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    • 11. 发明授权
    • Process for the preparation of esomeprazole and salts thereof
    • 艾美拉唑及其盐的制备方法
    • US08563733B2
    • 2013-10-22
    • US12855667
    • 2010-08-12
    • Fan WangLaura Kaye MontemayorDaqing CheStephen E. Horne
    • Fan WangLaura Kaye MontemayorDaqing CheStephen E. Horne
    • C07D401/12
    • C07D401/12Y02P20/55
    • A novel process for the preparation of omeprazole and its enantiomers, such as esomeprazole, as well as the preparation of related 2-(2-pyridinylmethyl-sulphinyl)-1H-benzimidazoles, including pantoprazole, lansoprazole and rabeprazole, as recemates or single enantiomers, and their alkali or alkaline salts has been developed. The novel process involves the surprising discovery that protection of the free-base benzimidazole sulfoxide (e.g. omeprazole or esomeprazole), by reaction with an alkyl, aryl or aralkyl chloroformate following oxidation of the corresponding sulfide, eliminates the need for its direct isolation. Subsequent removal of the protecting group with a solution of alkali or alkaline earth alkoxide in a C1-C4 alcohol directly provides the corresponding salt. By eliminating the need to handle the free-base benzimidazole sulfoxide, this advantageous procedure provides increased chemical yields over processes described in the art.
    • 一种用于制备奥美拉唑及其对映异构体的新方法,例如艾美拉唑,以及相关的2-(2-吡啶基甲基 - 亚磺酰基)-1H-苯并咪唑(包括泮托拉唑,兰索拉唑和雷贝拉唑)作为受体或单一对映异构体的制备, 并开发了它们的碱金属盐或碱金属盐。 该新方法涉及令人惊奇的发现:在相应的硫化物氧化后,通过与烷基,芳基或氯甲酸烷基酯反应来保护游离碱性苯并咪唑亚砜(例如奥美拉唑或埃索美拉唑)消除了对其直接分离的需要。 随后用碱金属或碱土金属醇溶液在C1-C4醇中除去保护基团直接提供相应的盐。 通过消除处理游离碱性苯并咪唑亚砜的需要,与本领域中描述的方法相比,该有利的方法提供了增加的化学产率。
    • 14. 发明授权
    • Method and apparatus for codebook-based feedback in a closed loop wireless communication system
    • 在闭环无线通信系统中用于基于码本的反馈的方法和装置
    • US08351544B2
    • 2013-01-08
    • US12334917
    • 2008-12-15
    • Bishwarup MondalAmitabha GhoshFan Wang
    • Bishwarup MondalAmitabha GhoshFan Wang
    • H04L27/00
    • H04B7/0478H04B7/0417H04B7/0639H04L5/0007H04L25/03343
    • A method and apparatus are provided for feedback for closed-loop transmitting with multiple transmit antenna elements and multiple receive antenna elements. A base station includes a codebook containing sets of weightings for the multiple transmit antenna elements, with each set of weightings identified by an index and the codebook known to the base station and a served mobile station (MS). The base station pre-codes pilot signals using a precoding matrix, preferably a unitary matrix, to produce pre-coded pilot signals, which precoding matrix may or may not be known to the MS and which precoding matrix may or may not be included in the codebook. The base station then transmits the pre-coded pilot signals to the MS via the multiple transmit antenna elements and, in response, receives an index to a set of weightings in the codebook for use in a subsequent transmission of a data stream.
    • 提供了一种用于具有多个发射天线元件和多个接收天线元件的闭环发射的反馈的方法和装置。 基站包括码本,其包含多个发射天线单元的加权集合,每一组加权由索引和基站已知的码本和被服务的移动台(MS)标识。 基站使用预编码矩阵,优选地是酉矩阵来预编码导频信号,以产生预编码的导频信号,预编码矩阵可以是MS也可以不是已知的,并且哪个预编码矩阵可以或可以不包括在 码本。 然后,基站经由多个发送天线元件向MS发送预先编码的导频信号,作为响应,接收到码本中的一组加权的索引,用于数据流的后续发送。
    • 17. 发明申请
    • Mesa edge shielding trench Schottky rectifier and method of manufacture thereof
    • Mesa边缘屏蔽沟槽肖特基整流器及其制造方法
    • US20120168893A1
    • 2012-07-05
    • US12982714
    • 2010-12-30
    • Wei LiuFan WangXiaozhong Sun
    • Wei LiuFan WangXiaozhong Sun
    • H01L29/47H01L21/20
    • H01L29/8725H01L29/66143
    • A mesa edge shielding trench Schottky rectifier includes a semiconductor substrate; an epitaxial layer grown on the first surface of the semiconductor substrate; a plurality of trenches spaced from each other and extended into the epitaxial layer, wherein an epitaxial region between two adjacent trenches forms the silicon mesa; a polysilicon region, having a T-shape, is separated from an inner wall of each of the trenches and a top surface of the epitaxial layer by an oxide layer, wherein a width of the top surface of the polysilicon region is bigger than an open size of each of the trenches; an anode electrode, deposited on an entire structure, forming an ohmic contact on the top surface of the polysilicon region and a Schottky contact on an exposed surface of the epitaxial layer; and a cathode electrode, deposited on the second surface of the semiconductor substrate, forming an ohmic contact thereon.
    • 台面边缘屏蔽沟槽肖特基整流器包括半导体衬底; 在半导体衬底的第一表面上生长的外延层; 多个沟槽彼此间隔开并延伸到外延层中,其中两个相邻沟槽之间的外延区域形成硅台面; 具有T形的多晶硅区域通过氧化物层与每个沟槽的内壁和外延层的顶表面分离,其中多晶硅区域的顶表面的宽度大于开放的 每个沟槽的大小; 沉积在整个结构上的阳极,在多晶硅区域的顶表面上形成欧姆接触,在外延层的暴露表面上形成肖特基接触; 和沉积在半导体衬底的第二表面上的阴极,在其上形成欧姆接触。
    • 18. 发明申请
    • ONLINE SECURE DEVICE PROVISIONING WITH ONLINE DEVICE BINDING USING WHITELISTS
    • 在线安全设备使用白名单在线设备绑定
    • US20120089839A1
    • 2012-04-12
    • US13267672
    • 2011-10-06
    • Xin QiuAlexander MedvinskyStuart P. MoskovicsJason A. PasionFan WangTing Yao
    • Xin QiuAlexander MedvinskyStuart P. MoskovicsJason A. PasionFan WangTing Yao
    • H04L9/32H04L9/30
    • H04L9/006H04L9/0891H04L9/14H04L9/321
    • One or more servers are provided including a session manager, authentication module, authorization module, encryption module, database, and protocol handler. The session manager is configured to receive requests for new identity data from network-enabled devices. Each request is authenticated first by the update server via its authentication module by validating the signature of the request message as well as the certificate chain trusted by the update server. The authorization module is configured to determine if the network-enabled devices specified on a whitelist are authorized to be provisioned with new identity data. The database is configured to receive new identity records generated by an identity data generation system. Each of the new identity records includes a new identifier. The new identifier is not associated or linked to any previously assigned/used identifiers and identity data, thus all the new identity records are generated independently and then loaded to the update server.
    • 提供一个或多个服务器,包括会话管理器,认证模块,授权模块,加密模块,数据库和协议处理程序。 会话管理器被配置为从网络启用的设备接收新的身份数据的请求。 通过验证请求消息的签名以及由更新服务器信任的证书链,通过其认证模块,更新服务器首先对每个请求进行认证。 授权模块被配置为确定白名单上指定的启用网络的设备是否被授权为新的身份数据提供。 数据库被配置为接收由身份数据生成系统生成的新的身份记录。 每个新的身份记录都包含一个新的标识符。 新标识符不与任何先前分配/使用的标识符和身份数据相关联或链接,因此所有新的身份记录都是独立生成的,然后加载到更新服务器。