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11. 发明授权

US08197824B2 Rapid, efficient purification of HSV-specific T-lymphocytes and HSV antigens identified via same 有权
标题翻译：通过相同鉴定的HSV特异性T淋巴细胞和HSV抗原的快速，有效的纯化
公开(公告)号：US08197824B2
公开(公告)日：2012-06-12
申请号：US12691309
申请日：2010-01-21
申请人： David M. Koelle , Zhi Liu , Lawrence Corey
发明人： David M. Koelle , Zhi Liu , Lawrence Corey
IPC分类号： A61K39/245
CPC分类号： A61K39/245 , A61K39/12 , A61K2039/5158 , A61K2039/5256 , C07K14/005 , C12N7/00 , C12N2710/16622 , C12N2710/16634 , C12N2710/24143
摘要： Described is a method of identifying an immunologically active antigen of a virus that attacks skin, as well as a method of enriching a population of lymphocytes for T lymphocytes that are specific to a virus that attacks skin. Also provided are HSV antigens and epitopes that are useful for the prevention and treatment of HSV infection that have been identified via the methods of the invention. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigen or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.
摘要翻译：描述了鉴定攻击皮肤的病毒的免疫活性抗原的方法，以及对侵袭皮肤的病毒特异性的T淋巴细胞的淋巴细胞群富集的方法。还提供了可用于预防和治疗已经通过本发明的方法鉴定的HSV感染的HSV抗原和表位。对本发明的抗原具有特异性的T细胞已经证明了对负载有病毒编码的肽表位的细胞的细胞毒性活性，并且在许多情况下，针对感染HSV的细胞。鉴定负责T细胞特异性的免疫原性抗原提供了改进的抗病毒治疗和预防策略。含有编码本发明抗原的抗原或多核苷酸的组合物提供有效靶向的疫苗，用于预防和治疗HSV感染。

12. 发明申请

US20120027790A1 IMMUNOLOGICAL HERPES SIMPLEX VIRUS ANTIGENS AND METHODS FOR USE THEREOF 有权
标题翻译：免疫学阴性复制病毒抗原及其使用方法
公开(公告)号：US20120027790A1
公开(公告)日：2012-02-02
申请号：US13276166
申请日：2011-10-18
申请人： David M. Koelle , Lawrence Corey
发明人： David M. Koelle , Lawrence Corey
IPC分类号： A61K39/245 , A61K35/76 , C12P21/06 , C12N7/01 , C12N1/21 , C12N15/63 , C07K14/03 , C07K7/08 , C07K14/035 , C07H21/04 , A61K47/00 , C12N5/02
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/55572 , A61K2039/57 , C07K2319/00 , C12N2710/16622 , C12N2710/16634
摘要： The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are antigens and/or their constituent epitopes confirmed to be recognized by T-cells derived from herpetic lesions or from uterine cervix. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.
摘要翻译：本发明提供可用于预防和治疗HSV感染的HSV抗原。本文公开了抗原和/或其组成表位，其被证实被来自疱疹病变或子宫颈的T细胞识别。对本发明的抗原具有特异性的T细胞已经证明了对负载有病毒编码的肽表位的细胞的细胞毒性活性，并且在许多情况下，针对感染HSV的细胞。鉴定负责T细胞特异性的免疫原性抗原提供了改进的抗病毒治疗和预防策略。含有编码本发明抗原的抗原或多核苷酸的组合物提供有效靶向的疫苗，用于预防和治疗HSV感染。

13. 发明授权

US07744903B2 Immunological herpes simplex virus antigens and methods for use thereof 有权
标题翻译：免疫性单纯疱疹病毒抗原及其使用方法
公开(公告)号：US07744903B2
公开(公告)日：2010-06-29
申请号：US11055477
申请日：2005-02-10
申请人： David M. Koelle , Lawrence Corey
发明人： David M. Koelle , Lawrence Corey
IPC分类号： A61K39/245
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/55572 , A61K2039/57 , C07K2319/00 , C12N2710/16622 , C12N2710/16634
摘要： The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are antigens and/or their constituent epitopes confirmed to be recognized by T-cells derived from herpetic lesions or from uterine cervix. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.
摘要翻译：本发明提供可用于预防和治疗HSV感染的HSV抗原。本文公开了抗原和/或其组成表位，其被证实被来自疱疹病变或子宫颈的T细胞识别。对本发明的抗原具有特异性的T细胞已经证明了对负载有病毒编码的肽表位的细胞的细胞毒性活性，并且在许多情况下，针对感染HSV的细胞。鉴定负责T细胞特异性的免疫原性抗原提供了改进的抗病毒治疗和预防策略。含有编码本发明抗原的抗原或多核苷酸的组合物提供有效靶向的疫苗，用于预防和治疗HSV感染。

14. 发明授权

US07078041B2 Rapid, efficient purification of HSV-specific T-lymphocytes and HSV antigens identified via same 失效
公开(公告)号：US07078041B2
公开(公告)日：2006-07-18
申请号：US10623429
申请日：2003-07-18
申请人： David M. Koelle , Zhi Liu , Lawrence Corey
发明人： David M. Koelle , Zhi Liu , Lawrence Corey
IPC分类号： A61K39/245
CPC分类号： A61K39/245 , A61K39/12 , A61K2039/5158 , A61K2039/5256 , C07K14/005 , C12N7/00 , C12N2710/16622 , C12N2710/16634 , C12N2710/24143
摘要： Described is a method of identifying an immunologically active antigen of a virus that attacks skin, as well as a method of enriching a population of lymphocytes for T lymphocytes that are specific to a virus that attacks skin. Also provided are HSV antigens and epitopes that are useful for the prevention and treatment of HSV infection that have been identified via the methods of the invention. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.

15. 发明授权

US06375952B1 Immunological herpes simplex virus antigens and methods for use thereof 有权
标题翻译：免疫性单纯疱疹病毒抗原及其使用方法
公开(公告)号：US06375952B1
公开(公告)日：2002-04-23
申请号：US09368770
申请日：1999-08-05
申请人： David M. Koelle , Lawrence Corey
发明人： David M. Koelle , Lawrence Corey
IPC分类号： A61K39245
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/55572 , A61K2039/57 , C07K2319/00 , C12N2710/16622 , C12N2710/16634
摘要： The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are antigens and/or their constituent epitopes confirmed to be recognized by T-cells derived from herpetic lesions or from uterine cervix. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.
摘要翻译：本发明提供可用于预防和治疗HSV感染的HSV抗原。本文公开了抗原和/或其组成表位，其被证实被来自疱疹病变或子宫颈的T细胞识别。对本发明的抗原具有特异性的T细胞已经证明了对负载有病毒编码的肽表位的细胞的细胞毒性活性，并且在许多情况下，针对感染HSV的细胞。鉴定负责T细胞特异性的免疫原性抗原提供了改进的抗病毒治疗和预防策略。含有编码本发明抗原的抗原或多核苷酸的组合物提供有效靶向的疫苗，用于预防和治疗HSV感染。

16. 发明授权

US09044447B2 Antigenic peptide of HSV-2 and methods for using same 有权
标题翻译： HSV-2的抗原肽及其使用方法
公开(公告)号：US09044447B2
公开(公告)日：2015-06-02
申请号：US13262833
申请日：2010-04-03
申请人： Lawrence Corey , Kerry J. Laing , Anna Wald , David M. Koelle
发明人： Lawrence Corey , Kerry J. Laing , Anna Wald , David M. Koelle
IPC分类号： A61K39/245 , A61K9/19 , C07K14/005 , A61K39/00 , C07K7/08 , A61K9/00
CPC分类号： A61K39/245 , A61K9/0019 , A61K39/00 , A61K2039/5158 , C07K14/005 , C12N7/00 , C12N2710/16622 , C12N2710/16634
摘要： The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection, including epitopes confirmed to be recognized by T-cells derived from herpetic lesions. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.
摘要翻译：本发明提供可用于预防和治疗HSV感染的HSV抗原，其包括确认为来自疱疹病变的T细胞识别的表位。对本发明的抗原具有特异性的T细胞已经证明了对负载有病毒编码的肽表位的细胞的细胞毒性活性，并且在许多情况下，针对感染HSV的细胞。鉴定负责T细胞特异性的免疫原性抗原提供了改进的抗病毒治疗和预防策略。含有编码本发明抗原的抗原或多核苷酸的组合物提供有效靶向的疫苗，用于预防和治疗HSV感染。

17. 发明授权

US08067010B2 Immunological herpes simplex virus antigens and methods for use thereof 有权
标题翻译：免疫性单纯疱疹病毒抗原及其使用方法
公开(公告)号：US08067010B2
公开(公告)日：2011-11-29
申请号：US12777156
申请日：2010-05-10
申请人： David M. Koelle , Lawrence Corey
发明人： David M. Koelle , Lawrence Corey
IPC分类号： A61K39/245 , A61K39/295 , A61K38/16 , A61K48/00 , C12N15/38 , C12N15/861 , C12N15/863 , C12N15/867 , C12N15/869 , C12N7/01 , C12N5/10
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/55572 , A61K2039/57 , C07K2319/00 , C12N2710/16622 , C12N2710/16634
摘要： The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are antigens and/or their constituent epitopes confirmed to be recognized by T-cells derived from herpetic lesions or from uterine cervix. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.
摘要翻译：本发明提供可用于预防和治疗HSV感染的HSV抗原。本文公开了抗原和/或其组成表位，其被证实被来自疱疹病变或子宫颈的T细胞识别。对本发明的抗原具有特异性的T细胞已经证明了对负载有病毒编码的肽表位的细胞的细胞毒性活性，并且在许多情况下，针对感染HSV的细胞。鉴定负责T细胞特异性的免疫原性抗原提供了改进的抗病毒治疗和预防策略。含有编码本发明抗原的抗原或多核苷酸的组合物提供有效靶向的疫苗，用于预防和治疗HSV感染。

18. 发明申请

US20100215693A1 IMMUNOLOGICAL HERPES SIMPLEX VIRUS ANTIGENS AND METHODS FOR USE THEREOF 有权
标题翻译：免疫学阴性复制病毒抗原及其使用方法
公开(公告)号：US20100215693A1
公开(公告)日：2010-08-26
申请号：US12777156
申请日：2010-05-10
申请人： David M. Koelle , Lawrence Corey
发明人： David M. Koelle , Lawrence Corey
IPC分类号： A61K39/12 , A61K31/7088 , A61K38/16 , C12N15/74 , C12N7/01 , C12P21/00 , A61K35/76 , C07K14/00 , C07H21/00 , C12N5/0783 , A61P37/04
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/55572 , A61K2039/57 , C07K2319/00 , C12N2710/16622 , C12N2710/16634
摘要： The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are antigens and/or their constituent epitopes confirmed to be recognized by T-cells derived from herpetic lesions or from uterine cervix. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.
摘要翻译：本发明提供可用于预防和治疗HSV感染的HSV抗原。本文公开了抗原和/或其组成表位，其被证实被来自疱疹病变或子宫颈的T细胞识别。对本发明的抗原具有特异性的T细胞已经证明了对负载有病毒编码的肽表位的细胞的细胞毒性活性，并且在许多情况下，针对感染HSV的细胞。鉴定负责T细胞特异性的免疫原性抗原提供了改进的抗病毒治疗和预防策略。含有编码本发明抗原的抗原或多核苷酸的组合物提供有效靶向的疫苗，用于预防和治疗HSV感染。

19. 发明授权

US07666434B2 Rapid, efficient purification of HSV-specific T-lymphocytes and HSV antigens identified via same 有权
标题翻译：通过相同鉴定的HSV特异性T淋巴细胞和HSV抗原的快速，有效的纯化
公开(公告)号：US07666434B2
公开(公告)日：2010-02-23
申请号：US12233280
申请日：2008-09-18
申请人： David M. Koelle , Zhi Liu , Lawrence Corey
发明人： David M. Koelle , Zhi Liu , Lawrence Corey
IPC分类号： A61K39/245
CPC分类号： A61K39/245 , A61K39/12 , A61K2039/5158 , A61K2039/5256 , C07K14/005 , C12N7/00 , C12N2710/16622 , C12N2710/16634 , C12N2710/24143
摘要： Described is a method of identifying an immunologically active antigen of a virus that attacks skin, as well as a method of enriching a population of lymphocytes for T lymphocytes that are specific to a virus that attacks skin. Also provided are HSV antigens and epitopes that are useful for the prevention and treatment of HSV infection that have been identified via the methods of the invention. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.
摘要翻译：描述了鉴定攻击皮肤的病毒的免疫活性抗原的方法，以及对侵袭皮肤的病毒特异性的T淋巴细胞的淋巴细胞群富集的方法。还提供了可用于预防和治疗已经通过本发明的方法鉴定的HSV感染的HSV抗原和表位。对本发明的抗原具有特异性的T细胞已经证明了对负载有病毒编码的肽表位的细胞的细胞毒性活性，并且在许多情况下，针对感染HSV的细胞。鉴定负责T细胞特异性的免疫原性抗原提供了改进的抗病毒治疗和预防策略。含有编码本发明抗原的抗原或多核苷酸的组合物提供有效靶向的疫苗，用于预防和治疗HSV感染。

20. 发明授权

US07431934B2 Rapid, efficient purification of HSV-specific T-lymphocytes and HSV antigens identified via same 有权
标题翻译：通过相同鉴定的HSV特异性T淋巴细胞和HSV抗原的快速，有效的纯化
公开(公告)号：US07431934B2
公开(公告)日：2008-10-07
申请号：US11364438
申请日：2006-02-28
申请人： David M. Koelle , Zhi Liu , Lawrence Corey
发明人： David M. Koelle , Zhi Liu , Lawrence Corey
IPC分类号： A61K39/12
CPC分类号： A61K39/245 , A61K39/12 , A61K2039/5158 , A61K2039/5256 , C07K14/005 , C12N7/00 , C12N2710/16622 , C12N2710/16634 , C12N2710/24143
摘要： Described is a method of identifying an immunologically active antigen of a virus that attacks skin, as well as a method of enriching a population of lymphocytes for T lymphocytes that are specific to a virus that attacks skin. Also provided are HSV antigens and epitopes that are useful for the prevention and treatment of HSV infection that have been identified via the methods of the invention. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.
摘要翻译：描述了鉴定攻击皮肤的病毒的免疫活性抗原的方法，以及对侵袭皮肤的病毒特异性的T淋巴细胞的淋巴细胞群富集的方法。还提供了可用于预防和治疗已经通过本发明的方法鉴定的HSV感染的HSV抗原和表位。对本发明的抗原具有特异性的T细胞已经证明了对负载有病毒编码的肽表位的细胞的细胞毒性活性，并且在许多情况下，针对感染HSV的细胞。鉴定负责T细胞特异性的免疫原性抗原提供了改进的抗病毒治疗和预防策略。含有编码本发明抗原的抗原或多核苷酸的组合物提供有效靶向的疫苗，用于预防和治疗HSV感染。

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