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11. 发明授权

US5202269A Method for immunochemical determination of hapten 失效
标题翻译： HAPTEN免疫组织化学测定方法
公开(公告)号：US5202269A
公开(公告)日：1993-04-13
申请号：US592612
申请日：1990-10-04
申请人： Michio Ito , Minoru Ogura , Hideki Kohno
发明人： Michio Ito , Minoru Ogura , Hideki Kohno
IPC分类号： G01N33/53 , G01N33/543
CPC分类号： G01N33/54313 , G01N33/54333 , Y10S436/817 , Y10S436/822
摘要： A method for immunochemical determination of a hapten in a sample is disclosed, in which(A) a high-molecular compound to which the hapten is bound (reagent A),(B) insoluble carrier particles carrying thereon an antibody to the hapten (reagent B), and(C) magnetic substance-containing insoluble carrier particles carrying thereon an antibody to an antigenic determinant in the high-molecular compound and different from the hapten (reagent C),are used. These three reagents are dispersed in the sample, then, a magnetic field is applied to separate from the reaction mixture unreacted reagent (C) and agglutinated particles formed from the reagent (B) and the reagent (C) through the reagent (A). The amount of the reagent (B) remaining dispersed in the reaction mixture is measured, thereby determining the extent of competitive inhibition to the agglutination of the reagent (B) and the reagent (C) through the reagent (A) by the reaction between the hapten in the sample and the reagent (B). The method of the present invention requires no troublesome operations such as separation-washing and is free from any problem is safety. By the method of the present invention, the concentration of a hapten in a sample is determined by simple operations in a short time and with high sensitivity.

12. 发明授权

US5195524A Flow imaging method by means of an MRI apparatus and apparatus for realizing same 失效
标题翻译：通过MRI装置和实现其的装置的流动成像方法
公开(公告)号：US5195524A
公开(公告)日：1993-03-23
申请号：US647563
申请日：1991-01-29
申请人： Kenji Takiguchi , Etsuji Yamamoto , Hideki Kohno
发明人： Kenji Takiguchi , Etsuji Yamamoto , Hideki Kohno
IPC分类号： G01P13/00 , A61B5/026 , A61B5/055 , G01R33/44 , G01R33/48 , G01R33/563
CPC分类号： A61B5/0263 , G01R33/56308 , G01R33/5635 , G01R33/56366
摘要： An MRI flow imaging method and apparatus wherein a width of a relevant region in a direction is set, in which fluid in a subject body flows, and a first 90.degree. radio frequency pulse is applied thereto to excite selectively a relevant region; a gradient magnetic field is applied thereto in a direction, in which it is desired to project the fluid, after an application of a first 90.degree. radio frequency pulse so that a magnetization signal in a projection direction is zero, a second radio frequency pulse is applied to a relevant region to excite the relevant region selectively, after new fluid has poured in the relevant region, an echo signal is measured by applying an encoding gradient magnetic field and a reading out gradient magnetic field in a form of a flow sensitive pulse capable of detecting an echo signal from the fluid, and an echo signal is processed to obtain a two-dimensional image of the fluid.
摘要翻译：一种MRI流程成像方法和装置，其中设定了被检体内的流体流过的朝向方向的相关区域的宽度，并且向其施加第一90°射频脉冲以选择性地激发相关区域; 在施加第一90°射频脉冲之后，在期望投射流体的方向上施加梯度磁场，使得投影方向上的磁化信号为零，第二射频脉冲为应用于相关区域以选择性地激发相关区域，在新流体流入相关区域之后，通过施加编码梯度磁场和读出梯度磁场来测量回波信号，其形式为流敏脉冲能力检测来自流体的回波信号，并且处理回波信号以获得流体的二维图像。

13. 发明授权

US5162737A Multi-echo NMR imaging method 失效
标题翻译：多回波核磁共振成像方法
公开(公告)号：US5162737A
公开(公告)日：1992-11-10
申请号：US807625
申请日：1991-12-13
申请人： Tatsuo Nozokido , Etsuji Yamamoto , Hideki Kohno
发明人： Tatsuo Nozokido , Etsuji Yamamoto , Hideki Kohno
IPC分类号： G01R33/485 , G01R33/54 , G01R33/565
CPC分类号： G01R33/4828 , G01R33/485 , G01R33/56563
摘要： A multi-echo NMR imaging method of obtaining images separated from each other with respect to two kinds of chemical shifts, typically, a fat image and a water image, includes performing the measurement of an object to be examined through a multi-echo sequence in which phase differences of .theta..sub.1 .noteq.n.pi. and .theta..sub.2 =2n.pi. (n=.+-.1, .+-.2, ---) are respectively produced for first and second echoes between two kinds of spins to be separated from each other, deriving first and second complex images of the object from the first and second echoes, respectively, performing the measurement of a phantom exhibiting one of the chemical shifts through the multi-echo sequence and deriving third and fourth complex images of the phantom, eliminating phase errors due to a static magnetic field inhomogeneity from the first and second images using phase data of the third and fourth images respectively, and eliminating phase error due to a magnetic permeability distribution to the object.
摘要翻译：一种多回波核磁共振成像方法，通过多个回波序列来获得相对于两种化学位移（通常为脂肪图像和水分图像）彼此分离的图像，包括：分别产生用于从每一个分离出的两种旋转之间的第一和第二回波的θ1的相位差分别为n pi和theta 2 = 2n pi（n = + / - 1，+/- 2，...）另外，分别从第一和第二回波导出对象的第一和第二复合图像，执行通过多回波序列显示化学位移之一的体模的测量，并导出体模的第三和第四复合图像，消除分别使用第三和第四图像的相位数据从第一和第二图像的静态磁场不均匀性引起的相位误差，并消除由于对物体的磁导率分布引起的相位误差。

14. 发明授权

US5045791A Nuclear magnetic resonance imaging method 失效
标题翻译：核磁共振成像法
公开(公告)号：US5045791A
公开(公告)日：1991-09-03
申请号：US492121
申请日：1990-03-13
申请人： Etsuji Yamamoto , Hideki Kohno
发明人： Etsuji Yamamoto , Hideki Kohno
IPC分类号： A61B5/055 , G01R33/48 , G01R33/54 , G01R33/561
CPC分类号： G01R33/561 , G01R33/54
摘要： A three-dimensional NMR imaging method using phase encoding field gradients along two direction is disclosed. The measurement of an NMR signal is repeated in such a manner that among all combinations of a plurality of magnitudes of gradient prepared for the phase encoding field gradient along one of the two directions and a plurality of magnitudes of gradient prepared for the phase encoding field gradient along the other direction, combinations in which the magnitude of the phase encoding field gradient along the one direction is not larger than a predetermined value, are selected preceding the remaining combinations. A first image reconstruction processing is performed for data trains acquired on the basis of the precedently selected combinations, thereby obtaining a crude image. The crude image is displayed to confirm whether the location of measurement is proper or not. After the confirmation, the remaining combinations are successively selected to continue the measurement of the NMR signal and a second image reconstruction processing is performed for all of data trains acquired, thereby obtaining a detailed image.
摘要翻译：公开了使用沿两个方向的相位编码场梯度的三维NMR成像方法。 NMR信号的测量以这样的方式重复：在沿着两个方向中的一个方向为相位编码场梯度准备的多个梯度大小的所有组合和为相位编码场梯度准备的多个梯度的量值沿着另一方向，在剩余组合之前选择其中沿着一个方向的相位编码场梯度的幅度不大于预定值的组合。对基于先前选择的组合获取的数据列执行第一图像重构处理，从而获得粗图像。显示粗图像以确认测量位置是否适当。在确认之后，依次选择剩余的组合以继续NMR信号的测量，并对所获取的所有数据列执行第二图像重建处理，从而获得详细的图像。

15. 发明授权

US5032793A NMR gated imaging apparatus 失效
标题翻译： NMR门控成像装置
公开(公告)号：US5032793A
公开(公告)日：1991-07-16
申请号：US478739
申请日：1990-02-09
申请人： Etsuji Yamamoto , Hiroshi Kanda , Hideki Kohno
发明人： Etsuji Yamamoto , Hiroshi Kanda , Hideki Kohno
IPC分类号： A61B5/055 , A61B8/08 , G01R33/28 , G01R33/385 , G01R33/567 , G01S15/02
CPC分类号： G01R33/5673 , A61B5/055 , A61B5/7285 , A61B8/08 , G01R33/28 , G01R33/385 , G01S15/025
摘要： Disclosed is an NMR gated imaging apparatus in which an ultrasonic pulse signal is repeatedly transmitted toward the heart of a human body from an ultrasonic transducer to detect the position of the heart on the basis of the time of detection of a peak of an echo signal, and excitation and measurement of an NMR signal are executed only when a peak detector generates a detection output signal having a level included in a predetermined range. Thus, the NMR signal is repeatedly measured according to a programmable phase encoding amount at a limited phase of gated imaging.
摘要翻译：公开了一种NMR门控成像装置，其中超声脉冲信号从超声换能器重复地向人体的心脏发送，以根据检测到回波信号的峰值的时间来检测心脏的位置，只有当峰值检测器产生具有包括在预定范围内的电平的检测输出信号时，才执行NMR信号的激发和测量。因此，根据在门控成像的有限阶段的可编程相位编码量重复测量NMR信号。

16. 发明授权

US4959613A NMR imaging apparatus 失效
标题翻译： NMR成像装置
公开(公告)号：US4959613A
公开(公告)日：1990-09-25
申请号：US319728
申请日：1989-03-07
申请人： Etsuji Yamamoto , Hideki Kohno
发明人： Etsuji Yamamoto , Hideki Kohno
IPC分类号： G01R33/20 , A61B5/055 , A61B10/00 , G01R33/38 , G01R33/385
CPC分类号： G01R33/385
摘要： A field gradient generator in an NMR imaging apparatus comprises three sets of field gradient generating coils for respectively generating field gradients in three orthogonal directions in a space to be observed. Each set of coils includes a plurality of unit coils through which individual currents respectively flow. There are prepared a plurality of unit drivers which are for exclusive uses of the respective unit coils or are connected arbitrarily to each unit coil. Thereby, the lowering of an allowable operating voltage is implemented by use of a parallel operation of the unit drivers.
摘要翻译： NMR成像装置中的场梯度发生器包括三组场梯度产生线圈，用于分别在要观察的空间中的三个正交方向上产生场梯度。每组线圈包括多个单独的线圈，各个电流分别通过该线圈流动。准备了用于各单元线圈的专用的多个单元驱动器或者任意地连接到每个单元线圈。因此，通过使用单元驱动器的并行操作来实现允许工作电压的降低。

17. 发明授权

US4740749A NMR imaging method 失效
标题翻译： NMR成像方法
公开(公告)号：US4740749A
公开(公告)日：1988-04-26
申请号：US56951
申请日：1987-06-03
申请人： Etsuji Yamamoto , Hideki Kohno
发明人： Etsuji Yamamoto , Hideki Kohno
IPC分类号： A61B10/00 , A61B5/055 , G01R33/32 , G01R33/48 , G01R33/54 , G01R33/56 , G06T1/00 , G01R33/20
CPC分类号： G01R33/482 , G01R33/56
摘要： In an imaging method called spin warp method in which a measuring sequence inclusive of nuclear spin excitation, application of phase-encoding gradient field, and measurement of NMR signals under the application of read-out gradient field, is repeated while changing the phase-encoding amount, and a data train thus obtained is subjected to the two-dimensional inverse Fourier transformation to reconstruct a magnetization distribution image of an object, wherein an NMR imaging method is characterized in that measurement of NMR signals is repeated a plural number of times for a particular phase-encoding amount only among many phase-encoding amounts, a plurality of NMR signals thus obtained are added up together and are averaged, and the data obtained by the addition and averaging is subjected to the two-dimensional inverse Fourier transformation.
摘要翻译：在改变相位编码的同时，重复在包括核自旋激发，包含相位编码梯度场的测量序列和读出梯度场应用中的NMR信号测量的称为自旋翘曲方法的成像方法中数量和这样获得的数据序列进行二维傅立叶逆变换，以重构物体的磁化分布图像，其中NMR成像方法的特征在于，对于一个或多个核磁共振信号的NMR信号的测量重复多次，特定相位编码量仅在许多相位编码量之中，将这样获得的多个NMR信号相加在一起并将其平均，并且通过加法和平均获得的数据进行二维傅里叶逆变换。

18. 发明授权

US4672318A Method of measuring the static magnetic field distribution in an NMR inspection system 失效
标题翻译：在NMR检查系统中测量静态磁场分布的方法
公开(公告)号：US4672318A
公开(公告)日：1987-06-09
申请号：US696909
申请日：1985-01-31
申请人： Kensuke Sekihara , Etsuji Yamamoto , Shigeru Matsui , Hideki Kohno
发明人： Kensuke Sekihara , Etsuji Yamamoto , Shigeru Matsui , Hideki Kohno
IPC分类号： G01R33/20 , A61B5/055 , A61B10/00 , G01R33/24 , G01R33/38 , G01R33/387
CPC分类号： G01R33/24
摘要： A method of measuring a static magnetic field distribution in a nuclear magnetic resonance (NMR) inspection system which comprises magnetic field generator for producing a static magnetic field, inclination or gradient magnetic fields and a high-frequency magnetic field, a signal detector for sensing nuclear magnetic resonance signals from an inspection sample, a computer for processing output signals from the signal detector and an output device for providing a computational result of the computer, wherein a time interval t.sub.1 from the center of a 90.degree.-pulse high-frequency magnetic field to the center of a 180.degree.-pulse high-frequency magnetic field is made different by a time difference t.sub.0 from a time interval t.sub.2 from the center of the 180.degree.-pulse high-frequency magnetic field to a peak of a spin echo, so that static magnetic field distribution is calculated based on the computer output which corresponds to the difference of the two time intervals.
摘要翻译：一种在核磁共振（NMR）检查系统中测量静磁场分布的方法，其包括用于产生静磁场，倾斜或梯度磁场和高频磁场的磁场发生器，用于感测核的信号检测器来自检查样本的磁共振信号，用于处理来自信号检测器的输出信号的计算机和用于提供计算机的计算结果的输出装置，其中从90°脉冲高频磁场的中心起的时间间隔t1 从180°脉冲高频磁场的中心到从180°脉冲高频磁场的中心到自旋回波的峰值的时间间隔t2由时间差t0变化到180°脉冲高频磁场的中心，因此基于对应于两个时间间隔的差的计算机输出来计算静态磁场分布。

19. 发明授权

US4621194A Radiation detecting apparatus 失效
标题翻译：辐射检测装置
公开(公告)号：US4621194A
公开(公告)日：1986-11-04
申请号：US517695
申请日：1983-07-27
申请人： Minoru Yoshida , Hiromichi Yamada , Yoko Uchida , Hideki Kohno , Hiroshi Takagi
发明人： Minoru Yoshida , Hiromichi Yamada , Yoko Uchida , Hideki Kohno , Hiroshi Takagi
IPC分类号： G01N23/04 , G01T1/164 , G01T1/20 , G01T1/22
CPC分类号： G01T1/1642 , G01T1/2018
摘要： A multielement scintillation radiation detector comprises a scintillator and a photosensitive detector, wherein to optically isolate between the adjacent radiation detectors, a thin light reflecting sheet on which a sponge material is attached is used to closely adhere to radiation shielding plates for partitioning each radiation detector.
摘要翻译：多元件闪烁放射线检测器包括闪烁体和光敏检测器，其中在相邻的辐射检测器之间进行光学隔离，使用其上附着有海绵材料的薄的光反射片，以紧密地附着到用于分隔每个辐射检测器的辐射屏蔽板。

20. 发明授权

US4453181A Scanning-image forming apparatus using photo response signal 失效
标题翻译：使用光响应信号的扫描图像形成装置
公开(公告)号：US4453181A
公开(公告)日：1984-06-05
申请号：US311889
申请日：1981-10-15
申请人： Chusuke Munakata , Hideki Kohno
发明人： Chusuke Munakata , Hideki Kohno
IPC分类号： G01R31/26 , G01R31/265 , G01R31/308 , H01L21/66 , H01L31/02 , H04N1/409 , H04N7/18
CPC分类号： G01R31/2656 , G01R31/308 , H04N1/409
摘要： A scanning-image forming apparatus using a photo-response signal according to this invention is constructed so that the photo-response signal obtained by scanning the surface of a semiconductor specimen with a photon beam is subjected to a 2nd differentiation, and that an image is displayed by employing the 2nd derivative of the photo-response signal as a modulation signal.
摘要翻译：使用根据本发明的光响应信号的扫描图像形成装置被构造成使得通过用光子束扫描半导体样品的表面而获得的光响应信号被进行第二微分，并且图像是通过采用光响应信号的二阶导数作为调制信号来显示。

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