专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明申请

US20070259997A1 Covalently Attached Nile Blue Derivatives For Optical Sensors 有权
标题翻译：用于光学传感器的共价连接的尼罗蓝衍生物
公开(公告)号：US20070259997A1
公开(公告)日：2007-11-08
申请号：US11558633
申请日：2006-11-10
申请人： Eric Bakker , Yu Qin
发明人： Eric Bakker , Yu Qin
IPC分类号： C08K5/34
CPC分类号： C08K5/0041
摘要： A composition comprising a pH indicator, a polymerizable group, and a spacer therebetween. The polymerizable group can be acrylate or methacrylate and the spacer can be an oxyalkayl group, an oxypropyl group, or an oxybenzoyl group. The composition can be polymerized to copolymers to form indicating polymers and optodes.
摘要翻译：包含pH指示剂，可聚合基团和间隔物的组合物。可聚合基团可以是丙烯酸酯或甲基丙烯酸酯，间隔基可以是氧化烯基，氧丙基或氧基苯甲酰基。组合物可以聚合成共聚物以形成指示聚合物和光催化剂。

12. 发明授权

US07226563B2 Ion-detecting sensors comprising plasticizer-free copolymers 有权
标题翻译：离子检测传感器包括不含增塑剂的共聚物
公开(公告)号：US07226563B2
公开(公告)日：2007-06-05
申请号：US10856665
申请日：2004-05-28
申请人： Eric Bakker , Yu Qin
发明人： Eric Bakker , Yu Qin
IPC分类号： G01N27/333 , G01N21/01 , G01N33/20
CPC分类号： C08F220/18 , C08F220/14 , C08F265/04 , C08F230/06
摘要： Plasticizer-free ion-detecting sensors for detecting a target ion in a sample are provided. The sensor comprises a plasticizer-free copolymer comprised of polymerized units of methacrylate monomers and a polymerizable ion exchanger, wherein the methacrylated monomers have pendent alkyl groups of different length and wherein the functionalized ion-exchanger is grafted into the copolymer through covalent linkages. The ion exchanger comprises a C-derivative of a halogenated closo-dodecacarborane anion having a polymerizable moiety. Sensors of this invention include carrier-based ion-selective electrodes or optodes such as thin film ion-specific optodes, particle-based optodes, or bulk optodes.
摘要翻译：提供了用于检测样品中的目标离子的无增塑剂离子检测传感器。该传感器包括由聚合单元的甲基丙烯酸酯单体和可聚合离子交换剂组成的不含增塑剂的共聚物，其中所述甲基丙烯酸酯化单体具有不同长度的侧链烷基，并且其中所述官能化离子交换剂通过共价键接枝到所述共聚物中。离子交换剂包含具有可聚合部分的卤代十六烷基硼烷阴离子的C-衍生物。本发明的传感器包括基于载体的离子选择性电极或光电极，例如薄膜离子特异性光电极，基于粒子的光电极或体光电极。

13. 发明授权

US07208121B2 Plasticizer-free-ion-detective sensors 有权
标题翻译：增塑剂离子检测传感器
公开(公告)号：US07208121B2
公开(公告)日：2007-04-24
申请号：US10313090
申请日：2002-12-05
申请人： Shane Peper , Yu Qin , Eric Bakker
发明人： Shane Peper , Yu Qin , Eric Bakker
IPC分类号： G01N27/333 , G01N21/01 , G01N21/64 , G01N33/20
CPC分类号： G01N27/3335
摘要： A plasticizer-free ion detective sensor for detecting a target ion in a sample is provided. The sensor comprises a copolymer of methacrylate monomers with pendant alkyl groups of different length, and an ionophore for detecting the target ion. The copolymer matrix of the present invention may be in a form of membrane or particles. The sensors of the present invention may be Carrier-based ion-selective electrodes (ISEs) or optodes such as thin film ion-specific optodes or particle-based optodes. The ionophore may be a target ionophore selective for a target ion H+, Li+, Na+, K+, Ca2+, or Mg2+. The ion detective sensor of the present invention may further include an ion exchanger such as halogenated carboranes. Also provided is an ion detective sensor comprising halogenated carboranes as ion exchangers. Particularly, trimethylammonium-2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 undecabromocarborane (TMAUBC) is used as ion exchangers.
摘要翻译：提供了一种用于检测样品中目标离子的无增塑剂的离子检测传感器。传感器包括甲基丙烯酸酯单体与不同长度的烷基侧链的共聚物和用于检测目标离子的离子载体。本发明的共聚物基质可以是膜或颗粒的形式。本发明的传感器可以是基于载体的离子选择性电极（ISE）或诸如薄膜离子特异性光电极或基于粒子的光电极的光电传感器。离子载体可以是目标离子载体，用于目标离子H +，SO 2 +，SO 2 +，SO 2 + >，Ca 2+ 2 +或Mg 2+。本发明的离子检测传感器还可以包括离子交换剂，例如卤代碳硼烷。还提供了一种离子检测传感器，其包含作为离子交换剂的卤代碳硼烷。特别地，使用三甲基铵-2,3,4,5,6,7,8,9,10,11和12十一碳三硼烷（TMAUBC）作为离子交换剂。

14. 发明申请

US20060278526A1 Long Lived Anion-Selective Sensors Based on a Covalently Attached Metalloporphyrin as Anion Receptor 失效
标题翻译：基于共价连接的金属卟啉作为阴离子受体的长寿命阴离子选择性传感器
公开(公告)号：US20060278526A1
公开(公告)日：2006-12-14
申请号：US11424185
申请日：2006-06-14
申请人： Eric Bakker , Yu Qin
发明人： Eric Bakker , Yu Qin
IPC分类号： G01N27/26
CPC分类号： C07D487/22 , G01N27/3335
摘要： A graft copolymer having metalloporphyrin ionophores covalently attached in a manner that prevents dimer formation is provided. A method of making the graft copolymer comprises polymerizing a functionalized metalloporphyrin monomer, which includes a polymerizable group, with a co-monomer. Methods for synthesizing the polymerizable metalloporphyrin monomers are provided. The graft copolymer can be incorporated into anion-selective membranes for use in anion-detecting sensors, which have improved longevity and response times.
摘要翻译：提供了以防止二聚体形成的方式共价连接的具有金属卟啉离子载体的接枝共聚物。制备接枝共聚物的方法包括使包含可聚合基团的官能化金属卟啉单体与共聚单体聚合。提供合成可聚合金属卟啉单体的方法。接枝共聚物可以并入用于阴离子检测传感器的阴离子选择性膜中，其具有改善的寿命和响应时间。

15. 发明授权

US08242203B2 Covalently attached nile blue derivatives for optical sensors 有权
标题翻译：用于光学传感器的共价连接的尼罗蓝衍生物
公开(公告)号：US08242203B2
公开(公告)日：2012-08-14
申请号：US11558633
申请日：2006-11-10
申请人： Eric Bakker , Yu Qin
发明人： Eric Bakker , Yu Qin
IPC分类号： C08L33/06
CPC分类号： C08K5/0041
摘要： A composition comprising a pH indicator, a polymerizable group, and a spacer therebetween. The polymerizable group can be acrylate or methacrylate and the spacer can be an oxyalkayl group, an oxypropyl group, or an oxybenzoyl group. The composition can be polymerized to copolymers to form indicating polymers and optodes.
摘要翻译：包含pH指示剂，可聚合基团和间隔物的组合物。可聚合基团可以是丙烯酸酯或甲基丙烯酸酯，间隔基可以是氧化烯基，氧丙基或氧基苯甲酰基。组合物可以聚合成共聚物以形成指示聚合物和光催化剂。

16. 发明授权

US08097135B2 Reversible electrochemical sensors for polyions 有权
标题翻译：用于多边形的可逆电化学传感器
公开(公告)号：US08097135B2
公开(公告)日：2012-01-17
申请号：US11494885
申请日：2006-07-27
申请人： Eric Bakker , Alexey Shvarev
发明人： Eric Bakker , Alexey Shvarev
IPC分类号： G01N27/327 , G01N27/333
CPC分类号： G01N33/492 , G01N27/327
摘要： The present invention is directed to a reversible electrochemical sensor for polyions. The sensor uses active extraction and ion stripping, which are controlled electrochemically. Spontaneous polyion extraction is suppressed by using membranes containing highly lipophilic electrolytes that possess no ion-exchange properties. Reversible extraction of polyions is induced by constant current pulse of fixed duration applied across the membrane. Subsequently, polyions are removed by applying a constant stripping potential. The sensors provide excellent stability and reversibility and allow for measurements of heparin concentration in whole blood samples via protamine titration. The sensors can also monitor a polyion concentration and an enzyme activity, wherein the polyion decomposition is directly proportional to the enzyme activity in a sample. Additionally, the sensors can monitor an enzyme inhibitor activity. Also, an immunoassay can be used to detect analytes by employing one of a polyion and an enzyme as markers.
摘要翻译：本发明涉及一种用于聚阴离子的可逆电化学传感器。传感器使用主动提取和离子剥离，电化学控制。通过使用不含离子交换性质的含有高亲脂性电解质的膜来抑制自发的聚阴离子提取。通过跨膜的固定持续时间的恒定电流脉冲诱导聚阴离子的可逆萃取。随后，通过施加恒定的剥离电势除去多边形。传感器提供优异的稳定性和可逆性，并允许通过鱼精蛋白滴定测量全血样品中的肝素浓度。传感器还可以监测聚离子浓度和酶活性，其中聚离子分解与样品中的酶活性成正比。此外，传感器可以监测酶抑制剂活性。此外，免疫测定可以用于通过使用聚离子和酶之一作为标记来检测分析物。

17. 发明授权

US07201876B2 Ion-detecting sensors comprising plasticizer-free copolymers 有权
标题翻译：离子检测传感器包括不含增塑剂的共聚物
公开(公告)号：US07201876B2
公开(公告)日：2007-04-10
申请号：US10384097
申请日：2003-03-07
申请人： Shane Peper , Yu Qin , Eric Bakker
发明人： Shane Peper , Yu Qin , Eric Bakker
IPC分类号： G01N27/333 , G01N21/01 , G01N33/20 , C07C69/00 , C07C233/00
CPC分类号： G01N27/3335
摘要： Ion-detecting sensors for detecting a target ion in a sample are provided. The sensor comprises a plasticizer-free copolymer comprised of polymerized units of methacrylate monomers having pendent alkyl groups of different length and a functionalized ionophore of said ion, wherein at least a portion of the functionalized ionophore is grafted into the copolymer through covalent linkages. Sensors may comprise ionophores such as hydrophilic crown ethers or functionalized derivative of 3-oxapentandiaminde-type ionophores. This invention further provides sensors for detecting target ions in a sample, comprising plasticizer-free molecularly imprinted polymers, wherein the polymers comprise polymerized units of methacrylate monomers having pendent alkyl groups of different length and a functionalized ionophore of said ion. In particular, a magnesium ion sensor comprising a functionalized derivative of a 3-oxapentandiaminde-type calcium ion-selective ionophore is provided. Sensors of this invention include carrier-based ion-selective electrodes or optodes such as thin film ion-specific optodes, particle-based optodes, or bulk optodes.
摘要翻译：提供了用于检测样品中的目标离子的离子检测传感器。传感器包括由不同长度的侧链烷基的甲基丙烯酸酯单体的聚合单元和所述离子的官能化离子载体组成的无增塑剂共聚物，其中至少一部分官能化离子载体通过共价键接枝到共聚物中。传感器可以包括离子载体，例如亲水性冠醚或3-氧杂 - 戊二胺型离子载体的官能化衍生物。本发明还提供用于检测样品中目标离子的传感器，其包括不含增塑剂的分子印迹聚合物，其中所述聚合物包含具有不同长度的侧链烷基的甲基丙烯酸酯单体的聚合单元和所述离子的官能化离子载体。特别地，提供了包含3-氧杂 - 戊二醛型钙离子选择性离子载体的官能化衍生物的镁离子传感器。本发明的传感器包括基于载体的离子选择性电极或光电极，例如薄膜离子特异性光电极，基于粒子的光电极或体光电极。

18. 发明申请

US20050023153A1 Reversible electrochemical sensors for polyions 失效
标题翻译：用于多边形的可逆电化学传感器
公开(公告)号：US20050023153A1
公开(公告)日：2005-02-03
申请号：US10887251
申请日：2004-07-08
申请人： Eric Bakker , Alexey Shvarev
发明人： Eric Bakker , Alexey Shvarev
IPC分类号： G01N17/00 , G01N27/26 , G01N27/333 , G01N27/42 , G01N33/49
CPC分类号： G01N27/3335
摘要： The present invention is directed to a reversible electrochemical sensor for polyions. The sensor uses active extraction and ion stripping, which are controlled electrochemically. Spontaneous polyion extraction is suppressed by using membranes containing highly lipophilic electrolytes that possess no ion-exchange properties. Reversible extraction of polyions is induced by constant current pulse of fixed duration applied across the membrane. Subsequently, polyions are removed by applying a constant stripping potential. The sensors provide excellent stability and reversibility and allow for measurements of heparin concentration in whole blood samples via protamine titration.
摘要翻译：本发明涉及一种用于聚阴离子的可逆电化学传感器。传感器使用主动提取和离子剥离，电化学控制。通过使用不含离子交换性质的含有高亲脂性电解质的膜来抑制自发的聚阴离子提取。通过跨膜的固定持续时间的恒定电流脉冲诱导聚阴离子的可逆萃取。随后，通过施加恒定的剥离电势除去多边形。传感器提供优异的稳定性和可逆性，并允许通过鱼精蛋白滴定测量全血样品中的肝素浓度。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式