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11. 发明授权

US08715655B2 Human anti-α9 integrin antibody 有权
标题翻译：人抗α9整联蛋白抗体
公开(公告)号：US08715655B2
公开(公告)日：2014-05-06
申请号：US12810939
申请日：2008-12-26
申请人： Masaharu Torikai , Daisuke Ishikawa , Toshihiro Nakashima , Hirofumi Higuchi , Fumihiko Sakai , Nobuchika Yamamoto , Hirotada Fujita , Katsunari Taguchi
发明人： Masaharu Torikai , Daisuke Ishikawa , Toshihiro Nakashima , Hirofumi Higuchi , Fumihiko Sakai , Nobuchika Yamamoto , Hirotada Fujita , Katsunari Taguchi
IPC分类号： A61K39/395 , C07K16/00 , C07K16/46 , C07K16/28 , G01N33/53
CPC分类号： C07K16/2839 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/622 , C07K2317/92 , C07K2319/00
摘要： The present invention provides a human anti-α9 integrin antibody or an antibody fragment which specifically recognize human α9 integrin and mouse α9 integrin, inhibit interaction with their ligands, particularly, the antibody or antibody fragment which recognize loop regions of human and mouse α9 integrins, a gene encoding the antibody or antibody fragment, a recombinant expression vector containing the gene, a transformant harboring the gene, production method of human anti-α9 integrin antibody or antibody fragment using the transformant, and an agent for the prophylaxis or treatment of rheumatoid arthritis which contains the antibody or antibody fragment.
摘要翻译：本发明提供一种人抗α9整联蛋白抗体或特异性识别人α9整联蛋白和小鼠α9整联蛋白的抗体片段，抑制与其配体的相互作用，特别是识别人和小鼠α9整联蛋白环区的抗体或抗体片段，编码抗体或抗体片段的基因，含有该基因的重组表达载体，携带该基因的转化体，使用该转化体的人抗-α9整联蛋白抗体的制备方法或抗体片段，以及预防或治疗类风湿性关节炎其含有抗体或抗体片段。

12. 发明申请

US20110059077A1 HUMANIZED ANTI-HUMAN ALPHA 9-INTEGRIN ANTIBODY 有权
标题翻译：人类抗人ALPHA 9整合抗体
公开(公告)号：US20110059077A1
公开(公告)日：2011-03-10
申请号：US12812341
申请日：2009-01-09
申请人： Kenji Uehara , Hirofumi Higuchi , Toshihiro Nakashima , Daisuke Ishikawa , Nobuchika Yamamoto , Hirotada Fujita , Fumihiko Sakai
发明人： Kenji Uehara , Hirofumi Higuchi , Toshihiro Nakashima , Daisuke Ishikawa , Nobuchika Yamamoto , Hirotada Fujita , Fumihiko Sakai
IPC分类号： C07K16/28 , C12N15/13 , C12N15/70 , C12N1/21 , C12P21/08 , A61K39/395
CPC分类号： C07K16/2839 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides a humanized anti-human α9 integrin antibody having improved activity and/or property as compared to a donor mouse anti-human α9 integrin antibody, namely, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:11 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:13 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:15 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:9, and a means for the prophylaxis or treatment of various diseases involving human α9 integrin in the pathogenesis, which uses the antibody.
摘要翻译：本发明提供与供体小鼠抗人α9整联蛋白抗体相比具有改善的活性和/或性质的人源化抗人α9整联蛋白抗体，即包含重链可变区的人源化抗人α9整联蛋白抗体，其包含的SEQ ID NO：11所示的氨基酸序列和由SEQ ID NO：17所示的氨基酸序列组成的轻链可变区，含有重链可变区的人源化抗人α9整联蛋白抗体由由SEQ ID NO：13所示的氨基酸序列和由SEQ ID NO：17所示的氨基酸序列组成的轻链可变区，包含由SEQ ID NO：17所示的重链可变区组成的人源化抗人α9整联蛋白抗体由SEQ ID NO：15所示的氨基酸序列和由SEQ ID NO：9所示的氨基酸序列组成的轻链可变区，以及用于预防或治疗涉及人α9整数的各种疾病的手段 rin在发病机制中，其使用抗体。

13. 发明申请

US20110014193A1 HUMANIZED ANTI-HUMAN ALPHA 9-INTEGRIN ANTIBODY 审中-公开
标题翻译：人类抗人ALPHA 9整合抗体
公开(公告)号：US20110014193A1
公开(公告)日：2011-01-20
申请号：US12812368
申请日：2009-07-09
申请人： Kenji Uehara , Hirofumi Higuchi , Toshihiro Nakashima , Daisuke Ishikawa , Nobuchika Yamamoto , Hirotada Fujita , Fumihiko Sakai
发明人： Kenji Uehara , Hirofumi Higuchi , Toshihiro Nakashima , Daisuke Ishikawa , Nobuchika Yamamoto , Hirotada Fujita , Fumihiko Sakai
IPC分类号： A61K39/395 , C07K16/00 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/06 , A61P19/02
CPC分类号： C07K16/2839 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides a humanized anti-human α9 integrin antibody having improved activity and/or property as compared to donor mouse anti-human α9 integrin antibody, namely, a humanized anti-human α9 integrin antibody comprising a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO: 1 or the amino acid sequence shown by SEQ ID NO: 1 wherein one or several amino acids are substituted, deleted, inserted and/or added and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO: 61 or the amino acid sequence shown by SEQ ID NO: 61 wherein one or several amino acids are substituted, deleted, inserted and/or added, as well as a means for preventing or treating various diseases involving human α9 integrin in their pathogenesis, which uses the antibody.
摘要翻译：本发明提供了与供体小鼠抗人α9整联蛋白抗体相比具有改善的活性和/或性质的人源化抗人α9整联蛋白抗体，即人源化抗人α9整联蛋白抗体，其包含由以下组成的重链可变区： SEQ ID NO：1所示的氨基酸序列或SEQ ID NO：1所示的氨基酸序列，其中一个或几个氨基酸被取代，缺失，插入和/或添加，以及由氨基酸组成的轻链可变区 SEQ ID NO：61所示的酸序列或SEQ ID NO：61所示的氨基酸序列，其中一个或几个氨基酸被取代，缺失，插入和/或添加，以及用于预防或治疗涉及人α9整合素在其发病机制中，其使用抗体。

14. 发明授权

US07807161B2 Humanized anti-human osteopontin antibody 失效
标题翻译：人源化抗人骨桥蛋白抗体
公开(公告)号：US07807161B2
公开(公告)日：2010-10-05
申请号：US11755671
申请日：2007-05-30
申请人： Nobuchika Yamamoto , Fumihiko Sakai , Hirofumi Higuchi , Masaharu Torikai , Toshihiro Nakashima
发明人： Nobuchika Yamamoto , Fumihiko Sakai , Hirofumi Higuchi , Masaharu Torikai , Toshihiro Nakashima
IPC分类号： A61K39/00 , A61K39/395 , C07K16/46 , C07K16/24
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/24 , C07K2317/56
摘要： The present invention provides a humanized anti-human osteopontin antibody having better activities (antigen binding activity, leukocyte migration inhibitory activity and the like) and/or stability (resistance to heat, low-pH conditions, denaturants and the like) than those of conventional anti-human osteopontin antibodies.
摘要翻译：本发明提供具有比常规的更好的活性（抗原结合活性，白细胞迁移抑制活性等）和/或稳定性（耐热，低pH条件，变性剂等）的人源化抗人骨桥蛋白抗体抗人骨桥蛋白抗体。

15. 发明申请

US20060139762A1 Projection image display apparatus and color correction method for the same 失效
标题翻译：投影图像显示装置和颜色校正方法相同
公开(公告)号：US20060139762A1
公开(公告)日：2006-06-29
申请号：US11230824
申请日：2005-09-21
申请人： Fumihiko Sakai
发明人： Fumihiko Sakai
IPC分类号： G02B3/00
CPC分类号： H04N9/3182
摘要： A holding unit holds a plurality of types of white balance adjustment color data with respect to colors of the plurality of projection surfaces. A projection control unit causes a projection unit to simultaneously project patterns having a plurality of colors based on the plurality of types of held color data, upon dividing the patterns into areas configured to be selected for each pattern. A selection control unit causes a designation unit to select a pattern which is whitest from the patterns having the plurality of projected colors. When a given pattern is selected from the patterns having the plurality of colors projected, a color data acquiring unit acquires color data corresponding to the selected pattern from the plurality of types of held color data. A color correction unit performs color correction of an image to be projected.
摘要翻译：保持单元保持关于多个投影表面的颜色的多种类型的白平衡调整颜色数据。投影控制单元使得投影单元在将图案划分成为每个图案被选择的区域时，基于多种类型的保持的颜色数据同时投影具有多种颜色的图案。选择控制单元使得指定单元从具有多个投影颜色的图案中选择最白的图案。当从具有投影的多种颜色的图案中选择给定图案时，颜色数据获取单元从多种类型的保持的颜色数据中获取与所选择的图案相对应的颜色数据。颜色校正单元执行要投影的图像的颜色校正。

16. 发明申请

US20110014213A1 HUMAN ANTI-ALPHA 9 INTEGRIN ANTIBODY 有权
标题翻译：人类抗ALPHA 9整合抗体
公开(公告)号：US20110014213A1
公开(公告)日：2011-01-20
申请号：US12810939
申请日：2008-12-26
申请人： Masaharu Torikai , Daisuke Ishikawa , Toshihiro Nakashima , Hirofumi Higuchi , Fumihiko Sakai , Nobuchika Yamamoto , Hirotada Fujita , Katsunari Taguchi
发明人： Masaharu Torikai , Daisuke Ishikawa , Toshihiro Nakashima , Hirofumi Higuchi , Fumihiko Sakai , Nobuchika Yamamoto , Hirotada Fujita , Katsunari Taguchi
IPC分类号： A61K39/395 , C07K16/28 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/02 , A61P19/02
CPC分类号： C07K16/2839 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/622 , C07K2317/92 , C07K2319/00
摘要： The present invention provides a human anti-α9 integrin antibody or an antibody fragment which specifically recognize human α9 integrin and mouse α9 integrin, inhibit interaction with their ligands, particularly, the antibody or antibody fragment which recognize loop regions of human and mouse α9 integrins, a gene encoding the antibody or antibody fragment, a recombinant expression vector containing the gene, a transformant harboring the gene, production method of human anti-α9 integrin antibody or antibody fragment using the transformant, and an agent for the prophylaxis or treatment of rheumatoid arthritis which contains the antibody or antibody fragment.
摘要翻译：本发明提供一种人抗α9整联蛋白抗体或特异性识别人α9整联蛋白和小鼠α9整联蛋白的抗体片段，抑制与其配体的相互作用，特别是识别人和小鼠α9整联蛋白环区的抗体或抗体片段，编码抗体或抗体片段的基因，含有该基因的重组表达载体，携带该基因的转化体，使用该转化体的人抗α9整联蛋白抗体的制备方法或抗体片段，以及预防或治疗类风湿性关节炎其含有抗体或抗体片段。

17. 发明授权

US07199937B2 Projection image display apparatus and color correction method for the same 失效
标题翻译：投影图像显示装置和颜色校正方法相同
公开(公告)号：US07199937B2
公开(公告)日：2007-04-03
申请号：US11230824
申请日：2005-09-21
申请人： Fumihiko Sakai
发明人： Fumihiko Sakai
IPC分类号： G02B3/00 , G03B21/00
CPC分类号： H04N9/3182
摘要： A holding unit holds a plurality of types of white balance adjustment color data with respect to colors of the plurality of projection surfaces. A projection control unit causes a projection unit to simultaneously project patterns having a plurality of colors based on the plurality of types of held color data, upon dividing the patterns into areas configured to be selected for each pattern. A selection control unit causes a designation unit to select a pattern which is whitest from the patterns having the plurality of projected colors. When a given pattern is selected from the patterns having the plurality of colors projected, a color data acquiring unit acquires color data corresponding to the selected pattern from the plurality of types of held color data. A color correction unit performs color correction of an image to be projected.
摘要翻译：保持单元保持关于多个投影表面的颜色的多种类型的白平衡调整颜色数据。投影控制单元使得投影单元在将图案划分成为每个图案被选择的区域时，基于多种类型的保持的颜色数据同时投影具有多种颜色的图案。选择控制单元使得指定单元从具有多个投影颜色的图案中选择最白的图案。当从具有投影的多种颜色的图案中选择给定图案时，颜色数据获取单元从多种类型的保持的颜色数据中获取与所选择的图案相对应的颜色数据。颜色校正单元执行要投影的图像的颜色校正。

18. 发明授权

US4364844A Catalyst for production of unsaturated carboxylic acid, preparation thereof and production of unsaturated carboxylic acid 失效
标题翻译：用于生产不饱和羧酸的催化剂，其制备和不饱和羧酸的生产
公开(公告)号：US4364844A
公开(公告)日：1982-12-21
申请号：US184178
申请日：1980-09-04
申请人： Sumio Umemura , Kyoji Ohdan , Fumihiko Sakai , Kenichi Suzuki , Yasuo Bando , Toshihiko Hogami , Masataka Fuginaga
发明人： Sumio Umemura , Kyoji Ohdan , Fumihiko Sakai , Kenichi Suzuki , Yasuo Bando , Toshihiko Hogami , Masataka Fuginaga
IPC分类号： C07C51/235 , B01J21/04 , B01J23/28 , B01J27/198 , B01J27/199 , B01J27/224 , B01J35/10 , C07B61/00 , C07C51/00 , C07C51/25 , C07C57/055 , C07C67/00 , B01J27/18 , B01J21/00
CPC分类号： C07C51/252 , B01J23/002 , B01J23/28 , B01J27/199 , B01J2523/00
摘要： An improved catalyst suitable for use in the production of an unsaturated carboxylic acid by the catalytic vapor phase oxidation of an unsaturated aldehyde is provided. In this catalyst, a heat-resistant inorganic substance, such as alumina, silica-alumina and silicon carbide, having a particle diameter of 3 through 10 mm, an apparent porosity of 35 through 60%, a water absorption of 20 through 50%, an average pore diameter of not less than 40 microns, a specific surface area of not more than 2 m.sup.2 /g and a bulk specific gravity of 1.5 through 2.0 is used for supporting a composition containing molybdenum, phosphorus, vanadium and the alkali metals. The use of the above-mentioned carrier results in the advantages that the unsaturated carboxylic acid, such as methacrylic acid, can be selectively produced from the unsaturated aldehyde at a high yield and that the mechanical strength of the catalyst is remarkably improved.
摘要翻译：提供了适用于通过不饱和醛的催化气相氧化生产不饱和羧酸的改进的催化剂。在该催化剂中，将粒径为3〜10mm，表观孔隙率为35〜60％，吸水率为20〜50％的耐热无机物质如氧化铝，二氧化硅 - 氧化铝和碳化硅，平均孔径不小于40微米，比表面积不超过2m 2 / g，堆积比重为1.5至2.0，用于支撑含有钼，磷，钒和碱金属的组合物。通过使用上述载体，可以得到不饱和羧酸（如甲基丙烯酸）可以高收率地从不饱和醛中选择性地制备的优点，催化剂的机械强度显着提高。

19. 发明授权

US4256914A Catalytic oxidation of methacrolein 失效
标题翻译：甲基丙烯醛的催化氧化
公开(公告)号：US4256914A
公开(公告)日：1981-03-17
申请号：US68198
申请日：1979-08-17
申请人： Sumio Umemura , Kyoji Ohdan , Fumihiko Sakai , Kenichi Suzuki , Toshihiko Hogami , Masataka Fuginaga
发明人： Sumio Umemura , Kyoji Ohdan , Fumihiko Sakai , Kenichi Suzuki , Toshihiko Hogami , Masataka Fuginaga
IPC分类号： B01J27/00 , C07B61/00 , C07C51/00 , C07C51/25 , C07C57/055 , C07C67/00
CPC分类号： C07C51/252
摘要： Methacrolein is catalytically oxidized into methacrylic acid in the vapor phase at a temperature of 200.degree. to 450.degree. C. The catalyst used is comprised of molybdenum, phosphorus, potassium and/or cesium, vanadium, silver and/or tellurium, and oxygen, and represented by the formula:Mo.sub.12 P.sub.a A.sub.b V.sub.c X.sub.d O.sub.ewherein A is K and/or Cs and X is Ag and/or Te, and a=0.5-5, b=0.1-4, c=0.05-3, d=0.001-2 and e is a positive number required by the valence states of the other elements present.
摘要翻译：所用的催化剂由钼，磷，钾和/或铯，钒，银和/或碲以及氧组成，并且气相中的甲基丙烯酸在气相中催化氧化成甲基丙烯酸。由式表示：Mo12PaAbVcXdOe其中A是K和/或Cs和X是Ag和/或Te，a = 0.5-5，b = 0.1-4，c = 0.05-3，d = 0.001-2，e是其他元素的价态所要求的正数。

20. 发明授权

US4177161A Catalytic oxidative process for producing maleic anhydride 失效
标题翻译：用于生产马来酸酐的催化氧化方法
公开(公告)号：US4177161A
公开(公告)日：1979-12-04
申请号：US902935
申请日：1978-05-05
申请人： Sumio Umemura , Kyoji Ohdan , Fumihiko Sakai , Yasuo Bando , Harumi Ikezawa
发明人： Sumio Umemura , Kyoji Ohdan , Fumihiko Sakai , Yasuo Bando , Harumi Ikezawa
IPC分类号： B01J23/16 , B01J23/22 , B01J23/847 , B01J27/198 , C07C51/25 , B01J27/14
CPC分类号： C07C51/25 , B01J23/16 , B01J23/22 , B01J23/8472 , B01J27/198 , C07C51/252
摘要： Unsaturated hydrocarbons having 4 to 6 carbon atoms are catalytically oxidized into maleic anhydride by using a catalyst, which consists essentially of oxides of (A) vanadium, (B) phosphorus, (C) titanium and (D) optionally at least one element selected from sodium, calcium, magnesium, iron, zirconium, boron, manganese, silver and molybdenum in the atomic ratios defined by the following formulaVP.sub.a Ti.sub.b X.sub.c O.sub.dwherein X is the element (D) set forth above and a=1.0 to 5.0, b=2.0 to 12.0 and c=0 to 1.0, and which catalyst is prepared by calcining a mixture of a vanadium-containing compound and titanium dioxide at a temperature of 650.degree. C. to 1,500.degree. C., incorporating into the mixture a phosphorus-containing compound and optionally the element "X"-containing compound and, then, heating the resulting mixture.
摘要翻译：具有4-6个碳原子的不饱和烃通过使用催化剂催化氧化成马来酸酐，所述催化剂基本上由（A）钒，（B）磷，（C）钛和（D）的氧化物组成，任选地至少一种选自钠，钙，镁，铁，锆，硼，锰，银和钼，其原子比由下式VPaTibXcOd定义，其中X是上述元素（D），a = 1.0至5.0，b = 2.0至12.0 并且c = 0至1.0，并且通过在650℃至1500℃的温度下煅烧含钒化合物和二氧化钛的混合物来制备该催化剂，将含磷化合物和任选地含有元素“X”的化合物，然后加热所得混合物。

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