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11. 发明申请

US20070032530A1 Phenylpyridine derivatives 失效
标题翻译：苯基吡啶衍生物
公开(公告)号：US20070032530A1
公开(公告)日：2007-02-08
申请号：US11497145
申请日：2006-08-01
申请人： Birgit Bossenmaier , Thomas Friess , Rolf Juchem , Lothar Kling , Irene Kolm , Hans-Willi Krell , Thomas von Hirschheydt , Edgar Voss
发明人： Birgit Bossenmaier , Thomas Friess , Rolf Juchem , Lothar Kling , Irene Kolm , Hans-Willi Krell , Thomas von Hirschheydt , Edgar Voss
IPC分类号： A61K31/4439 , C07D403/02
CPC分类号： C07D401/12
摘要： The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing such compounds and their manufacture, as well as the use of such compounds in the control or prevention of illnesses such as cancer.
摘要翻译：本发明涉及式I化合物：其药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有这些化合物的药物组合物及其制备方法以及这些化合物在控制或预防癌症等疾病。

12. 发明申请

US20050267179A1 NOVEL THIOETHER DERIVATIVES 失效
标题翻译：新型三氯乙烯衍生物
公开(公告)号：US20050267179A1
公开(公告)日：2005-12-01
申请号：US11132082
申请日：2005-05-18
申请人： Birgit Bossenmaier , Walter-Gunar Friebe , Thomas Friess , Lothar Kling , Ulrike Reiff , Edgar Voss
发明人： Birgit Bossenmaier , Walter-Gunar Friebe , Thomas Friess , Lothar Kling , Ulrike Reiff , Edgar Voss
IPC分类号： A61K31/422 , A61P35/00 , C07D413/02 , C07D413/12
CPC分类号： C07D413/12
摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.
摘要翻译：本发明的目的是式（I）化合物的药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物组合物及其制备方法，以及上述化合物在控制或预防癌症等疾病。

13. 发明授权

US07005526B2 Thioether derivatives 失效
标题翻译：硫醚衍生物
公开(公告)号：US07005526B2
公开(公告)日：2006-02-28
申请号：US11132082
申请日：2005-05-18
申请人： Birgit Bossenmaier , Walter-Gunar Friebe , Thomas Friess , Lothar Kling , Ulrike Reiff , Edgar Voss
发明人： Birgit Bossenmaier , Walter-Gunar Friebe , Thomas Friess , Lothar Kling , Ulrike Reiff , Edgar Voss
IPC分类号： C07D263/32 , C07D249/04 , A61K31/422 , A61K31/4192
CPC分类号： C07D413/12
摘要： Objects of the present invention are the compounds of formula (I) formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.
摘要翻译：本发明的目的是式（I）式（I）的化合物，化学式id =“CHEM-US-00001”num =“000

14. 发明授权

US06911553B1 Osteoblast-specific mitogens and drugs containing such compounds 失效
标题翻译：成骨细胞特异性有丝分裂原和含有此类化合物的药物
公开(公告)号：US06911553B1
公开(公告)日：2005-06-28
申请号：US09675943
申请日：2000-09-29
申请人： Angelika Esswein , Lothar Kling
发明人： Angelika Esswein , Lothar Kling
IPC分类号： C07F9/09 , C07F9/06
CPC分类号： C07F9/091
摘要： The invention is directed to compounds of formula (I) wherein R1 alkyl, alkenyl or alkynyl having from 6 to 24 carbon atoms; n=0-12; X=oxygen or NH; and the physiologically safe salts, esters, optically active forms, racemates and derivatives thereof which can be metabolized in vivo to yield compounds of general formula (I), methods of preparing same, and drugs containing said compounds, for treating bone metabolic disorders.
摘要翻译：本发明涉及式（I）化合物，其中R 1，R 2，R 2，R 2， n = 0-12; X =氧或NH; 以及其可在体内代谢产生通式（I）的化合物，其制备方法和含有所述化合物的药物用于治疗骨代谢紊乱的生理上安全的盐，酯，光学活性形式，外消旋体及其衍生物。

15. 发明授权

US06809175B1 Cadherin derived growth factor and its use 失效
标题翻译：钙粘蛋白衍生生长因子及其用途
公开(公告)号：US06809175B1
公开(公告)日：2004-10-26
申请号：US09509559
申请日：2000-11-27
申请人： Wolf-Georg Forssmann , Ludger Standker , Markus Meyer , Hossein Mostafavi , Hans-Georg Opitz , Lothar Kling
发明人： Wolf-Georg Forssmann , Ludger Standker , Markus Meyer , Hossein Mostafavi , Hans-Georg Opitz , Lothar Kling
IPC分类号： C07K1400
CPC分类号： C07K14/705 , A61K38/00 , C07K14/475
摘要： A peptide referred to as cadherin-derived growth factor (CDGF) the sequence of which corresponds to a partial sequence of a pre-pro-cadherin, said pre-pro-cadherin comprising the domains signal sequence, pro sequence cadherin repeats, transmembrane region and intracellular domain, characterized in that the sequence of said peptide comprises the pro sequence, that at least one of the other domains of the pre-pro-cadherin is lacking, and that said peptide has cell-proliferative, cell-protective and/or cell-differential properties.
摘要翻译：称为钙粘蛋白衍生生长因子（CDGF）的肽，其序列对应于前前钙粘蛋白的部分序列，所述前前钙粘蛋白包含结构域信号序列，前序列钙粘着蛋白重复序列，跨膜区和细胞内结构域，其特征在于所述肽的序列包含前序列，所述前体前钙粘蛋白的至少一个其他结构域缺乏，并且所述肽具有细胞增殖，细胞保护和/或细胞差分属性。

16. 发明授权

US06444832B1 Amino alcohol derivatives, method of producing said derivatives and medicaments containing them 失效
标题翻译：氨基醇衍生物，所述衍生物的制造方法和含有它们的药物
公开(公告)号：US06444832B1
公开(公告)日：2002-09-03
申请号：US09407981
申请日：1999-09-29
申请人： Angelika Esswein , Lothar Kling , Ulrike Leser , Walter-Gunar Friebe
发明人： Angelika Esswein , Lothar Kling , Ulrike Leser , Walter-Gunar Friebe
IPC分类号： C07C23100
CPC分类号： C07C233/18 , C07C233/20
摘要： Compounds of formula I in which R1 denotes hydrogen or methyl R2 denotes lower straight-chained or branched alkyl with 1 to 10 carbon atoms R3 denotes hydrogen or lower alkyl n denotes 0-12 R4 denotes alkyl, alkenyl or alkinyl with 6 to 24 carbon atoms, processes for the production thereof as well as pharmaceutical agents containing these compounds for the treatment of osteoporosis.
摘要翻译： R1表示氢或甲基R2的式Iin化合物表示具有1至10个碳原子的较低直链或支链烷基R 3表示氢或低级烷基，表示0-12R 4表示具有6至24个碳原子的烷基，烯基或炔基，其制备方法以及含有这些化合物用于治疗骨质疏松症的药剂。

17. 发明申请

US20050203064A1 Novel oxidized thioether derivatives 失效
标题翻译：新型氧化型硫醚衍生物
公开(公告)号：US20050203064A1
公开(公告)日：2005-09-15
申请号：US11073065
申请日：2005-03-04
申请人： Birgit Bossenmaier , Walter-Gunar Friebe , Thomas Friess , Lothar Kling , Matthias Rueth , Edgar Voss
发明人： Birgit Bossenmaier , Walter-Gunar Friebe , Thomas Friess , Lothar Kling , Matthias Rueth , Edgar Voss
IPC分类号： C07D413/12 , C07D417/12 , A61K31/675 , A61K31/4164 , A61K31/421 , A61K31/426 , C07D263/30 , C07D277/22
CPC分类号： C07D417/12 , C07D413/12
摘要： The present invention provides the compounds of formula I their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译：本发明提供式I化合物的药学上可接受的盐或酯，对映异构体形式，非对映异构体和外消旋物，上述化合物的制备，含有它们的药物组合物及其制备方法以及使用上述控制或预防疾病如癌症的化合物。

18. 发明授权

US06429288B1 Peptides containing an arginine mimetic for the treatment of bone metabolic disorders, their production, and drugs containing these compounds 失效
标题翻译：含有精氨酸模拟物的肽用于治疗骨代谢紊乱，其生产和含有这些化合物的药物
公开(公告)号：US06429288B1
公开(公告)日：2002-08-06
申请号：US09486679
申请日：2000-03-31
申请人： Angelika Esswein , Eike Hoffmann , Lothar Kling , Silvia Konetschny-Rapp
发明人： Angelika Esswein , Eike Hoffmann , Lothar Kling , Silvia Konetschny-Rapp
IPC分类号： C07K508
CPC分类号： C07D403/12 , A61K38/00 , C07D207/20 , C07K5/0205 , C07K5/0207 , C07K5/1024 , C07K14/635
摘要： Arginine mimetic peptides according to Formula I of this application have a stimulating effect on bone formation and are useful for the treatment of bone metabolic disorders.
摘要翻译：根据本申请式I的精氨酸模拟肽对骨形成具有刺激作用，并且可用于治疗骨代谢紊乱。

19. 发明授权

US5888967A Use of plasminogen activators to stimulate local bone growth 失效
标题翻译：使用纤溶酶原激活剂刺激局部骨生长
公开(公告)号：US5888967A
公开(公告)日：1999-03-30
申请号：US492
申请日：1998-02-09
申请人： Konrad Honold , Lothar Kling , Kurt Lang , Ulrike Leser
发明人： Konrad Honold , Lothar Kling , Kurt Lang , Ulrike Leser
IPC分类号： A61K47/48 , A61K38/16 , A61K38/46 , A61K38/49 , A61L27/00 , A61P43/00 , A61K38/00
CPC分类号： A61K38/49 , A61K38/164
摘要： Described herein is a method of promoting osteogenesis in a patient in need thereof by administering a plasminogen activator which activates the zymogen plasminogen by cleavage between arginine 506 and valine 561 to form the serine protease plasmin.
摘要翻译： PCT No.PCT / EP96 / 03345 Sec。 371日期：1998年2月9日 102（e）1998年2月9日PCT PCT 1996年7月30日PCT公布。公开号WO97 / 05891 日期1997年2月20日描述了通过施用纤维蛋白溶酶原激活剂来促进有需要的患者的成骨的方法，所述纤溶酶原激活剂通过在精氨酸506和缬氨酸561之间切割而激活酶原纤溶酶原，以形成丝氨酸蛋白酶纤溶酶。

20. 发明授权

US06197759B1 Osteoblast-specific mitogens and drugs containing such compounds 有权
标题翻译：成骨细胞特异性有丝分裂原和含有此类化合物的药物
公开(公告)号：US06197759B1
公开(公告)日：2001-03-06
申请号：US09508714
申请日：2000-04-11
申请人： Angelika Esswein , Lothar Kling
发明人： Angelika Esswein , Lothar Kling
IPC分类号： A61K31661
CPC分类号： C07F9/091
摘要： Osteoblast-specific mitogens and drugs containing such compounds can be used for treating metabolic bone diseases. These compounds include lysophosphatidylic acid derivatives selected from the group consisting of compounds of formula: wherein R1=alkenyl or alkynyl having from 6 to 24 carbon atoms; n=0-12; X=oxygen or NH; the compounds (all-cis-5,8,11,14)-eicosatetraenoic acid 2-hydroxy-3-phosphonooxypropyl ester; cis-9, cis-12-octadecadienoic acid 2-hydroxy-3-phosphonooxypropyl ester; (all-cis-9,12,15)-octadecatrienoic acid 2-hydroxy-3-phosphonooxypropyl ester; cis-9-octadecenoic acid 2-hydroxy-3-phosphonooxypropyl ester; and erucic acid 2-hydroxy-3-phosphonooxypropylester being excluded, and the physiologically tolerable salts, esters, optically active forms, and racemates of said compounds, and derivatives of said compounds, salts, esters, optically active forms and racemates which can be metabolized in vivo to yield the corresponding compound of formula (I).
摘要翻译：成骨细胞特异性有丝分裂原和含有此类化合物的药物可用于治疗代谢性骨病。这些化合物包括选自下式的化合物的溶血磷脂酰衍生物：其中R1 =具有6至24个碳原子的烯基或炔基; n = 0-12; X =氧或NH;化合物（全顺式-5， 8,11,14） - 二十碳四烯酸2-羟基-3-膦酰氧基丙基酯; 顺式-9，顺式-12-十八碳二烯酸2-羟基-3-膦酰氧基丙基酯; （全顺式-9,12,15） - 十八碳三烯酸2-羟基-3-膦酰氧丙基酯; 顺-9-十八碳烯酸2-羟基-3-膦酰氧基丙酯; 和芥酸2-羟基-3-膦酰氧基丙基酯，以及所述化合物的生理上可耐受的盐，酯，旋光形式和外消旋物，以及所述化合物的衍生物，盐，酯，旋光活性物质和可被代谢的外消旋体在体内产生相应的式（I）化合物。

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