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11. 发明申请

US20060204524A1 Genetically engineered clostridial genes, proteins encoded by the engineered genes, and uses thereof 有权
标题翻译：基因工程梭菌基因，由工程基因编码的蛋白质及其用途
公开(公告)号：US20060204524A1
公开(公告)日：2006-09-14
申请号：US11284930
申请日：2005-11-22
申请人： Konstantin Ichtchenko , Philip Band
发明人： Konstantin Ichtchenko , Philip Band
IPC分类号： A61K39/08 , C07K14/33
CPC分类号： C12N9/52 , A61K39/00 , A61K39/08 , A61K2039/6037 , C07K14/33 , C12Y304/24069 , Y02A50/469
摘要： The present invention relates to an isolated Clostridial neurotoxin propeptide having a light chain region, a heavy chain region, where the light and heavy chain regions are linked by a disulfide bond, and an intermediate region connecting the light and heavy chain regions. An isolated nucleic acid molecule encoding a Clostridial neurotoxin propeptide is also disclosed. Also disclosed is an isolated, physiologically active Clostridial neurotoxin produced by cleaving a Clostridial neurotoxin propeptide, a vaccine or antidote thereof, and methods of immunizing against or treating for toxic effects of Clostridial neurotoxins. Methods of expressing recombinant physiologically active Clostridial neurotoxins are also disclosed. Also disclosed is a chimeric protein having a heavy chain region of a Clostridial neurotoxin and a protein with therapeutic functionality. A treatment method is also disclosed.
摘要翻译：本发明涉及具有轻链区域的轻链和重链区域通过二硫键连接的轻链区域和连接轻链区域和重链区域的中间区域的分离的梭菌神经毒素前肽。还公开了编码梭菌神经毒素前肽的分离的核酸分子。还公开了通过切割梭菌神经毒素前肽，疫苗或解毒剂产生的分离的，生理活性的梭菌神经毒素，以及针对或治疗梭菌神经毒素的毒性作用的方法。还公开了表达重组生理活性梭菌神经毒素的方法。还公开了具有梭菌神经毒素的重链区域和具有治疗功能的蛋白质的嵌合蛋白质。还公开了一种治疗方法。

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