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11. 发明授权

US07868054B2 Phenylglyoxalic esters generated by photolysis of low migratable fragments 有权
标题翻译：通过低迁移片段的光解产生的苯乙醛酸酯
公开(公告)号：US07868054B2
公开(公告)日：2011-01-11
申请号：US11914245
申请日：2006-05-10
申请人： Stefano Romagnano , Gabriele Norcini , Marco Visconti , Giuseppe Libassi
发明人： Stefano Romagnano , Gabriele Norcini , Marco Visconti , Giuseppe Libassi
IPC分类号： C08F2/50 , C08J3/28
CPC分类号： G03F7/031 , C07C69/738 , C07C323/61 , C08F2/50 , Y10S522/909
摘要： The present invention concerns photopolymerisable systems comprising reactive oligomers and/or monomers having ethylenically unsaturated groups and at least one phenylglyoxalic ester that, by photochemical decomposition, generates fragments having low migratability and low odor.
摘要翻译：本发明涉及包含具有烯属不饱和基团的反应性低聚物和/或单体和至少一种苯基乙醛酸酯的可光聚合体系，其通过光化学分解产生低迁移性和低气味的碎片。

12. 发明授权

US07202012B2 Compositions for positive heat sensitive lithographic printing plates 失效
标题翻译：正热敏平版印刷版的组合物
公开(公告)号：US07202012B2
公开(公告)日：2007-04-10
申请号：US10508277
申请日：2003-03-18
申请人： Gabriele Norcini , Stefano Romagnano , Marco Visconti , Giuseppe Li Bassi
发明人： Gabriele Norcini , Stefano Romagnano , Marco Visconti , Giuseppe Li Bassi
IPC分类号： G03F7/032
CPC分类号： C09D161/06 , B41C1/1008 , B41C2210/02 , B41C2210/06 , B41C2210/22 , B41C2210/262 , C08K5/53
摘要： A composition for positive heat sensitive computer-to-plate (CTP) lithographic printing plates comprising a phenolic resin and an IR absorber characterized by the fact that the composition contains from 1 to 30% w/w of an organic oxygenated phosphorous compound chosen from the group of general formula (I): wherein R1, R2, and R3 are independently a C4–C8 alkyl group or an aryl group.
摘要翻译：包括酚醛树脂和IR吸收剂的用于正热敏电脑对平板（CTP）平版印刷版的组合物，其特征在于所述组合物含有1至30％w / w的有机氧化磷化合物，其选自通式（I）组：

13. 发明申请

US20100196826A1 Photoinitiators for Energy Curing 审中-公开
标题翻译：光能引发剂能量固化
公开(公告)号：US20100196826A1
公开(公告)日：2010-08-05
申请号：US12678639
申请日：2008-09-05
申请人： Stefano Romagnano , Gabriele Norcini , Giuseppe Li Bassi , Marco Visconti , Celine Dietlin , Xavier Allonas , Jean Pierre Fouassier
发明人： Stefano Romagnano , Gabriele Norcini , Giuseppe Li Bassi , Marco Visconti , Celine Dietlin , Xavier Allonas , Jean Pierre Fouassier
IPC分类号： G03F7/20 , G03F7/004 , C07C333/00 , C07C269/00
CPC分类号： C08F2/50 , G03F7/031
摘要： Photopolymerisable systems for coatings or photolithography comprising radically photopolimerisable oligomers and/or monomers having ethylenically unsaturated groups and, as photoinitiator, at least one compound of formula (I).
摘要翻译：用于涂料或光刻的可光聚合体系包括自由基可光聚合的低聚物和/或具有烯属不饱和基团的单体和作为光引发剂的至少一种式（I）的化合物。

14. 发明申请

US20060246228A1 Clear photopolymerizable systems for the preparation of high thickness coatings 失效
公开(公告)号：US20060246228A1
公开(公告)日：2006-11-02
申请号：US10566880
申请日：2004-08-03
申请人： Gabriele Norcini , Stefano Romagnano , Marco Visconti , Giuseppe Li Bassi
发明人： Gabriele Norcini , Stefano Romagnano , Marco Visconti , Giuseppe Li Bassi
IPC分类号： B05D7/08 , C07D265/32
CPC分类号： C07D295/108 , C07C45/46 , C07C45/63 , C07C45/64 , C07C49/84 , C07C225/16 , C07C2601/14 , C08F2/50 , G03F7/031
摘要： The present invention relates to clear photopolymerisable systems for the preparation of high thickness coatings, to a procedure for their application and to the solid surfaces coated with them.

15. 发明申请

US20050181298A1 Compositions for positive heat sensitive lithographic pringting plates 失效
标题翻译：正热敏平版印刷板的组成
公开(公告)号：US20050181298A1
公开(公告)日：2005-08-18
申请号：US10508277
申请日：2003-03-18
申请人： Gabriele Norcini , Stefano Romagnano , Marco Visconti , Giuseppe Li Bassi
发明人： Gabriele Norcini , Stefano Romagnano , Marco Visconti , Giuseppe Li Bassi
IPC分类号： G03F7/004 , B41C1/10 , C08K5/53 , C09D161/06 , G03F7/00 , G03C1/73
CPC分类号： C09D161/06 , B41C1/1008 , B41C2210/02 , B41C2210/06 , B41C2210/22 , B41C2210/262 , C08K5/53
摘要： The invention relates to a composition for positive heat sensitive CTP lithographic printing plates comprising a phenolic resin and an IR absorber characterized by the fact that it contains from 1 to 30% w/w of an organic oxygenated phosphorous compound chosen from the group of general formula (I): wherein R1, R2, R3 are independently: C3-C12 linear or branched alkyl; phenyl or heteroaryl eventually substituted with R4, wherein R4 is halogen, C1-C12 linear or branched alkyl, C1-C12 linear or branched alkoxyl; OR5 wherein R5 is C3-C12 linear or branched alkyl, phenyl or heteroaryl eventually substituted with R4, wherein R4 is halogen, C1-C12 linear or branched alkyl, C1-C12 linear or branched alkoxyl.
摘要翻译：本发明涉及一种用于阳性热敏CTP平版印刷版的组合物，其包含酚醛树脂和IR吸收剂，其特征在于其含有1至30％（重量）的有机氧化磷化合物，其选自通式（I）化合物：其中R 1，R 2，R 3，R 3独立地是C 3 -C 直链或支链烷基; 最后被R 4取代的苯基或杂芳基，其中R 4是卤素，C 1 -C 12直链或支链烷基，C 1 -C 12直链或支链烷氧基; 或其中R 5是C 3 -C 12直链或支链烷基，苯基或杂芳基，最后被 R 4，其中R 4是卤素，C 1 -C 12直链或支链烷基，C _{C 1 -C 12直链或支链烷氧基。}

16. 发明授权

US06340684B1 Phthalazine derivatives as phosphodiesterase 4 inhibitors 失效
标题翻译：酞嗪衍生物作为磷酸二酯酶4抑制剂
公开(公告)号：US06340684B1
公开(公告)日：2002-01-22
申请号：US09764983
申请日：2001-01-22
申请人： Mauro Napoletano , Gabriele Norcini , Giancarlo Grancini , Franco Pellacini , Gabriele Morazzoni
发明人： Mauro Napoletano , Gabriele Norcini , Giancarlo Grancini , Franco Pellacini , Gabriele Morazzoni
IPC分类号： A61K31502
CPC分类号： C07D401/06 , C07D237/30 , C07D237/32 , C07D237/34 , C07D405/06
摘要： The present invention provides a compound selected from the group including: N-3-acetyl-1-(3,5-dichloropyridin-4-ylmethyl)-5-cyclopentyloxy-6-methoxy-4H-phthalazine; 6,7-dimethoxy-1-pyridin-4-ylmethyl-4-thiazol-2-yl-phthalazine; 1-(6,7-dimethoxy-4-pyridin-4-ylmethyl-1H-phthalazin-2-yl)ethanone; 2-methanesulphonyl-6,7-dimethoxy-4-pyridin-4-ylmethyl-1,2-dihydrophthalazine; 2-formyl-6,7-dimethoxy-4-pyridin-4-ylmethyl-1,2-dihydrophthalazine; 1-(6,7-dimethoxy-4-pyridin-4-ylmethyl-1H-phthalazin-2-yl)-1-imidazol-1-ylmethanone; 1-(3,5-dichloro-pyridin-4-ylmethyl)-3-methansulphonyl-6-difluoromethoxy-5-(tetrahydro-furan-2-yloxy)-4H-phthalazine; N→O derivatives thereof; and pharmaceutically acceptable salts thereof. The invention also provides a pharmaceutical composition, which contains a therapeutically effective amount of the above compound in admixture with a pharmaceutically acceptable carrier.
摘要翻译：本发明提供了选自以下的化合物：N-3-乙酰基-1-（3,5-二氯吡啶-4-基甲基）-5-环戊基氧基-6-甲氧基-4H-酞嗪; 6,7-二甲氧基-1-吡啶-4-基甲基-4-噻唑-2-基 - 酞嗪; 1-（6,7-二甲氧基-4-吡啶-4-基甲基-1H-酞嗪-2-基）乙酮; 2-甲磺酰基-6,7-二甲氧基-4-吡啶-4-基甲基-1,2-二氢酞嗪; 2-甲酰基-6,7-二甲氧基-4-吡啶-4-基甲基-1,2-二氢酞嗪; 1-（6,7-二甲氧基-4-吡啶-4-基甲基-1H-酞嗪-2-基）-1-咪唑-1-基甲酮; 1-（3,5-二氯 - 吡啶-4-基甲基）-3-甲磺酰基-6-二氟甲氧基-5-（四氢 - 呋喃-2-基氧基）-4H-酞嗪; 其N-> O衍生物; 及其药学上可接受的盐。本发明还提供一种药物组合物，其含有治疗有效量的上述化合物与药学上可接受的载体的混合物。

17. 发明授权

US5438047A Diphosphates of catecholamines and pharmaceutical compositions containing them 失效
标题翻译：儿茶酚胺的二磷酸盐和含有它们的药物组合物
公开(公告)号：US5438047A
公开(公告)日：1995-08-01
申请号：US204394
申请日：1994-03-28
申请人： Francesco Santangelo , Cesare Casagrande , Gabriele Norcini
发明人： Francesco Santangelo , Cesare Casagrande , Gabriele Norcini
IPC分类号： C07F9/12 , A61K31/66
CPC分类号： C07F9/12
摘要： Diphosphates of catecholamines having formula (I) wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and X have the meanings reported in the description, are useful in the therapy of cardiovascular and renal diseases. ##STR1##
摘要翻译：式（I）的儿茶酚胺的二磷酸盐其中R，R 1，R 2，R 3，R 4，R 5，R 6，R 7和X具有说明书中报道的含义，可用于治疗心血管和肾脏疾病。（一）

18. 发明授权

US5151414A Phenoxyethyl amine compounds active on the cardiovascular system 失效
标题翻译：活性在心脏血管系统上的羟基乙胺化合物
公开(公告)号：US5151414A
公开(公告)日：1992-09-29
申请号：US738608
申请日：1991-07-31
申请人： Cesare Casagrande , Gabriele Norcini , Francesco Santangelo , Claudio Semeraro
发明人： Cesare Casagrande , Gabriele Norcini , Francesco Santangelo , Claudio Semeraro
IPC分类号： A61K31/135 , A61K31/215 , A61K31/265 , A61K31/27 , A61K31/33 , A61K31/66 , A61P9/00 , A61P9/08 , A61P9/12 , A61P25/28 , C07C217/14 , C07C217/20 , C07C219/26 , C07C219/28 , C07C271/44 , C07D521/00 , C07F9/12
CPC分类号： C07C271/44 , C07C217/20 , C07F9/12 , C07C2102/10
摘要： Compounds of formula ##STR1## (wherein R, R.sub.1, R.sub.2, R.sub.3, n, m and p have the meanings reported in the specification), their preparation and the compositions for pharmaceutical use containing them as active ingredient are described.The compounds of formula I have dopaminergic vasodilator activity and they may be used in pharmaceutical field.

19. 发明授权

US06492360B1 Phthalazine derivatives phosphodiesterase 4 inhibitors 失效
公开(公告)号：US06492360B1
公开(公告)日：2002-12-10
申请号：US09976436
申请日：2001-10-15
申请人： Mauro Napoletano , Gabriele Norcini , Giancarlo Grancini , Franco Pellacini , Gian Marco Leali , Gabriele Morazzoni
发明人： Mauro Napoletano , Gabriele Norcini , Giancarlo Grancini , Franco Pellacini , Gian Marco Leali , Gabriele Morazzoni
IPC分类号： A61K31502
CPC分类号： C07D401/06 , C07D237/30 , C07D237/32 , C07D237/34 , C07D401/14 , C07D405/06 , C07D417/04 , C07D417/14
摘要： Compounds of formula (I), wherein is a single or double bond; Z is NH, methylene, a (C2-C6)alkylene chain optionally branched and/or unsaturated and/or interrupted by a (C5-C7)cycloalkyl residue; A is phenyl or heterocycle optionally substituted or a COR4 group wherein R4 is hydroxy, (C1-C6)-alkoxy, amino optionally substituted; R is a (C1-C6)alkyl or polyfluoro(C1-C6)alkyl group; R1 is absent when is a double bond or, when is a single bond, is (a) hydrogen; (b) (C1-C6)alkyl optionally substituted; (c) —COR6 wherein R6 is hydrogen, aryl, aryl-(C1-C6)alkyl, amino optionally alkylated or monohydroxylated, hydroxy, (C1-C4)alkoxy, carboxy, (C1-C4)alkoxycarbonyl, formula (1), or (C1-C4)alkyl optionally substituted by heterocycle; (d) (C1-C4)-alkylsulfonyl; R2 represents two hydrogen atoms or a group —O when is a single bond, or, when is a double bond, R2 is hydrogen, cyano, (C1-C4)alkoxycarbonyl, amido, optionally substituted aryl or heterocycle, (C1-C8)alkyl, (C2-C8)alkenyl or (C2-C8)alkynyl optionally branched and/or substituted; aryloxy, heterocyclyloxy, aryl-(C1-C4)alkoxy, heterocyclyloxy-(C1-C4)alkoxy, amino substituted by one or two (C1-C4)-alkyl group(s), arylamino, heterocyclylamino, aryl-(C1-C4)alkylamino, heterocyclyl-(C1-C4)-alkylamino; R3 is hydrogen, or a (C1-C8)alkyl, (C2-C8)alkenyl or (C2-C8)alkynyl group optionally substituted, and optionally interrupted; the N→O derivatives of the compounds of formula (I) and the pharmaceutically acceptable salts thereof are PDE 4 inhibitors.

20. 发明授权

US06358973B1 Benzazine derivatives as phosphodiesterase 4 inhibitors 失效
标题翻译：苯并嗪衍生物作为磷酸二酯酶4抑制剂
公开(公告)号：US06358973B1
公开(公告)日：2002-03-19
申请号：US09806496
申请日：2001-04-13
申请人： Mauro Napoletano , Gabriele Norcini , Giancarlo Grancini , Franco Pellacini , Gabriele Morazzoni , Lorenzo Pradella
发明人： Mauro Napoletano , Gabriele Norcini , Giancarlo Grancini , Franco Pellacini , Gabriele Morazzoni , Lorenzo Pradella
IPC分类号： C07D4006
CPC分类号： C07D401/06
摘要： Compounds of formula I: wherein A is a heterocycle containing a nitrogen atom and optionally saturated or unsaturated and optionally further substituted by an oxo group (═O); R is: hydrogen, cyano, (C1-4)alkoxycarbonyl, carbamoyl; optionally substituted (C4-7)-cycloalkyl, aryl or heterocycle; (C1-8)alkyl, (C2-8)alkenyl or (C2-8)alkynyl optionally branched and/or substituted by (C4-7) cycloalkyl, aryl or heterocycle; aryloxy, heterocyclyloxy, aryl(C1-4)alkoxy, heterocyclyl(C1-4)alkoxy, amino substituted by one or two (C1-4)alkyl group(s), aryl-amino, heterocyclyl-amino, aryl(C1-4)alkyl-amino, or heterocyclyl(C1-4)alkylamino; Y is methylene or ethylene; W is an optionally substituted aryl or heterocycle; R1 is hydrogen, (C4-7)cycloalkyl or a (C2-8)alkyl, (C2-8)alkenyl or (C2-8)alkynyl group optionally substituted by hydroxy, oxo, (C4-7)cycloalkyl, aryl or heterocycle, and optionally interrupted by one or more heteroatom(s) or heterogroup(s); R2 is a (C1-6)alkyl or polyfluoro(C1-6)alkyl group; the N→O derivatives of the compounds of formula I and the pharmaceutically acceptable salts thereof. The compounds of formula (I) are PDE 4 inhibitors and may be used in compositions and methods involving PDE 4 inhibition.
摘要翻译：式I化合物：其中A是含有氮原子，任选饱和或不饱和并任选进一步被氧代基（= O）取代的杂环; R为：氢，氰基，（C 1-4）烷氧基羰基，氨基甲酰基; 任选取代的（C 4-7） - 环烷基，芳基或杂环; （C 1-8）烷基，（C 2-8）烯基或任选被（C 4-7）环烷基，芳基或杂环支链和/或取代的（C 2-8）炔基; 芳氧基，杂环氧基，芳基（C 1-4）烷氧基，杂环基（C 1-4）烷氧基，被一个或两个（C 1-4）烷基取代的氨基，芳基 - 氨基，杂环基 - 氨基，芳基）烷基 - 氨基或杂环基（C 1-4）烷基氨基; Y是亚甲基或亚乙基; W是任选取代的芳基或杂环; R1是氢，（C4-7）环烷基或（C2-8）烷基，（C2-8）烯基或（C2-8）炔基，任选被羟基，氧代，（C 4-7）环烷基，芳基或杂环并且任选被一个或多个杂原子或杂团中断; R2是（C1-6）烷基或多氟（C1-6）烷基; 式I化合物的N-> O衍生物及其药学上可接受的盐。式（I）化合物是PDE 4抑制剂，可用于涉及PDE4抑制的组合物和方法。

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