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11. 发明申请

US20050159677A1 Biopsy device with aperture orientation and improved tip 有权
标题翻译：具有孔径取向和改善尖端的活检装置
公开(公告)号：US20050159677A1
公开(公告)日：2005-07-21
申请号：US11014413
申请日：2004-12-16
申请人： Martin Shabaz , Richard Quick , Frank Louw , Paul Lubock , Jason Safabash
发明人： Martin Shabaz , Richard Quick , Frank Louw , Paul Lubock , Jason Safabash
IPC分类号： A61B10/00 , A61B10/02 , A61B17/00 , A61B17/32 , A61B17/34 , A61B19/00
CPC分类号： A61B10/0275 , A61B10/0283 , A61B17/32002 , A61B17/32053 , A61B17/3417 , A61B90/30 , A61B2010/0208 , A61B2010/0225 , A61B2017/00207 , A61B2017/00473 , A61B2017/2911 , A61B2017/2925 , A61B2017/3405 , A61B2090/3908 , A61B2090/3987
摘要： The invention is directed to a system and device for separating and collecting a tissue specimen from a target site within a patient. The device includes a probe component which is releasably secured to the driver component. The probe component has an elongated tubular section, a penetrating distal tip and a tissue receiving aperture in the distal end of the tubular section proximal to the distal tip, and a tissue cutting member which is slidably disposed within the probe member to cut a tissue specimen drawn into the interior of the device through the aperture by applying a vacuum to the inner lumen of the tissue cutting member. The driver has drive members for operating the elements of the probe component. The tissue penetrating distal tip preferably has a triple concave curvature shape with three curved cutting edges leading to a sharp distal point.
摘要翻译：本发明涉及一种用于从患者内的目标部位分离和收集组织标本的系统和装置。该装置包括可释放地固定到驱动器部件的探针部件。探针部件具有细长的管状部分，穿透远侧末端和在远端顶端的管状部分的远端中的组织接收孔，以及组织切割构件，其可滑动地设置在探针构件内以切割组织标本通过对组织切割构件的内腔施加真空而通过孔被吸入装置的内部。驱动器具有用于操作探头部件的元件的驱动部件。组织穿透的远侧末端优选地具有三凹曲面形状，其具有三个弯曲的切割边缘，其导致尖锐的远端点。

12. 发明授权

US06497706B1 Biopsy device and method of use 有权
标题翻译：活检装置及使用方法
公开(公告)号：US06497706B1
公开(公告)日：2002-12-24
申请号：US09717176
申请日：2000-11-16
申请人： Fred H. Burbank , Frank Louw , Paul Lubock
发明人： Fred H. Burbank , Frank Louw , Paul Lubock
IPC分类号： A61B1818
CPC分类号： A61B10/0275 , A61B10/02 , A61B10/0266 , A61B10/0283 , A61B10/04 , A61B17/32056 , A61B17/320725 , A61B17/3417 , A61B18/14 , A61B18/148 , A61B18/1482 , A61B18/1487 , A61B18/1492 , A61B90/37 , A61B2010/0208 , A61B2018/00208 , A61B2018/00214 , A61B2018/00267 , A61B2018/00291 , A61B2018/00333 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1412 , A61B2018/1425 , A61B2018/1455 , A61B2018/1475 , A61B2018/162 , A61B2090/3908
摘要： A device and method of using the device to access a desired tissue site within a patient's body and separating a tissue specimen from the tissue site suitable for evaluation. The device includes a probe member having an arcuate tissue cutting RF powered electrode secured to and distally spaced from the distal end of the probe and a small dimensioned distal extremity which when an inner lumen thereof is subjected to a vacuum, secured tissue for the specimen to the surface of the distal extremity. A circular RF powered cutting electrode preferably secured to and spaced from the distal end of an outer sheath which when operatively energized with high frequency electrical power and longitudinally moved along the shaft of the probe member severs the tissue specimen secured to the surface of the distal extremity of the probe member from the tissue site. The outer sheath covers the separated specimen.
摘要翻译：一种使用该装置来访问患者体内期望的组织部位并将组织标本与适于评估的组织部位分离的装置和方法。该装置包括探针构件，该探针构件具有固定到探针的远端并且远离其距离探针远端的弧形组织切割RF供电的电极，以及小尺寸的远端，当其内腔经受真空时，用于样本的固定的组织远端的表面。圆形RF动力切割电极优选地固定到外护套的远端并且与外护套的远端隔开，当外部护套以高频电功能被激活并且沿着探针构件的轴沿纵向移动时，其将固定到远端的表面的组织样本的探针构件。外护套覆盖分离的试样。

13. 发明授权

US10299881B2 Marker or filler forming fluid 有权
公开(公告)号：US10299881B2
公开(公告)日：2019-05-28
申请号：US12214947
申请日：2008-06-24
申请人： Fred H. Burbank , Michael L. Jones , Frank Louw , Paul Lubock
发明人： Fred H. Burbank , Michael L. Jones , Frank Louw , Paul Lubock
IPC分类号： A61B90/00 , A61K49/22
摘要： A solution for forming a marker or filler mass for an intracorporeal site. The solution contains a polar, water soluble non-aqueous solvent such as dimethyl sulfoxide and a bioabsorbable, essentially water insoluble polymer such as polylactic acid, or copolymers of lactic acid and glycolic acid. The solution may be delivered to the biopsy site by a suitable syringe and delivery tube. The delivery tube is preferably provided with a releasable radiopaque element on the distal tip which can be released within the polymeric marker mass formed in the biopsy cavity.

14. 发明授权

US08224424B2 Tissue site markers for in vivo imaging 有权
标题翻译：用于体内成像的组织位点标记
公开(公告)号：US08224424B2
公开(公告)日：2012-07-17
申请号：US12460052
申请日：2009-07-13
申请人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Richard L. Quick , Frank Louw , Stephen A. De Santis
发明人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Richard L. Quick , Frank Louw , Stephen A. De Santis
IPC分类号： A61B5/00 , A61B6/00 , A61B19/00
CPC分类号： A61M37/0069 , A61B6/12 , A61B8/0833 , A61B10/02 , A61B90/39 , A61B2017/00004 , A61B2090/08021 , A61B2090/3908 , A61B2090/3925 , A61B2090/3987 , A61K49/006 , A61K49/222
摘要： The invention is directed biopsy site markers and methods of marking a biopsy site, so that the location of the biopsy cavity is readily visible by conventional imaging methods, particularly by ultrasonic imaging. The biopsy site markers of the invention have high ultrasound reflectivity, presenting a substantial acoustic signature from a small marker, so as to avoid obscuring diagnostic tissue features in subsequent imaging studies, and can be readily distinguished from biological features. The several disclosed embodiments of the biopsy site marker of the invention have a high contrast of acoustic impedance as placed in a tissue site, so as to efficiently reflect and scatter ultrasonic energy, and preferably include gas-filled internal pores. The markers may have a non-uniform surface contour to enhance the acoustic signature. The markers have a characteristic form which is recognizably artificial during medical imaging. The biopsy site marker may be accurately fixed to the biopsy site so as to resist migration from the biopsy cavity when a placement instrument is withdrawn, and when the marked tissue is subsequently moved or manipulated.
摘要翻译：本发明涉及活检部位标记和标记活组织检查部位的方法，使得活检腔的位置通过常规成像方法，特别是通过超声成像容易看到。本发明的活检部位标记物具有高的超声反射率，从小标记物呈现出实质的声学特征，以避免在随后的成像研究中掩盖诊断组织特征，并且可以容易地与生物特征区别开来。本发明的活检部位标记物的几个公开的实施方案具有放置在组织部位中的声阻抗的高对比度，以便有效地反射和散射超声能量，并且优选地包括气体填充的内部孔。标记可以具有不均匀的表面轮廓以增强声学特征。标记具有在医学成像期间可识别人造的特征形式。可以将活检部位标记物精确地固定到活检部位，以便当放置放置器械被取出时以及随后标记的组织被移动或操纵时抵抗从活检腔的迁移。

15. 发明授权

US07877133B2 Marker or filler forming fluid 有权
标题翻译：标记或填料成型液
公开(公告)号：US07877133B2
公开(公告)日：2011-01-25
申请号：US10444428
申请日：2003-05-23
申请人： Fred H. Burbank , Michael L. Jones , Frank Louw , Paul Lubock
发明人： Fred H. Burbank , Michael L. Jones , Frank Louw , Paul Lubock
IPC分类号： A61B6/00 , A61B10/00
CPC分类号： A61B90/39 , A61B2090/3908 , A61B2090/3925 , A61B2090/3933 , A61B2090/3987 , A61K49/226
摘要： A solution for forming a marker or filler mass for an intracorporeal site. The solution contains a polar, water soluble non-aqueous solvent such as dimethyl sulfoxide and a bioabsorbable, essentially water insoluble polymer such as polylactic acid, or copolymers of lactic acid and glycolic acid. The solution may be delivered to the biopsy site by a suitable syringe and delivery tube. The delivery tube is preferably provided with a releasable radiopaque element on the distal tip which can be released within the polymeric marker mass formed in the biopsy cavity.
摘要翻译：用于形成体内部位的标记物或填充剂块的溶液。该溶液含有极性的水溶性非水溶剂如二甲基亚砜和生物可吸收的，基本上不溶于水的聚合物如聚乳酸，或乳酸和乙醇酸的共聚物。溶液可以通过合适的注射器和输送管递送到活检部位。输送管优选地设置在远端上的可释放的不透射线元件，其可以在形成于活检腔内的聚合物标记块内释放。

16. 发明申请

US20070161925A1 Biopsy device with inner cutter 审中-公开
标题翻译：内切刀活检装置
公开(公告)号：US20070161925A1
公开(公告)日：2007-07-12
申请号：US11714360
申请日：2007-03-06
申请人： Richard Quick , Frank Louw , Paul Lubock , Martin Shabaz
发明人： Richard Quick , Frank Louw , Paul Lubock , Martin Shabaz
IPC分类号： A61B10/00
CPC分类号： A61B10/0266 , A61B10/02 , A61B10/0233 , A61B10/0275 , A61B10/0283 , A61B17/32002 , A61B17/3417 , A61B90/30 , A61B90/39 , A61B2010/0208 , A61B2010/0225 , A61B2017/0046 , A61B2017/00473 , A61B2017/3405 , A61B2017/3454 , A61B2090/0811 , A61B2090/309 , A61M1/0058 , B23Q17/2404 , F21V33/0068
摘要： The invention is directed to devices and methods for accessing a desired target site within a patient's body and for separating and collecting a tissue specimen from the target site. The device includes a probe member or cannula with a penetrating distal tip, and a tissue cutting member which is disposed within the probe member to cut a tissue specimen from supporting tissue at the biopsy site. This probe is releasably secured to a housing to provide a plurality of discrete orientations of the probe about its longitudinal axis. Vacuum may be provided to the inner lumen of the cutting member to transport tissue through the inner lumen thereof. Rotation (and optionally longitudinal reciprocation) of the tissue cutter is effective to separate a tissue specimen from surrounding tissue at the target site. Vacuum or fluid pressure may be used to move the specimen cut from the target site proximally within the inner lumen defined at least in part by the cutting member for collection. An elongated accessing cannula having an tissue receiving aperture communicating with an inner lumen of the accessing cannula, may be provided with the device and is preferably concentrically disposed within the probe member and about the tissue cutter. The tissue cutting surface of the tissue cutter preferably is longitudinally oriented and may be at an angle with respect to the longitudinal axis of the tissue cutter.
摘要翻译：本发明涉及用于访问患者体内期望的目标部位并用于从目标部位分离和收集组织标本的装置和方法。该装置包括具有穿透性远侧末端的探针构件或套管，以及组织切割构件，其设置在探针构件内以从活组织检查部位的支撑组织切割组织样本。该探针可释放地固定到壳体以提供探针围绕其纵向轴线的多个离散定向。可以向切割构件的内腔提供真空以将组织输送通过其内腔。组织切割器的旋转（和任选的纵向往复运动）有效地将组织标本与目标部位的周围组织分离。可以使用真空或流体压力来将从目标位置切割的样本移动到至少部分地由切割构件限定的内腔内用于收集。具有与进入插管的内腔连通的组织接收孔的细长进入套管可以设置有该装置，并且优选地同心地设置在探针构件内并且围绕组织切割器。组织切割器的组织切割表面优选地纵向定向并且可以相对于组织切割器的纵向轴线成一定角度。

17. 发明申请

US20070032740A1 Biopsy device with fluid delivery to tissue specimens 审中-公开
标题翻译：活组织检查装置，液体输送到组织标本
公开(公告)号：US20070032740A1
公开(公告)日：2007-02-08
申请号：US11197827
申请日：2005-08-05
申请人： Richard Quick , Martin Shabaz , Frank Louw , Paul Lubock , Jason Safabash
发明人： Richard Quick , Martin Shabaz , Frank Louw , Paul Lubock , Jason Safabash
IPC分类号： A61B10/00
CPC分类号： A61B10/0275 , A61B10/0283 , A61B2010/0208 , A61B2010/0225
摘要： The invention is directed to a system and method for separating and collecting one or more tissue specimens from a target site within a patient and flushing the specimen to remove blood, debris and the like before the specimen is removed from the biopsy device. The flow of flushing fluid to the tissue collector is preferably controlled to coincide with delivery of one or more specimens to the collecting tray or basket of the device or after the receipt of the specimen within the tissue collector to ensure that the fluid is applied to a fresh specimen. The tissue tray or basket within the tissue collector has an open or foraminous portion to facilitate removal of fluid, such as the applied fluid and blood, and other debris from the tissue specimens on the tray. Vacuum is provided within the tissue collector, preferably under the tray to remove fluid and debris from the collector interior.
摘要翻译：本发明涉及一种用于从患者内的目标部位分离和收集一个或多个组织样本的系统和方法，并且在从活检装置移除样本之前冲洗样本以除去血液，碎屑等。冲洗流体到组织收集器的流动优选地被控制以与一个或多个样品递送到装置的收集盘或篮子之间或者在组织收集器内接收到样本之后确保将流体施加到新鲜标本。组织收集器内的纸巾托盘或篮子具有开放或有孔的部分，以有助于从托盘上的组织标本中去除流体，例如所施加的流体和血液以及其它碎屑。在组织收集器内提供真空，优选在托盘下面，以从收集器内部去除流体和碎屑。

18. 发明申请

US20060276723A1 Tissue cutting member for a biopsy device 有权
公开(公告)号：US20060276723A1
公开(公告)日：2006-12-07
申请号：US11438955
申请日：2006-05-22
申请人： Paul Lubock , Frank Louw , Richard Quick
发明人： Paul Lubock , Frank Louw , Richard Quick
IPC分类号： A61B10/00
CPC分类号： A61B10/0275 , A61B10/0283 , A61B17/320016 , A61B17/3417
摘要： The invention is directed to tissue cutting members and biopsy devices with such tissue cutting member for separating a tissue specimen from a patient's body at a target site. The tissue cutting member is slidably disposed within an inner lumen of an elongated probe member of the biopsy device to cut a tissue specimen drawn into the interior of an outer cannula of the biopsy device through a tissue receiving aperture in the probe. The tissue cutting member has a tubular distal portion with a distal tip having an outer tissue cutting edge, an inner tissue receiving aperture, and a longitudinally oriented opening with a closed proximal end and open distal end which opens to the inner tissue receiving aperture to facilitate flaring of the distal tubular portion. The cutting member has at least one opening in a wall of the tubular portion to maintain a vacuum during use.

19. 发明申请

US20060149162A1 Graphical user interface for tissue biopsy system 有权
标题翻译：用于组织活检系统的图形用户界面
公开(公告)号：US20060149162A1
公开(公告)日：2006-07-06
申请号：US11284641
申请日：2005-11-22
申请人： Derek Daw , Frank Louw , Paul Lubock , Richard Quick , Martin Shabaz
发明人： Derek Daw , Frank Louw , Paul Lubock , Richard Quick , Martin Shabaz
IPC分类号： A61B10/00
CPC分类号： A61B5/061 , A61B5/742 , A61B10/0266 , A61B10/0275 , A61B90/10 , A61B90/37 , A61B2034/254
摘要： A graphical user interface is disclosed for a tissue biopsy system having a tissue cutting member adapted for cutting one or more tissue specimens from tissue at a target site within a patient. The graphical user interface includes a first GUI area representing a first region of the target site from which the tissue cutting member has separated one or more tissue specimens. The graphical user interface further includes a second GUI area, visually distinguishable from the first GUI area, representing a second region from which the tissue cutting member may separate one or more additional tissue specimens from tissue at the target site.
摘要翻译：公开了一种用于组织活检系统的图形用户界面，该组织活检系统具有适于从患者内的目标部位的组织切割一个或多个组织标本的组织切割构件。图形用户界面包括代表目标站点的第一区域的第一GUI区域，组织切割构件从该第一区域分离出一个或多个组织标本。图形用户界面还包括第二GUI区域，其可视地与第一GUI区域区分开，代表第二区域，组织切割构件可从该第二区域将一个或多个附加的组织标本与目标部位的组织分开。

20. 发明授权

US06993375B2 Tissue site markers for in vivo imaging 有权
公开(公告)号：US06993375B2
公开(公告)日：2006-01-31
申请号：US10823053
申请日：2004-04-12
申请人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Richard L. Quick , Frank Louw , Stephen A. De Santis
发明人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Richard L. Quick , Frank Louw , Stephen A. De Santis
IPC分类号： A61B19/00
CPC分类号： A61M37/0069 , A61B6/12 , A61B8/0833 , A61B10/02 , A61B90/39 , A61B2017/00004 , A61B2090/08021 , A61B2090/3908 , A61B2090/3925 , A61B2090/3987 , A61K49/006 , A61K49/222
摘要： The invention is directed biopsy site markers and methods of marking a biopsy site, so that the location of the biopsy cavity is readily visible by conventional imaging methods, particularly by ultrasonic imaging. The biopsy site markers of the invention have high ultrasound reflectivity, presenting a substantial acoustic signature from a small marker, so as to avoid obscuring diagnostic tissue features in subsequent imaging studies, and can be readily distinguished from biological features. The several disclosed embodiments of the biopsy site marker of the invention have a high contrast of acoustic impedance as placed in a tissue site, so as to efficiently reflect and scatter ultrasonic energy, and preferably include gas-filled internal pores. The markers may have a non-uniform surface contour to enhance the acoustic signature. The markers have a characteristic form which is recognizably artificial during medical imaging. The biopsy site marker may be accurately fixed to the biopsy site so as to resist migration from the biopsy cavity when a placement instrument is withdrawn, and when the marked tissue is subsequently moved or manipulated.

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