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11. 发明申请

US20100311783A1 STEREOSELECTIVE PROCESS AND CRYSTALLINE FORMS OF A CAMPTOTHECIN 有权
标题翻译：角蛋白的选择性方法和结晶形式
公开(公告)号：US20100311783A1
公开(公告)日：2010-12-09
申请号：US12857743
申请日：2010-08-17
申请人： Paolo Carminati , Maria Ornella Tinti , Mauro Marzi , Fabrizio Giorgi , Walter Cabri , Marco Alpegiani , Domenico Vergani , Paolo Ghetti
发明人： Paolo Carminati , Maria Ornella Tinti , Mauro Marzi , Fabrizio Giorgi , Walter Cabri , Marco Alpegiani , Domenico Vergani , Paolo Ghetti
IPC分类号： A61K31/4375 , C07D491/22 , A61P35/00
CPC分类号： C07D491/22
摘要： A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]-camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystalline forms of gimatecan are also obtainable by using the same stereoselective process.
摘要翻译：本文公开了制备7 - [（E） - 叔丁氧基亚氨基甲基] - 喜树碱（也称为gimatecan）的立体选择性方法。随着在合适的不同溶剂混合物中进一步溶解和沉淀步骤的添加，也可以通过使用相同的立体选择性方法获得四种新的结晶形式的gimatecan。

12. 发明授权

US08124769B2 Stereoselective process and crystalline forms of a camptothecin 有权
标题翻译：喜树碱的立体选择性方法和结晶形式
公开(公告)号：US08124769B2
公开(公告)日：2012-02-28
申请号：US12857743
申请日：2010-08-17
申请人： Paolo Carminati , Maria Ornella Tinti , Mauro Marzi , Fabrizio Giorgi , Walter Cabri , Marco Alpegiani , Domenico Vergani , Paolo Ghetti
发明人： Paolo Carminati , Maria Ornella Tinti , Mauro Marzi , Fabrizio Giorgi , Walter Cabri , Marco Alpegiani , Domenico Vergani , Paolo Ghetti
IPC分类号： C07D471/00 , A01N43/42
CPC分类号： C07D491/22
摘要： A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]-camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystalline forms of gimatecan are also obtainable by using the same stereoselective process.
摘要翻译：本文公开了制备7 - [（E） - 叔丁氧基亚氨基甲基] - 喜树碱（也称为gimatecan）的立体选择性方法。随着在合适的不同溶剂混合物中进一步溶解和沉淀步骤的添加，也可以通过使用相同的立体选择性方法获得四种新的结晶形式的gimatecan。

13. 发明授权

US08101758B2 Stereoselective process and crystalline forms of a camptothecin 有权
公开(公告)号：US08101758B2
公开(公告)日：2012-01-24
申请号：US12857776
申请日：2010-08-17
申请人： Paolo Carminati , Maria Ornella Tinti , Mauro Marzi , Fabrizio Giorgi , Walter Cabri , Marco Alpegiani , Domenico Vergani , Paolo Ghetti
发明人： Paolo Carminati , Maria Ornella Tinti , Mauro Marzi , Fabrizio Giorgi , Walter Cabri , Marco Alpegiani , Domenico Vergani , Paolo Ghetti
IPC分类号： C07D471/00 , A01N43/42
CPC分类号： C07D491/22
摘要： A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]-camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystalline forms of gimatecan are also obtainable by using the same stereoselective process.

14. 发明授权

US07799921B2 Stereoselective process and crystalline forms of a camptothecin 有权
标题翻译：喜树碱的立体选择性方法和结晶形式
公开(公告)号：US07799921B2
公开(公告)日：2010-09-21
申请号：US11721282
申请日：2005-12-16
申请人： Paolo Carminati , Maria Ornella Tinti , Mauro Marzi , Fabrizio Giorgi , Walter Cabri , Marco Alpegiani , Domenico Vergani , Paolo Ghetti
发明人： Paolo Carminati , Maria Ornella Tinti , Mauro Marzi , Fabrizio Giorgi , Walter Cabri , Marco Alpegiani , Domenico Vergani , Paolo Ghetti
IPC分类号： C07D471/00 , A01N43/42
CPC分类号： C07D491/22
摘要： A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]-camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystalline forms of gimatecan are also obtainable by using the same stereoselective process.
摘要翻译：本文公开了制备7 - [（E） - 叔丁氧基亚氨基甲基] - 喜树碱（也称为gimatecan）的立体选择性方法。随着在合适的不同溶剂混合物中进一步溶解和沉淀步骤的添加，也可以通过使用相同的立体选择性方法获得四种新的结晶形式的gimatecan。

15. 发明授权

US08598384B2 Crystalline teglicar 失效
标题翻译：结晶晶格
公开(公告)号：US08598384B2
公开(公告)日：2013-12-03
申请号：US12672099
申请日：2008-07-31
申请人： Walter Cabri , Mauro Marzi , Fabrizio Giorgi , Emanuela Tassoni
发明人： Walter Cabri , Mauro Marzi , Fabrizio Giorgi , Emanuela Tassoni
IPC分类号： C07C229/00 , A01N33/02
CPC分类号： C07C275/16
摘要： The present invention relates to a new crystalline form of R-4-trimethylammonium-3-(tetradecylcarbamoyl)-amino butyrate (also named crystalline Form I of ST 1326 or teglicar), a process for its preparation and pharmaceutical compositions containing same.
摘要翻译：本发明涉及一种新的结晶形式的R-4-三甲基铵-3-（十四烷基氨基甲酰基） - 氨基丁酸酯（也称为ST1326的晶体形式I或晶体），其制备方法和含有它的药物组合物。

16. 发明申请

US20080076915A1 Epoxidation of 17-oxo-15,16-Methylene Steroids with Sulfoxonium Ylides 审中-公开
标题翻译：用硫氧烷Yl环氧化17-氧代-15,16-亚甲基甾类化合物
公开(公告)号：US20080076915A1
公开(公告)日：2008-03-27
申请号：US11858976
申请日：2007-09-21
申请人： Walter Cabri , Fabio Benedetti , Marco Alpegiani , Manuela Rodriquez , Cinzia Bottai
发明人： Walter Cabri , Fabio Benedetti , Marco Alpegiani , Manuela Rodriquez , Cinzia Bottai
IPC分类号： C07J71/00
CPC分类号： C07J53/008
摘要： A process for the epoxidation of 17-oxo-15,16-methylene steroids, in particular of drospirenone precursors, comprising the use of sulfoxonium ylides, in particular of dimethylsulfoxonium methyl ylide. The process allows to prepare in good yields 17-spiro epoxides, which can be easily transformed into 17-spironolacto-steroids.
摘要翻译：一种用于环氧化17-氧代-15,16-亚甲基类固醇，特别是屈螺酮前体的方法，其包括使用氧化锍内鎓盐，特别是二甲基亚砜肟甲基叶立德。该方法允许以良好的产率制备17-螺环氧化物，其可以容易地转化为17-螺甾醇类固醇。

17. 发明申请

US20050079223A1 Method for obtaining novel lutein-based formulations 有权
标题翻译：获得新颖的叶黄素制剂的方法
公开(公告)号：US20050079223A1
公开(公告)日：2005-04-14
申请号：US10498434
申请日：2002-12-20
申请人： Antonio Estrella De Castro , Nieves Fraile Yecora , Manuel Oliver Ruiz , Angel Muñoz , Juan Lopez Ortiz , Walter Cabri
发明人： Antonio Estrella De Castro , Nieves Fraile Yecora , Manuel Oliver Ruiz , Angel Muñoz , Juan Lopez Ortiz , Walter Cabri
IPC分类号： A23L1/275 , A23L1/30 , A23L1/303 , A61K8/30 , A61K8/34 , A61K9/16 , A61K9/50 , A61K31/015 , A61K31/355 , C07C403/02
CPC分类号： C07C403/24
摘要： The present invention describes a method of preparation of formulations of microcrystalline lutein, particularly in the form of esters, which are resistant to oxidation and are soluble in hydrophilic and/or lipophilic media. For these formulations, the esters of lutein are mixed with antioxidants, vegetable oils and/or organic solvents, and this initial mixture is submitted to various stages depending on the type of final formulation required. These formulations are suitable for direct application as colourants in the pharmaceutical, food and cosmetics fields. They can also be used as diet supplements.
摘要翻译：本发明描述了一种制备微晶叶黄素制剂的方法，特别是以酯的形式，它们耐氧化并且可溶于亲水和/或亲脂性介质。对于这些制剂，叶黄素的酯与抗氧化剂，植物油和/或有机溶剂混合，并且根据所需的最终制剂的类型将该初始混合物进行各种阶段。这些制剂适合直接用作制药，食品和化妆品领域的着色剂。它们也可以用作饮食补品。

18. 发明授权

US06642378B1 Process for the synthesis of beta-lactam derivatives 失效
标题翻译：合成β-内酰胺衍生物的方法
公开(公告)号：US06642378B1
公开(公告)日：2003-11-04
申请号：US10031990
申请日：2002-03-13
申请人： Walter Cabri , Enrico Siviero , Paola Luigia Daverio , Tania Cristiano , Claudio Felisi , Davide Longoni
发明人： Walter Cabri , Enrico Siviero , Paola Luigia Daverio , Tania Cristiano , Claudio Felisi , Davide Longoni
IPC分类号： C07D50104
CPC分类号： C07D501/00
摘要： The invention is directed towards a process for the preparation of Cefuroxime acid or for a corresponding pharmaceutically acceptable salt or ester. The process comprises the carbamoylation of a Cefuroxime precursor with an activated isocyanate. Additionally, the process is characterized by the fact that a carbonic C1-C4 alkyl ester is used as a solvent for the carbamoylation reaction.
摘要翻译：本发明涉及制备头孢呋辛酸或相应的药学上可接受的盐或酯的方法。该方法包括头孢呋辛前体与活化的异氰酸酯的氨基甲酰化反应。此外，该方法的特征在于使用碳酸C1-C4烷基酯作为氨基甲酰化反应的溶剂。

19. 发明授权

US06403603B1 Process for the preparation of 9-amino camptothecin 失效
标题翻译：制备9-氨基喜树碱的方法
公开(公告)号：US06403603B1
公开(公告)日：2002-06-11
申请号：US08284129
申请日：1994-08-02
申请人： Angelo Bedeschi , Walter Cabri , Ilaria Candiani , Franco Zarini
发明人： Angelo Bedeschi , Walter Cabri , Ilaria Candiani , Franco Zarini
IPC分类号： C07D49122
CPC分类号： C07D491/22
摘要： 9-Amino-20(S)-camptothecin (I) is prepared by reducing 12-nitro-20(S)-camptothecin (II); converting the resulting 12-amino-20(S)-camptothecin (III) into a compound of formula (IV) wherein X is a group which can be reductively removed; reacting the compound of formula (IV) with a nitrating agent, to obtain thereby the corresponding 9-nitro-20(S)-camptothecin compound of formula (V) substituted at the 12-position by the group X; reducing in a single step the compound of formula (V), so obtaining the 9-amino-20(S)-camptothecin of formula (I); or reducing the compound of formula (V), so obtaining the corresponding 9-amino-20(S)-camptothecin compound of formula (VI) substituted at the 12-position by the group X and reductively removing the X group from the compound of formula (VI), so obtaining 9-amino-20(S)-camptothecin.
摘要翻译：通过还原12-硝基-20（S） - 喜树碱（II）制备9-氨基-20（S） - 喜树碱（I）将所得的12-氨基-20（S） - 喜树碱（III）转化成式（IV）的化合物，其中X是可被还原去除的基团; 使式（Ⅳ）化合物与硝化剂反应，由此获得在X-12位被12位取代的相应的9-硝基-20（S）喜树碱化合物。在一步中还原式（Ⅴ）化合物，从而得到式（I）的9-氨基-20（S） - 喜树碱; 或降低式（Ⅴ）化合物，从而得到在X基上被12位取代的相应的式（Ⅵ）的9-氨基-20（S） - 喜树碱化合物，并将X基团从式（VI），因此得到9-氨基-20（S） - 喜树碱。

20. 发明授权

US4933290A Process for the enzymatic separation of the optical isomers of racemic oxazolidinonic derivatives 失效
标题翻译：外消旋恶唑烷酮衍生物的光学异构体的酶分离方法
公开(公告)号：US4933290A
公开(公告)日：1990-06-12
申请号：US137721
申请日：1987-12-24
申请人： Pietro Cesti , Daniele Bianchi , Franco Francalanci , Walter Cabri
发明人： Pietro Cesti , Daniele Bianchi , Franco Francalanci , Walter Cabri
IPC分类号： C12P17/14 , C12P41/00
CPC分类号： C12P17/14 , C12P41/004
摘要： There is disclosed a process for the biotechnological resolution, by enzymatic esterification of the corresponding racemic mixture of the S(+) and R(-) optical isomers of the oxazolidinonic compounds having formula (I): ##STR1## wherein R represents a, linear or branched, C.sub.1 -C.sub.8 alkyl group, which process is characterized in that, the racemic 3-alkyl-5-hydroxymethyl-oxazolidin-2-one derivative of formula (I) is reacted with an esterifying compound, selected from esters having formula (III): ##STR2## wherein R represents a, linear or branched, C.sub.1 -C.sub.10 alkyl or alkenyl group and R" represents a linear or branched, C.sub.1 -C.sub.4 alkyl, alkenyl group, a haloalkyl (chlorine, bromine) group or a diacyl glycerolic group or from acids having formula (IV):R'"--COOH (IV)wherein R'" represents a, linear or branched, C.sub.1 -C.sub.20 alkyl or alkenyl group or from anhydrides having formula (V): ##STR3## wherein R.sup.IV represents a, linear or branched, C.sub.1 -C.sub.6 alkyl group, in the presence of an enzyme, immobilized on a porous carrier, capable of giving rise selectively to the esterification reaction of the R(-) isomer, while leaving the S(+) isomer substantially unchanged, which latter is then separated according to known techniques.

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