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11. 发明授权

US07867170B2 Method and apparatus for non-invasively measuring hemodynamic parameters using parametrics 有权
标题翻译：使用参数非侵入性测量血液动力学参数的方法和装置
公开(公告)号：US07867170B2
公开(公告)日：2011-01-11
申请号：US10838404
申请日：2004-05-03
申请人： Stuart L. Gallant , Gregory I. Voss , William H. Markle
发明人： Stuart L. Gallant , Gregory I. Voss , William H. Markle
IPC分类号： A61B5/02
CPC分类号： A61B5/021 , A61B5/6843 , A61B2562/02 , A61B2562/0247 , G06F19/00
摘要： An improved method and apparatus for non-invasively assessing one or more hemodynamic parameters associated with the circulatory system of a living organism. In one aspect, the invention comprises a method of measuring a hemodynamic parameter (e.g., arterial blood pressure) by applanating or compressing portions of tissue proximate to the blood vessel of concern until a desired condition is achieved, and then measuring the hemodynamic parameter. Such applanation effectively mitigates transfer and other losses created by the tissue proximate to the blood vessel, thereby facilitating accurate and robust tonometric measurement. An algorithm adapted to maintain optimal levels of applanation is also described. Methods and apparatus for scaling such hemodynamic parameter measurements based on subject physiology, and providing treatment to the subject based on the measured parameters, are also disclosed.
摘要翻译：一种用于非侵入性评估与生物体的循环系统相关联的一个或多个血液动力学参数的改进的方法和装置。在一个方面，本发明包括通过压缩或压缩靠近所关注的血管的组织的部分直到达到所需条件，然后测量血液动力学参数来测量血液动力学参数（例如，动脉血压）的方法。这种扁平化有效地减轻了靠近血管的组织产生的转移和其它损失，从而有助于准确和稳健的测量计量。还描述了适于维持最佳压平水平的算法。还公开了基于受试者生理学来缩放这种血液动力学参数测量以及基于测量参数向对象提供治疗的方法和装置。

12. 发明授权

US06228034B1 Apparatus and method for non-invasively monitoring a subjects arterial blood pressure 失效
标题翻译：非侵入性监测受试者动脉血压的装置和方法
公开(公告)号：US06228034B1
公开(公告)日：2001-05-08
申请号：US09120069
申请日：1998-07-20
申请人： Gregory I. Voss , Alvis J. Somerville , Stephen H. O'Leary
发明人： Gregory I. Voss , Alvis J. Somerville , Stephen H. O'Leary
IPC分类号： A61B502
CPC分类号： A61B5/022
摘要： Apparatus is disclosed for non-invasively monitoring a subject's blood pressure, in which a pressure sensor assembly that includes a pressure transducer is compressed against tissue overlying an artery, with sufficient force to compress the artery. A motor first servo control system optimizes the amount of artery compression, which occurs at a mean transmural pressure of about zero, by modulating one side of a lever arm compressing the assembly against the tissue, creating a pressure signal indicative of transmural pressure. Since different pressure effects are realized according to the amount of artery compression, an appropriate control signal can be produced that provides for a second motor to adjust the other side of the lever arm to provide the optimum compression of the assembly into the tissue overlying the artery. The apparatus is optimally positioned over an artery by including an ultrasonic blood flow sensor configured to sense the flow of blood under the pressure transducer.
摘要翻译：公开了用于非侵入性地监测受试者的血压的装置，其中包括压力换能器的压力传感器组件被压缩在动脉上方的组织上，具有足够的力来压缩动脉。电动机第一伺服控制系统通过调节杠杆臂的一侧压缩组件抵抗组织来优化在平均透壁压力约为零时发生的动脉压缩量，产生指示透壁压的压力信号。由于根据动脉压力的量实现了不同的压力效应，因此可以产生适当的控制信号，其提供第二电动机以调节杠杆臂的另一侧，以将组件的最佳压缩提供到覆盖动脉的组织中。该装置通过包括构造成感测压力传感器下方的血液流动的超声波血流传感器而优选地定位在动脉上。

13. 发明授权

US5609576A Fluid flow impedance monitoring system 失效
标题翻译：流体阻抗监测系统
公开(公告)号：US5609576A
公开(公告)日：1997-03-11
申请号：US305904
申请日：1994-09-13
申请人： Gregory I. Voss , Robert D. Butterfield , Gail D. Baura , Casper W. Barnes
发明人： Gregory I. Voss , Robert D. Butterfield , Gail D. Baura , Casper W. Barnes
IPC分类号： A61M5/00 , A61M5/168 , A61M31/00
CPC分类号： A61M5/16859 , Y10S128/13 , Y10S128/925
摘要： Impedance to fluid flow in a fluid delivery line is measured. Two techniques are used depending on the flow rate selected. For high flow rates, the pump is controlled to vary the flow rate and the change in pressure is divided by the change in flow to directly determine the resistance. For low flow rates, a processor controls the pump to pump flow quantities in accordance with a pseudo-random binary code. The resulting pressure signal sensed at the conduit is decoded in accordance with that code. Pressures received during code periods of no flow are subtracted from pressures received during code periods of flow. Pressure offset is also removed and a least squares estimation approach is used with a linear prediction model to determine impedance. The coefficients determined in the model are used to calculate the resistance to fluid flow of the system. A quality supervisor monitors the resistance determination process and controls the display of resistance depending on the quality determined. A resistance display continuously displays the resistance of the system.
摘要翻译：测量流体输送管线中的流体流动的阻抗。取决于所选择的流量，使用两种技术。对于高流量，泵被控制以改变流量，并且压力变化除以流量的变化以直接确定阻力。对于低流量，处理器根据伪随机二进制码控制泵泵流量。根据该代码对在管道处感测到的压力信号进行解码。在流量代码期间收到的压力中，从无流量代码期间收到的压力减去。还消除了压力偏移，并且使用最小二乘估计方法与线性预测模型来确定阻抗。在模型中确定的系数用于计算系统对流体流动的阻力。质量监督人员监控电阻确定过程，并根据所确定的质量控制电阻显示。电阻显示连续显示系统的电阻。

14. 发明申请

US20110263991A1 METHOD AND APPARATUS FOR CONTROL OF NON-INVASIVE PARAMETER MEASUREMENTS 有权
标题翻译：用于控制非入侵参数测量的方法和装置
公开(公告)号：US20110263991A1
公开(公告)日：2011-10-27
申请号：US13180315
申请日：2011-07-11
申请人： Gregory J. Martin , Gregory I. Voss , Manouchehr Goharlaee , Stuart L. Gallant , Warren Craycroft
发明人： Gregory J. Martin , Gregory I. Voss , Manouchehr Goharlaee , Stuart L. Gallant , Warren Craycroft
IPC分类号： A61B5/021 , A61B5/026 , A61B5/02
CPC分类号： A61B5/721 , A61B5/0048 , A61B5/02007 , A61B5/021 , A61B5/0225 , A61B5/7207 , A61B5/7264 , A61B5/7282 , A61B5/7285
摘要： Improved methods and apparatus for non-invasively assessing one or more parameters associated with fluidic systems such as the circulatory system of a living organism, when such parameters are potentially affected by other concurrent events. In one exemplary embodiment, apparatus and methods for compensating for occlusive events (e.g., pressure cuff inflation) occurring ipsilateral to the location of parameter measurement are disclosed. Upon passive detection of signal degradation resulting from the event, the apparatus selectively enters a “wait state” wherein further processing of the hemodynamic data is suspended until the degrading event subsides. This behavior mitigates any adverse effects the event might have on the accuracy of the representation of the measured hemodynamic parameter generated by the system. In another exemplary embodiment, the measured data is analyzed in order to classify the type of event (e.g., occlusive or other), such classification allowing the system to appropriately tailor its response to the event.
摘要翻译：改进的方法和装置，用于非侵入性地评估与流体系统相关联的一个或多个参数，例如活体的循环系统，当这些参数可能受到其他并发事件的影响时。在一个示例性实施例中，公开了用于补偿与参数测量位置同侧出现的闭塞事件（例如，压力袖带充气）的装置和方法。在被动检测由事件导致的信号劣化时，该装置选择性地进入“等待状态”，其中暂停血液动力学数据的进一步处理，直到降解事件消退。该行为减轻了事件可能对由系统产生的测量的血液动力学参数的表示的准确性的任何不利影响。在另一个示例性实施例中，分析测量数据以便将事件的类型（例如，闭塞或其他）分类，允许系统适当地定制其对事件的响应。

15. 发明授权

US07291112B2 Method and apparatus for control of non-invasive parameter measurements 有权
标题翻译：用于控制非侵入性参数测量的方法和装置
公开(公告)号：US07291112B2
公开(公告)日：2007-11-06
申请号：US10393660
申请日：2003-03-20
申请人： Gregory J. Martin , Gregory I. Voss , Manouchehr Goharlaee , Stuart L. Gallant , Warren Craycroft
发明人： Gregory J. Martin , Gregory I. Voss , Manouchehr Goharlaee , Stuart L. Gallant , Warren Craycroft
IPC分类号： A61B5/02
CPC分类号： A61B5/022 , A61B5/02007 , A61B5/02028 , A61B5/024 , A61B5/684 , A61B5/6843 , A61B5/7203 , A61B5/7207 , A61B5/7264
摘要： Improved methods and apparatus for non-invasively assessing one or more parameters associated with fluidic systems such as the circulatory system of a living organism, when such parameters are potentially affected by other concurrent events. In one exemplary embodiment, apparatus and methods for compensating for occlusive events (e.g., pressure cuff inflation) occurring ipsilateral to the location of parameter measurement are disclosed. Upon passive detection of signal degradation resulting from the event, the apparatus selectively enters a “wait state” wherein further processing of the hemodynamic data is suspended until the degrading event subsides. This behavior mitigates any adverse effects the event might have on the accuracy of the representation of the measured hemodynamic parameter generated by the system. In another exemplary embodiment, the measured data is analyzed in order to classify the type of event (e.g., occlusive or other), such classification allowing the system to appropriately tailor its response to the event.
摘要翻译：改进的方法和装置，用于非侵入性地评估与流体系统相关联的一个或多个参数，例如活体的循环系统，当这些参数可能受到其他并发事件的影响时。在一个示例性实施例中，公开了用于补偿与参数测量位置同侧出现的闭塞事件（例如，压力袖带充气）的装置和方法。在被动检测由事件导致的信号劣化时，该装置选择性地进入“等待状态”，其中暂停血液动力学数据的进一步处理，直到降解事件消退。该行为减轻了事件可能对由系统产生的测量的血液动力学参数的表示的准确性的任何不利影响。在另一个示例性实施例中，分析测量数据以便将事件的类型（例如，闭塞或其他）分类，允许系统适当地定制其对事件的响应。

16. 发明授权

US06974419B1 Method and apparatus for control of non-invasive parameter measurements 失效
标题翻译：用于控制非侵入性参数测量的方法和装置
公开(公告)号：US06974419B1
公开(公告)日：2005-12-13
申请号：US10211115
申请日：2002-08-01
申请人： Gregory I. Voss , Gregory J. Martin , Manouchehr Goharlaee
发明人： Gregory I. Voss , Gregory J. Martin , Manouchehr Goharlaee
IPC分类号： A61B5/02
CPC分类号： A61B5/022 , A61B5/02007 , A61B5/02028 , A61B5/024 , A61B5/684 , A61B5/6843 , A61B5/7203 , A61B5/7207 , A61B5/7264
摘要： Improved methods and apparatus for non-invasively assessing one or more parameters associated with fluidic systems such as the circulatory system of a living organism. In a first aspect, an improved method of continuously measuring pressure from a compressible vessel is disclosed, wherein a substantially optimal level of compression for the vessel is achieved and maintained using perturbations (e.g., modulation) of the compression level of the vessel. In one exemplary embodiment, the modulation is conducted according to a pseudo-random binary sequence (PBRS). In a second aspect, an improved apparatus for determining the blood pressure of a living subject is disclosed, the apparatus generally comprising a pressure sensor and associated processor with a computer program defining a plurality of operating states related to the sensed pressure data. Methods for pressure waveform correction and reacquisition, as well as treatment using the present invention, are also disclosed.
摘要翻译：用于非侵入性评估与诸如活体的循环系统的流体系统相关联的一个或多个参数的改进的方法和装置。在第一方面，公开了一种从可压缩容器连续测量压力的改进方法，其中使用容器的压缩水平的扰动（例如，调制）来实现和维持容器的基本上最佳的压缩水平。在一个示例性实施例中，根据伪随机二进制序列（PBRS）进行调制。在第二方面，公开了一种用于确定活体的血压的改进装置，所述装置通常包括压力传感器和与计算机程序相关联的处理器，所述计算机程序定义与感测的压力数据有关的多个操作状态。还公开了压力波形校正和再吸收的方法以及使用本发明的处理。

17. 发明授权

US5964711A Apparatus and method for non-invasively monitoring a subject's arterial blood pressure 失效
标题翻译：非侵入性监测受试者动脉血压的装置和方法
公开(公告)号：US5964711A
公开(公告)日：1999-10-12
申请号：US54288
申请日：1998-04-02
申请人： Gregory I. Voss , Alvis J. Somerville
发明人： Gregory I. Voss , Alvis J. Somerville
IPC分类号： A61B5/022 , A61B5/021 , A61B5/00
CPC分类号： A61B5/021
摘要： Apparatus is disclosed for non-invasively monitoring a subject's blood pressure, in which a flexible diaphragm that encloses a fluid-filled chamber is compressed against tissue overlying an artery, with sufficient force to compress the artery. A first, relatively slow servo control system optimizes the amount of artery compression, which occurs at a mean transmural pressure of about zero, by modulating the volume of fluid within the chamber and noting the resulting effect on the pressure within the chamber. Since different pressure effects are realized according to the amount of artery compression, an appropriate control signal can be produced that provides the optimum mean diaphragm pressure. In addition, a second, relatively fast servo control system supplies the fluid to and from the chamber, so as to compensate for pressure variations within artery. This minimizes variations in the artery's effective diameter, whereby the pressure within the fluid-filled chamber closely follows the actual arterial pulse waveform.
摘要翻译：公开了用于非侵入性地监测受试者血压的装置，其中围绕动脉的组织压缩包围流体填充腔的柔性隔膜，具有足够的力来压缩动脉。第一个相对较慢的伺服控制系统通过调节腔内流体的体积并注意到对室内的压力的影响来优化在平均透壁压约为零的情况下发生的动脉压缩量。由于根据动脉压力的量实现不同的压力效应，因此可以产生适当的控制信号，其提供最佳的平均隔膜压力。此外，第二个相对较快的伺服控制系统向腔室供应流体，从而补偿动脉内的压力变化。这使得动脉的有效直径的变化最小化，由此流体填充室内的压力紧跟实际的动脉脉搏波形。

18. 发明授权

US08961426B2 Method and apparatus for control of non-invasive parameter measurements 有权
标题翻译：用于控制非侵入性参数测量的方法和装置
公开(公告)号：US08961426B2
公开(公告)日：2015-02-24
申请号：US13180315
申请日：2011-07-11
申请人： Gregory J. Martin , Gregory I. Voss , Manouchehr Goharlaee , Stuart L. Gallant , Warren Craycroft
发明人： Gregory J. Martin , Gregory I. Voss , Manouchehr Goharlaee , Stuart L. Gallant , Warren Craycroft
IPC分类号： A61B5/02 , A61B5/00 , A61B5/021
CPC分类号： A61B5/721 , A61B5/0048 , A61B5/02007 , A61B5/021 , A61B5/0225 , A61B5/7207 , A61B5/7264 , A61B5/7282 , A61B5/7285
摘要： Improved methods and apparatus for non-invasively assessing one or more parameters associated with fluidic systems such as the circulatory system of a living organism, when such parameters are potentially affected by other concurrent events. In one exemplary embodiment, apparatus and methods for compensating for occlusive events (e.g., pressure cuff inflation) occurring ipsilateral to the location of parameter measurement are disclosed. Upon passive detection of signal degradation resulting from the event, the apparatus selectively enters a “wait state” wherein further processing of the hemodynamic data is suspended until the degrading event subsides. This behavior mitigates any adverse effects the event might have on the accuracy of the representation of the measured hemodynamic parameter generated by the system. In another exemplary embodiment, the measured data is analyzed in order to classify the type of event (e.g., occlusive or other), such classification allowing the system to appropriately tailor its response to the event.
摘要翻译：改进的方法和装置，用于非侵入性地评估与流体系统相关联的一个或多个参数，例如活体的循环系统，当这些参数可能受到其他并发事件的影响时。在一个示例性实施例中，公开了用于补偿与参数测量位置同侧出现的闭塞事件（例如，压力袖带充气）的装置和方法。在被动检测由事件导致的信号劣化时，该装置选择性地进入“等待状态”，其中暂停血液动力学数据的进一步处理，直到降解事件消退。该行为减轻了事件可能对由系统产生的测量的血液动力学参数的表示的准确性的任何不利影响。在另一个示例性实施例中，分析测量数据以便将事件的类型（例如，闭塞或其他）分类，允许系统适当地定制其对事件的响应。

19. 发明申请

US20110237961A1 METHODS AND APPARATUS FOR CONTROL OF NON-INVASIVE PARAMETER MEASUREMENTS 有权
标题翻译：用于控制非入侵参数测量的方法和装置
公开(公告)号：US20110237961A1
公开(公告)日：2011-09-29
申请号：US13154315
申请日：2011-06-06
申请人： Gregory I. Voss , Gregory J. Martin , Manouchehr Goharlaee
发明人： Gregory I. Voss , Gregory J. Martin , Manouchehr Goharlaee
IPC分类号： A61B5/021
CPC分类号： A61B5/022 , A61B5/02007 , A61B5/02028 , A61B5/024 , A61B5/684 , A61B5/6843 , A61B5/7203 , A61B5/7207 , A61B5/7264
摘要： Improved methods and apparatus for non-invasively assessing one or more parameters associated with fluidic systems such as the circulatory system of a living organism. In a first aspect, an improved method of continuously measuring pressure from a compressible vessel is disclosed, wherein a substantially optimal level of compression for the vessel is achieved and maintained using perturbations (e.g., modulation) of the compression level of the vessel. In one exemplary embodiment, the modulation is conducted according to a pseudo-random binary sequence (PBRS). In a second aspect, an improved apparatus for determining the blood pressure of a living subject is disclosed, the apparatus generally comprising a pressure sensor and associated processor with a computer program defining a plurality of operating states related to the sensed pressure data. Methods for pressure waveform correction and reacquisition, as well as treatment using the present invention, are also disclosed.
摘要翻译：用于非侵入性评估与诸如活体的循环系统的流体系统相关联的一个或多个参数的改进的方法和装置。在第一方面，公开了一种从可压缩容器连续测量压力的改进方法，其中使用容器的压缩水平的扰动（例如，调制）来实现和维持容器的基本上最佳的压缩水平。在一个示例性实施例中，根据伪随机二进制序列（PBRS）进行调制。在第二方面，公开了一种用于确定活体的血压的改进的装置，该装置通常包括压力传感器和与计算机程序相关联的处理器，该计算机程序定义与感测的压力数据相关的多个操作状态。还公开了压力波形校正和再吸收的方法以及使用本发明的处理。

20. 发明授权

US07976471B2 Method and apparatus for control of non-invasive parameter measurements 有权
标题翻译：用于控制非侵入性参数测量的方法和装置
公开(公告)号：US07976471B2
公开(公告)日：2011-07-12
申请号：US11982975
申请日：2007-11-05
申请人： Gregory J. Martin , Gregory I. Voss , Manouchehr Goharlaee , Stuart L. Gallant , Warren Craycroft
发明人： Gregory J. Martin , Gregory I. Voss , Manouchehr Goharlaee , Stuart L. Gallant , Warren Craycroft
IPC分类号： A61B5/02
CPC分类号： A61B5/721 , A61B5/0048 , A61B5/02007 , A61B5/021 , A61B5/0225 , A61B5/7207 , A61B5/7264 , A61B5/7282 , A61B5/7285
摘要： Improved methods and apparatus for non-invasively assessing one or more parameters associated with fluidic systems such as the circulatory system of a living organism, when such parameters are potentially affected by other concurrent events. In one exemplary embodiment, apparatus and methods for compensating for occlusive events (e.g., pressure cuff inflation) occurring ipsilateral to the location of parameter measurement are disclosed. Upon passive detection of signal degradation resulting from the event, the apparatus selectively enters a “wait state” wherein further processing of the hemodynamic data is suspended until the degrading event subsides. This behavior mitigates any adverse effects the event might have on the accuracy of the representation of the measured hemodynamic parameter generated by the system. In another exemplary embodiment, the measured data is analyzed in order to classify the type of event (e.g., occlusive or other), such classification allowing the system to appropriately tailor its response to the event.
摘要翻译：改进的方法和装置，用于非侵入性地评估与流体系统相关联的一个或多个参数，例如活体的循环系统，当这些参数可能受到其他并发事件的影响时。在一个示例性实施例中，公开了用于补偿与参数测量位置同侧出现的闭塞事件（例如，压力袖带充气）的装置和方法。在被动检测由事件导致的信号劣化时，该装置选择性地进入“等待状态”，其中暂停血液动力学数据的进一步处理，直到降解事件消退。该行为减轻了事件可能对由系统产生的测量的血液动力学参数的表示的准确性的任何不利影响。在另一个示例性实施例中，分析测量数据以便将事件的类型（例如，闭塞或其他）分类，允许系统适当地定制其对事件的响应。

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