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11. 发明申请

US20090042902A1 THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN 有权
标题翻译：治疗药物有用的治疗药物
公开(公告)号：US20090042902A1
公开(公告)日：2009-02-12
申请号：US12240688
申请日：2008-09-29
申请人： Qun Sun , Xiaoming Zhou
发明人： Qun Sun , Xiaoming Zhou
IPC分类号： A61K31/496 , A61P25/00 , C07D417/04 , C07D401/04
CPC分类号： C07D401/04 , C07D403/04 , C07D417/04
摘要： A compound of formula: wherein Ar, Ar1, Ar2, R3, R4, R5, R6, R13, m, t, and x are disclosed herein, or a pharmaceutically acceptable salt thereof (a “Hydroxyiminopiperazine Compound”); compositions comprising an effective amount of a Hydroxyiminopiperazine Compound; and methods for treating or preventing pain and other conditions in an animal comprising administering to an animal in need thereof an effective amount of a Hydroxyiminopiperazine Compound are disclosed.
摘要翻译：式中的化合物：其中Ar，Ar1，Ar2，R3，R4，R5，R6，R13，m，t和x在本文中公开，或其药学上可接受的盐（“羟基亚氨基哌嗪化合物”）; 包含有效量的羟基亚氨基哌嗪化合物的组合物; 以及用于治疗或预防动物中的疼痛和其它病症的方法，包括向有需要的动物施用有效量的羟基亚氨基哌嗪化合物。

12. 发明授权

US07279493B2 Therapeutic agents useful for treating pain 有权
标题翻译：用于治疗疼痛的治疗剂
公开(公告)号：US07279493B2
公开(公告)日：2007-10-09
申请号：US10607563
申请日：2003-06-27
申请人： Donald J. Kyle , Qun Sun , Laykea Tafesse , Chongwu Zhang , Xiaoming Zhou
发明人： Donald J. Kyle , Qun Sun , Laykea Tafesse , Chongwu Zhang , Xiaoming Zhou
IPC分类号： C07D277/04 , A61K43/80
CPC分类号： C07D213/74 , C07D213/85 , C07D237/20 , C07D239/42 , C07D241/20 , C07D285/06 , C07D333/16
摘要： A compound of formula: wherein A, Ar, R3, R6, and m are disclosed herein, or a pharmaceutically acceptable salt thereof (a “Cyanoiminopiperazine Compound”), compositions comprising an effective amount of a Cyanoiminopiperazine Compound, and methods for treating or preventing pain, urinary incontinence, an ulcer, inflammatory-bowel disease, irritable-bowel syndrome, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression in an animal comprising administering to an animal in need thereof an effective amount of a Cyanoiminopiperazine Compound are disclosed.
摘要翻译：式中的化合物：其中A，Ar，R 3，R 6和m在本文中公开，或其药学上可接受的盐（“氰基亚氨基哌嗪化合物”），包含有效量的氰基亚氨基哌嗪化合物的组合物，治疗或预防疼痛，尿失禁，溃疡，炎性肠病，肠易激综合征，成瘾性疾病，帕金森病，帕金森综合征，焦虑症，癫痫，中风，包括给予一个或多个癫痫发作，瘙痒症状，精神病，认知障碍，记忆缺陷，限制性脑功能，亨廷顿氏舞蹈病，肌萎缩性侧索硬化，痴呆，视网膜病变，肌肉痉挛，偏头痛，呕吐，运动障碍或抑郁症公开了有效量的氰酰亚胺哌嗪化合物的需要动物。

13. 发明申请

US20060199824A1 Therapeutic agents useful for treating pain 有权
标题翻译：用于治疗疼痛的治疗剂
公开(公告)号：US20060199824A1
公开(公告)日：2006-09-07
申请号：US11337271
申请日：2006-01-20
申请人： Qun Sun , Kate Wen , Xiaoming Zhou
发明人： Qun Sun , Kate Wen , Xiaoming Zhou
IPC分类号： A61K31/506 , A61K31/497 , A61K31/501 , A61K31/4545 , A61K31/454 , C07D417/02 , C07D413/02 , C07D403/02 , C07D401/02
CPC分类号： C07D417/14 , C07D401/04
摘要： Piperidine Compounds; compositions comprising a Piperidine Compound; and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Piperidine Compound are disclosed. In one embodiment, the Piperidine Compound has the formula: and pharmaceutically acceptable salts thereof, wherein Ar1, Ar2, X, R3, R4, and m are as disclosed herein.
摘要翻译：哌啶化合物; 包含哌啶化合物的组合物; 以及用于治疗或预防疼痛，UI，溃疡，IBD，IBS，成瘾性障碍，帕金森病，帕金森综合征，焦虑，癫痫，中风，癫痫发作，瘙痒症状，精神病，认知障碍，记忆缺陷，受限制脑功能，亨廷顿舞蹈病，肌萎缩性侧索硬化，痴呆，视网膜病变，肌肉痉挛，偏头痛，呕吐，运动障碍或抑郁症，包括向有需要的动物施用有效量的哌啶化合物。在一个实施方案中，哌啶化合物具有下式：及其药学上可接受的盐，其中Ar 1，Ar 2，X，R 3， R 4，且m如本文所公开。

14. 发明授权

US08058292B2 Therapeutic agents useful for treating pain 有权
标题翻译：用于治疗疼痛的治疗剂
公开(公告)号：US08058292B2
公开(公告)日：2011-11-15
申请号：US12786043
申请日：2010-05-24
申请人： Donald J. Kyle , Qun Sun , Xiaoming Zhou
发明人： Donald J. Kyle , Qun Sun , Xiaoming Zhou
IPC分类号： A61K31/4427 , C07D401/04 , C07D401/12
CPC分类号： C07D401/04 , C07D401/12
摘要： The invention provides a compound of formula (I): (where R1, Q, A and R2 are disclosed herein) or a pharmaceutically acceptable salt thereof (a “Pyridine-alkynyl Compound”); pharmaceutical compositions comprising an effective amount of a Pyridine-alkynyl Compound; and methods for treating or preventing a condition such as pain, urinary incontinence, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, a seizure, stroke, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression in an animal comprising administering to an animal in need thereof an effective amount of a Pyridine-alkynyl Compound.
摘要翻译：本发明提供式（I）化合物：其中R 1，Q，A和R 2在本文中公开）或其药学上可接受的盐（“吡啶 - 炔基化合物”）; 包含有效量的吡啶 - 炔基化合物的药物组合物; 以及用于治疗或预防诸如疼痛，尿失禁，成瘾性障碍，帕金森病，帕金森综合征，焦虑，癫痫，癫痫发作，中风，瘙痒症状，精神病，认知障碍，记忆缺陷，限制性脑功能亨廷顿舞蹈病，肌萎缩性侧索硬化症，痴呆症，视网膜病变，肌肉痉挛，偏头痛，呕吐，运动障碍或抑郁症，包括向有需要的动物施用有效量的吡啶 - 炔基化合物。

15. 发明申请

US20100256111A1 THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN 有权
标题翻译：治疗药物有用的治疗药物
公开(公告)号：US20100256111A1
公开(公告)日：2010-10-07
申请号：US12786043
申请日：2010-05-24
申请人： Donald J. Kyle , Qun Sun , Xiaoming Zhou
发明人： Donald J. Kyle , Qun Sun , Xiaoming Zhou
IPC分类号： A61K31/4427 , C07D211/98 , C07D211/94 , A61K31/4545 , C07D401/12 , A61P13/00 , A61P21/00 , A61P25/00 , A61P29/00
CPC分类号： C07D401/04 , C07D401/12
摘要： The invention provides a compound of formula (I): (where R1, Q, A and R2 are disclosed herein) or a pharmaceutically acceptable salt thereof (a “Pyridine-alkynyl Compound”); pharmaceutical compositions comprising an effective amount of a Pyridine-alkynyl Compound; and methods for treating or preventing a condition such as pain, urinary incontinence, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, a seizure, stroke, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression in an animal comprising administering to an animal in need thereof an effective amount of a Pyridine-alkynyl Compound.
摘要翻译：本发明提供式（I）化合物：其中R 1，Q，A和R 2在本文中公开）或其药学上可接受的盐（“吡啶 - 炔基化合物”）; 包含有效量的吡啶 - 炔基化合物的药物组合物; 以及用于治疗或预防诸如疼痛，尿失禁，成瘾性障碍，帕金森病，帕金森综合征，焦虑，癫痫，癫痫发作，中风，瘙痒症状，精神病，认知障碍，记忆缺陷，限制性脑功能亨廷顿舞蹈病，肌萎缩性侧索硬化症，痴呆症，视网膜病变，肌肉痉挛，偏头痛，呕吐，运动障碍或抑郁症，包括向有需要的动物施用有效量的吡啶 - 炔基化合物。

16. 发明申请

US20080153835A1 Therapeutic agents useful for treating pain 有权
标题翻译：用于治疗疼痛的治疗剂
公开(公告)号：US20080153835A1
公开(公告)日：2008-06-26
申请号：US11899379
申请日：2007-09-04
申请人： Donald J. Kyle , Qun Sun , Laykea Tafesse , Chongwu Zhang , Xiaoming Zhou
发明人： Donald J. Kyle , Qun Sun , Laykea Tafesse , Chongwu Zhang , Xiaoming Zhou
IPC分类号： A61K31/501 , C07D401/04 , A61K31/497 , A61P25/04
CPC分类号： C07D213/74 , C07D213/85 , C07D237/20 , C07D239/42 , C07D241/20 , C07D285/06 , C07D333/16
摘要： A compound of formula: wherein A, Ar, R3, R6, and m are disclosed herein, or a pharmaceutically acceptable salt thereof (a “Cyanoiminopiperazine Compound”), compositions comprising an effective amount of a Cyanoiminopiperazine Compound, and methods for treating or preventing pain, urinary incontinence, an ulcer, inflammatory-bowel disease, irritable-bowel syndrome, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression in an animal comprising administering to an animal in need thereof an effective amount of a Cyanoiminopiperazine Compound are disclosed.
摘要翻译：式中的化合物：其中A，Ar，R 3，R 6和m在本文中公开，或其药学上可接受的盐（“氰基亚氨基哌嗪化合物”），包含有效量的氰基亚氨基哌嗪化合物的组合物，治疗或预防疼痛，尿失禁，溃疡，炎性肠病，肠易激综合征，成瘾性疾病，帕金森病，帕金森综合征，焦虑症，癫痫，中风，包括给予一个或多个癫痫发作，瘙痒症状，精神病，认知障碍，记忆缺陷，限制性脑功能，亨廷顿氏舞蹈病，肌萎缩性侧索硬化，痴呆，视网膜病变，肌肉痉挛，偏头痛，呕吐，运动障碍或抑郁症公开了有效量的氰酰亚胺哌嗪化合物的需要动物。

17. 发明授权

US07022714B2 Aryl substituted benzimidazoles and their use as sodium channel blockers 有权
标题翻译：芳基取代的苯并咪唑及其作为钠通道阻断剂的用途
公开(公告)号：US07022714B2
公开(公告)日：2006-04-04
申请号：US10630896
申请日：2003-07-31
申请人： Qun Sun , Xiaoming Zhou , Donald J. Kyle
发明人： Qun Sun , Xiaoming Zhou , Donald J. Kyle
IPC分类号： A61K31/454 , C07D401/06 , C07D401/14
CPC分类号： C07D403/06 , C07D235/08 , C07D235/12
摘要： This invention relates aryl substituted benzimidazoles of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein R1, R2, R10 and n are defined in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
摘要翻译：本发明涉及式I的芳基取代的苯并咪唑或其药学上可接受的盐，前药或溶剂合物，其中R 1，R 2，R 10， >和n在本说明书中定义。本发明还涉及式I化合物用于治疗全身和局部缺血后的神经元损伤，用于治疗或预防神经变性疾病如肌萎缩性侧索硬化（ALS）以及治疗，预防或改善的用途作为抗惊厥剂，作为抗惊厥剂，作为抗躁狂抑制剂，作为局部麻醉剂，作为抗心律失常药物和用于治疗或预防糖尿病性神经病变。

18. 发明授权

US08349842B2 Therapeutic agents useful for treating pain 有权
公开(公告)号：US08349842B2
公开(公告)日：2013-01-08
申请号：US12506040
申请日：2009-07-20
申请人： Qun Sun , Kate Xin Wen , Xiaoming Zhou
发明人： Qun Sun , Kate Xin Wen , Xiaoming Zhou
IPC分类号： A61K31/497
CPC分类号： C07D417/14 , C07D401/04
摘要： Piperidine Compounds; compositions comprising a Piperidine Compound; and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Piperidine Compound are disclosed. In one embodiment, the Piperidine Compound has the formula: and pharmaceutically acceptable salts thereof, wherein Ar1, Ar2, X, R3, R4, and m are as disclosed herein.

19. 发明申请

US20110281885A1 THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN 审中-公开
标题翻译：治疗药物有用的治疗药物
公开(公告)号：US20110281885A1
公开(公告)日：2011-11-17
申请号：US12879885
申请日：2010-09-10
申请人： Donald J. Kyle , Qun Sun , Laykea Tafesse , Chongwu Zhang , Xiaoming Zhou
发明人： Donald J. Kyle , Qun Sun , Laykea Tafesse , Chongwu Zhang , Xiaoming Zhou
IPC分类号： A61K31/496 , A61K31/497 , C12N5/07 , C07D417/04 , C07D401/04 , A61P25/00
CPC分类号： C07D213/74 , C07D213/85 , C07D237/20 , C07D239/42 , C07D241/20 , C07D285/06 , C07D333/16
摘要： A compound of formula: wherein A, Ar, R3, R6, and m are disclosed herein, or a pharmaceutically acceptable salt thereof (a “Cyanoiminopiperazine Compound”), compositions comprising an effective amount of a Cyanoiminopiperazine Compound, and methods for treating or preventing pain, urinary incontinence, an ulcer, inflammatory-bowel disease, irritable-bowel syndrome, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression in an animal comprising administering to an animal in need thereof an effective amount of a Cyanoiminopiperazine Compound are disclosed.
摘要翻译：本文公开的其中A，Ar，R 3，R 6和m的化合物或其药学上可接受的盐（“氰基亚氨基哌嗪化合物”），包含有效量的氰基亚氨基哌嗪化合物的组合物，以及治疗或预防的方法疼痛，尿失禁，溃疡，炎性肠病，肠易激综合征，成瘾性疾病，帕金森病，帕金森综合征，焦虑症，癫痫，中风，癫痫发作，瘙痒症状，精神病，认知障碍，记忆缺陷，限制性脑功能，亨廷顿氏舞蹈病，肌萎缩性侧索硬化，痴呆，视网膜病变，肌肉痉挛，偏头痛，呕吐，运动障碍或抑郁症，包括向有需要的动物施用有效量的氰基亚氨基哌嗪化合物。

20. 发明申请

US20110082152A1 THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN 审中-公开
标题翻译：治疗药物有用的治疗药物
公开(公告)号：US20110082152A1
公开(公告)日：2011-04-07
申请号：US12943739
申请日：2010-11-10
申请人： Qun Sun , Xiaoming Zhou
发明人： Qun Sun , Xiaoming Zhou
IPC分类号： A61K31/501 , C07D403/04 , C12N5/071 , A61P29/02 , A61P25/04
CPC分类号： C07D401/04 , C07D403/04 , C07D417/04
摘要： A compound of formula: wherein Ar, Ar1, Ar2, R3, R4, R5, R6, R13, m, t, and x are disclosed herein, or a pharmaceutically acceptable salt thereof (a “Hydroxyiminopiperazine Compound”); compositions comprising an effective amount of a Hydroxyiminopiperazine Compound; and methods for treating or preventing pain and other conditions in an animal comprising administering to an animal in need thereof an effective amount of a Hydroxyiminopiperazine Compound are disclosed.
摘要翻译：式中的化合物：其中Ar，Ar1，Ar2，R3，R4，R5，R6，R13，m，t和x在本文中公开，或其药学上可接受的盐（“羟基亚氨基哌嗪化合物”）; 包含有效量的羟基亚氨基哌嗪化合物的组合物; 以及用于治疗或预防动物中的疼痛和其它病症的方法，包括向有需要的动物施用有效量的羟基亚氨基哌嗪化合物。

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