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11. 发明授权

US09572781B2 Orally disintegrating tablet compositions comprising combinations of non-opioid and opioid analgesics 有权
标题翻译：口服崩解片剂组合物，其包含非阿片样物质和阿片样镇痛药的组合
公开(公告)号：US09572781B2
公开(公告)日：2017-02-21
申请号：US12772776
申请日：2010-05-03
申请人： Gopi Venkatesh , Michael Gosselin , James Clevenger , Jin-Wang Lai
发明人： Gopi Venkatesh , Michael Gosselin , James Clevenger , Jin-Wang Lai
IPC分类号： A61K9/16 , A61K9/50
CPC分类号： A61K9/5047 , A61K9/2081 , A61K9/5073 , A61K9/5078 , A61K9/5084 , A61K31/00 , A61K31/192 , A61K31/196 , A61K31/40 , A61K31/405 , A61K31/407 , A61K31/415 , A61K31/4415 , A61K31/4468 , A61K31/485 , A61K31/5415 , A61K31/60 , A61K45/06 , A61K2300/00
摘要： The present invention is directed to pharmaceutical compositions comprising a plurality of taste-masked non-opioid analgesic/opioid analgesic drug-containing microparticles, dosage forms comprising such pharmaceutical compositions (such as an orally disintegrating tablet), and methods of making the pharmaceutical compositions and dosage forms of the present invention. Dosage forms comprising the pharmaceutical compositions of the present invention are improved homogeneous blends of non-opioid and opioid analgesics which provide for more convenient and palatable administration of drug combinations, for example for treating pain.
摘要翻译：本发明涉及包含多种掩味的非阿片类镇痛/阿片类止痛药物的微粒的药物组合物，包含这种药物组合物的剂型（例如口腔崩解片），以及制备该药物组合物的方法和本发明的剂型。包含本发明的药物组合物的剂型是非阿片类和阿片类止痛剂的改进的均匀共混物，其提供药物组合的更方便和可口的给药，例如用于治疗疼痛。

12. 发明申请

US20110081411A1 Orally Administered Corticosteroid Compositions 有权
标题翻译：口服给药的皮质类固醇组合物
公开(公告)号：US20110081411A1
公开(公告)日：2011-04-07
申请号：US12896005
申请日：2010-10-01
申请人： Stephen Perrett , Fredric Jay Cohen , Gopi Venkatesh
发明人： Stephen Perrett , Fredric Jay Cohen , Gopi Venkatesh
IPC分类号： A61K9/48 , C07J3/00 , A61K31/569 , A61K9/16 , A61K9/14 , A61P29/00 , A61P31/12 , A61P31/10
CPC分类号： A61K9/0065 , A61K9/0053 , A61K9/0056 , A61K9/006 , A61K9/06 , A61K9/08 , A61K31/56 , A61K31/569 , A61K31/58 , A61K45/06 , A61K47/38 , A61K2300/00
摘要： The present invention is directed to orally administered corticosteroid compositions. The present invention also provides a method for treating a condition associated with inflammation of the gastrointestinal tract in an individual. The method comprises administering to an individual in need thereof a pharmaceutical composition of the present invention.
摘要翻译：本发明涉及口服给药的皮质类固醇组合物。本发明还提供了治疗与个体中胃肠道炎症有关的病症的方法。该方法包括向有需要的个体施用本发明的药物组合物。

13. 发明授权

US07790199B2 Modified release dosage forms of skeletal muscle relaxants 有权
公开(公告)号：US07790199B2
公开(公告)日：2010-09-07
申请号：US12236723
申请日：2008-09-24
申请人： Gopi Venkatesh , James M. Clevenger
发明人： Gopi Venkatesh , James M. Clevenger
IPC分类号： A61K9/14
CPC分类号： A61K31/135 , A61K9/0053 , A61K9/1652 , A61K9/2054 , A61K9/4808 , A61K9/4866 , A61K9/5078 , A61K31/137 , A61K31/5513 , Y10T29/49826
摘要： A unit dosage form, such as a capsule or the like, for delivering a skeletal muscle relaxant, such as cyclobenzaprine hydrochloride, into the body in an extended or sustained release fashion comprising one or more populations of drug-containing particles (beads, pellets, granules, etc.) is disclosed. At least one bead population exhibits a pre-designed sustained release profile. Such a drug delivery system is designed for once-daily oral administration to maintain an adequate plasma concentration—time profile, thereby providing relief of muscle spasm associated with painful musculoskeletal conditions over a 24 hour period.

14. 发明授权

US07387793B2 Modified release dosage forms of skeletal muscle relaxants 有权
标题翻译：骨骼肌松弛剂的改性释放剂型
公开(公告)号：US07387793B2
公开(公告)日：2008-06-17
申请号：US10713929
申请日：2003-11-14
申请人： Gopi Venkatesh , James M. Clevenger
发明人： Gopi Venkatesh , James M. Clevenger
IPC分类号： A61K9/14
CPC分类号： A61K31/135 , A61K9/0053 , A61K9/1652 , A61K9/2054 , A61K9/4808 , A61K9/4866 , A61K9/5078 , A61K31/137 , A61K31/5513 , Y10T29/49826
摘要： A unit dosage form, such as a capsule or the like, for delivering a skeletal muscle relaxant, such as cyclobenzaprine hydrochloride, into the body in an extended or sustained release fashion comprising one or more populations of drug-containing particles (beads, pellets, granules, etc.) is disclosed. At least one bead population exhibits a pre-designed sustained release profile. Such a drug delivery system is designed for once-daily oral administration to maintain an adequate plasma concentration—time profile, thereby providing relief of muscle spasm associated with painful musculoskeletal conditions over a 24 hour period.
摘要翻译：用于以延长或持续释放的方式将骨骼肌松弛剂（例如盐酸环苯扎林）输送到体内的单位剂型，包括一种或多种含药颗粒群（珠粒，丸粒，颗粒等）。至少一个珠粒表现出预先设计的持续释放特征。这种药物递送系统设计为每日一次口服给药以维持足够的血浆浓度 - 时间特征，从而在24小时内缓解与疼痛的肌肉骨骼病症相关的肌肉痉挛。

15. 发明申请

US20060269607A1 Timed, sustained release systems for propranolol 有权
公开(公告)号：US20060269607A1
公开(公告)日：2006-11-30
申请号：US11500892
申请日：2006-08-09
申请人： Phillip Percel , Krishna Vishnupad , Gopi Venkatesh
发明人： Phillip Percel , Krishna Vishnupad , Gopi Venkatesh
IPC分类号： A61K9/24
CPC分类号： A61K9/5084 , A61K9/5078 , A61K31/138
摘要： A unit dosage form, such as a capsule or the like for delivering drugs into the body in a circadian release fashion, is comprising of one or more populations of propranolol-containing particles (beads, pellets, granules, etc.). Each bead population exhibits a pre-designed rapid or sustained release profile with or without a predetermined lag time of 3 to 5 hours. Such a circadian rhythm release cardiovascular drug delivery system is designed to provide a plasma concentration-time profile, which varies according to physiological need during the day, i.e., mimicking the circadian rhythm and severity/manifestation of a cardiovascular disease, predicted based on pharmaco-kinetic and pharmaco-dynamic considerations and in vitro/in vivo correlations.

16. 发明申请

US20060078614A1 Taste-masked pharmaceutical compositions 有权
标题翻译：口感掩蔽的药物组合物
公开(公告)号：US20060078614A1
公开(公告)日：2006-04-13
申请号：US11248596
申请日：2005-10-12
申请人： Gopi Venkatesh
发明人： Gopi Venkatesh
IPC分类号： A61K9/26
CPC分类号： A61K9/0056 , A61K9/2077
摘要： There is provided a method for preparing an orally disintegrating tablet (ODT) composition comprising microparticles of one or more taste-masked active pharmaceutical ingredient(s), rapidly-dispersing microgranules, and other optional, pharmaceutically acceptable excipients wherein the ODT disintegrates on contact with saliva in the buccal cavity in about 60 seconds forming a smooth, easy-to-swallow suspension. Furthermore, the microparticles (crystals, granules, beads or pellets containing the active) applied with a taste-masking membrane comprising a combination of water-insoluble and gastrosoluble polymers release not less than about 60% of the dose is in the stomach in about 30 minutes, thus maximizing the probability of achieving bioequivalence to the reference IR product having rapid onset of action (short Tmax). A process for preparing such compositions for oral administration using conventional fluid-bed equipment and rotary tablet press is also disclosed.
摘要翻译：提供了一种制备包含一种或多种掩味活性药物成分，快速分散微粒和其它任选的药学上可接受的赋形剂的微粒的口腔崩解片（ODT）组合物的方法，其中ODT与口腔唾液在约60秒内形成平滑，易于吞咽的悬浮液。此外，应用包含水不溶性和胃溶性聚合物组合的掩味膜的微粒（晶体，颗粒，含有活性物质的颗粒或颗粒）不少于约60％的剂量在胃中约30 分钟，从而最大化实现具有快速起效作用的参考IR产物的生物等效性的概率（短T max max）。还公开了使用常规流化床设备和旋转式压片机制备用于口服给药的组合物的方法。

17. 发明授权

US08784884B2 Pancreatic enzyme compositions and methods for treating pancreatitis and pancreatic insufficiency 有权
标题翻译：胰腺酶组合物和治疗胰腺炎和胰腺功能不全的方法
公开(公告)号：US08784884B2
公开(公告)日：2014-07-22
申请号：US12568064
申请日：2009-09-28
申请人： Stephen Perrett , Ruth Thieroff-Ekerdt , Gopi Venkatesh , Konstantinos Efthymiopoulos
发明人： Stephen Perrett , Ruth Thieroff-Ekerdt , Gopi Venkatesh , Konstantinos Efthymiopoulos
IPC分类号： A61K9/48 , A61K9/14 , A61K38/43 , A61K38/54 , A61P1/18
CPC分类号： A61K9/16 , A61K9/2813 , A61K9/2866 , A61K9/4808 , A61K9/5084 , A61K38/00 , A61K38/465 , A61K38/48
摘要： Compositions of the present invention, comprising the combination of enterically coated and uncoated pancreatic enzyme-containing beads are useful for treating or preventing pancreatitis pain, and optionally disorders associated with digestive enzyme deficiencies.
摘要翻译：包含肠溶包衣和未包被胰酶的珠的组合的本发明的组合物可用于治疗或预防胰腺炎疼痛，以及任选与消化酶缺陷相关的病症。

18. 发明授权

US08771729B2 Orally administered corticosteroid compositions 有权
标题翻译：口服给药皮质类固醇组合物
公开(公告)号：US08771729B2
公开(公告)日：2014-07-08
申请号：US12896005
申请日：2010-10-01
申请人： Stephen Perrett , Fredric Jay Cohen , Gopi Venkatesh
发明人： Stephen Perrett , Fredric Jay Cohen , Gopi Venkatesh
IPC分类号： A61K9/48 , A61K31/569 , A61K9/16 , A61K9/14 , A61P29/00
CPC分类号： A61K9/0065 , A61K9/0053 , A61K9/0056 , A61K9/006 , A61K9/06 , A61K9/08 , A61K31/56 , A61K31/569 , A61K31/58 , A61K45/06 , A61K47/38 , A61K2300/00
摘要： The present invention is directed to orally administered corticosteroid compositions. The present invention also provides a method for treating a condition associated with inflammation of the gastrointestinal tract in an individual. The method comprises administering to an individual in need thereof a pharmaceutical composition of the present invention.
摘要翻译：本发明涉及口服给药的皮质类固醇组合物。本发明还提供了治疗与个体中胃肠道炎症有关的病症的方法。该方法包括向有需要的个体施用本发明的药物组合物。

19. 发明申请

US20120128764A1 CONTROLLED-RELEASE COMPOSITIONS COMPRISING A PROTON PUMP INHIBITOR 审中-公开
标题翻译：控制释放包含原子泵抑制剂的组合物
公开(公告)号：US20120128764A1
公开(公告)日：2012-05-24
申请号：US13202959
申请日：2010-02-23
申请人： Gopi Venkatesh , Michael Gosselin , Jin-Wang Lai , Christian Stollberg , Flavio Fabiani
发明人： Gopi Venkatesh , Michael Gosselin , Jin-Wang Lai , Christian Stollberg , Flavio Fabiani
IPC分类号： A61K9/48 , B05D5/00 , A61K31/4439 , A61K9/20 , A61K9/16
CPC分类号： A61K9/5078 , A61K9/2081
摘要： The present invention relates to pharmaceutical compositions, and methods of preparing such compositions, comprising one or more populations of controlled-release particles comprising one or more proton pump inhibitors. The present invention also relates to pharmaceutical dosage forms, including orally disintegrating tablets, tablets, capsules, and methods for their preparation.
摘要翻译：本发明涉及药物组合物和制备这种组合物的方法，其包含一种或多种包含一种或多种质子泵抑制剂的控制释放颗粒群。本发明还涉及药物剂型，包括口服崩解片剂，片剂，胶囊剂及其制备方法。

20. 发明申请

US20110064799A1 Pancreatic Enzyme Compositions and Methods for Treating Pancreatitis and Pancreatic Insufficiency 有权
标题翻译：胰腺酶组合物和治疗胰腺炎和胰腺功能不全的方法
公开(公告)号：US20110064799A1
公开(公告)日：2011-03-17
申请号：US12568064
申请日：2009-09-28
申请人： Stephen Perrett , Ruth Thieroff-Ekerdt , Gopi Venkatesh , Konstantinos Efthymiopoulos
发明人： Stephen Perrett , Ruth Thieroff-Ekerdt , Gopi Venkatesh , Konstantinos Efthymiopoulos
IPC分类号： A61K9/48 , A61K9/14 , A61K38/43 , A61K38/54 , A61P1/18
CPC分类号： A61K9/16 , A61K9/2813 , A61K9/2866 , A61K9/4808 , A61K9/5084 , A61K38/00 , A61K38/465 , A61K38/48
摘要： Compositions of the present invention, comprising the combination of enterically coated and uncoated pancreatic enzyme-containing beads are useful for treating or preventing pancreatitis pain, and optionally disorders associated with digestive enzyme deficiencies.
摘要翻译：包含肠溶包衣和未包被胰酶的珠的组合的本发明的组合物可用于治疗或预防胰腺炎疼痛，以及任选与消化酶缺陷相关的病症。

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