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11. 发明申请

US20080138850A1 Skin Model 审中-公开
标题翻译：皮肤模型
公开(公告)号：US20080138850A1
公开(公告)日：2008-06-12
申请号：US11948543
申请日：2007-11-30
申请人： Gabriele Vielhaber , Paolo Pertile
发明人： Gabriele Vielhaber , Paolo Pertile
IPC分类号： C12Q1/02
CPC分类号： G01N33/5088
摘要： The present invention relates to the use of a pig skin sample as a skin model, particularly for the assessment of pharmacological and cosmetic effects.
摘要翻译：本发明涉及猪皮肤样品作为皮肤模型的用途，特别是用于评估药理和美容效果。

12. 发明申请

US20080095719A1 Blackberry Extract 有权
标题翻译：黑莓提取物
公开(公告)号：US20080095719A1
公开(公告)日：2008-04-24
申请号：US11629753
申请日：2005-06-16
申请人： Martina Herrmann , Holger Joppe , Helge Franke , Gabriele Vielhaber
发明人： Martina Herrmann , Holger Joppe , Helge Franke , Gabriele Vielhaber
IPC分类号： A61K36/73 , A61K8/97 , A61Q11/00
CPC分类号： A61K8/97 , A61K36/73 , A61K2800/782 , A61Q11/00 , A61Q19/08 , A61K2300/00
摘要： The invention concerns a blackberry leaf extract and its uses, in particular to slow down skin ageing, to treat the oral and pharyngeal cavity, and there in particular to prevent and slow down periodontitis and the excessive degradation of the periodontal connective tissue as well as damage to the teeth caused by matrix metalloproteinases
摘要翻译：本发明涉及黑莓叶提取物及其用途，特别是减缓皮肤老化，以治疗口腔和咽腔，特别是预防和减缓牙周炎和牙周结缔组织的过度降解以及损伤由基质金属蛋白酶引起的牙齿

13. 发明申请

US20160166488A1 MEDICAMENT 审中-公开
标题翻译：药物
公开(公告)号：US20160166488A1
公开(公告)日：2016-06-16
申请号：US14892109
申请日：2014-02-20
申请人： Gabriele VIELHABER , Marielle LE MAIRE , SYMRISE AG
发明人： Gabriele Vielhaber , Marielle Le Maire
IPC分类号： A61K8/49 , A61Q19/08 , A61Q5/00 , A61K8/41 , A61K8/40 , A61K8/29 , A61K8/36 , A61K8/35 , A61K8/37 , A61K8/60 , A61K8/67 , A61K8/86 , A61K8/92 , A61K8/26 , A61K8/891 , A61K8/73 , A61K8/34 , A61K8/44 , A61K8/81 , A61K8/31 , A61Q19/00 , A61Q17/04
CPC分类号： A61K8/4946 , A61K8/26 , A61K8/29 , A61K8/31 , A61K8/345 , A61K8/35 , A61K8/36 , A61K8/375 , A61K8/40 , A61K8/415 , A61K8/44 , A61K8/4966 , A61K8/60 , A61K8/678 , A61K8/73 , A61K8/8158 , A61K8/86 , A61K8/891 , A61K8/922 , A61K2800/592 , A61K2800/782 , A61Q5/00 , A61Q17/04 , A61Q19/004 , A61Q19/08
摘要： Proposed is a drug containing (a) at least one compound of Formula (I) provided that R1 denotes H or CH3 and R2 denotes H or COOH, or salts thereof, and (b) at least one UV protection factor for the inhibition of MMP-1 expression induced by UV radiation.
摘要翻译：提出的是含有（a）至少一种式（I）化合物的药物，条件是R1表示H或CH3，R2表示H或COOH，或其盐，和（b）至少一种用于抑制MMP的UV保护因子 -1表达由紫外线辐射诱导。

14. 发明授权

US09060943B2 Compositions comprising trans-tert-butyl cyclohexanol as skin irritation-reducing agent 有权
标题翻译：包含反式叔丁基环己醇作为皮肤刺激性还原剂的组合物
公开(公告)号：US09060943B2
公开(公告)日：2015-06-23
申请号：US13263016
申请日：2009-04-09
申请人： Gabriele Vielhaber , Heiko Oertling , Claudia Gömann , Antje Köhler , Michael Krohn , Holger Zinke
发明人： Gabriele Vielhaber , Heiko Oertling , Claudia Gömann , Antje Köhler , Michael Krohn , Holger Zinke
IPC分类号： A61K8/34 , A23C9/13 , A23C11/10 , A23L1/30 , A23L2/02 , A23L2/39 , A61K8/02 , A61K31/045 , A61K45/06 , A61Q5/02 , A61Q11/00 , A61Q15/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/04
CPC分类号： A61K8/34 , A23C9/1307 , A23C11/103 , A23L2/02 , A23L2/39 , A23L33/10 , A61K8/0216 , A61K8/0229 , A61K31/045 , A61K45/06 , A61K2800/75 , A61K2800/874 , A61K2800/92 , A61Q5/02 , A61Q11/00 , A61Q15/00 , A61Q17/04 , A61Q19/004 , A61Q19/005 , A61Q19/02 , A61Q19/04 , A61K2300/00
摘要： The present invention primarily relates to the use of trans-tert-butyl cyclohexanol as skin irritation-reducing agent as well as compositions (formulations) having a skin irritation-reducing action comprising trans-tert-butyl cyclohexanol as skin irritation-reducing agent.
摘要翻译：本发明主要涉及反式叔丁基环己醇作为皮肤刺激性还原剂的用途以及具有皮肤刺激减少作用的组合物（制剂），其包括作为皮肤刺激性还原剂的反式叔丁基环己醇。

15. 发明申请

US20100239695A1 BLACKBERRY LEAF EXTRACT AS AN ACTIVE INGREDIENT AGAINST SKIN IRRITATIONS AND INFLAMMATIONS 有权
标题翻译：黑莓叶提取物作为防止皮肤刺激和炎症的主要成分
公开(公告)号：US20100239695A1
公开(公告)日：2010-09-23
申请号：US12095679
申请日：2006-11-30
申请人： Gabriele Vielhaber , Martina Herrmann , Imke Meyer , Holger Joppe
发明人： Gabriele Vielhaber , Martina Herrmann , Imke Meyer , Holger Joppe
IPC分类号： A61K36/73 , A61P17/00 , A61P29/00
CPC分类号： A61K36/73 , A61K2300/00
摘要： The present invention concerns the field of plant extracts and their uses, in particular for cosmetic, oral hygiene and pharmaceutical purposes. In particular the invention concerns blackberry leaf extracts and preparations and medicaments containing them, as well as their use to inhibit irritating and inflammatory skin conditions.
摘要翻译：本发明涉及植物提取物及其用途，特别是用于化妆品，口腔卫生和药物目的。特别地，本发明涉及黑莓叶提取物和含有它们的制剂和药物，以及它们用于抑制刺激性和炎性皮肤病症的用途。

16. 发明申请

US20090208433A1 AH Receptor Antagonists 有权
公开(公告)号：US20090208433A1
公开(公告)日：2009-08-20
申请号：US12299234
申请日：2007-04-30
申请人： Martina Herrmann , Oskar Koch , Gabriele Vielhaber , Jean Krutmann
发明人： Martina Herrmann , Oskar Koch , Gabriele Vielhaber , Jean Krutmann
IPC分类号： A61K31/122 , C07C49/755 , A61P17/16 , A61Q17/04 , A61K8/49 , C07C45/00
CPC分类号： A61K31/122 , A61K8/046 , A61K8/35 , A61Q5/02 , A61Q5/12 , A61Q17/04 , A61Q19/00 , A61Q19/004 , A61Q19/08
摘要： The invention relates to the field of aryl hydrocarbon receptor (Ah receptor; AhR) antagonists and their uses.

17. 发明申请

US20090028804A1 AhR mediators 审中-公开
标题翻译： AhR调解员
公开(公告)号：US20090028804A1
公开(公告)日：2009-01-29
申请号：US12095095
申请日：2006-11-28
申请人： Jean Krutmann , Martina Herrmann , Gabriele Vielhaber , Jakob Ley , Oskar Koch
发明人： Jean Krutmann , Martina Herrmann , Gabriele Vielhaber , Jakob Ley , Oskar Koch
IPC分类号： A61K8/33 , C12Q1/68 , C40B30/06 , C40B60/12 , A61P43/00 , A61Q17/04 , C07D311/22 , C07D307/78 , A61K31/352
CPC分类号： A61Q19/04 , A61K8/494 , A61K8/498 , C07D307/80 , C12Q1/6883 , C12Q2600/148
摘要： The invention relates to a method for finding and assessing agonists [and] antagonists of the aryl hydrocarbon receptor (Ah receptor; AhR), to the agonists and antagonists themselves and to uses thereof.
摘要翻译：本发明涉及一种用于发现和评估激动剂和拮抗剂本身的激动剂[和]芳烃受体（Ah受体; AhR）的拮抗剂及其用途的方法。

18. 发明授权

US09987217B2 Blackberry extract 有权
公开(公告)号：US09987217B2
公开(公告)日：2018-06-05
申请号：US11629753
申请日：2005-06-16
申请人： Martina Herrmann , Holger Joppe , Helge Franke , Gabriele Vielhaber
发明人： Martina Herrmann , Holger Joppe , Helge Franke , Gabriele Vielhaber
IPC分类号： A61K8/97 , A61K36/73 , A61Q11/00 , A61Q19/08
CPC分类号： A61K8/97 , A61K36/73 , A61K2800/782 , A61Q11/00 , A61Q19/08 , A61K2300/00
摘要： The invention concerns a blackberry leaf extract and its uses, in particular to slow down skin aging, to treat the oral and pharyngeal cavity, and there in particular to prevent and slow down periodontitis and the excessive degradation of the periodontal connective tissue as well as damage to the teeth caused by matrix metalloproteinases.

19. 发明授权

US09072676B2 Cyclohexyl carbamate compounds as skin and/or hair lightening actives 有权
标题翻译：环己基氨基甲酸酯化合物作为皮肤和/或发亮活性物质
公开(公告)号：US09072676B2
公开(公告)日：2015-07-07
申请号：US13699494
申请日：2010-05-25
申请人： Gabriele Vielhaber , Heiko Oertling , Nicole Titze , Claudia Gömann , Rahim Brodhage
发明人： Gabriele Vielhaber , Heiko Oertling , Nicole Titze , Claudia Gömann , Rahim Brodhage
IPC分类号： A61Q5/08 , A61Q19/02 , A61K8/44 , A61K8/42 , C08L5/00 , A61K31/27 , A61K45/06 , A61Q17/04
CPC分类号： A61K8/44 , A61K8/40 , A61K8/42 , A61K8/445 , A61K31/27 , A61K45/06 , A61Q17/04 , A61Q19/02 , C08L5/00
摘要： The present invention relates to the cosmetic, dermatological or therapeutic use of certain cyclohexyl carbamate compounds of formula (I) given below, preferably as skin and/or hair lightening (whitening) actives. The invention further relates to compositions and cosmetic, dermatological or therapeutic products comprising one or more compounds of formula (I) suitable for lightening human skin and/or hair and corresponding methods. The invention further relates to compounds of formula (I) as a drug, their use for the preparation of a pharmaceutical composition for lightening human skin and/or hair and to novel compounds of formula (I) wherein A denotes wherein X, Y and Z independently of one another denote hydrogen, C1-C4-alkyl or C2-C4 -alkenyl, wherein optionally two of the radicals X, Y and Z are covalently bonded to one another under formation of a bicyclic ring system, in such a bicyclic ring system two of the radicals X, Y and Z together preferably form a radical having 1 to 4 carbon atoms, preferably a hydrocarbon radical having 1 to 3 carbon atoms, B denotes NR1R2, wherein R1 denotes hydrogen or an organic radical having 1 to 14 carbon atoms, R2 denotes an organic radical having 1 to 14 carbon atoms, and wherein optionally R1 and R2 are covalently bonded to one another, preferably so that B is a 3 to 8 membered ring.
摘要翻译：本发明涉及以下给出的某些式（I）环己基氨基甲酸酯化合物的化妆品，皮肤病学或治疗用途，优选作为皮肤和/或发白（增白）活性物质。本发明还涉及包含一种或多种适合于减轻人类皮肤和/或头发的相应方法的式（I）化合物的组合物和化妆品，皮肤病学或治疗产品。本发明还涉及作为药物的式（I）化合物，其用于制备用于减轻人类皮肤和/或头发的药物组合物的用途和新的式（I）化合物，其中A表示其中X，Y和Z 彼此独立地表示氢，C 1 -C 4 - 烷基或C 2 -C 4 - 烯基，其中任选地，两个基团X，Y和Z彼此共价键合形成双环体系，在这种双环体系中两个基团X，Y和Z一起优选形成具有1至4个碳原子的基团，优选具有1至3个碳原子的烃基，B表示NR1R2，其中R1表示氢或具有1至14个碳原子的有机基团 R 2表示碳原子数为1〜14的有机基团，且R 1和R 2中任选具有共价键，优选为B为3〜8元环。

20. 发明申请

US20130156710A1 CYCLOHEXYL CARBAMATE COMPOUNDS AS SKIN AND/OR HAIR LIGHTENING ACTIVES 有权
标题翻译： CYCLOHEXYL CARBAMATE化合物作为皮肤和/或头发照明活动
公开(公告)号：US20130156710A1
公开(公告)日：2013-06-20
申请号：US13699494
申请日：2010-05-25
申请人： Gabriele Vielhaber , Heiko Oertling , Nicole Titze , Claudia Gömann , Rahim Brodhage
发明人： Gabriele Vielhaber , Heiko Oertling , Nicole Titze , Claudia Gömann , Rahim Brodhage
IPC分类号： A61K8/44 , A61K45/06 , A61Q19/02 , A61Q17/04 , A61K31/27
CPC分类号： A61K8/44 , A61K8/40 , A61K8/42 , A61K8/445 , A61K31/27 , A61K45/06 , A61Q17/04 , A61Q19/02 , C08L5/00
摘要： The present invention relates to the cosmetic, dermatological or therapeutic use of certain cyclohexyl carbamate compounds of formula (I) given below, preferably as skin and/or hair lightening (whitening) actives. The invention further relates to compositions and cosmetic, dermatological or therapeutic products comprising one or more compounds of formula (I) suitable for lightening human skin and/or hair and corresponding methods. The invention further relates to compounds of formula (I) as a drug, their use for the preparation of a pharmaceutical composition for lightening human skin and/or hair and to novel compounds of formula (I) wherein A denotes wherein X, Y and Z independently of one another denote hydrogen, C1-C4-alkyl or C2-C4-alkenyl, wherein optionally two of the radicals X, Y and Z are covalently bonded to one another under formation of a bicyclic ring system, in such a bicyclic ring system two of the radicals X, Y and Z together preferably form a radical having 1 to 4 carbon atoms, preferably a hydrocarbon radical having 1 to 3 carbon atoms, B denotes NR1, R2, wherein R1 denotes hydrogen or an organic radical having 1 to 14 carbon atoms, R2 denotes an organic radical having 1 to 14 carbon atoms, and wherein optionally R1 and R2 are covalently bonded to one another, preferably so that B is a 3 to 8 membered ring.
摘要翻译：本发明涉及以下给出的某些式（I）环己基氨基甲酸酯化合物的化妆品，皮肤病学或治疗用途，优选作为皮肤和/或发白（增白）活性物质。本发明还涉及包含一种或多种适合于减轻人类皮肤和/或头发的相应方法的式（I）化合物的组合物和化妆品，皮肤病学或治疗产品。本发明还涉及作为药物的式（I）化合物，其用于制备用于减轻人类皮肤和/或头发的药物组合物的用途和新的式（I）化合物，其中A表示其中X，Y和Z 彼此独立地表示氢，C 1 -C 4 - 烷基或C 2 -C 4 - 烯基，其中任选地，两个基团X，Y和Z彼此共价键合形成双环体系，在这种双环体系中基团X，Y和Z中的两个一起优选形成具有1至4个碳原子的基团，优选地具有1至3个碳原子的烃基，B表示NR 1，R 2，其中R 1表示氢或具有1至14个的有机基团碳原子，R 2表示具有1至14个碳原子的有机基团，并且其中任选地R 1和R 2彼此共价键合，优选使得B为3至8元环。

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