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11. 发明授权

US08346347B2 Skin optical characterization device 失效
标题翻译：皮肤光学表征装置
公开(公告)号：US08346347B2
公开(公告)日：2013-01-01
申请号：US11522124
申请日：2006-09-15
申请人： Gregory Altshuler , Guangming Wang , Henry Zenzie
发明人： Gregory Altshuler , Guangming Wang , Henry Zenzie
IPC分类号： A61B6/00 , G01J1/42 , A61B18/18 , A61B5/06
CPC分类号： A61B5/0082 , A61B5/0059 , A61B5/443 , A61B5/444 , A61B5/445 , A61B5/6843
摘要： The present invention is generally directed to dermatological devices and methods in which one or more skin characteristics, such as the melanin index, are determined by analyzing radiation backscattered from a skin region illuminated by at least one, and preferably, two or more wavelengths, e.g., in a range of about 600 nm to about 900 nm. In many embodiments, the radiation is coupled to the skin via a waveguide, and an optical sensor is employed to ascertain contact between the waveguide (e.g., a waveguide surface adapted for contact with the skin) and the skin.
摘要翻译：本发明一般涉及皮肤病学装置和方法，其中通过分析由至少一个，优选地，两个或更多个波长照射的皮肤区域反向散射的辐射来确定一种或多种皮肤特征，例如黑色素指数，例如在约600nm至约900nm的范围内。在许多实施例中，辐射通过波导耦合到皮肤，并且使用光学传感器来确定波导（例如，适于与皮肤接触的波导表面）和皮肤之间的接触。

12. 发明申请

US20070060819A1 Skin optical characterization device 失效
标题翻译：皮肤光学表征装置
公开(公告)号：US20070060819A1
公开(公告)日：2007-03-15
申请号：US11522124
申请日：2006-09-15
申请人： Gregory Altshuler , Guangming Wang , Henry Zenzie
发明人： Gregory Altshuler , Guangming Wang , Henry Zenzie
IPC分类号： A61B6/00 , A61B5/00
CPC分类号： A61B5/0082 , A61B5/0059 , A61B5/443 , A61B5/444 , A61B5/445 , A61B5/6843
摘要： The present invention is generally directed to dermatological devices and methods in which one or more skin characteristics, such as the melanin index, are determined by analyzing radiation backscattered from a skin region illuminated by at least one, and preferably, two or more wavelengths, e.g., in a range of about 600 nm to about 900 nm. In many embodiments, the radiation is coupled to the skin via a waveguide, and an optical sensor is employed to ascertain contact between the waveguide (e.g., a waveguide surface adapted for contact with the skin) and the skin.
摘要翻译：本发明一般涉及皮肤病学装置和方法，其中通过分析由至少一个，优选地，两个或更多个波长照射的皮肤区域反向散射的辐射来确定一种或多种皮肤特征，例如黑色素指数，例如在约600nm至约900nm的范围内。在许多实施例中，辐射通过波导耦合到皮肤，并且使用光学传感器来确定波导（例如，适于与皮肤接触的波导表面）和皮肤之间的接触。

13. 发明申请

US20060161143A1 Light energy delivery head 失效
公开(公告)号：US20060161143A1
公开(公告)日：2006-07-20
申请号：US11301340
申请日：2005-12-12
申请人： Gregory Altshuler , Henry Zenzie
发明人： Gregory Altshuler , Henry Zenzie
IPC分类号： A61B18/18
CPC分类号： A61B18/203 , A61B2018/00005 , A61B2018/00011 , A61B2018/00041 , A61B2018/00452 , A61B2018/00458 , A61B2018/00476 , A61B2090/065 , A61N5/0617 , A61N2005/005 , A61N2005/007
摘要： A light energy delivery head is provided which, in one aspect, mounts laser diode bars or other light energy emitters in a heat sink block which is adapted to cool both the emitters and a surface of a medium with which the head is in contact and to which it is applying light energy. In another aspect, various retroreflection configurations are provided which optimize retroreflection of back-scattered light energy from the medium. The size of the aperture through which light energy is applied to the medium is also controlled so as to provide a desired amplification coefficient as a result of retroreflection.

14. 发明申请

US20050215988A1 Method and apparatus for medical treatment utilizing long duration electromagnetic radiation 审中-公开
标题翻译：使用长时间电磁辐射的医疗方法和装置
公开(公告)号：US20050215988A1
公开(公告)日：2005-09-29
申请号：US11090896
申请日：2005-03-25
申请人： Gregory Altshuler , Michael Smotrich , Henry Zenzie , Michael Smirnov , R. Anderson , Dieter Manstein , Eliot Battle
发明人： Gregory Altshuler , Michael Smotrich , Henry Zenzie , Michael Smirnov , R. Anderson , Dieter Manstein , Eliot Battle
IPC分类号： A61B17/00 , A61B18/20 , A61N5/02 , A61N5/06
CPC分类号： A61B18/203 , A61B2017/00172 , A61B2018/00452 , A61B2018/00476
摘要： A method and apparatus are provided for performing a medical procedure on a patient, for example a dermatological procedure, by use of electromagnetic radiation (EMR) having a relatively low peak power, and in particular a peak power low enough so as not to result in a phase change in the heater or chromophore absorbing radiation which would result in a significant reduction in its absorption, and of relatively long duration which is generally greater than, sometimes significantly greater than, the thermal relaxation time of the irradiated target.
摘要翻译：提供了一种方法和装置，用于通过使用具有相对低的峰值功率的电磁辐射（EMR），特别是足够低的峰值功率来对患者执行医疗程序，例如皮肤病学程序，以便不会导致吸收辐射的加热器或发色团的相变将导致其吸收的显着降低，并且相对长的持续时间通常大于有时显着大于照射的靶的热松弛时间。

15. 发明授权

US08915948B2 Method and apparatus for photothermal treatment of tissue at depth 有权
标题翻译：深层组织光热处理方法及装置
公开(公告)号：US08915948B2
公开(公告)日：2014-12-23
申请号：US12032004
申请日：2008-02-15
申请人： Gregory B. Altshuler , Andrei V. Erofeev , Henry Zenzie , Richard Rox Anderson , Dieter Manstein , James Burke, III , Andrew Radl , Michael Z. Smirnov
发明人： Gregory B. Altshuler , Andrei V. Erofeev , Henry Zenzie , Richard Rox Anderson , Dieter Manstein , James Burke, III , Andrew Radl , Michael Z. Smirnov
IPC分类号： A61N5/06 , A61B5/00 , A61B18/20 , A61N7/00 , A61B18/00 , A61N1/32 , A61B18/14
CPC分类号： A61N5/0625 , A61B5/6843 , A61B18/14 , A61B18/203 , A61B2018/00005 , A61B2018/00011 , A61B2018/00452 , A61B2018/00458 , A61B2018/00476 , A61N1/20 , A61N1/32 , A61N1/328 , A61N1/36 , A61N5/0613 , A61N5/0616 , A61N7/00 , A61N2005/0659 , A61N2007/0008 , A61N2007/0034
摘要： The present invention provides method and apparatus for treating tissue in a region at depth by applying optical radiation thereto of a wavelength able to reach the depth of the region and of a selected relatively low power for a duration sufficient for the radiation to effect the desired treatment while concurrently cooling tissue above the selected region to protect such tissue. Treatment may be enhanced by applying mechanical, acoustic or electrical stimulation to the region.
摘要翻译：本发明提供了通过向其施加能够达到该区域的深度的波长并且选择相对较低的功率持续足以使辐射实现所需治疗的持续时间的光辐射来治疗深度区域中的组织的方法和装置同时同时冷却选定区域上方的组织以保护这种组织。可以通过对该区域施加机械，声学或电刺激来增强治疗。

16. 发明授权

US4047914A Internally supported multi-stage sleeve filter 失效
标题翻译：内置多级套筒式过滤器
公开(公告)号：US4047914A
公开(公告)日：1977-09-13
申请号：US727204
申请日：1976-09-27
申请人： Elwood F. Hansen , Arnold Goldberg , Henry Zenzie , Kermit Giroward
发明人： Elwood F. Hansen , Arnold Goldberg , Henry Zenzie , Kermit Giroward
IPC分类号： B01D39/20 , B01D46/10 , B01D46/02
CPC分类号： B01D46/10 , B01D39/2017
摘要： A self-supporting, self-gasketing, multi-stage, variable density glass fiber sleeve filter is disclosed and includes a reusable internal wire frame with a composite, low velocity fluid entry filter member on one side of the frame and a fluid egress member on the other side of the frame. The fluid entry filter member is made of two or more layers of medium to long filament puffed glass fiber that differ in thickness and density. The entry and egress members are stitched along longitudinal edge portions so as to form an open ended sleeve that can be slid on and off of the reusable frame. The sleeve is dimensioned such that when it is slid onto the frame both the entry and egress members are tensioned across the frame such that the entry member is outwardly curved with respect to the egress member.
摘要翻译：公开了一种自支撑，自密封，多级，可变密度的玻璃纤维套筒过滤器，并且包括可重复使用的内部线框架，其具有在框架的一侧上的复合低速流体入口过滤器构件和流体出口构件框架的另一边。流体入口过滤器构件由厚度和密度不同的两层或多层中长丝膨化玻璃纤维制成。入口和出口构件沿着纵向边缘部分被缝合，以形成能够在可再使用框架上滑动的开口套筒。套筒的尺寸使得当其滑动到框架上时，入口和出口构件跨过框架张紧，使得入口构件相对于出口构件向外弯曲。

17. 发明申请

US20080319430A1 Eye-Safe Device For Treatment Of Skin Tissue 审中-公开
标题翻译：用于治疗皮肤组织的眼睛安全装置
公开(公告)号：US20080319430A1
公开(公告)日：2008-12-25
申请号：US12143520
申请日：2008-06-20
申请人： Henry Zenzie , Gregory B. Altshuler , Oldrich M. Laznicka, JR.
发明人： Henry Zenzie , Gregory B. Altshuler , Oldrich M. Laznicka, JR.
IPC分类号： A61B18/20
CPC分类号： A61B18/203 , A61B2017/00026 , A61B2017/00106 , A61B2018/00452 , A61B2090/065 , A61H23/02
摘要： Methods and devices are described that provide for eye-safe treatments using a photocosmetic device on skin tissue. In particular, various eye-safety devices protect the eye, including both the retina and the iris, as well as provide additional skin safety. The devices and methods described are particularly useful in consumer devices, but are useful in other devices also.
摘要翻译：描述了提供在皮肤组织上使用光敏装置的眼睛安全治疗的方法和装置。特别地，各种眼睛安全装置保护眼睛，包括视网膜和虹膜，以及提供额外的皮肤安全性。所描述的设备和方法在消费者设备中特别有用，但在其他设备中也是有用的。

18. 发明申请

US20120323229A1 EYE-SAFE DEVICE FOR TREATMENT OF SKIN TISSUE 审中-公开
标题翻译：用于治疗皮肤组织的眼睛安全装置
公开(公告)号：US20120323229A1
公开(公告)日：2012-12-20
申请号：US13600607
申请日：2012-08-31
申请人： Henry Zenzie , Gregory B. Altshuler , Oldrich M. Laznicka
发明人： Henry Zenzie , Gregory B. Altshuler , Oldrich M. Laznicka
IPC分类号： A61B18/18 , A61N5/06
CPC分类号： A61B18/203 , A61B2017/00026 , A61B2017/00106 , A61B2018/00452 , A61B2090/065 , A61H23/02
摘要： Methods and devices are described that provide for eye-safe treatments using a photocosmetic device on skin tissue. In particular, various eye-safety devices protect the eye, including both the retina and the iris, as well as provide additional skin safety. The devices and methods described are particularly useful in consumer devices, but are useful in other devices also.
摘要翻译：描述了提供在皮肤组织上使用光敏装置的眼睛安全治疗的方法和装置。特别地，各种眼睛安全装置保护眼睛，包括视网膜和虹膜，以及提供额外的皮肤安全性。所描述的设备和方法在消费者设备中特别有用，但在其他设备中也是有用的。

19. 发明申请

US20050197655A1 Method and apparatus for removing corneal tissue with infrared laser radiation and short pulse mid-infrared parametric generator for surgery 审中-公开
公开(公告)号：US20050197655A1
公开(公告)日：2005-09-08
申请号：US10996458
申请日：2004-11-26
申请人： William Telfair , Hanna Hoffman , Henry Zenzie , Peter Moulton , Paul Yoder
发明人： William Telfair , Hanna Hoffman , Henry Zenzie , Peter Moulton , Paul Yoder
IPC分类号： A61F9/007 , A61B17/00 , A61F20060101 , A61F9/008 , A61F9/01 , A61F9/013 , A61B18/20
CPC分类号： A61F9/008 , A61B18/20 , A61B2017/00694 , A61F9/00804 , A61F9/00814 , A61F2009/00846 , A61F2009/00872 , A61F2009/00882 , A61F2009/00897 , G02F1/39 , G02F2203/15
摘要： A surgical technique for removing corneal tissue with scanned infrared radiation is disclosed which utilizes short mid-infrared laser pulses to provide a tissue removal mechanism based on photospallation. Photospallation is a photomechanical ablation mechanism which results from the absorption of incident radiation by the corneal tissue. Since photospallation is a mechanical ablation process, very little heat is generated in the unablated adjacent tissue. The disclosed surgical system includes a scanning beam delivery system which allows uniform irradiation of the treatment region and utilizes low energy outputs to achieve controlled tissue removal. A real-time servo-controlled dynamic eye tracker, based on a multiple-detector arrangement, is also disclosed which senses the motion of the eye and provides signals that are proportional to the errors in the lateral alignment of the eye relative to the axis of the laser beam. Temporal and frequency discrimination are preferably utilized to distinguish the tracking illumination from the ambient illumination and the surgical laser beam. A laser parametric generator for surgical applications is disclosed which utilizes short-pulse, mid-infrared radiation. The mid-infrared radiation may be produced by a pump laser source, such as a neodymium-doped laser, which is parametrically down converted in a suitable nonlinear crystal to the desired mid-infrared range. The short pulses reduce unwanted thermal effects and changes in adjacent tissue to potentially submicron-levels. The parametrically converted radiation source preferably produces pulse durations shorter than 25 ns at or near 3.0 microns but preferably close to the water absorption maximum associated with the tissue. The down-conversion to the desired mid-infrared wavelength is preferably produced by a nonlinear crystal such as KTP or its isomorphs. In one embodiment, a non-critically phased-matched crystal is utilized to shift the wavelength from a near-infrared laser source emitting at or around 880 to 900 nm to the desired 2.9-3.0 microns wavelength range. A fiber, fiber bundle or another waveguide means utilized to separate the pump laser from the optical parametric oscillation (OPO) cavity is also included as part of the invention.

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