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11. 发明申请

US20110144504A1 METHOD AND APPARATUS FOR OPTICAL IMAGING VIA SPECTRAL ENCODING 有权
标题翻译：通过光谱编码进行光学成像的方法和装置
公开(公告)号：US20110144504A1
公开(公告)日：2011-06-16
申请号：US12946635
申请日：2010-11-15
申请人： Guillermo J. Tearney , Dvir Yelin , Brett Eugene Bouma
发明人： Guillermo J. Tearney , Dvir Yelin , Brett Eugene Bouma
IPC分类号： A61B6/00
CPC分类号： G01N33/4833 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/6852 , G01B9/02 , G01B9/02027 , G01B9/02049 , G01B9/02064 , G01B9/02087 , G01B9/02091 , G01B9/04 , G01N21/25 , G01N21/27 , G01N21/4795 , G01N21/6458 , G01N21/6486 , G01N23/046 , G01N2021/1765 , G01N2223/419 , G02B21/0028 , G02B23/2423 , G02B23/243 , G02B23/2461 , G02B23/2476
摘要： Method, apparatus and arrangement according an exemplary embodiment of the present invention can be provided for generating an image of at least one portion of an anatomical structure. For example, the portion can have an area greater than about 1 mm2, and the image can have a resolution a transverse resolution that is below about 10 μm. For example, light can be scanned over such portion so as to generate first information which is related to the portion, where the light may be provided through a diffraction arrangement to generate a spectrally dispersed line. Method, apparatus and arrangement according to a further exemplary embodiment of the present invention can be provided for positioning a radiation or optical beam within an anatomical structure based on signals generated by scanning a portion of the structure using the same or a different beam.
摘要翻译：可以提供根据本发明的示例性实施例的方法，装置和装置，用于生成解剖结构的至少一部分的图像。例如，该部分可以具有大于约1mm 2的面积，并且图像可以具有低于约10μm的横向分辨率的分辨率。例如，可以在这样的部分上扫描光，以便产生与该部分相关的第一信息，其中可以通过衍射装置提供光以产生光谱分散的线。可以提供根据本发明的另一示例性实施例的方法，装置和装置，用于基于通过使用相同或不同的束扫描结构的一部分而产生的信号来将辐射或光束定位在解剖结构内。

12. 发明申请

US20110058178A1 ARRANGEMENTS AND METHODS FOR PROVIDING MULTIMODALITY MICROSCOPIC IMAGING OF ONE OR MORE BIOLOGICAL STRUCTURES 有权
标题翻译：提供一种或多种生物结构的多重微观显微成像的安排和方法
公开(公告)号：US20110058178A1
公开(公告)日：2011-03-10
申请号：US12943762
申请日：2010-11-10
申请人： Guillermo J. Tearney , Dvir Yelin , Benjamin J. Vakoc , Wang-Yuhl Oh , Brett Eugene Bouma
发明人： Guillermo J. Tearney , Dvir Yelin , Benjamin J. Vakoc , Wang-Yuhl Oh , Brett Eugene Bouma
IPC分类号： G01B9/02
CPC分类号： G01N33/4833 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/6852 , G01B9/02 , G01B9/02027 , G01B9/02049 , G01B9/02064 , G01B9/02087 , G01B9/02091 , G01B9/04 , G01N21/25 , G01N21/27 , G01N21/4795 , G01N21/6458 , G01N21/6486 , G01N23/046 , G01N2021/1765 , G01N2223/419 , G02B21/0028 , G02B23/2423 , G02B23/243 , G02B23/2461 , G02B23/2476
摘要： Method and apparatus according to an exemplary embodiment of the present invention can be provided. For example, first data associated with a first signal received from at least one region of at least one sample can be provided based on a first modality, and second data associated with a second signal received from the at least one sample can be provided based on a second modality which is different from the first modality. Third data associated with a reference can be received. Further data can be generated based on the first, second and third data. In addition, third data associated with a second signal received from the at least one sample can be obtained. Each of the third data can be based on a further modality which is different from the first modality and the second modality, and the further data can be further determined based on the third data. Further, the first modality can be a spectral-encoded modality, and the second modality can be a non-spectral-encoding modality.
摘要翻译：可以提供根据本发明的示例性实施例的方法和装置。例如，可以基于第一模态来提供与从至少一个样本的至少一个区域接收的第一信号相关联的第一数据，并且可以基于从至少一个样本接收的与第二信号相关联的第二数据基于第二种模式与第一种模式不同。可以接收与参考相关联的第三数据。可以基于第一，第二和第三数据生成进一步的数据。此外，可以获得与从至少一个样本接收的第二信号相关联的第三数据。第三数据中的每一个可以基于与第一模态和第二模态不同的另一模态，并且可以基于第三数据进一步确定另外的数据。此外，第一模式可以是频谱编码模式，并且第二模态可以是非频谱编码模式。

13. 发明授权

US07889348B2 Arrangements and methods for facilitating photoluminescence imaging 有权
标题翻译：促进光致发光成像的安排和方法
公开(公告)号：US07889348B2
公开(公告)日：2011-02-15
申请号：US11549397
申请日：2006-10-13
申请人： Guillermo J. Tearney , Dvir Yelin , Benjamin J. Vakoc , Brett Eugene Bouma , Jason T. Motz
发明人： Guillermo J. Tearney , Dvir Yelin , Benjamin J. Vakoc , Brett Eugene Bouma , Jason T. Motz
IPC分类号： G01B9/02 , G01J3/45 , G01J3/30
CPC分类号： A61B5/0071 , A61B1/043 , A61B1/07 , A61B5/0066 , A61B5/0075 , A61B5/0084 , A61B5/7257 , G01N21/6408 , G01N21/6456 , G01N21/6458 , G01N2021/6419 , G01N2021/6421
摘要： Exemplary systems and methods for obtaining a photoluminescence radiation from at least one portion of a sample can be provided. For example, using the exemplary embodiment, it is possible to receive a first radiation and disperse the first radiation into at least one second radiation and at least one third radiation. The second and third radiations can be provided to different locations of the portion. In addition, it is possible to receive the photoluminescence radiation from the portion based on the second and third radiations.
摘要翻译：可以提供用于从样品的至少一部分获得光致发光辐射的示例性系统和方法。例如，使用示例性实施例，可以接收第一辐射并将第一辐射分散到至少一个第二辐射和至少一个第三辐射中。第二和第三辐射可以被提供到该部分的不同位置。此外，可以基于第二和第三辐射从该部分接收光致发光辐射。

14. 发明授权

US08838213B2 Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample, and effecting such portion(s) 有权
标题翻译：用于获得和提供与样品的至少一部分相关联的成像信息并实现这样的部分的装置和方法，
公开(公告)号：US08838213B2
公开(公告)日：2014-09-16
申请号：US11875676
申请日：2007-10-19
申请人： Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin
发明人： Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin
IPC分类号： A61B1/07 , A61B18/22 , A61B5/00
CPC分类号： A61B1/07 , A61B5/0066 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B18/22 , A61B2017/00061
摘要： Exemplary apparatus and process can be provided for imaging information associated with at least one portion of a sample. For example, (i) at least two first different wavelengths of at least one first electro-magnetic radiation can be provided within a first wavelength range provided on the portion of the sample so as to determine at least one first transverse location of the portion, and (ii) at least two second different wavelengths of at least one second electro-magnetic radiation are provided within a second wavelength range provided on the portion so as to determine at least one second transverse location of the portion. The first and second ranges can east partially overlap on the portion. Further, a relative phase between at least one third electro-magnetic radiation electro-magnetic radiation being returned from the sample and at least one fourth electro-magnetic radiation returned from a reference can be obtained to determine a relative depth location of the portion. First information of the portion based on the first transverse location and the relative depth location, and second information of the portion based on the second transverse location and the relative depth location can be obtained. The imaging information may include the first and second information.
摘要翻译：可以提供示例性装置和过程用于与样品的至少一部分相关联的成像信息。例如，（i）至少两个第一不同波长的至少一个第一电磁辐射可以在提供在样品部分上的第一波长范围内提供，以便确定该部分的至少一个第一横向位置，和（ii）至少两个第二不同波长的至少一个第二电磁辐射被提供在设置在该部分上的第二波长范围内，以便确定该部分的至少一个第二横向位置。第一和第二范围可以在该部分上部分重叠。此外，可以获得从样品返回的至少一个第三电磁辐射电磁辐射与从基准返回的至少一个第四电磁辐射之间的相对相位，以确定该部分的相对深度位置。可以获得基于第一横向位置和相对深度位置的部分的第一信息，以及基于第二横向位置和相对深度位置的部分的第二信息。成像信息可以包括第一和第二信息。

15. 发明授权

US08818149B2 Spectrally-encoded endoscopy techniques, apparatus and methods 有权
标题翻译：光谱编码的内窥镜检查技术，仪器和方法
公开(公告)号：US08818149B2
公开(公告)日：2014-08-26
申请号：US13427463
申请日：2012-03-22
申请人： Milen Shishkov , Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin , Nicusor Iftimia
发明人： Milen Shishkov , Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin , Nicusor Iftimia
IPC分类号： G02B6/32 , G02B6/34 , G02B6/06
CPC分类号： G02B23/2453 , A61B1/00167 , A61B1/00188 , A61B1/002 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0084 , A61B5/0086 , B24B9/14 , G01J3/02 , G01J3/0205 , G01J3/0208 , G01J3/0218 , G01J3/0256 , G01J3/18 , G02B5/18 , G02B23/2469 , G02B23/26
摘要： Exemplary apparatus for obtaining information for a structure can be provided. For example, the exemplary apparatus can include at least one first optical fiber arrangement which is configured to transceive at least one first electro-magnetic radiation, and can include at least one fiber. The exemplary apparatus can also include at least one second focusing arrangement in optical communication with the optical fiber arrangement. The second arrangement can include a ball lens, and be configured to focus and provide there through the first electro-magnetic radiation to generate the focused electro-magnetic radiation. Further, the exemplary apparatus can include at least at least one dispersive third arrangement which can receive a particular radiation (e.g., the first electro-magnetic radiation(s) and/or the focused electro-magnetic radiation), and forward a dispersed radiation thereof to at least one section of the structure.
摘要翻译：可以提供用于获得结构信息的示例性装置。例如，示例性装置可以包括被配置为收发至少一个第一电磁辐射的至少一个第一光纤布置，并且可以包括至少一个光纤。示例性装置还可以包括与光纤布置光学通信的至少一个第二聚焦装置。第二布置可以包括球形透镜，并且被配置成通过第一电磁辐射聚焦并提供在其上，以产生聚焦的电磁辐射。此外，示例性装置可以包括至少一个能够接收特定辐射（例如，第一电磁辐射和/或聚焦电磁辐射）的分散第三装置，并且将其分散的辐射到结构的至少一个部分。

16. 发明申请

US20140204604A1 IMAGING SYSTEM AND RELATED TECHNIQUES 有权
标题翻译：成像系统及相关技术
公开(公告)号：US20140204604A1
公开(公告)日：2014-07-24
申请号：US14089454
申请日：2013-11-25
申请人： Brett Eugene Bouma , Guillermo J. Tearney , Dvir Yelin
发明人： Brett Eugene Bouma , Guillermo J. Tearney , Dvir Yelin
IPC分类号： G01N21/47 , G02B6/036
CPC分类号： G01N21/474 , G01N21/47 , G02B6/02 , G02B6/02042 , G02B6/036 , G02B6/03605 , G02B6/03622 , G02B6/03638 , G02B6/4298 , G02B23/2469 , G02B23/26 , G02B26/10 , G02B27/48
摘要： A method and apparatus for imaging using a double-clad fiber is described.
摘要翻译：描述了使用双包层光纤进行成像的方法和装置。

17. 发明授权

US08760663B2 Method and apparatus for optical imaging via spectral encoding 有权
标题翻译：通过频谱编码进行光学成像的方法和装置
公开(公告)号：US08760663B2
公开(公告)日：2014-06-24
申请号：US13437697
申请日：2012-04-02
申请人： Guillermo J. Tearney , Dvir Yelin , Brett Eugene Bouma
发明人： Guillermo J. Tearney , Dvir Yelin , Brett Eugene Bouma
IPC分类号： G01B9/02
CPC分类号： G01N33/4833 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/6852 , G01B9/02 , G01B9/02027 , G01B9/02049 , G01B9/02064 , G01B9/02087 , G01B9/02091 , G01B9/04 , G01N21/25 , G01N21/27 , G01N21/4795 , G01N21/6458 , G01N21/6486 , G01N23/046 , G01N2021/1765 , G01N2223/419 , G02B21/0028 , G02B23/2423 , G02B23/243 , G02B23/2461 , G02B23/2476
摘要： Exemplary method, apparatus and arrangement can be provided for obtaining information associated with a sample such as a portion of an anatomical structure. The information can be generated using first data, which can be based on a signal obtained from a location on the sample, and second data, where the second data can be obtained by combining a second signal received from the sample with a third reference signal. An image of a portion of the sample can also be generated based on the information. For example, the first data can be associated with spectral encoding microscopy data, and the second data can be associated with optical coherence tomography data.
摘要翻译：可以提供示例性方法，装置和布置来获得与诸如解剖结构的一部分的样本相关联的信息。可以使用可以基于从样本上的位置获得的信号的第一数据和第二数据来生成信息，其中可以通过将从样本接收的第二信号与第三参考信号组合来获得第二数据。也可以基于该信息生成样本的一部分的图像。例如，第一数据可以与光谱编码显微镜数据相关联，并且第二数据可以与光学相干断层扫描数据相关联。

18. 发明申请

US20130100455A1 METHOD AND APPARATUS FOR OPTICAL IMAGING VIA SPECTRAL ENCODING 有权
公开(公告)号：US20130100455A1
公开(公告)日：2013-04-25
申请号：US13437697
申请日：2012-04-02
申请人： Guillermo J. Tearney , Dvir Yelin , Brett Eugene Bouma
发明人： Guillermo J. Tearney , Dvir Yelin , Brett Eugene Bouma
IPC分类号： G01B9/02
CPC分类号： G01N33/4833 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/6852 , G01B9/02 , G01B9/02027 , G01B9/02049 , G01B9/02064 , G01B9/02087 , G01B9/02091 , G01B9/04 , G01N21/25 , G01N21/27 , G01N21/4795 , G01N21/6458 , G01N21/6486 , G01N23/046 , G01N2021/1765 , G01N2223/419 , G02B21/0028 , G02B23/2423 , G02B23/243 , G02B23/2461 , G02B23/2476
摘要： Exemplary method, apparatus and arrangement can be provided for obtaining information associated with a sample such as a portion of an anatomical structure. The information can be generated using first data, which can be based on a signal obtained from a location on the sample, and second data, where the second data can be obtained by combining a second signal received from the sample with a third reference signal. An image of a portion of the sample can also be generated based on the information. For example, the first data can be associated with spectral encoding microscopy data, and the second data can be associated with optical coherence tomography data.

19. 发明申请

US20120328241A1 Apparatus for Obtaining Information For A Structure Using Spectrally-Encoded Endoscopy Techniques and Methods for Producing One or More Optical Arrangements 有权
标题翻译：用于使用光谱编码内窥镜技术获得信息的装置和用于产生一个或多个光学布置的方法
公开(公告)号：US20120328241A1
公开(公告)日：2012-12-27
申请号：US13427463
申请日：2012-03-22
申请人： Milen Shishkov , Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin , Nicusor Iftimia
发明人： Milen Shishkov , Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin , Nicusor Iftimia
IPC分类号： G02B6/32 , B24B1/00 , G02B6/34
CPC分类号： G02B23/2453 , A61B1/00167 , A61B1/00188 , A61B1/002 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0084 , A61B5/0086 , B24B9/14 , G01J3/02 , G01J3/0205 , G01J3/0208 , G01J3/0218 , G01J3/0256 , G01J3/18 , G02B5/18 , G02B23/2469 , G02B23/26
摘要： Exemplary apparatus for obtaining information for a structure can be provided. For example, the exemplary apparatus can include at least one first optical fiber arrangement which is configured to transceive at least one first electro-magnetic radiation, and can include at least one fiber. The exemplary apparatus can also include at least one second focusing arrangement in optical communication with the optical fiber arrangement. The second arrangement can include a ball lens, and be configured to focus and provide there through the first electro-magnetic radiation to generate focused electro-magnetic radiation. Further, the exemplary apparatus can include at least at least one dispersive third arrangement which can receive a particular radiation (e.g., the first and/or focused electro-magnetic radiation(s), and forward a dispersed radiation thereof to at least one section of the structure. An end of the fiber(s) can be directly connected to the second focusing arrangement and/or the third arrangement(s).
摘要翻译：可以提供用于获得结构信息的示例性装置。例如，示例性装置可以包括被配置为收发至少一个第一电磁辐射的至少一个第一光纤布置，并且可以包括至少一个光纤。示例性装置还可以包括与光纤布置光学通信的至少一个第二聚焦装置。第二布置可以包括球透镜，并且被配置为通过第一电磁辐射聚焦并提供其中以产生聚焦的电磁辐射。此外，示例性装置可以包括至少一个可接收特定辐射（例如，第一和/或聚焦的电磁辐射）并且将其分散的辐射转发到至少一个部分的分散第三布置纤维的一端可以直接连接到第二聚焦装置和/或第三装置。

20. 发明授权

US08145018B2 Apparatus for obtaining information for a structure using spectrally-encoded endoscopy techniques and methods for producing one or more optical arrangements 有权
标题翻译：用于使用光谱编码的内窥镜检查技术获得结构信息的装置和用于产生一个或多个光学装置的方法
公开(公告)号：US08145018B2
公开(公告)日：2012-03-27
申请号：US11623852
申请日：2007-01-17
申请人： Milen Shishkov , Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin , Nicusor Iftimia
发明人： Milen Shishkov , Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin , Nicusor Iftimia
IPC分类号： G02B6/32 , G02B6/34 , G02B6/06
CPC分类号： G02B23/2453 , A61B1/00167 , A61B1/00188 , A61B1/002 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0084 , A61B5/0086 , B24B9/14 , G01J3/02 , G01J3/0205 , G01J3/0208 , G01J3/0218 , G01J3/0256 , G01J3/18 , G02B5/18 , G02B23/2469 , G02B23/26
摘要： Exemplary apparatus for obtaining information for a structure can be provided. For example, first optical fiber arrangement(s) can be provided which transceives at least one first electro-magnetic radiation, and can include at least one fiber. Second focusing arrangement(s) can be provided in optical communication with the optical fiber arrangement. The second arrangement can be configured to focus and provide there through the first electro-magnetic radiation. Third dispersive arrangement(s) can receive a particular radiation which is the first electro-magnetic radiation and/or the focused electro-magnetic radiation, and forward a dispersed radiation thereof to at least one section of the structure. At least one end of the fiber can be directly connected to the second focusing arrangement and/or the third dispersive arrangement.
摘要翻译：可以提供用于获得结构信息的示例性装置。例如，可以提供收发至少一个第一电磁辐射的第一光纤布置，并且可以包括至少一个光纤。可以提供与光纤装置的光通信中的第二聚焦装置。第二布置可以被配置成通过第一电磁辐射聚焦并提供到那里。第三分散布置可以接收作为第一电磁辐射和/或聚焦电磁辐射的特定辐射，并将其分散的辐射转发到结构的至少一个部分。光纤的至少一端可以直接连接到第二聚焦装置和/或第三色散装置。

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