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11. 发明授权

US5438992A Flow-induced artifact elimination in magnetic resonance images 失效
标题翻译：磁共振图像中的流感神经消除
公开(公告)号：US5438992A
公开(公告)日：1995-08-08
申请号：US146393
申请日：1993-11-01
申请人： John M. Siegel, Jr. , David N. Ku , John N. Oshinski , Roderic I. Pettigrew
发明人： John M. Siegel, Jr. , David N. Ku , John N. Oshinski , Roderic I. Pettigrew
IPC分类号： G01R33/56 , G01R33/563 , A61B5/055
CPC分类号： G01R33/563 , G01R33/56
摘要： Magnetic resonance imaging of a blood vessel exhibits flow artifacts, or signal loss, around a constriction (26) due to turbulent fluid flow. Signal loss in a region (27) prior to the constricted region (26) is primarily caused by convective acceleration, and this signal loss is substantially eliminated by performing an acceleration compensation process. Signal loss in a region (32) situated after the constriction (26) is primarily caused by velocity fluctuations, and this signal loss is cured by an imaging process which does not rely on the phase of the electromagnetic excitation signal(s) for spatial localization. Examples of imaging processes for minimizing signal loss due to turbulence include a projection reconstruction process (34) and a two dimensional slice selection process (56). Further, the two dimensional slice selection process (56) may be used for generating instantaneous velocities of fluid flowing through a fluid channel. Also, if a number of instantaneous velocities are produced over a time period, then fluctuation velocities can be determined via time-resolved averaging.
摘要翻译：血管的磁共振成像由于湍流流动而在收缩（26）周围显示出流动假象或信号损失。在收缩区域（26）之前的区域（27）中的信号损失主要由对流加速度引起，并且通过执行加速度补偿处理基本上消除了该信号损失。位于收缩（26）之后的区域（32）中的信号损失主要是由速度波动引起的，并且该信号损失通过不依赖于用于空间定位的电磁激励信号的相位的成像过程来固化。用于使由湍流引起的信号损失最小化的成像处理的示例包括投影重建处理（34）和二维切片选择处理（56）。此外，二维切片选择过程（56）可用于产生流过流体通道的流体的瞬时速度。此外，如果在一段时间内产生多个瞬时速度，则可以通过时间分辨平均来确定波动速度。

12. 发明授权

US09180000B2 Device for tissue repair 有权
标题翻译：组织修复装置
公开(公告)号：US09180000B2
公开(公告)日：2015-11-10
申请号：US13980925
申请日：2012-01-20
申请人： Sabine Cantournet , Laurent Corte , Fabrice Detrez , David N. Ku , Mohammed Cherkaoui , Frances Baxter , Jason Bach
发明人： Sabine Cantournet , Laurent Corte , Fabrice Detrez , David N. Ku , Mohammed Cherkaoui , Frances Baxter , Jason Bach
IPC分类号： A61F2/08
CPC分类号： A61F2/08 , A61F2250/0018
摘要： A based device for use as tissue repair includes a median part between two end parts. The median and end parts have a different tensile stiffness.
摘要翻译：用作组织修复的基于装置的装置包括两个端部之间的中间部分。中间和端部具有不同的拉伸刚度。

13. 发明授权

US08318192B2 Method of making load bearing hydrogel implants 有权
标题翻译：制造承载水凝胶植入物的方法
公开(公告)号：US08318192B2
公开(公告)日：2012-11-27
申请号：US12273450
申请日：2008-11-18
申请人： Barbara D. Boyan , Robert E. Guldberg , Stephen J. Kennedy , David N. Ku
发明人： Barbara D. Boyan , Robert E. Guldberg , Stephen J. Kennedy , David N. Ku
IPC分类号： A61F2/02
CPC分类号： A61L27/56 , A61F2/3094 , A61F2/442 , A61F2002/30011 , A61F2002/30014 , A61F2002/30784 , A61F2250/0018 , A61F2250/0023 , A61L27/52 , A61L2430/38
摘要： Implantable biomaterials, particularly hydrogel substrates with porous surfaces, and methods for enhancing the compatibility of biomaterials with living tissue, and for causing physical attachment between biomaterials and living tissues are provided. Also provided are implants suitable for load-bearing surfaces in hard tissue repair, replacement, or augmentation, and to methods of their use. One embodiment of the invention relates to an implantable spinal disc prosthesis.
摘要翻译：提供可植入生物材料，特别是具有多孔表面的水凝胶基质，以及用于增强生物材料与活组织的相容性以及引起生物材料与活组织之间的物理附着的方法。还提供了适用于硬组织修复，替换或增加中的承载表面的植入物及其使用方法。本发明的一个实施例涉及一种可植入的椎间盘假体。

14. 发明申请

US20120004571A1 LUNG AEROSOL COLLECTION DEVICE 有权
标题翻译： LUNG航空收集装置
公开(公告)号：US20120004571A1
公开(公告)日：2012-01-05
申请号：US13141908
申请日：2009-12-21
申请人： David N. Ku , Larry J. Anderson , Prem A. Midha , Harris L. Bergman , Tamera Scholz
发明人： David N. Ku , Larry J. Anderson , Prem A. Midha , Harris L. Bergman , Tamera Scholz
IPC分类号： A61B10/00
CPC分类号： A61B5/097 , A61B5/082 , A61B2010/0087 , G01N33/497
摘要： A device for collecting material from lung aerosols. The device functions by collecting aerosols from the lower airway separated from material in the by collecting air from the upper airway in a chamber that when full causes the remaining exhaled aerosols from the lungs to be captured by a filter. The filter collects sample of material from the separated lung aerosols.
摘要翻译：用于从肺气溶胶收集材料的装置。该装置通过从下部气道中收集气溶胶而起作用，其通过在室中从上呼吸道收集空气而收集气体，当其完全导致剩余的来自肺部的呼出气溶胶被过滤器捕获时。过滤器从分离的肺气溶胶中收集材料样品。

15. 发明授权

US08895073B2 Hydrogel implant with superficial pores 有权
标题翻译：具有浅表孔的水凝胶植入物
公开(公告)号：US08895073B2
公开(公告)日：2014-11-25
申请号：US13052826
申请日：2011-03-21
申请人： Barbara D. Boyan , Robert E. Guldberg , Stephen J. Kennedy , David N. Ku , Zvi Schwartz
发明人： Barbara D. Boyan , Robert E. Guldberg , Stephen J. Kennedy , David N. Ku , Zvi Schwartz
IPC分类号： A61K9/50 , A61L27/56 , A61F2/44 , A61L27/52 , A61F2/30
CPC分类号： A61L27/56 , A61F2/3094 , A61F2/442 , A61F2002/30011 , A61F2002/30014 , A61F2002/30784 , A61F2250/0018 , A61F2250/0023 , A61L27/52 , A61L2430/38
摘要： Implantable biomaterials, particularly hydrogel substrates with porous surfaces, and methods for enhancing the compatibility of biomaterials with living tissue, and for causing physical attachment between biomaterials and living tissues are provided. Also provided are implants suitable for load-bearing surfaces in hard tissue repair, replacement, or augmentation, and to methods of their use. One embodiment of the invention relates to an implantable spinal disc prosthesis.
摘要翻译：提供可植入生物材料，特别是具有多孔表面的水凝胶基质，以及用于增强生物材料与活组织的相容性以及引起生物材料与活组织之间的物理附着的方法。还提供了适用于硬组织修复，替换或增加中的承载表面的植入物及其使用方法。本发明的一个实施例涉及一种可植入的椎间盘假体。

16. 发明申请

US20140039620A1 DEVICE FOR TISSUE REPAIR 有权
标题翻译：用于组织修复的装置
公开(公告)号：US20140039620A1
公开(公告)日：2014-02-06
申请号：US13980925
申请日：2012-01-20
申请人： Sabine Cantournet , Laurent Corte , Fabrice Detrez , David N. Ku , Mohammed Cherkaoui , Frances Baxter , Jason Bach
发明人： Sabine Cantournet , Laurent Corte , Fabrice Detrez , David N. Ku , Mohammed Cherkaoui , Frances Baxter , Jason Bach
IPC分类号： A61F2/08
CPC分类号： A61F2/08 , A61F2250/0018
摘要： A based device for use as tissue repair includes a median part between two end parts. The median and end parts have a different tensile stiffness.
摘要翻译：用作组织修复的基于装置的装置包括两个端部之间的中间部分。中间和端部具有不同的拉伸刚度。

17. 发明授权

US08038920B2 Methods of producing PVA hydrogel implants and related devices 有权
标题翻译：生产PVA水凝胶植入物及相关装置的方法
公开(公告)号：US08038920B2
公开(公告)日：2011-10-18
申请号：US11626405
申请日：2007-01-24
申请人： Guilhem Denoziere , David N. Ku
发明人： Guilhem Denoziere , David N. Ku
IPC分类号： B29C45/14
CPC分类号： A61F2/30965 , A61F2/30771 , A61F2/3094 , A61F2002/30014 , A61F2002/30069 , A61F2002/30075 , A61F2002/30133 , A61F2002/30556 , A61F2002/30576 , A61F2002/30884 , A61F2002/30909 , A61F2002/3092 , A61F2002/30957 , A61F2002/4495 , A61F2210/0061 , A61F2230/0015 , A61F2250/0009 , A61F2250/0018 , A61F2310/00365 , A61L27/16 , A61L27/52 , C08L29/04
摘要： Methods of fabricating elastomeric implants employ a mold with PVA crystals and irrigant added to the mold independent of each other. Related molds are also described.
摘要翻译：制造弹性体植入物的方法使用具有PVA晶体的模具和冲洗剂，彼此独立地添加到模具中。还描述了相关模具。

18. 发明申请

US20090263446A1 METHOD OF MAKING LOAD BEARING HYDROGEL IMPLANTS 有权
标题翻译：负载承载水压铸造方法
公开(公告)号：US20090263446A1
公开(公告)日：2009-10-22
申请号：US12273450
申请日：2008-11-18
申请人： Barbara D. Boyan , Robert E. Guldberg , Stephen J. Kennedy , David N. Ku
发明人： Barbara D. Boyan , Robert E. Guldberg , Stephen J. Kennedy , David N. Ku
IPC分类号： A61K9/00 , B05D3/00 , A61P19/02
CPC分类号： A61L27/56 , A61F2/3094 , A61F2/442 , A61F2002/30011 , A61F2002/30014 , A61F2002/30784 , A61F2250/0018 , A61F2250/0023 , A61L27/52 , A61L2430/38
摘要： Implantable biomaterials, particularly hydrogel substrates with porous surfaces, and methods for enhancing the compatibility of biomaterials with living tissue, and for causing physical attachment between biomaterials and living tissues are provided. Also provided are implants suitable for load-bearing surfaces in hard tissue repair, replacement, or augmentation, and to methods of their use. One embodiment of the invention relates to an implantable spinal disc prosthesis.
摘要翻译：提供可植入生物材料，特别是具有多孔表面的水凝胶基质，以及用于增强生物材料与活组织的相容性以及引起生物材料与活组织之间的物理附着的方法。还提供了适用于硬组织修复，替换或增加中的承载表面的植入物及其使用方法。本发明的一个实施例涉及一种可植入的椎间盘假体。

19. 发明授权

US06377832B1 System and method for analyzing a medical image 失效
标题翻译：用于分析医学图像的系统和方法
公开(公告)号：US06377832B1
公开(公告)日：2002-04-23
申请号：US09272862
申请日：1999-03-19
申请人： Harris L. Bergman , David N. Ku
发明人： Harris L. Bergman , David N. Ku
IPC分类号： A61B505
CPC分类号： A61B5/7264 , A61B5/0261 , A61B5/055 , A61B5/411 , A61B5/7267 , G06T7/0012 , G06T7/62 , G06T7/64 , G06T7/66 , G06T2207/30101 , Y10S128/925
摘要： Disclosed is a system and method for determining a severity of a stenosis in a blood vessel depicted in a magnetic resonance imaging (MRI) data set. The system comprises a neural network configured to calculate the severity of the stenosis in the blood vessel based upon a number of input parameters, and the input parameters including at least one characteristic of a signal void associated with the stenosis in the MRI data set. The input parameters may include, for example, a flow rate of blood through the blood vessel, a length of a longitudinal axis of the signal void, and an average image intensity along the longitudinal axis of the signal void as well as other input parameters.
摘要翻译：公开了一种用于确定在磁共振成像（MRI）数据集中描绘的血管狭窄严重程度的系统和方法。该系统包括神经网络，其被配置为基于输入参数的数量来计算血管狭窄的严重性，并且输入参数包括与MRI数据集中的狭窄相关联的信号空隙的至少一个特征。输入参数可以包括例如通过血管的血液的流速，信号空隙的纵轴的长度，以及沿着信号空隙的纵轴的平均图像强度以及其它输入参数。

20. 发明授权

US4954519A Isocoumarins with basic substituents as serine proteases inhibitors, anticoagulants and anti-inflammatory agents 失效
标题翻译：具有碱性取代基的异香豆素作为丝氨酸蛋白酶抑制剂，抗凝剂和抗炎剂
公开(公告)号：US4954519A
公开(公告)日：1990-09-04
申请号：US374980
申请日：1989-07-03
申请人： James C. Powers , Chih-Min Kam , Steven W. Oweida , David N. Ku
发明人： James C. Powers , Chih-Min Kam , Steven W. Oweida , David N. Ku
IPC分类号： C07D311/76
CPC分类号： C07D311/76 , Y10S514/822
摘要： Substituted isocoumarins, their use in inhibiting serine proteases with trypsin-like, chymotrypsin-like and elastase-like specificity and their roles as anticoagulant agents, and anti-inflammatory agents.
摘要翻译：取代的异香豆素，它们用于抑制胰蛋白酶样丝氨酸蛋白酶，胰凝乳蛋白酶样和弹性蛋白酶样特异性及其作为抗凝血剂和抗炎剂的作用。

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