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    • 18. 发明申请
    • METHOD AND SYSTEM FOR EVALUATING FLUID FLOW THROUGH A HEAT EXCHANGER
    • 通过热交换器评估流体流动的方法和系统
    • US20080083526A1
    • 2008-04-10
    • US11949939
    • 2007-12-04
    • David YoungJohn CoatesJames Snow
    • David YoungJohn CoatesJames Snow
    • F28F99/00
    • G01K17/06F28D1/035F28F2200/00F28F2265/16G01K17/12G01K2201/00
    • A heat exchanger evaluation system (84) includes a refrigeration subsystem (126) and a platform (94) in communication with the subsystem (126) for attachment of a heat exchanger (32). The system (84) further includes a thermal imaging camera (168) and a monitor (100). A method (180) entails routing a fluid (38) through the heat exchanger (32) via the refrigeration subsystem (126). The camera (168) detects the temperature variation across the heat exchanger (32) as the fluid (38) flows through the heat exchanger, and provides successive thermal images representing the temperature variation responsive to the flow of the fluid (38). The thermal images are utilized to determine an efficacy of the flow through the heat exchanger (32). In particular, a determination can be made as to whether the flow deviates from a pre-determined flow path (79) of the fluid (38) through the heat exchanger.
    • 热交换器评估系统(84)包括与用于附接热交换器(32)的子系统(126)连通的制冷子系统(126)和平台(94)。 系统(84)还包括热成像相机(168)和监视器(100)。 方法(180)需要经由制冷子系统(126)将流体(38)路由穿过热交换器(32)。 当流体(38)流过热交换器时,照相机(168)检测穿过热交换器(32)的温度变化,并响应于流体(38)的流动提供代表温度变化的连续热图像。 热图像用于确定通过热交换器(32)的流动的功效。 特别地,可以确定流体是否偏离流体(38)的预定流动路径(79)通过热交换器。
    • 19. 发明申请
    • Individualized anti-cancer antibodies
    • 个性化的抗癌抗体
    • US20080019965A1
    • 2008-01-24
    • US11777551
    • 2007-07-13
    • David YoungMiyoko Takahashi
    • David YoungMiyoko Takahashi
    • A61K39/395C07K16/18G01N33/53
    • C07K16/00A61K2039/505C07K16/30C07K2317/73G01N33/57484G01N33/6854G01N2500/00
    • The present invention relates to a method for producing patient specific anti-cancer antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies customized for the individual patient that can be used for therapeutic and diagnostic purposes. The invention further relates to the process by which the antibodies are made and to their methods of use. The antibodies can be made specifically for one tumor derived from a particular patient and are selected on the basis of their cancer cell cytotoxicity and simultaneous lack of toxicity for non-cancerous cells. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat tumor metastases. The anti-cancer antibodies can be conjugated to red blood cells obtained from that patient and re-infused for treatment of metastases based upon the recognition that metastatic cancers are usually well vascularized and the delivery of anti-cancer antibodies by red blood cells can have the effect of concentrating the antibodies at the site of the tumor.
    • 本发明涉及使用新的筛选范例来生产患者特异性抗癌抗体的方法。 通过使用癌细胞细胞毒性分离抗癌抗体作为终点,该方法使得可以为可用于治疗和诊断目的的个体患者定制抗癌抗体。 本发明还涉及制备抗体的方法及其使用方法。 抗体可以专门针对来自特定患者的一种肿瘤进行制备,并且基于它们的癌细胞细胞毒性和对非癌细胞同时缺乏毒性进行选择。 抗体可用于帮助分期和诊断癌症,并可用于治疗肿瘤转移。 抗癌抗体可以与从该患者获得的红细胞结合,并且基于认识到转移性癌症通常是良好血管化并且红细胞递送抗癌抗体可以具有 将抗体集中在肿瘤部位的作用。