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11. 发明授权

US6092121A Method and apparatus for electronically integrating data captured in heterogeneous information systems 失效
标题翻译：用于电子集成异构信息系统中捕获的数据的方法和装置
公开(公告)号：US6092121A
公开(公告)日：2000-07-18
申请号：US993232
申请日：1997-12-18
申请人： William E. Bennett , Richard F. Boehme , Samuel Kallner , Stephen E. Levy , Paul M. Matchen , Michael J. Ryan , Richard D. Thompson
发明人： William E. Bennett , Richard F. Boehme , Samuel Kallner , Stephen E. Levy , Paul M. Matchen , Michael J. Ryan , Richard D. Thompson
IPC分类号： G06Q10/00 , G06Q30/00 , G06Q40/00 , H04L29/06 , H04L29/08 , G06F15/16 , G06F15/17
CPC分类号： H04L67/2823 , H04L67/327 , H04L69/08
摘要： Reliable and secure transmission of information over the Internet is provided in a financial transaction processing system. The system electronically integrates data captured in heterogeneous information systems and transmits that data reliably and securely over the Internet between multiple diverse servers. The system includes at least one local computer system which electronically captures information input by a user of the computer system. The local computer system can access one or more remote servers via the Internet for form a dynamically reconfigurable wide area network (WAN). The remote servers electronically transfer data to heterogeneous information systems translated into their natural communications protocol and data format.
摘要翻译：在金融交易处理系统中提供了通过互联网的信息的可靠和安全的传输。该系统将异构信息系统中捕获的数据进行电子整合，并通过Internet在多个不同的服务器之间可靠而安全地传输数据。该系统包括至少一个本地计算机系统，其电子地捕获计算机系统的用户输入的信息。本地计算机系统可以通过因特网访问一个或多个远程服务器，以形成动态可重配置的广域网（WAN）。远程服务器将数据传输到异构信息系统，将其转换为自然通信协议和数据格式。

12. 发明授权

US5122457A Expression systems utilizing bacteriophage T7 promoters, gene sequences, and T7 RNA polymerase 失效
标题翻译：表达系统利用细菌T7促进剂，基因序列和T7 RNA聚合酶
公开(公告)号：US5122457A
公开(公告)日：1992-06-16
申请号：US423839
申请日：1989-10-19
申请人： Richard L. Reim , Satwant K. Narula , Michael J. Ryan , Paul J. Leibowitz
发明人： Richard L. Reim , Satwant K. Narula , Michael J. Ryan , Paul J. Leibowitz
IPC分类号： C07K14/56 , C12N1/21 , C12N9/12 , C12N15/09 , C12N15/54 , C12N15/55 , C12N15/70 , C12P21/00 , C12R1/19
CPC分类号： C12N9/1247 , C07K14/56 , C12N15/70
摘要： Expression systems which utilize bacteriophage T7 RNA mutant polymerases and promoter regions are provided by this invention. These systems are utilized to produce large quantities of useful polypeptides and proteins.
摘要翻译：利用噬菌体T7RNA突变型聚合酶和启动子区的表达系统由本发明提供。这些系统用于生产大量有用的多肽和蛋白质。

13. 发明授权

US08708182B2 Method and container lid to manipulate a container opening liner 失效
标题翻译：方法和容器盖来操纵容器开口衬垫
公开(公告)号：US08708182B2
公开(公告)日：2014-04-29
申请号：US12510058
申请日：2009-07-27
申请人： Andrew T. Tilton , Lanny D. Baker , Carl Feducia , Michael J. Ryan , James A. Whisenhunt
发明人： Andrew T. Tilton , Lanny D. Baker , Carl Feducia , Michael J. Ryan , James A. Whisenhunt
IPC分类号： B65D51/20 , B65D53/04
CPC分类号： B65D53/04 , B65D41/045
摘要： A container includes a body forming an interior and having a sidewall with a distal edge portion forming an opening to the interior. A liner is disposed over the opening and includes an inner portion and an outermost radial portion disposed radially outwardly of the distal edge portion. A lid including an interior surface and at least one tab projecting inward from the interior surface is disposed over the liner and engages the body. The liner is sized to be releasably rotatably secured within the lid while the lid is initially attached to the body so that the at least one tab remains generally rotationally fixed relative to the outermost radial portion while being assembled to the body. The at least one tab is arrange to press the outermost radial portion while the lid is being removed from the body so that the outermost radial portion maintains a bent orientation.
摘要翻译：容器包括形成内部并具有侧壁的主体，其具有形成到内部的开口的远侧边缘部分。衬套设置在开口上方，并且包括设置在远侧边缘部分的径向外侧的内部部分和最外侧径向部分。包括内表面和从内表面向内突出的至少一个突舌的盖设置在衬套上并与身体接合。衬套的尺寸被设计成可释放地可旋转地固定在盖内，同时盖最初附接到主体上，使得至少一个凸片在组装到主体的同时相对于最外侧的径向部分保持大致旋转地固定。至少一个突片布置成在盖子从主体移除的同时按压最外侧的径向部分，使得最外侧的径向部分保持弯曲取向。

14. 发明授权

US07065563B2 Visible multi-level online-offline configuration control 失效
公开(公告)号：US07065563B2
公开(公告)日：2006-06-20
申请号：US10022135
申请日：2001-12-12
申请人： Shah Mohammad Rezaul Islam , Mark E. Molander , Michael J. Ryan
发明人： Shah Mohammad Rezaul Islam , Mark E. Molander , Michael J. Ryan
IPC分类号： G06F15/177
CPC分类号： H04L41/0883 , H04L41/0213 , H04L41/082 , H04L41/0879 , H04L67/1097 , H04L67/322 , H04L67/325 , H04L69/329
摘要： A method and system presents a plurality of selections to a user for updating a system configuration from the choices of: an immediate mode, a scheduled queued mode, a queued mode, and an optimized activation mode. The immediate mode activates all change requests immediately. The scheduled queued mode queues all change requests and activates the change requests at a predetermined time. The queued mode queues all change requests and activates the change requests after receiving a triggering event. The optimized activation mode analyzes the system usage to determine and optimally vary the mode among the immediate mode, the scheduled queued mode, and the queued mode.

15. 发明授权

US06843646B2 Nickel blow mold and holder defining heat transfer passages therebetween 失效
标题翻译：镍吹塑模具和支架在其间限定热传递通道
公开(公告)号：US06843646B2
公开(公告)日：2005-01-18
申请号：US10045567
申请日：2001-10-19
申请人： Michael J. Ryan , Reinhart Weber
发明人： Michael J. Ryan , Reinhart Weber
IPC分类号： B29C33/04 , B29C49/48 , B29C49/64
CPC分类号： B29C33/046 , B29C33/04 , B29C49/4823
摘要： An air cooled or heated blow mold is shown having a mold cavity shell and a mold holder. The mold cavity shell is made by a process of nickel vapour deposition and so requires no hand finishing or polishing. The mold cavity shell has a cavity portion with a front face defining a cavity in the shape of a portion of a product to be molded. The mold holder is located rearwardly of the mold cavity shell and defines an inner wall spaced from the mold cavity shell cavity portion to define a heat transfer passage between the inner wall and the cavity portion. In use, air is passed through the heat transfer passage to transfer heat to or from the mold cavity shell.
摘要翻译：空气冷却或加热的吹塑模具被示出具有模腔外壳和模具保持器。模腔外壳通过镍蒸气沉积工艺制成，因此不需要手工精加工或抛光。模腔外壳具有空腔部分，其前表面限定待成型产品的一部分形状的空腔。模具保持器位于模腔外壳的后方并且限定与模腔壳体空腔部分间隔开的内壁，以在内壁和空腔部分之间限定热传递通道。在使用中，空气通过传热通道以将热量传递到模腔壳体或从模腔壳体传热。

16. 发明授权

US06328256B1 Low-height tunable tilt rotor downstop 有权
标题翻译：低高度可调倾斜转子下降
公开(公告)号：US06328256B1
公开(公告)日：2001-12-11
申请号：US09408337
申请日：1999-09-29
申请人： Michael J. Ryan , Brett R. Zimmerman
发明人： Michael J. Ryan , Brett R. Zimmerman
IPC分类号： B64C2722
CPC分类号： B64C27/322 , B64C29/0033 , Y10T403/32861 , Y10T403/32868
摘要： A improved tilt rotor aircraft comprising an airframe, at least one wing member coupled to the airframe, and at least one tilt rotor assembly carried by the at least one wing member. The improved tilt rotor aircraft includes a low-height tunable downstop assembly for isolating static and dynamic lateral loads between the tilt rotor assemblies and the wings. The low-height tunable downstop assembly comprises a pivotable striker assembly having an adjustable stiffness, and a cradle assembly adapted to releasably receive the striker assembly. The low-height tunable downstop assembly isolates yaw loads while providing a stiff vertical support.
摘要翻译：一种改进的倾斜转子飞行器，包括机身，联接到机身的至少一个翼构件以及由所述至少一个翼构件承载的至少一个倾斜转子组件。改进的倾斜转子飞行器包括用于隔离倾斜转子组件和机翼之间的静态和动态横向载荷的低高度可调降压组件。低高度可调降压组件包括具有可调刚度的可枢转撞击器组件，以及适于可释放地接收撞击器组件的支架组件。低高度可调降压装置隔离偏航载荷，同时提供刚性垂直支撑。

17. 发明授权

US6138160A System with wake up server and wake up monitor for facilitating dial up connection between two application partners via internet 失效
标题翻译：系统具有唤醒服务器和唤醒监视器，便于通过互联网在两个应用程序合作伙伴之间拨号连接
公开(公告)号：US6138160A
公开(公告)日：2000-10-24
申请号：US177385
申请日：1998-10-23
申请人： Stephen Joy Boies , Stephen Eric Levy , Michael J. Ryan
发明人： Stephen Joy Boies , Stephen Eric Levy , Michael J. Ryan
IPC分类号： H04L12/12 , G06F15/173
CPC分类号： H04L12/12 , Y02B60/34
摘要： A wake up server permits both parties (the receiver and the responder) to be connected to the Internet only when a request or response is to be delivered. The wake up server consists of two parts; a server, which contains the telephone numbers of all machines (application partners) that dial to connect to the Internet, and on each application partner, a process monitor that monitors the telephone line and detects when a ring occurs. When an application partner is unable to deliver a request or response to another application partner, a request is sent to the wake up server to activate the target application partner. The wake up server dials the telephone number of the requested application partner and waits for ringing to occur. The wake up server then disconnects (i.e., hangs up the telephone line). The wake up monitor detects the ring and immediately dials to connect to the Internet. When the original application partner tries to send the response or request again, the process will now be successful. Application partners stay connected until a specified time of inactivity or other application initiated event signaling that the connection is no longer required. The application partners then activate their respective wake up monitors, which disconnect the application partners from the Internet and wait again for a ring from the wake up server.
摘要翻译：唤醒服务器允许双方（接收方和响应者）只有在要传送请求或响应时才连接到Internet。唤醒服务器由两部分组成：一个服务器，其中包含拨号连接到互联网的所有机器（应用程序合作伙伴）的电话号码，以及每个应用程序合作伙伴，监视电话线并检测发生何时发生的进程监视器。当应用程序合作伙伴无法向另一个应用程序合作伙伴传递请求或响应时，将向唤醒服务器发送请求以激活目标应用程序伙伴。唤醒服务器拨打所请求的应用程序伙伴的电话号码，并等待发生呼叫。然后唤醒服务器断开连接（即挂断电话线路）。唤醒监视器检测环，并立即拨号连接到Internet。当原始应用程序伙伴尝试再次发送响应或请求时，该过程现在将成功。应用程序合作伙伴保持连接，直到指定的不活动时间或其他应用程序启动的事件信号表明不再需要连接。应用程序伙伴然后激活他们各自的唤醒监视器，从而将应用程序合作伙伴与互联网断开连接，并再次等待来自唤醒服务器的响铃。

18. 发明授权

US5965429A Strain for the production of 6-demethyltetracycline, method for producing the strain and vector for use in the method 失效
标题翻译：用于生产6-脱甲基四环素的菌株，生产菌株的方法和用于该方法的载体
公开(公告)号：US5965429A
公开(公告)日：1999-10-12
申请号：US31855
申请日：1998-02-27
申请人： Michael J. Ryan
发明人： Michael J. Ryan
IPC分类号： C12N1/21 , C12N15/52 , C12P29/00 , C07H21/04 , C12N15/76
CPC分类号： C12R1/485 , C12N15/52 , C12P29/00 , Y10S435/889
摘要： Recombinant S. aureofaciens cells are provided. These cells comprise: (a) at least one CTC 11 gene; and (b) optionally(i) a CTC 09 gene;(ii) a CTC 03 gene; or(iii) a combination thereof;wherein:the CTC 11 gene is chromosomal, extra-chromosomal, or chromosomal and extra-chromosomal;the CTC 09 gene, CTC 03 gene, or a combination thereof is chromosomal, extra-chromosomal, or a combination thereof; expression of the CTC 11 gene is enhanced over that of a wild-type S. aureofaciens cell; andoptionally, the CTC 09 gene, the CTC 03 gene, or both of the CTC 09 gene and the CTC 03 gene are inactivated.The present invention also contemplates vector pLP21329 and vectors for allelic replacement in a S. aureofaciens host cell. The vectors comprise:(a) a functional E. coli origin of replication;(b) a functional Streptomyces origin of replication;(c) a functional gene that imparts a positively selectable phenotype on the host cell; and((d) a ribosomal S12 gene which is expressed in Streptomyces such that it imparts sensitivity to streptomycin to the host cell. In another embodiment, a method of mutating a target gene of a biosynthetic pathway of Streptomyces is disclosed. The method comprises(a) replacing the genomic copy of the target gene with a selectable marker gene through homologous recombination to form a first recombinant strain; and(b) replacing the selectable marker gene in the first recombinant strain with an altered copy of the target gene through homologous recombination to form a second recombinant strain.
摘要翻译：提供重组金黄色葡萄球菌细胞。这些细胞包含：（a）至少一种CTC 11基因; 和（b）任选地（i）CTC09基因; （ii）CTC03基因; 或（iii）其组合; 其中：CTC 11基因是染色体，染色体外或染色体和染色体外的; CTC09基因，CTC03基因或其组合是染色体，染色体外或其组合; CTC 11基因的表达比野生型金黄色葡萄球菌细胞的表达增强; 并且任选地，CTC09基因，CTC03基因或CTC09基因和CTC03基因两者都被灭活。本发明还考虑载体pLP21329和用于在金黄色葡萄球菌属宿主细胞中等位基因置换的载体。载体包括：（a）功能性大肠杆菌复制起点; （b）功能性链霉菌复制起点; （c）在宿主细胞上赋予正选择的表型的功能性基因; 公开了（d）在链霉菌中表达的核糖体S12基因，使得其对宿主细胞具有对链霉素的敏感性，在另一个实施方案中，公开了链霉菌生物合成途径的靶基因突变的方法，该方法包括（ a）通过同源重组用选择性标记基因替换目标基因的基因组拷贝以形成第一重组菌株;和（b）通过同源重组用靶基因的改变拷贝替换第一重组菌株中的选择性标记基因以形成第二重组菌株。

19. 发明授权

US5589385A Cloning of the biosynthetic pathway for chlortetracycline and tetracycline formation and cosmids useful therein 失效
公开(公告)号：US5589385A
公开(公告)日：1996-12-31
申请号：US125468
申请日：1993-09-22
申请人： Michael J. Ryan , Jason A. Lotvin , Nancy Strathy , Susan E. Fantini
发明人： Michael J. Ryan , Jason A. Lotvin , Nancy Strathy , Susan E. Fantini
IPC分类号： C12N15/52 , C12N15/76 , C12P29/00 , C12Q1/18 , C12N1/21
CPC分类号： C12N15/76 , C12N15/52 , C12P29/00 , C12Q1/18
摘要： The present invention describes a purified and isolated nucleic acid molecule which encodes for the biosynthetic pathway of tetracycline, chlortetracycline or an analogue thereof. The invention relates to the isolation and cloning of the nucleic acid molecule in an isolated fragment from Streptomyces aureofaciens and the expression of the biosynthetic gene in a heterologous host such as Streptomyces lividans.

20. 发明授权

US4118057A Reusable, tamper-indicating seal 失效
标题翻译：可重复使用，防篡改密封
公开(公告)号：US4118057A
公开(公告)日：1978-10-03
申请号：US880924
申请日：1978-02-24
申请人： Michael J. Ryan
发明人： Michael J. Ryan
IPC分类号： G09F3/03 , E05C19/18
CPC分类号： G09F3/0394 , Y10T292/48 , Y10T70/8243
摘要： A reusable, tamper-indicating seal comprises a drum confined within a fixed body and rotatable in one direction therewithin, the top of the drum constituting a tray carrying a large number of small balls of several different colors. The fixed body contains parallel holes for looping a seal wire therethrough. The base of the drums carries cams adapted to coact with cam followers to lock the wire within the seal at one angular position of the drum. A channel in the fixed body -- visible from outside the seal -- adjacent the tray constitutes a segregated location for a small plurality of the colored balls. A spring in the tray forces colored balls into the segregated location at one angular position of the drum, further rotation securing the balls in position and the wires in the seal. A wedge-shaped plough removes the balls from the segregated location, at a different angular position of the drum, the wire being unlocked at the same position. A new pattern of colored balls will appear in the segregated location when the seal is relocked.
摘要翻译：可重复使用的防篡改密封件包括限定在固定体内并能够沿其一个方向旋转的滚筒，滚筒的顶部构成载有多个不同颜色的大量小球的托盘。固定体包含用于环绕密封线的平行孔。鼓的底部承载适于与凸轮从动件共同作用的凸轮，以将钢丝锁定在滚筒的一个角度位置处的密封件内。固定体中的通道 - 从密封件的外部可见 - 邻近托盘构成用于少量多个彩色球的分离位置。托盘中的弹簧迫使彩色球进入转鼓的一个角度位置的隔离位置，进一步转动将球固定在适当位置，并将电线固定在密封件中。楔形犁从滚筒的不同角度位置从分离的位置移除球，线在同一位置被解锁。当密封件被重新锁定时，分离位置将出现一种新的彩色图案。

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