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12. 发明申请

US20150366866A1 METHODS OF TREATING CHOLANGIOCARCINOMA 审中-公开
标题翻译：治疗胆囊癌的方法
公开(公告)号：US20150366866A1
公开(公告)日：2015-12-24
申请号：US14761518
申请日：2014-01-17
申请人： Vincent A. Miller , FOUNDATION MEDICINE, INC.
发明人： Siraj Mahamed Ali , Matthew J. Hawryluk , Jie He , Doron Lipson , Vincent A. Miller , Jeffrey S. Ross , Philip James Stephens
IPC分类号： A61K31/5025 , C07K16/40 , C12Q1/68 , G01N33/573 , C12N9/12 , A61K31/4412 , C12N15/113
CPC分类号： A61K31/5025 , A61K31/404 , A61K31/435 , A61K31/4412 , A61K31/4439 , A61K31/47 , A61K31/496 , A61K31/498 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/5383 , A61K31/553 , A61K45/06 , C07K14/705 , C07K14/71 , C07K16/40 , C07K2319/00 , C12N9/12 , C12N15/1137 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12Q1/6883 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158 , C12Y207/10001 , G01N33/573 , G01N2333/912 , G01N2500/04
摘要： Methods and compositions for treating cholangiocarcinoma.
摘要翻译：治疗胆管癌的方法和组合物。

13. 发明申请

US20140221329A1 NOVEL ESTROGEN RECEPTOR MUTATIONS AND USES THEREOF 审中-公开
标题翻译：新雌激素受体突变及其用途
公开(公告)号：US20140221329A1
公开(公告)日：2014-08-07
申请号：US14251856
申请日：2014-04-14
申请人： FOUNDATION MEDICINE, INC.
发明人： Maureen T. Cronin , Garrett Michael Frampton , Doron Lipson , Vincent A. Miller , Gary Palmer , Jeffrey S. Ross , Philip James Stephens , Roman Yelensky
IPC分类号： C12Q1/68 , A61K31/439 , A61K31/567
CPC分类号： C12Q1/6886 , A61K31/416 , A61K31/4196 , A61K31/423 , A61K31/428 , A61K31/436 , A61K31/437 , A61K31/439 , A61K31/4439 , A61K31/472 , A61K31/536 , A61K31/5415 , A61K31/565 , A61K31/567 , A61K31/675 , A61K45/06 , C07K14/72 , C07K16/2869 , C07K2317/34 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156
摘要： Novel mutant ESR1 molecules and uses are disclosed.
摘要翻译：公开了新型突变体ESR1分子和用途。

16. 发明授权

US11450438B2 System and method for outcome tracking and analysis 有权
公开(公告)号：US11450438B2
公开(公告)日：2022-09-20
申请号：US16579496
申请日：2019-09-23
申请人： FOUNDATION MEDICINE, INC.
发明人： Michael Pellini , Gary Palmer , Mary Patricia Lancelotta , Matthew J. Hawryluk , Vincent A. Miller
IPC分类号： G16H70/60 , G16B30/00 , G16H15/00 , G16H10/60 , G16H10/20 , G16H50/20 , G16H20/10
摘要： A system for tracking and analyzing cancer treatment and outcome information includes a user interface (UI) component for allowing selection of an alteration, an affected gene, an affected pathway, a tumor type, and/or a treatment; a processor configured to receive treatment information and outcome information associated with a patient population; organize the treatment information and the outcome information into at least one tuple; and generate outcome summary information; and an analysis component configured to compare a current patient record for a current patient to existing treatment information for the patient population, identify similar patients in the patient population based on information in the current patient record, and filter a grouping of similar patients; the processor is further configured to display, on the UI component, the outcome summary information; enable navigation within the treatment and outcome information; and identify, based on the outcome information, an appropriate treatment for the current patient.

18. 发明授权

US10093983B2 Estrogen receptor mutations and uses thereof 有权
公开(公告)号：US10093983B2
公开(公告)日：2018-10-09
申请号：US14753397
申请日：2015-06-29
申请人： FOUNDATION MEDICINE, INC.
发明人： Maureen T. Cronin , Garrett Michael Frampton , Doron Lipson , Vincent A. Miller , Gary Palmer , Jeffrey S. Ross , Philip James Stephens , Roman Yelensky
IPC分类号： G01N33/53 , C12Q1/6886 , A61K31/4196 , A61K31/565 , A61K31/675 , A61K31/439 , A61K31/567 , A61K31/416 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/4439 , A61K31/472 , A61K31/536 , A61K31/5415 , A61K45/06 , C07K14/72 , C07K16/28 , A61K31/436
摘要： Novel mutant ESR1 molecules and uses are disclosed.

19. 发明申请

US20140337052A1 SYSTEM AND METHOD FOR OUTCOME TRACKING AND ANALYSIS 审中-公开
标题翻译：用于观察跟踪和分析的系统和方法
公开(公告)号：US20140337052A1
公开(公告)日：2014-11-13
申请号：US14146742
申请日：2014-01-03
申请人： FOUNDATION MEDICINE, INC.
发明人： Michael Pellini , Gary Palmer , Mary P. Lancelotta , Matthew J. Hawryluk , Vincent A. Miller
IPC分类号： G06F19/00
CPC分类号： G06F19/3456 , G06F19/32 , G06Q50/24 , G16B30/00 , G16H10/60 , G16H15/00
摘要： Provided are systems and methods for capturing outcome information associated with various cancer treatments. The system facilitates capture and analysis of cancer treatment information and associated outcome information. The treatment and outcome information can include genomic analysis and information on treatment of different cancers. The system can store and analyze any one or more of: tumor type, genomic alterations (e.g., genes and associated alterations, gene sequence mutations, alterations, amplifications, deletions, etc.), and treatment data (including, for example, treatments targeted to specific genes and/or genomic alterations). Users of the outcome system can supply and use the treatment and outcome information to facilitate diagnosis and therapy decisions. User interfaces within the system can be configured to allow users to easily locate outcome information associated with particular treatments of tumors having certain genomic alterations.
摘要翻译：提供了用于捕获与各种癌症治疗相关的结果信息的系统和方法。该系统有助于捕获和分析癌症治疗信息和相关的结果信息。治疗和结果信息可以包括基因组分析和治疗不同癌症的信息。该系统可以存储和分析以下中的一种或多种：肿瘤类型，基因组改变（例如，基因和相关的改变，基因序列突变，改变，扩增，缺失等）和治疗数据（包括例如靶向治疗到特定基因和/或基因组改变）。结果系统的用户可以提供和使用治疗和结果信息来促进诊断和治疗决策。可以将系统内的用户界面配置为允许用户轻松定位与具有某些基因组改变的肿瘤的特定治疗相关联的结果信息。

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