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11. 发明授权

US09512109B2 Agonists that enhance binding of integrin-expressing cells to integrin receptors 有权
标题翻译：增强整合素表达细胞与整联蛋白受体结合的激动剂
公开(公告)号：US09512109B2
公开(公告)日：2016-12-06
申请号：US13885537
申请日：2011-11-16
申请人： Ronald J. Biediger , William C. Gundlach, IV , Robert V. Market , Michael M. Savage , Peter Vanderslice
发明人： Ronald J. Biediger , William C. Gundlach, IV , Robert V. Market , Michael M. Savage , Peter Vanderslice
IPC分类号： C07D333/20 , C07D409/14 , C07D275/02 , A61K47/48 , C07C271/20 , C07C311/08 , C07D213/64 , C07D317/60 , A61K35/17 , A61K35/51 , C07D333/10 , C07D409/12 , C07D413/14 , A61K35/12 , C07C229/34 , C07C271/22 , C07D333/24
CPC分类号： C07D333/20 , A61K35/12 , A61K35/17 , A61K35/51 , C07C229/34 , C07C271/20 , C07C271/22 , C07C311/08 , C07D213/64 , C07D275/02 , C07D317/60 , C07D333/10 , C07D333/24 , C07D409/12 , C07D409/14 , C07D413/14
摘要： A method of enhancing binding of cells to an integrin-binding ligand comprises treating integrin-expressing cells in vitro with an agonist of integrin, wherein the integrin is selected from the group consisting of α4β1, α5β1, α4β7, αvβ3 and αLβ2, and contacting the treated cells with an integrin-binding ligand; integrin agonist compounds having the general formula I; methods of treating integrin-expressing cells with such agonists to enhance binding; and therapeutic methods comprising administering agonist-treated cells or agonist compounds to a mammal.
摘要翻译：增强细胞与整联蛋白结合配体的结合的方法包括用整联蛋白激动剂在体外处理整联蛋白表达细胞，其中所述整联蛋白选自α4β1，α5β1，α4β7，αvβ3和αLβ2，并使用整联蛋白结合配体处理的细胞; 具有通式I的整联蛋白激动剂化合物; 用这种激动剂治疗整合素表达细胞以增强结合的方法; 和包括向哺乳动物施用经激动剂处理的细胞或激动剂化合物的治疗方法。

12. 发明申请

US20130236434A1 AGONISTS THAT ENHANCE BINDING OF INTEGRIN-EXPRESSING CELLS TO INTEGRIN RECEPTORS 有权
标题翻译：增强整合表达细胞以激活受体的激素
公开(公告)号：US20130236434A1
公开(公告)日：2013-09-12
申请号：US13885537
申请日：2011-11-16
申请人： Ronald J. Biediger , William C. Gundlach, IV , Robert V. Market , Michael M. Savage , Peter Vanderslice
发明人： Ronald J. Biediger , William C. Gundlach, IV , Robert V. Market , Michael M. Savage , Peter Vanderslice
IPC分类号： A61K47/48 , C07D317/60 , C07D275/02 , C07D213/64 , C07D409/14 , C07C271/20 , C07D333/20 , C07C311/08
CPC分类号： C07D333/20 , A61K35/12 , A61K35/17 , A61K35/51 , C07C229/34 , C07C271/20 , C07C271/22 , C07C311/08 , C07D213/64 , C07D275/02 , C07D317/60 , C07D333/10 , C07D333/24 , C07D409/12 , C07D409/14 , C07D413/14
摘要： A method of enhancing binding of cells to an integrin-binding ligand comprises treating integrin-expressing cells in vitro with an agonist of integrin, wherein the integrin is selected from the group consisting of α4β1, α5β1, α4β7, αvβ3 and αLβ2, and contacting the treated cells with an integrin-binding ligand; integrin agonist compounds having the general formula I; methods of treating integrin-expressing cells with such agonists to enhance binding; and therapeutic methods comprising administering agonist-treated cells or agonist compounds to a mammal.
摘要翻译：增强细胞与整联蛋白结合配体的结合的方法包括用整联蛋白激动剂在体外处理整联蛋白表达细胞，其中所述整联蛋白选自α4β1，α5β1，α4β7，alphavbeta3和αLβ2，并使用整联蛋白结合配体处理的细胞; 具有通式I的整联蛋白激动剂化合物; 用这种激动剂治疗整合素表达细胞以增强结合的方法; 和包括向哺乳动物施用经激动剂处理的细胞或激动剂化合物的治疗方法。

13. 发明授权

US6096773A Compounds that inhibit the binding of integrins to their receptors 有权
标题翻译：抑制整联蛋白与其受体结合的化合物
公开(公告)号：US6096773A
公开(公告)日：2000-08-01
申请号：US292459
申请日：1999-04-15
申请人： Ian L. Scott , Bore G. Raju , Ronald J. Biediger , Vanessa O. Grabbe , Jamal Kassir , Karin M. Keller , Timothy P. Kogan, deceased , Shuqun Lin , Robert V. Market
发明人： Ian L. Scott , Bore G. Raju , Ronald J. Biediger , Vanessa O. Grabbe , Jamal Kassir , Karin M. Keller , Timothy P. Kogan, deceased , Shuqun Lin , Robert V. Market
IPC分类号： C07D317/44 , A61K31/16 , A61K31/357 , A61K31/36 , A61K31/38 , A61K31/381 , A61K31/404 , A61K31/4184 , A61K31/425 , A61K31/427 , A61K31/443 , A61K31/4433 , A61K31/4525 , A61K31/495 , A61K31/496 , A61K31/5377 , A61P1/04 , A61P3/10 , A61P9/10 , A61P11/06 , A61P17/00 , A61P19/02 , A61P25/00 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07C233/00 , C07D233/02 , C07D277/30 , C07D317/60 , C07D333/20 , C07D333/24 , C07D333/36 , C07D405/00 , C07D405/12 , C07D405/14 , C07D409/00 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , A61K31/19 , A61K31/41 , C07D317/50
CPC分类号： C07D417/14 , C07D317/60 , C07D333/20 , C07D333/24 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14
摘要： A method for the inhibition of the binding of .alpha..sub.4 .beta..sub.1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions comprising such compounds; and the use of such compounds either as above, or in formulations for the control or prevention of diseases states in which .alpha..sub.4 .beta..sub.1 is involved.
摘要翻译：抑制α4β1整联蛋白与其受体结合的方法，例如VCAM-1（血管细胞粘附分子-1）和纤连蛋白; 抑制这种结合的化合物; 包含这些化合物的药物活性组合物; 以及如上所述或在用于控制或预防涉及α4β1的疾病状态的制剂中的这些化合物的使用。

14. 发明授权

US06194448B1 N, N-disubstituted amides that inhibit the binding of integrins to their receptors 有权
标题翻译：抑制整联蛋白与其受体结合的N，N-二取代酰胺
公开(公告)号：US06194448B1
公开(公告)日：2001-02-27
申请号：US09417857
申请日：1999-10-14
申请人： Ronald J. Biediger , Vanessa O. Grabbe , George W. Holland , Jamal M. Kassir , Timothy P. Kogan , Shuqun Lin , Robert V. Market , Bore G. Raju , Ian L. Scott , Chengde Wu
发明人： Ronald J. Biediger , Vanessa O. Grabbe , George W. Holland , Jamal M. Kassir , Timothy P. Kogan , Shuqun Lin , Robert V. Market , Bore G. Raju , Ian L. Scott , Chengde Wu
IPC分类号： A61K3138
CPC分类号： C07D417/14 , C07D317/60 , C07D333/20 , C07D333/24 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14
摘要： A method for the inhibition of the binding of &agr;4&bgr;1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions comprising such compounds; and the use of such compounds either as above, or in formulations for the control or prevention of diseases states in which &agr;4&bgr;1 is involved.
摘要翻译：抑制α4β1整联蛋白与其受体结合的方法，例如VCAM-1（血管细胞粘附分子-1）和纤连蛋白; 抑制这种结合的化合物; 包含这些化合物的药物活性组合物; 以及使用上述化合物或在制剂中用于控制或预防涉及α4β1的疾病状态。

15. 发明授权

US06262084B1 Compounds that inhibit the binding of integrins to their receptors 有权
标题翻译：抑制整联蛋白与其受体结合的化合物
公开(公告)号：US06262084B1
公开(公告)日：2001-07-17
申请号：US09417886
申请日：1999-10-14
申请人： Ronald J. Biediger , Vanessa O. Grabbe , George W. Holland , Jamal Kassir , Karin M. Keller , Timothy P. Kogan , Shuqun Lin , Robert V. Market , Bore G. Raju , Ian L. Scott , Chengde Wu
发明人： Ronald J. Biediger , Vanessa O. Grabbe , George W. Holland , Jamal Kassir , Karin M. Keller , Timothy P. Kogan , Shuqun Lin , Robert V. Market , Bore G. Raju , Ian L. Scott , Chengde Wu
IPC分类号： A61K31192
CPC分类号： C07D417/14 , C07D317/60 , C07D333/20 , C07D333/24 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14
摘要： A method for the inhibition of the binding of &agr;4&bgr;1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions thereof; and the use of the compounds either as above, or in formulations for the control or prevention of diseases states in which &agr;4&bgr;1 is involved.
摘要翻译：抑制α4β1整联蛋白与其受体结合的方法，例如VCAM-1（血管细胞粘附分子-1）和纤连蛋白; 抑制这种结合的化合物; 其药物活性组合物; 以及如上所述的化合物或用于控制或预防涉及α4β1的疾病状态的制剂中的用途。

16. 发明授权

US06972296B2 Carboxylic acid derivatives that inhibit the binding of integrins to their receptors 有权
标题翻译：抑制整联蛋白与其受体结合的羧酸衍生物
公开(公告)号：US06972296B2
公开(公告)日：2005-12-06
申请号：US09973142
申请日：2001-10-09
申请人： Ronald J. Biediger , Qi Chen , E. Radford Decker , George W. Holland , Jamal M. Kassir , Wen Li , Robert V. Market , Ian L. Scott , Chengde Wu , Jian Li
发明人： Ronald J. Biediger , Qi Chen , E. Radford Decker , George W. Holland , Jamal M. Kassir , Wen Li , Robert V. Market , Ian L. Scott , Chengde Wu , Jian Li
IPC分类号： C07D221/04 , A61K31/435 , A61K31/44 , A61K31/4412 , A61K31/4704 , A61K31/495 , A61K31/50 , A61K31/505 , A61P1/00 , A61P3/10 , A61P9/10 , A61P11/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/08 , C07D207/416 , C07D211/86 , C07D213/02 , C07D213/62 , C07D213/69 , C07D213/72 , C07D213/75 , C07D215/22 , C07D215/38 , C07D221/16 , C07D237/16 , C07D237/22 , C07D239/28 , C07D239/46 , C07D239/47 , C07D317/46 , C07D317/60 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/06 , C07D471/04 , C07D498/04 , C07K14/78 , C07D211/72
CPC分类号： C07D213/75 , C07D215/22 , C07D221/04 , C07D221/16 , C07D237/22 , C07D239/47 , C07D317/60 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D417/06 , C07D471/04
摘要： A method for the inhibition of the binding of α4β1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions comprising such compounds; and to the use of such compounds either a above, or in formulations for the control or prevention of diseases states in which α4β1 is involved.
摘要翻译：用于抑制α4A/β1整联蛋白与其受体例如VCAM-1（血管细胞粘附分子-1）和纤连蛋白的结合的方法; 抑制这种结合的化合物; 包含这些化合物的药物活性组合物; 以及上述或在制剂中使用这些化合物用于控制或预防涉及α4β1的疾病状态。

17. 发明授权

US07812038B2 Carboxylic acid derivatives that inhibit the binding of integrins to their receptors 有权
标题翻译：抑制整联蛋白与其受体结合的羧酸衍生物
公开(公告)号：US07812038B2
公开(公告)日：2010-10-12
申请号：US11152695
申请日：2005-06-14
申请人： Ronald J. Biediger , Qi Chen , E. Radford Decker , George W. Holland , Jamal M. Kassir , Wen Li , Robert V. Market , Ian L. Scott , Chengde Wu , Jian Li
发明人： Ronald J. Biediger , Qi Chen , E. Radford Decker , George W. Holland , Jamal M. Kassir , Wen Li , Robert V. Market , Ian L. Scott , Chengde Wu , Jian Li
IPC分类号： A61K31/4412
CPC分类号： C07D213/75 , C07D215/22 , C07D221/04 , C07D221/16 , C07D237/22 , C07D239/47 , C07D317/60 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D417/06 , C07D471/04
摘要： A method for the inhibition of the binding of α4β1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions comprising such compounds; and to the use of such compounds either a above, or in formulations for the control or prevention of diseases states in which α4β1 is involved.
摘要翻译：抑制α4和bgr1整联蛋白与其受体例如VCAM-1（血管细胞粘附分子-1）和纤连蛋白的结合的方法; 抑制这种结合的化合物; 包含这些化合物的药物活性组合物; 以及使用上述化合物或用于控制或预防涉及α4和bgr1的疾病状态的制剂。

18. 发明授权

US07288538B2 Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists 失效
公开(公告)号：US07288538B2
公开(公告)日：2007-10-30
申请号：US10924180
申请日：2004-08-23
申请人： Chengde Wu , Daxin Gao , Ronald Biediger , Jie Chen , Robert V. Market
发明人： Chengde Wu , Daxin Gao , Ronald Biediger , Jie Chen , Robert V. Market
IPC分类号： A61K31/5375 , A61K31/4523 , A61K31/4025 , A61K31/381 , C07D413/10 , C07D409/10
CPC分类号： C07D207/16 , A61K31/16 , A61K31/40 , A61K31/445 , A61K31/497 , C07D209/08 , C07D209/44 , C07D213/74 , C07D237/08 , C07D239/26 , C07D241/42 , C07D295/135 , C07D333/38 , C07D401/12 , C07D403/12 , C07D409/12
摘要： The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use.

19. 发明授权

US5344555A Treatment of oils using reaction products of epoxides and tertiary amines 失效
标题翻译：使用环氧化物和叔胺的反应产物处理油
公开(公告)号：US5344555A
公开(公告)日：1994-09-06
申请号：US21655
申请日：1993-02-22
申请人： Glenn L. Roof , Lawrence N. Kremer , Robert V. Market
发明人： Glenn L. Roof , Lawrence N. Kremer , Robert V. Market
IPC分类号： C10G21/20 , C10G29/20
CPC分类号： C10G29/20
摘要： Sour sulfhydryl group containing oils are treated with an effective amount of a sweetening, hydrogen sulfide vapor reducing quaternary ammonium compound of the formula ##STR1## (a) wherein (i) R.sup.1, R.sup.2 and R.sup.3 are hydrocarbon groups including alkyl, aryl, alkaryl or arylalkyl groups, of up to 24 carbon atoms, and if an alkyl group, may include a cycloalkyl; with the proviso that two of R.sup.1, R.sup.2 and R.sup.3 may be in saturated heterocyclic ring which includes said nitrogen atom and may also include an oxygen atom; and (ii) at least one of R.sup.1, R.sup.2 and R.sup.3 has two or more carbon atoms; and (b) wherein R.sup.4, R.sup.5, R.sup.6 and R.sup.7 independently are hydrogen or a hydrocarbon group of up to six carbon atoms, with the proviso that two of R.sup.4, R.sup.5, R.sup.6 and R.sup.7 may be in a cycloalkane ring. The compounds used in this treatment are especially suitable for high boiling, heavy residual fuels under low mix conditions.
摘要翻译：含有巯基的油用有效量的式（a）的甜味硫化氢蒸气还原季铵化合物处理，其中（i）R 1，R 2和R 3是烃基，包括烷基，芳基，烷芳基或最多24个碳原子的芳基烷基，如果烷基可以包括环烷基; 条件是R1，R2和R3中的两个可以是包含所述氮原子的饱和杂环，并且还可以包括氧原子; 和（ii）R 1，R 2和R 3中的至少一个具有两个或更多个碳原子; 和（b）其中R4，R5，R6和R7独立地是氢或至多6个碳原子的烃基，条件是R4，R5，R6和R7中的两个可以在环烷烃环中。在这种处理中使用的化合物特别适用于低混合条件下的高沸点重残留燃料。

20. 发明授权

US5190640A Treatment of oils using aminocarbinols 失效
标题翻译：使用氨基甲醇处理油
公开(公告)号：US5190640A
公开(公告)日：1993-03-02
申请号：US761467
申请日：1991-09-18
申请人： Glenn L. Roof , Lawrence N. Kremer , Robert V. Market
发明人： Glenn L. Roof , Lawrence N. Kremer , Robert V. Market
IPC分类号： C10G29/20
CPC分类号： C10G29/20
摘要： Sour sulfhydryl group containing oils and gases are treated with an effective amount of a sweetening, hydrogen sulfide quantity reducing aminocarbinol of the formulaR.sub.2 N--CH(--R.sup.1)OHwherein R.sup.1 is hydrogen or a hydrocarbyl or inertly substituted hydrocarbyl and each R is independently hydrocarbyl or inertly substituted hydrocarbyl or both R groups are collectively a divalent hydrocarbon or ether radical combined with the nitrogen of the aminocarbinol to form a heterocyclic ring represented by the formula(--R--R--)>N--CH(--R.sup.1)OH.The aminocarbinols used in this treatment are especially suitable for sour gases and high boiling, heavy residual fuels under low mix conditions.
摘要翻译：含有巯基的油和气体用有效量的减硫硫化氢减少式R 2 N-CH（-R 1）OH的氨基甲醇进行处理，其中R1是氢或烃基或惰性取代的烃基，每个R独立地是烃基或惰性取代的烃基或两个R基团一起是与氨基甲醇的氮组合的二价烃或醚基，形成由式（-RR - ）> N-CH（-R1）OH表示的杂环。该处理中使用的氨基甲醇在低混合条件下特别适用于酸性气体和高沸点重残留燃料。

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