，烷硫基，烷酰基，羧基，烷氧基羰基，CN，NO 2，任选取代的氨基，苯基，环烷基等， -OA-NR6R7; m为0〜3]，苯基 - 烷氧基羰基，烷酰基，苯基烷酰基等。 R11为H或烷基; R 12是环烷基或任选取代的苯基; 并且W是以下基团： - （CH 2）p（p为3至5）或-CH = CH-（CH 2）q（q为1至3），这些基团的碳原子任选被O，S， SO，SO 2或基团-N（R）12，并且这些基团具有任选1至3个烷基，烷氧基羰基，羧基，OH，O，烷酰氧基等取代基，它们具有优良的加压素拮抗活性，可用作血管扩张剂降压药，水利尿剂，血小板凝集抑制剂，以及含有该化合物作为活性成分的血管加压素拮抗剂组合物。

14. 发明授权

US5300513A Carbostyril derivatives and pharmaceutical composition containing the same 失效
标题翻译：碳青霉烯衍生物和含有其的药物组合物
公开(公告)号：US5300513A
公开(公告)日：1994-04-05
申请号：US740676
申请日：1991-08-06
申请人： Hidenori Ogawa , Hisashi Miyamoto , Kazumi Kondo , Hiroshi Yamashita , Kenji Nakaya , Hajime Komatsu , Michinori Tanaka , Kazuyoshi Kitano , Takafumi Fujiioka , Shuji Teramoto , Michiaki Tominaga , Yoichi Yabuuchi
发明人： Hidenori Ogawa , Hisashi Miyamoto , Kazumi Kondo , Hiroshi Yamashita , Kenji Nakaya , Hajime Komatsu , Michinori Tanaka , Kazuyoshi Kitano , Takafumi Fujiioka , Shuji Teramoto , Michiaki Tominaga , Yoichi Yabuuchi
IPC分类号： A61K31/47 , A61K31/4709 , A61K31/54 , A61P1/16 , A61P3/08 , A61P5/00 , A61P7/00 , A61P7/02 , A61P7/10 , A61P9/08 , A61P9/12 , A61P13/02 , A61P15/00 , C07D215/22 , C07D215/36 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14
CPC分类号： C07D401/04 , C07D401/06 , C07D401/14
摘要： Novel carbostyril derivatives of the formula: ##STR1## wherein X is 0 or S; Y is H or alkyl; R.sup.A is a group of the ##STR2## {wherein n is 1 or 2, A is alkylene, R.sup.1 is benzoyl having optionally 1-3 substituents, R.sup.2A is ##STR3## is (i) alkoxy, (ii) substituted or unsubstituted 5- or 6-membered heterocylic group, (iii) alkenylthio, (iv) pyrrolidinyl-alkyl--S--, (v) pyrrolidinyl-alkyl--SO--, (vi) pyrrolidinyl-alkyl--SO.sub.2 --, (vii) --O--B--NR.sup.4 R.sup.5 [B is alkylene having optionally OH, R.sup.4 is H, R.sup.5 is tricyclo[3.3.1.1]decanyl, tricyclo[3.3.1.1]decanylalkyl, etc., or R.sup.4 and R.sup.5 may together form a group of ##STR4## (R.sup.6 is substituted or unsubstituted amino)] or (viii) substituted alkoxy; m is 1 to 3]}, which have excellent vasopressin antagonistic activities and are useful as vasodilator, hypotensive agent, water diuretics, platelet agglutination inhibitor, and a vasopressin antagonistic composition containing the compound as the active ingredient.
摘要翻译：新型喹诺酮衍生物，其结构式如下：（*化学结构*）其中X为0或S; Y是H或烷基; RA是一组（*化学结构*）（其中n为1或2，A为亚烷基，R 1为具有任选1-3个取代基的苯甲酰基，R A2为（*化学结构*）为（i）烷氧基，（ii ）取代或未取代的5-或6-元杂环基团，（ⅲ）链烯基硫代，（ⅳ）吡咯烷基 - 烷基-S-，（ⅴ）吡咯烷基 - 烷基-SO-，（vi）吡咯烷基 - 烷基-SO 2 - ）-OB-NR4R5（B是任选OH的亚烷基，R4是H，R5是三环（3.3.1.1）癸基，三环（3.3.1.1）癸烷基烷基等，或者R4和R5可以一起形成（* 化学结构*）（R6为取代或未取代的氨基））或（viii）取代的烷氧基; m为1至3）），其具有优异的加压素拮抗活性，可用作血管扩张剂，降血压药，利尿剂，血小板凝集抑制剂，和含有该化合物作为活性成分的血管加压素拮抗剂组合物。

15. 发明授权

US5753644A Vasopressin antagonist and oxytocin antagonist 失效
标题翻译：加压素拮抗剂和催产素拮抗剂
公开(公告)号：US5753644A
公开(公告)日：1998-05-19
申请号：US732595
申请日：1996-10-15
申请人： Hidenori Ogawa , Kazumi Kondo , Hiroshi Yamashita , Kenji Nakaya , Hajime Komatsu , Michinori Tanaka , Kazuyoshi Kitano , Michiaki Tominaga , Yoichi Yabuuchi
发明人： Hidenori Ogawa , Kazumi Kondo , Hiroshi Yamashita , Kenji Nakaya , Hajime Komatsu , Michinori Tanaka , Kazuyoshi Kitano , Michiaki Tominaga , Yoichi Yabuuchi
IPC分类号： C07D223/16 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D521/00 , A61K31/55
CPC分类号： C07D223/16 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12
摘要： An object of the present invention is to provide a vasopressin antagonist and oxytocin antagonist. The vasopressing antagonist and oxytocin antagonist according to the present invention contain, as the active ingredient, a benzoheterocyclic compound represented by the general formula (1): ##STR1## (wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and the carbon-carbon bond between 4- and 5-positions in the benzoazepine skeleton are the same as defined in claims 1, 2 and 3.) or salt thereof.
摘要翻译：本发明的目的是提供一种血管加压素拮抗剂和催产素拮抗剂。根据本发明的血管加压拮抗剂和催产素拮抗剂含有作为活性成分的由通式（1）表示的苯并杂环化合物：其中R1，R2，R3，R4，R5和碳 - 碳键在苯并吖庚因骨架中的4-和5-位之间与权利要求1,2和3中所定义的相同）或其盐。

16. 发明授权

US5622947A Benzoheterocyclic compounds and vasopressin antagonist and oxytocin antagonist compositions containing a benzoheterocyclic compound 失效
标题翻译：含有苯并杂环化合物的苯并杂环化合物和加压素拮抗剂和催产素拮抗剂组合物
公开(公告)号：US5622947A
公开(公告)日：1997-04-22
申请号：US244424
申请日：1994-05-25
申请人： Hidenori Ogawa , Kazumi Kondo , Hiroshi Yamashita , Kenji Nakaya , Hajime Komatsu , Michinori Tanaka , Kazuyoshi Kitano , Michiaki Tominaga , Yoichi Yabuuchi
发明人： Hidenori Ogawa , Kazumi Kondo , Hiroshi Yamashita , Kenji Nakaya , Hajime Komatsu , Michinori Tanaka , Kazuyoshi Kitano , Michiaki Tominaga , Yoichi Yabuuchi
IPC分类号： C07D223/16 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D521/00 , A61K31/55
CPC分类号： C07D223/16 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12
摘要： An object of the present invention is to provide a vasopressin antagonist and oxytocin antagonist.The vasopressing antagonist and oxytocin antagonist according to the present invention contain, as the active ingredient, a benzoheterocyclic compound represented by the general formula (1): ##STR1## (wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and the carbon-carbon bond between 4- and 5-positions in the benzoazepine skeleton are the same as defined in claims 1, 2 and 3.) or salt thereof.
摘要翻译： PCT No.PCT / JP93 / 01483第 371日期：1994年5月25日 102（e）日期1994年5月25日PCT提交1993年10月15日PCT公布。公开号WO94 / 08582 日本1994年4月28日本发明的目的是提供一种血管加压素拮抗剂和催产素拮抗剂。根据本发明的血管加压拮抗剂和催产素拮抗剂含有作为活性成分的由通式（1）表示的苯并杂环化合物：其中R1，R2，R3，R4，R5和碳 - 碳键在苯并吖庚因骨架中的4-和5-位之间与权利要求1,2和3中所定义的相同）或其盐。

17. 发明授权

US4971970A Benzoheterocyclic compounds 失效
公开(公告)号：US4971970A
公开(公告)日：1990-11-20
申请号：US424501
申请日：1989-10-20
申请人： Hisashi Miyamoto , Hiroshi Yamashita , Michiaki Tominaga , Yoichi Yabuuchi
发明人： Hisashi Miyamoto , Hiroshi Yamashita , Michiaki Tominaga , Yoichi Yabuuchi
IPC分类号： A61K31/47 , A61K31/495 , A61P31/04 , C07D215/38 , C07D401/04
CPC分类号： C07D215/38
摘要： Novel 3-formyl-4-oxoquinoline compounds of the formula: ##STR1## wherein R.sup.1 is hydrogen atom or a lower alkanoyl, R.sup.2 is hydrogen atom or a lower alkyl, R.sup.3 is a lower alkyl, and X is halogen, and pharmaceutically acceptable salts thereof, said compounds having excellent antimicrobial activity and hence being useful as an antimicrobial agent, and a pharmaceutical composition containing said compound as an active ingredient.

18. 发明授权

US5266577A Method of treating congestive heart failure using carbostyril derivatives 失效
标题翻译：使用喹诺酮衍生物治疗充血性心力衰竭的方法
公开(公告)号：US5266577A
公开(公告)日：1993-11-30
申请号：US734958
申请日：1991-07-24
申请人： Takafumi Fujioka , Shuji Teramoto , Michiaki Tominaga , Yoichi Yabuuchi
发明人： Takafumi Fujioka , Shuji Teramoto , Michiaki Tominaga , Yoichi Yabuuchi
IPC分类号： A61K31/47 , C07D215/22 , C07D215/227 , C07D215/54 , C07D401/12 , C07D409/12 , C07D215/16
CPC分类号： C07D215/227 , A61K31/47 , C07D215/54 , C07D401/12 , C07D409/12
摘要： Method for the treatment of congestive heart failure or paroxymal frequent heart pulse using a carbostyril derivative of formula: ##STR1## wherein R.sup.1 is H or CN, and R.sup.2 and R.sup.3 are each H, alkyl optionally substituted by OH, cycloalkyl, alkenyl, phenyl, phenylalkyl having optionally substituents of alkoxyalkoxy, halogen, alkoxy, NO.sub.2, alkyl, CN, alkylthio or alkylsulfinyl on phenyl ring and having optionally OH-substituent on alkyl moiety, phenylsulfonylalkyl having optionally alkoxy substituent on phenyl ring, phenylthioalkyl, phenylsulfinylalkyl having optionally substituents of halogen or alkoxy on phenyl ring, phenoxyalkyl having optionally substituents of halogen or alkoxy on phenyl ring, pyridylalkyl having optionally substituents of halogen or alkoxy on pyridine ring, thienylalkyl, benzoylalkyl, anilinothiocarbonyl, benzoyl, pyridyl, phenylalkenyl, or group of -A-NR.sup.4 R.sup.5 (R.sup.4 and R.sup.5 are each alkyl or phenyl having optionally substituents of halogen or alkoxy on phenyl ring, and A is alkylene which may be interrupted with O), and a salt thereof, and novel carbostyril derivatives, and pharmaceutical composition for prophylaxis and treatment of heart diseases containing said novel carbostyril derivative.
摘要翻译：使用下式的喹诺酮衍生物治疗充血性心力衰竭或阵发性频繁心脏脉搏的方法：其中R1是H或CN，R2和R3各自为H，任选地被OH，环烷基，烯基，苯基，在烷基部分上具有烷氧基烷氧基，卤素，烷氧基，NO2，烷基，CN，烷硫基或烷基亚磺酰基的任意取代基的苯基烷基，在苯环上具有任选烷氧基取代基的苯基磺酰基烷基，苯硫基烷基，具有卤素取代基的苯基亚磺酰基烷基或苯基环上的烷氧基，在苯环上具有卤素或烷氧基的任意取代基的苯氧基烷基，在吡啶环上具有卤素或烷氧基的任意取代基的吡啶基烷基，噻吩烷基，苯甲酰基烷基，苯硫基硫代羰基，苯甲酰基，吡啶基，苯基烯基或-A-NR4R5基团（ R4和R5各自为苯基上的烷基或具有卤素或烷氧基的任意取代基的苯基，A为a 可被O取代的亚烷基及其盐，以及新的喹诺酮衍生物，以及用于预防和治疗含有所述新型喹诺酮衍生物的心脏病的药物组合物。

19. 再颁专利

USRE37556E1 Superoxide radical inhibitor 有权
标题翻译：超氧自由基抑制剂
公开(公告)号：USRE37556E1
公开(公告)日：2002-02-19
申请号：US09245914
申请日：1999-02-08
申请人： Masatoshi Chihiro , Hajime Komatsu , Michiaki Tominaga , Yoichi Yabuuchi
发明人： Masatoshi Chihiro , Hajime Komatsu , Michiaki Tominaga , Yoichi Yabuuchi
IPC分类号： C07D41304
CPC分类号： C07D277/68 , C07D277/24 , C07D413/04 , C07D417/04 , C07D417/14 , C07D513/04 , C07F9/6539 , C07H13/04 , C07H15/26
摘要： A superoxide radical inhibitor containing, as an effective ingredient, an azole derivative represented by the general formula (1), [wherein R1 represents a phenyl group which may have 1-3 lower alkoxy groups as substituent(s) on the phenyl ring, a phenyl group having a lower alkylenedioxy group, or the like; R2 represents a hydrogen atom, a phenyl group, a halogen atom, a lower alkoxycarbonyl group, a lower alkyl group, an amino-lower alkyl group which may have a lower alkyl group as a substituent, a dihydrocarbostyril group, or the like; R3 represents a group of the formula, (R4B represents a hydroxyl group, a carboxy group, a lower alkenyl group or a lower alkyl group, m represents 0, 1 or 2); X represents a sulfur atom or an oxygen atom] or a salt thereof.
摘要翻译：含有作为有效成分的通式（1）表示的唑衍生物的超氧自由基抑制剂，[其中R 1表示苯基上可具有1-3个低级烷氧基作为取代基的苯基，具有低亚烷基二氧基的苯基等; R2表示氢原子，苯基，卤素原子，低级烷氧基羰基，低级烷基，可具有低级烷基作为取代基的氨基 - 低级烷基，二氢喹诺酮基等; R3表示式（R4B表示羟基，羧基，低级烯基或低级烷基，m表示0,1或2）。 X表示硫原子或氧原子]或其盐。

20. 发明授权

US5654317A Antiarrhythmic agent 失效
标题翻译：抗心律失常药
公开(公告)号：US5654317A
公开(公告)日：1997-08-05
申请号：US403891
申请日：1995-03-17
申请人： Takafumi Fujioka , Shuji Teramoto , Michiaki Tominaga , Yoichi Yabuuchi
发明人： Takafumi Fujioka , Shuji Teramoto , Michiaki Tominaga , Yoichi Yabuuchi
IPC分类号： A61K31/47 , A61K31/4704
CPC分类号： A61K31/4704 , A61K31/47
摘要： An antiarrhythmic agent which comprises as an active ingredient a carbostyril derivative of the formula: ##STR1## wherein R.sub.1 is hydrogen atom or a lower alkyl group, and R.sub.2 is a phenyl-lower alkyl group which has optionally 1 to 3 substituents of a lower alkoxy group on the phenyl ring, or a pharmaceutically acceptable salt thereof.
摘要翻译： PCT No.PCT / JP93 / 01294 Sec。 371日期1995年3月17日 102（e）1995年3月17日PCT 1993年9月10日PCT公布。出版物WO94 / 06427 日期：1994年3月31日一种抗心律失常药，其包含下式的喹诺酮衍生物作为活性成分：其中R1是氢原子或低级烷基，R2是具有任选的苯基 - 低级烷基苯基环上1至3个低级烷氧基的取代基，或其药学上可接受的盐。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式