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    • 16. 发明授权
    • Production of carboxylic acids from carbonylation of alcohol
    • 从醇的羰基化生产羧酸
    • US5227519A
    • 1993-07-13
    • US840175
    • 1992-02-24
    • Ying-Chih LinYeong-Cheong Lee
    • Ying-Chih LinYeong-Cheong Lee
    • C07C51/12
    • C07C51/12
    • This invention relates to an improved process for synthesizing carboxylic acids by the carbonylation of alcohol. An alcohol such as methanol is reacted with carbon monoxide in a liquid reaction medium containing a rhodium (Rh) catalyst stabilized with an haloacetic acid, especially trifluoroacetic acid (TFAA), along with alkyl iodide such as methyl iodide (MeI) in specified proportions. The present reaction system is not only characterized by unexpectedly high catalyst stability, but also characterized by the high reaction rate for the formation of acetic acid. The improvement resides in the employment of trifluoroacetic acid as the catalyst promoter at a temperature from 180.degree. C. to 200.degree. C. The primary advantage of the catalyst system of this invention is the enhancement of the rate of carbonylation. The other advantage of the catalyst system is that they are readily soluble and thermally stable, making them resistant to deposition.
    • 本发明涉及通过醇的羰基化合成羧酸的改进方法。 醇等甲醇与含有用卤代乙酸特别是三氟乙酸(TFAA)稳定的铑(Rh)催化剂的液体反应介质一起与一氧化碳一起与特定比例的碘代甲烷(MeI)等烷基碘反应。 本反应体系不仅具有意想不到的高催化剂稳定性,而且其特征还在于形成乙酸的反应速度高。 改进在于在180℃至200℃的温度下使用三氟乙酸作为催化剂促进剂。本发明的催化剂体系的主要优点是提高了羰基化速率。 催化剂体系的另一个优点是它们易于溶解和热稳定,使其具有耐沉积性。