会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 13. 发明授权
    • Directly compressible high load acetaminophen formulations
    • 直接可压缩的高负荷对乙酰氨基酚制剂
    • US5965166A
    • 1999-10-12
    • US964917
    • 1997-11-05
    • Edward A. HunterJoseph A. ZeleznikBob E. Sherwood
    • Edward A. HunterJoseph A. ZeleznikBob E. Sherwood
    • A61K9/20A61K31/165A61K31/167A61K47/04A61K47/12A61K47/38A61P29/02A61K9/14
    • A61K9/2009A61K31/167A61K9/2054A61K9/2095Y10S977/904Y10S977/906Y10S977/915
    • Direct compressed solid pharmaceutical dosage forms containing:a) from about 40 to about 95% by weight acetaminophen;b) from about 1 to about 60% by weight of a direct compression vehicle comprising microcrystalline cellulose; andc) from about 0.01 to about 4.0% by weight of a pharmaceutically-acceptable lubricant are disclosed. The acetaminophen and direct compression vehicle are combined under high shear conditions which are sufficient to transform acetaminophen and direct compression vehicle into a homogenous granulate without degradation. In preferred aspects of the invention, the lubricant is also combined with the acetaminophen and direct compression vehicle under high shear conditions. Methods of preparing the directly compressed solid pharmaceutical dosage forms and methods of treatment with the dosage forms are also disclosed. The methods are particularly well suited for preparing directly compressed dosage forms containing high load (i.e., up to 80% or greater) amounts of acetaminophen based on the weight of the total tablet.
    • 直接压缩固体药物剂型,其含有:a)约40至约95重量%的对乙酰氨基酚; b)约1至约60重量%的包含微晶纤维素的直接压缩载体; 和c)约0.01至约4.0重量%的药学上可接受的润滑剂。 对乙酰氨基酚和直接压缩载体在高剪切条件下组合,足以将对乙酰氨基酚和直接压缩载体转化成均匀的颗粒而不降解。 在本发明的优选方面,润滑剂还在高剪切条件下与对乙酰氨基酚和直接压缩载体组合。 还公开了制备直接压片的固体药物剂型的方法和剂型的治疗方法。 该方法特别适用于制备基于总片剂重量的含有高负荷量(即高达80%或更多)量的对乙酰氨基酚的直接压缩剂型。
    • 15. 发明授权
    • Pharmaceutical excipient having improved compressibility
    • 药物赋形剂具有改善的压缩性
    • US06471994B1
    • 2002-10-29
    • US09384130
    • 1999-08-27
    • John N. StaniforthBob E. SherwoodEdward A. Hunter
    • John N. StaniforthBob E. SherwoodEdward A. Hunter
    • A16K914
    • A61K9/2013A61K9/2009A61K9/2018A61K9/2036A61K9/205A61K9/2054Y10S977/906
    • A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide. An extra low moisture excipient is provided which exhibits improved compressibility as compared to conventional microcrystalline cellulose, while providing a moisture content of from about 0.5 to 2.5% LOD, preferably between about 0.5 and about 1.8%, more preferably between 0.8 and 1.5%, and most preferably between about 0.8 and about 1.2 %.
    • 公开了具有改进的压缩性的微晶纤维素基赋形剂,无论是用于直接压片,干法制粒还是湿法制粒。 赋形剂是微晶纤维素颗粒的聚集物和约0.1%至约20%的微晶纤维素重量的二氧化硅颗粒,其中微晶纤维素和二氧化硅彼此紧密结合。 新型赋形剂中使用的二氧化硅具有约1纳米至约100微米的粒度。 最优选地,二氧化硅是胶体二氧化硅的等级。 提供了与常规微晶纤维素相比显示出改进的可压缩性的超低水分赋形剂,同时提供约0.5至2.5%的LOD,优选约0.5至约1.8%,更优选0.8至1.5%的水分含量,以及 最优选在约0.8至约1.2%之间。