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11. 发明申请

US20090048313A1 2-AMIDO-THIAZOLE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF 有权
标题翻译：展示ATP-利用酶抑制活性的2-氨基 - 噻唑基化合物及其组合物及其用途
公开(公告)号：US20090048313A1
公开(公告)日：2009-02-19
申请号：US12167908
申请日：2008-07-03
申请人： John K. Dickson, JR. , Carl Nicholas Hodge , Jose Serafin Mendoza , Ke Chen
发明人： John K. Dickson, JR. , Carl Nicholas Hodge , Jose Serafin Mendoza , Ke Chen
IPC分类号： A61K31/426 , A61P3/00 , A61P19/00 , A61P35/00 , A61P9/00
CPC分类号： C07D417/04 , C07D277/46 , C07D417/12 , C07D417/14
摘要： 2-Amido-4-substituted-aryl-thiazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, methods of using compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions comprising compounds exhibiting ATP-utilizing enzyme inhibitory activity, are disclosed.
摘要翻译：公开了具有ATP利用酶抑制活性的2-酰氨基-4-取代 - 芳基 - 噻唑基化合物，使用显示出ATP-利用酶抑制活性的化合物的方法，以及包含显示出ATP-利用酶抑制活性的化合物的组合物。

12. 发明授权

US6071930A Method for treating tumors using 2-aryl-naphthyridin-4-ones 失效
标题翻译：使用2-芳基 - 萘啶-4-酮治疗肿瘤的方法
公开(公告)号：US6071930A
公开(公告)日：2000-06-06
申请号：US363101
申请日：1999-07-29
申请人： Kuo-Hsiung Lee , Ke Chen , Sheng-Chu Kuo
发明人： Kuo-Hsiung Lee , Ke Chen , Sheng-Chu Kuo
IPC分类号： A61K31/4375 , A61P17/06 , A61P19/06 , A61P35/00 , A61P43/00 , C07D213/74 , C07D471/04
CPC分类号： C07D213/74 , C07D471/04
摘要： The present invention provides compounds of Formula I: ##STR1## wherein A and R.sub.1 -R.sub.8 are defined herein. The compounds of Formula I inhibit the polymerization of tubulin and possess antimitotic activity. The compounds of Formula I may be useful for the treatment of psoriasis, gout, papiloma, warts, and a variety of tumors.
摘要翻译：本发明提供式I化合物：其中A和R 1 -R 8在本文中定义。式I的化合物抑制微管蛋白的聚合并具有抗生物活性。式I的化合物可用于治疗牛皮癣，痛风，乳头状瘤，疣和各种肿瘤。

13. 发明授权

US5359662A Active noise control system 失效
标题翻译：主动噪声控制系统
公开(公告)号：US5359662A
公开(公告)日：1994-10-25
申请号：US875775
申请日：1992-04-29
申请人： Yi Yuan , Nick S. Kapsokavathis , Ke Chen , Sen M. Kuo
发明人： Yi Yuan , Nick S. Kapsokavathis , Ke Chen , Sen M. Kuo
IPC分类号： G10K11/178 , G10K11/16
CPC分类号： G10K11/1786 , G10K2210/1282 , G10K2210/3032 , G10K2210/3039 , G10K2210/3042 , G10K2210/3046 , G10K2210/3211 , G10K2210/3212 , G10K2210/511
摘要： A active noise control system is described for attenuating an undesirable noise that containing multiple noise components having different frequencies. The system includes a configuration of signal generators and corresponding paired adaptive filters. Each signal generator produces a generator output signal containing one or more sinusoidal signal components, with each signal component having a frequency corresponding to a respective one of the noise frequency components. Separate signal generators are used to produce those sinusoidal components having frequencies corresponding to noise component that are adjacent with respect to their frequencies. Each adaptive filter operates on the generator output signal produced by its corresponding paired signal generator in accordance with its filtering characteristics to provide a respective filtered output signal. The filtered output signals from each adaptive filter are summed to obtain an output canceling signal, which drives an actuator to produce output canceling waves that are superpositioned with the undesirable noise. An error sensor measures the level of residual noise resulting from the superposition of the canceling waves and the undesirable noise, and provides an error signal for adapting the characteristics of the adaptive filters so as to minimize the level of residual noise.
摘要翻译：描述了一种主动噪声控制系统，用于衰减包含具有不同频率的多个噪声分量的不期望的噪声。该系统包括信号发生器和相应的配对自适应滤波器的配置。每个信号发生器产生包含一个或多个正弦信号分量的发生器输出信号，每个信号分量具有对应于噪声频率分量中的相应一个的频率。单独的信号发生器用于产生具有对应于相对于其频率相邻的噪声分量的频率的那些正弦分量。每个自适应滤波器根据其对应的配对信号发生器根据其滤波特性产生的发生器输出信号进行操作，以提供相应的滤波输出信号。将来自每个自适应滤波器的经滤波的输出信号相加以获得输出抵消信号，其驱动致动器以产生与不期望的噪声叠加的输出消除波。误差传感器测量由消除波的叠加和不期望的噪声引起的残余噪声的水平，并且提供用于适应自适应滤波器的特性的误差信号，以便使残余噪声的水平最小化。

14. 发明申请

US20210232014A1 ELECTROCHROMIC DEVICES WITH INCREASED LIFETIME 有权
公开(公告)号：US20210232014A1
公开(公告)日：2021-07-29
申请号：US17126926
申请日：2020-12-18
申请人： Jianguo Mei , Kejie Zhao , Ke Chen , Xiaokang Wang
发明人： Jianguo Mei , Kejie Zhao , Ke Chen , Xiaokang Wang
IPC分类号： G02F1/161 , G02F1/155 , G02F1/1516
摘要： An electrochromic device, including a first transparent conductor layer, an electrochromic layer, a toughened interface layer positioned between and operationally connected in electric communication with the first transparent conductor layer and the electrochromic layer, an electrolyte operationally connected to the electrochromic layer, an ion storage layer operationally connected to the solid electrolyte layer, and a second transparent conductor layer operationally connected to the ion storage layer. The electrochromic device remains substantially free of interfacial delamination between the first transparent conductive and the electrochromic layer for at least 10,000 duty cycles.

15. 发明授权

US07795290B2 2-amido-thiazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof 有权
标题翻译：具有ATP-利用酶抑制活性的2-酰氨基 - 噻唑类化合物及其组合物及其用途
公开(公告)号：US07795290B2
公开(公告)日：2010-09-14
申请号：US12167908
申请日：2008-07-03
申请人： John K. Dickson, Jr. , Carl Nicholas Hodge , Jose Serafin Mendoza , Ke Chen
发明人： John K. Dickson, Jr. , Carl Nicholas Hodge , Jose Serafin Mendoza , Ke Chen
IPC分类号： A61K31/426 , A61K31/427 , C07D277/28
CPC分类号： C07D417/04 , C07D277/46 , C07D417/12 , C07D417/14
摘要： 2-Amido-4-substituted-aryl-thiazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, methods of using compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions comprising compounds exhibiting ATP-utilizing enzyme inhibitory activity, are disclosed.
摘要翻译：公开了具有ATP利用酶抑制活性的2-酰氨基-4-取代 - 芳基 - 噻唑基化合物，使用显示出ATP-利用酶抑制活性的化合物的方法，以及包含显示出ATP-利用酶抑制活性的化合物的组合物。

16. 发明授权

US07410988B2 2-Amido-thiazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof 有权
标题翻译：具有ATP利用酶抑制活性的2-酰氨基 - 噻唑类化合物及其组合物及其用途
公开(公告)号：US07410988B2
公开(公告)日：2008-08-12
申请号：US11202927
申请日：2005-08-11
申请人： John K. Dickson, Jr. , Carl Nicholas Hodge , Jose Serafin Mendoza , Ke Chen
发明人： John K. Dickson, Jr. , Carl Nicholas Hodge , Jose Serafin Mendoza , Ke Chen
IPC分类号： A61K31/426 , C07D277/28
CPC分类号： C07D417/04 , C07D277/46 , C07D417/12 , C07D417/14
摘要： 2-Amido-4-substituted-aryl-thiazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, methods of using compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions comprising compounds exhibiting ATP-utilizing enzyme inhibitory activity, are disclosed.
摘要翻译：公开了具有ATP利用酶抑制活性的2-酰氨基-4-取代 - 芳基 - 噻唑基化合物，使用显示出ATP-利用酶抑制活性的化合物的方法，以及包含显示出ATP-利用酶抑制活性的化合物的组合物。

17. 发明授权

US10152778B2 Real-time face beautification features for video images 有权
公开(公告)号：US10152778B2
公开(公告)日：2018-12-11
申请号：US15127787
申请日：2015-09-11
申请人： INTEL CORPORATION , Ke Chen , Zhipin Deng , Xiaoxia Cai , Chen Wang , Yi-Jen Chiu , Ya-ti Peng , Lidong Xu
发明人： Ke Chen , Zhipin Deng , Xiaoxia Cai , Chen Wang , Yi-Jen Chiu , Ya-Ti Peng , Lidong Xu
IPC分类号： G06T5/20 , G06K9/00 , G06T3/00 , G06T11/60
摘要： Systems, apparatus, articles, and methods are described below including operations for real-time face beautification features for video images.

18. 发明申请

US20080242709A1 2-AMIDO-4-ISOXAZOLYL THIAZOLE COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF 审中-公开
标题翻译：展示ATP-利用酶抑制活性的2-氨基-4-异丙唑噻唑化合物及其组合物及其用途
公开(公告)号：US20080242709A1
公开(公告)日：2008-10-02
申请号：US11836528
申请日：2007-08-09
申请人： John K. Dickson , Carl Nicholas Hodge , Ke Chen
发明人： John K. Dickson , Carl Nicholas Hodge , Ke Chen
IPC分类号： A61K31/427 , C07D277/28 , A61P35/00
CPC分类号： C07D471/04 , C07D417/14
摘要： 2-Amido-4-isoxazolyl thiazole compounds exhibiting ATP-utilizing enzyme inhibitory activity, methods of using compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions comprising compounds exhibiting ATP-utilizing enzyme inhibitory activity, are disclosed.
摘要翻译：公开了表现出ATP利用酶抑制活性的2-酰氨基-4-异恶唑噻唑化合物，使用表现出ATP-利用酶抑制活性的化合物的方法，以及包含显示出ATP-利用酶抑制活性的化合物的组合物。

19. 发明申请

US20070287706A1 Certain substituted quinolones, compositions, and uses thereof 审中-公开
标题翻译：某些取代的喹诺酮类，组合物及其用途
公开(公告)号：US20070287706A1
公开(公告)日：2007-12-13
申请号：US11803140
申请日：2007-05-10
申请人： John Dickson , Ke Chen , Carl Hodge
发明人： John Dickson , Ke Chen , Carl Hodge
IPC分类号： A61K31/47 , A61K31/538 , A61P11/06 , A61P17/06 , A61P19/02 , A61P25/16 , A61P25/28 , A61P27/02 , A61P27/06 , A61P3/04 , A61P3/10 , A61P31/04 , A61P31/10 , A61P31/12 , A61P35/00 , A61P35/02 , A61P9/00 , C07D215/227 , C07D265/36
CPC分类号： C07D215/227 , C07D215/22
摘要： Certain quinolone-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, methods of using compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions comprising compounds exhibiting ATP-utilizing enzyme inhibitory activity, are disclosed.
摘要翻译：公开了一些具有ATP利用酶抑制活性的喹诺酮类化合物，使用表现出ATP-利用酶抑制活性的化合物的方法，以及包含表现出ATP-利用酶抑制活性的化合物的组合物。

20. 发明授权

US06229016B1 Method for treating tumors using 2-aryl-naphthyridin-4-ones 失效
标题翻译：使用2-芳基 - 萘啶-4-酮治疗肿瘤的方法
公开(公告)号：US06229016B1
公开(公告)日：2001-05-08
申请号：US09536436
申请日：2000-03-27
申请人： Kuo-Hsiung Lee , Ke Chen , Sheng-Chu Kuo
发明人： Kuo-Hsiung Lee , Ke Chen , Sheng-Chu Kuo
IPC分类号： C07D47102
CPC分类号： C07D213/74 , C07D471/04
摘要： The present invention provides compounds of Formula I: wherein A and R1-R8 are defined herein. The compounds of Formula I inhibit the polymerization of tubulin and possess antimitotic activity. The compounds of Formula I may be useful for the treatment of psoriasis, gout, papiloma, warts, and a variety of tumors.
摘要翻译：本发明提供式I化合物：其中A和R 1 -R 8在本文中定义。式I的化合物抑制微管蛋白的聚合并具有抗生物活性。式I的化合物可用于治疗牛皮癣，痛风，乳头状瘤，疣和各种肿瘤。

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