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11. 发明申请

US20150232549A1 ANTI-VEGF ANTIBODIES 有权
公开(公告)号：US20150232549A1
公开(公告)日：2015-08-20
申请号：US14636782
申请日：2015-03-03
申请人： Genentech, Inc.
发明人： Germaine FUH , Hans-Peter GERBER , Wei-Ching LIANG , Frederic FELLOUSE , Sachdev S. SIDHU , Christian WIESMANN
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/005 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/6845
摘要： Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.

12. 发明申请

US20220033515A1 MULTISPECIFIC ANTIBODIES 有权
公开(公告)号：US20220033515A1
公开(公告)日：2022-02-03
申请号：US17232537
申请日：2021-04-16
申请人： Genentech, Inc.
发明人： Germaine FUH , Jenny M. BOSTROM
IPC分类号： C07K16/32 , C07K16/22 , C07K16/28 , C07K16/42 , C07K16/46
摘要： The invention provides multispecific antibodies and methods of making and using such antibodies.

13. 发明申请

US20160257744A1 DUAL SPECIFIC ANTIBODIES 审中-公开
标题翻译：双特异性抗体
公开(公告)号：US20160257744A1
公开(公告)日：2016-09-08
申请号：US15167030
申请日：2016-05-27
申请人： Genentech, Inc.
发明人： Germaine FUH , Chingwei V. LEE , Patrick KOENIG
IPC分类号： C07K16/24 , A61K39/395 , A61K45/06
摘要： The invention provides dual specific antibodies and methods of making and using such antibodies. In general, the dual specific antibodies are generated by identification of a monospecific antibody having light chain variable region VL residues that are electrostatic or hydrophobic and altering the nucleic acid sequence encoding one or more solvent accessible residues in the VH of the antibody either alone or in combination with alteration of the nucleic acid sequence encoding the VL of the antibody. The altered VH and the VL are expressed and dual specific antibodies, or antigen-binding fragments thereof, are selected. Exemplary dual specific antibodies are also provided as well as methods of using the antibodies.
摘要翻译：本发明提供了双重特异性抗体及其制备和使用方法。通常，双特异性抗体通过鉴定具有静电或疏水性的轻链可变区VL残基的单特异性抗体并且改变编码抗体VH中一个或多个溶剂可及残基的核酸序列，与编码抗体VL的核酸序列的改变的组合。表达改变的VH和VL，并选择双特异性抗体或其抗原结合片段。还提供了示例性的双特异性抗体以及使用抗体的方法。

14. 发明申请

US20150315290A1 MULTISPECIFIC ANTIBODIES 审中-公开
标题翻译：多重抗体
公开(公告)号：US20150315290A1
公开(公告)日：2015-11-05
申请号：US14665697
申请日：2015-03-23
申请人： Genentech, Inc.
发明人： Jenny M. BOSTROM , Germaine FUH
IPC分类号： C07K16/32 , A61K45/06 , A61K39/395 , C07K16/22
CPC分类号： C07K16/32 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K16/2863 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/92 , C07K2317/94
摘要： The invention provides multispecific antibodies and methods of making and using such antibodies.
摘要翻译：本发明提供多特异性抗体以及制备和使用这些抗体的方法。

15. 发明公开

US20240067752A1 ANTI-HtrA1 ANTIBODIES AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：US20240067752A1
公开(公告)日：2024-02-29
申请号：US18474445
申请日：2023-09-26
申请人： Genentech, Inc.
发明人： Robert F. KELLEY , Daniel K. KIRCHHOFER , Joyce LAI , Chingwei V. LEE , Wei-Ching LIANG , Michael T. LIPARI , Kelly M. LOYET , Tao SAI , Menno VAN LOOKEREN CAMPAGNE , Yan WU , Germaine FUH
IPC分类号： C07K16/40 , A61K39/395
CPC分类号： C07K16/40 , A61K39/3955 , A61K2039/507 , C07K2317/24 , C07K2317/34 , C07K2317/53 , C07K2317/55 , C07K2317/92 , C07K2317/94
摘要： The present invention provides anti-HtrA1 antibodies (including bispecific anti-HtrA1 anti-Factor D antibodies) and methods of making and using the same, for example, in methods of treating HtrA1-associated disorders, ocular disorders, and/or complement-associated disorders.

16. 发明申请

US20200222547A1 HYDROGEL CROSS-LINKED HYALURONIC ACID PRODRUG COMPOSITIONS AND METHODS 审中-公开
公开(公告)号：US20200222547A1
公开(公告)日：2020-07-16
申请号：US16575749
申请日：2019-09-19
申请人： Genentech, Inc. , Ascendis Pharma A/S
发明人： Sebastian STARK , Thomas KNAPPE , Harald RAU , Nicola BISEK , Burkhardt LAUFER , Samuel WEISBROD , Tobias VOIGT , Germaine FUH , Patrick KOENIG , Chingwei Vivian LEE , Daniela BUMBACA YADAV
IPC分类号： A61K47/61 , A61K47/69 , A61K39/395 , A61K9/00
摘要： The present invention relates to hydrogel prodrug compositions comprising cross-linked hyaluronic acid (HA), or a derivative or a salt thereof, wherein the cross-linker system comprises a biodegradable spacer, wherein the cross-linked HA comprises a conjugated drug-linker, and wherein the linker is capable of releasing the drug under physiological conditions. The present invention further relates to methods for preparing the hydrogel prodrug compositions. The present invention further relates to methods for treating an ocular condition using the hydrogel compositions.

17. 发明申请

US20190100581A1 OPTIMIZED VARIANTS OF ANTI-VEGF ANTIBODIES 审中-公开
公开(公告)号：US20190100581A1
公开(公告)日：2019-04-04
申请号：US16033499
申请日：2018-07-12
申请人： Genentech, Inc.
发明人： Patrick KOENIG , Chingwei Vivian LEE , Karthikan RAJAGOPAL , Amin FAMILI , Germaine FUH
IPC分类号： C07K16/22 , C07K16/46 , A61K47/61 , C12N15/10 , C12N15/115 , C07K16/44 , A61K47/34 , A61K47/60 , C07K14/475 , A61K39/395 , A61K39/00
摘要： The present invention provides anti-VEGF antibodies and compositions that include anti-VEGF antibodies (e.g., antibody conjugates, fusion proteins, and polymeric formulations), and uses thereof, for example for treatment of disorders associated with pathological angiogenesis. The present invention also provides methods of identifying antibody variants with improved properties, for example, enhanced binding affinity, stability, pharmacokinetics, and/or expression.

18. 发明申请

US20190031750A1 OPTIMIZED VARIANTS OF ANTI-VEGF ANTIBODIES 审中-公开
公开(公告)号：US20190031750A1
公开(公告)日：2019-01-31
申请号：US16033353
申请日：2018-07-12
申请人： Genentech, Inc.
发明人： Patrick KOENIG , Chingwei Vivian LEE , Karthikan RAJAGOPAL , Amin FAMILI , Germaine FUH
IPC分类号： C07K16/22 , A61K47/60 , C07K16/46 , A61K47/61 , C12N15/10 , A61K39/395 , C12N15/115
摘要： The present invention provides anti-VEGF antibodies and compositions that include anti-VEGF antibodies (e.g., antibody conjugates, fusion proteins, and polymeric formulations), and uses thereof, for example for treatment of disorders associated with pathological angiogenesis. The present invention also provides methods of identifying antibody variants with improved properties, for example, enhanced binding affinity, stability, pharmacokinetics, and/or expression.

19. 发明申请

US20170145113A1 ANTI-HtrA1 ANTIBODIES AND METHODS OF USE THEREOF 有权
公开(公告)号：US20170145113A1
公开(公告)日：2017-05-25
申请号：US15336171
申请日：2016-10-27
申请人： Genentech, Inc.
发明人： Robert F. KELLEY , Daniel K. KIRCHHOFER , Joyce LAI , Chingwei V. LEE , Wei-Ching LIANG , Michael T. LIPARI , Kelly M. LOYET , Tao SAI , Menno VAN LOOKEREN CAMPAGNE , Yan WU , Germaine FUH
IPC分类号： C07K16/40
摘要： The present invention provides anti-HtrA1 antibodies (including bispecific anti-HtrA1 anti-Factor D antibodies) and methods of making and using the same, for example, in methods of treating HtrA1-associated disorders, ocular disorders, and/or complement-associated disorders.

20. 发明申请

US20150175689A1 ANTI-VEGF ANTIBODIES 审中-公开
标题翻译：抗VEGF抗体
公开(公告)号：US20150175689A1
公开(公告)日：2015-06-25
申请号：US14603693
申请日：2015-01-23
申请人： GENENTECH, INC.
发明人： Germaine FUH , Hans-Peter GERBER , Wei-Ching LIANG , Frederic FELLOUSE , Sachdev S. SIDHU , Christian WIESMANN
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/55 , A61K2039/552 , C07K16/005 , C07K16/32 , C07K2317/20 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/6845
摘要： Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.
摘要翻译：公开了抗VEGF抗体及其变体，包括对VEGF结合具有高亲和力的抗体。还提供了使用噬菌体展示技术与初始文库产生和选择具有所需结合和其他生物活性的抗VEGF抗体的方法。进一步考虑的是抗体在研究，诊断和治疗应用中的用途。

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