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11. 发明申请

US20130245091A1 Compositions for Targeted Delivery of siRNA 有权
公开(公告)号：US20130245091A1
公开(公告)日：2013-09-19
申请号：US13615938
申请日：2012-09-14
申请人： David B. Rozema , David L. Lewis , Darren H. Wakefield , Torsten Hoffmann , Eric A. Kitas , Peter Mohr , Philipp Hadwiger , Wilma Thuer , Linda Valis
发明人： David B. Rozema , David L. Lewis , Darren H. Wakefield , Torsten Hoffmann , Eric A. Kitas , Peter Mohr , Philipp Hadwiger , Wilma Thuer , Linda Valis
IPC分类号： A61K47/32 , A61K47/48
CPC分类号： C12N15/113 , A61K9/08 , A61K31/713 , A61K47/32 , A61K47/549 , A61K47/60 , A61K47/65 , A61K48/0041 , C12N15/111 , C12N15/87 , C12N2310/14 , C12N2310/141 , C12N2310/3515 , C12N2320/32
摘要： The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers.

12. 发明授权

US09011919B2 Compositions for targeted delivery of siRNA 有权
标题翻译：用于靶向递送siRNA的组合物
公开(公告)号：US09011919B2
公开(公告)日：2015-04-21
申请号：US13615938
申请日：2012-09-14
申请人： David B. Rozema , David L. Lewis , Darren H. Wakefield , Torsten Hoffmann , Eric Kitas , Peter Mohr , Philipp Hadwiger , Wilma Thuer , Linda Valis
发明人： David B. Rozema , David L. Lewis , Darren H. Wakefield , Torsten Hoffmann , Eric Kitas , Peter Mohr , Philipp Hadwiger , Wilma Thuer , Linda Valis
IPC分类号： A61K9/14 , C07H21/02 , C07K1/00 , A61K47/32 , A61K9/08 , A61K48/00 , C12N15/11 , C12N15/87 , A61K47/48
CPC分类号： C12N15/113 , A61K9/08 , A61K31/713 , A61K47/32 , A61K47/549 , A61K47/60 , A61K47/65 , A61K48/0041 , C12N15/111 , C12N15/87 , C12N2310/14 , C12N2310/141 , C12N2310/3515 , C12N2320/32
摘要： The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers.
摘要翻译：本发明涉及用于将体内RNA干扰（RNAi）多核苷酸靶向递送至肝细胞的组合物。靶向RNAi多核苷酸与共靶向递送聚合物一起施用。递送聚合物提供膜穿透功能，用于将RNAi多核苷酸从细胞外部移动到细胞内。可逆修饰提供对递送聚合物的生理反应性。

13. 发明授权

US09249179B2 Galactose cluster-pharmacokinetic modulator targeting moiety for siRNA 有权
标题翻译：用于siRNA的半乳糖簇 - 药代动力学调节剂靶向部分
公开(公告)号：US09249179B2
公开(公告)日：2016-02-02
申请号：US13327271
申请日：2011-12-15
申请人： Philipp Hadwiger , Torsten Hoffmann , Eric A. Kitas , Peter Mohr , Ingo Roehl , Linda Valis , David B. Rozema , David L. Lewis , Darren H. Wakefield
发明人： Philipp Hadwiger , Torsten Hoffmann , Eric A. Kitas , Peter Mohr , Ingo Roehl , Linda Valis , David B. Rozema , David L. Lewis , Darren H. Wakefield
IPC分类号： A61K31/7088 , C07H21/02
CPC分类号： C07K5/1021 , C07H21/02
摘要： The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cell in vivo. The pharmacokinetic modulator improve in vivo targeting compared to the targeting ligand alone. Targeting ligand-pharmacokinetic modulator targeting moiety targeted RNAi polynucleotides can be administered in vivo alone or together with co-targeted delivery polymers.
摘要翻译：本发明涉及用于靶向将RNA干扰（RNAi）多核苷酸递送至细胞体内的组合物。与单独的靶向配体相比，药代动力学调节剂改善体内靶向。靶向配体 - 药代动力学调节剂靶向部分靶向的RNAi多核苷酸可以单独施用或与共靶向递送聚合物一起施用。

14. 发明授权

US07101995B2 Compositions and processes using siRNA, amphipathic compounds and polycations 有权
公开(公告)号：US07101995B2
公开(公告)日：2006-09-05
申请号：US10157674
申请日：2002-05-28
申请人： David L. Lewis , James E. Hagstrom , Hans Herweijer , Aaron G. Loomis , Sean D. Monahan , Jon A. Wolff
发明人： David L. Lewis , James E. Hagstrom , Hans Herweijer , Aaron G. Loomis , Sean D. Monahan , Jon A. Wolff
IPC分类号： C08L79/00 , C07H21/04 , A61K48/00 , C12N15/87
CPC分类号： C12N15/1137 , A61K31/58 , A61K31/74 , A61K38/00 , A61K48/00 , C12N15/111 , C12N15/88 , C12N2310/14 , C12N2320/32 , C12N2710/24111 , C12Y206/01002 , A61K2300/00
摘要： Described is a deliverable composition with low toxicity comprising an amphipathic compound, a polycation, and a siRNA. The composition may be used in the process of delivering a siRNA to an animal cell or more particularly, a mammal cell.

15. 发明授权

US07601367B2 Compositions and processes using siRNA, amphipathic compounds and polycations 有权
标题翻译：使用siRNA，两亲性化合物和聚阳离子的组合物和方法
公开(公告)号：US07601367B2
公开(公告)日：2009-10-13
申请号：US10845968
申请日：2004-05-14
申请人： Sean D. Monahan , David L. Lewis , Hans Herweijer , Jon A. Wolff , James E. Hagstrom , Aaron G. Loomis , Vladimir Trubetskoy , Lori Higgs
发明人： Sean D. Monahan , David L. Lewis , Hans Herweijer , Jon A. Wolff , James E. Hagstrom , Aaron G. Loomis , Vladimir Trubetskoy , Lori Higgs
IPC分类号： A61K9/127 , C07H21/04 , C12N15/88
CPC分类号： C12N15/111 , A61K31/495 , A61K31/58 , A61K31/7105 , A61K31/74 , A61K48/0025 , A61K48/0041 , C07H21/04 , C12N15/88 , C12N2310/14 , C12N2320/32 , A61K2300/00
摘要： Described is a deliverable composition with low toxicity comprising an amphipathic compound, a polycation, and a siRNA. The composition may be used in the process of delivering a siRNA to an animal cell or more particularly, a mammal cell.
摘要翻译：描述了具有低毒性的可递送组合物，其包含两亲性化合物，聚阳离子和siRNA。组合物可以用于将siRNA递送到动物细胞或更特别是哺乳动物细胞的过程中。

16. 发明授权

US07781415B2 Process for delivering sirna to cardiac muscle tissue 失效
标题翻译：将精神神经递送至心肌组织的过程
公开(公告)号：US07781415B2
公开(公告)日：2010-08-24
申请号：US10770588
申请日：2004-02-03
申请人： Hans Herweijer , Julia Hegge , Jon A. Wolff , David L. Lewis
发明人： Hans Herweijer , Julia Hegge , Jon A. Wolff , David L. Lewis
IPC分类号： A61K48/00
CPC分类号： A61K48/0083
摘要： A process for delivering a polynucleotide to a cardiac tissue cell in a mammal is described, comprising introducing a composition consisting of a polynucleotide into a blood vessel and increasing permeability of the blood vessel to the polynucleotide. The polynucleotide can be a small interfering RNA or microRNA and inhibit gene expression in the cell.
摘要翻译：描述了将多核苷酸递送至哺乳动物心脏组织细胞的方法，包括将由多核苷酸组成的组合物引入血管并增加血管对多核苷酸的通透性。多核苷酸可以是小干扰RNA或微小RNA并抑制细胞中的基因表达。

17. 发明授权

US09074336B2 Form part for a frost protected shallow footing system 有权
标题翻译：形成霜冻保护浅基础系统的一部分
公开(公告)号：US09074336B2
公开(公告)日：2015-07-07
申请号：US13796953
申请日：2013-03-12
申请人： David L. Lewis
发明人： David L. Lewis
IPC分类号： E02D27/00
CPC分类号： E02D27/013 , E02D27/00 , E02D2200/1664 , E02D2250/0023 , E04G13/00
摘要： A permanent frost protected shallow foundation footing for a building is assembled from a plurality of form parts arranged in a chain that is partially below ground level to form a foundation perimeter. The form parts are made of a lightweight material such as insulating foam material shaped as an elongated sectional unit with an overhang part overhanging a cavity part of an interior cavity. The interior cavity has an opening for receiving a concrete pour concurrent with a concrete pour of a floor. Open ends of the assembled sectional units abut each other in end-to-end alignment to form an elongated cavity inside the perimeter chain of form parts that is filled with concrete. The overhang part may have a foot shape that fits inside the interior cavity of another form part that may also have a foot shape for compact storage or transport prior to assembly.
摘要翻译：用于建筑物的永久防霜保护的浅基础基础从布置在部分地下水平的链条中的多个形式部件组装以形成基础周边。形状部件由轻质材料制成，例如形状为细长截面单元的绝缘泡沫材料，其具有悬垂在内部空腔的空腔部分上的突出部分。内部空腔具有用于接收混凝土浇注的开口，同时具有地板的混凝土浇筑。组装的截面单元的开口端部以端对端的对准方式彼此邻接，以在填充有混凝土的成形部件的周边链条中形成细长的空腔。突出部分可以具有适合在另一形状部分的内腔内的脚形，其也可以具有足部形状，用于在组装之前进行紧凑的存储或运输。

18. 发明授权

US08640501B2 Neck ring and method of making for a glass container forming machine 有权
标题翻译：颈环和玻璃容器成型机的制造方法
公开(公告)号：US08640501B2
公开(公告)日：2014-02-04
申请号：US12080974
申请日：2008-04-08
申请人： Robin L. Flynn , David L. Lewis
发明人： Robin L. Flynn , David L. Lewis
IPC分类号： C03B11/00
CPC分类号： C03B9/325 , C03B9/48 , Y02P40/57
摘要： A neck ring for molding a glass container neck finish that includes at least one closure attachment feature. The neck ring includes two semi-annular bi-metal neck ring halves, each consisting essentially of a neck ring insert of wear-resistant metal construction, and a neck ring body of heat-conductive metal construction different from said wear-resistant metal construction and formed around said neck ring insert so as to embed it in said neck ring body. Each of said neck ring halves has a glass-contacting cavity face that includes a first surface portion formed by said inserts for molding the at least one closure attachment feature on the neck finish, and a second surface portion formed by said bodies for molding portions of the neck finish excluding the at least one closure attachment feature.
摘要翻译：用于模制玻璃容器颈部的颈环，其包括至少一个闭合附接特征。颈环包括两个半环形双金属颈环半部，每个半环形二环颈部半部分基本上由耐磨金属结构的颈环插入件和不同于所述耐磨金属结构的导热金属结构的颈环体和形成在所述颈环插入件周围，以便将其嵌入所述颈环体中。每个所述颈环半部具有玻璃接触腔体表面，其包括由所述插入件形成的第一表面部分，所述第一表面部分用于模制颈部末端处的至少一个封闭附接特征，以及由所述主体形成的第二表面部分，用于模制部分不包括至少一个闭合件附接特征的颈部完成。

19. 发明申请

US20110271626A1 Radiant Thermal Barrier 有权
标题翻译：辐射热障
公开(公告)号：US20110271626A1
公开(公告)日：2011-11-10
申请号：US13101331
申请日：2011-05-05
申请人： David L. Lewis
发明人： David L. Lewis
IPC分类号： E04B1/78
CPC分类号： E04D13/1625 , E04B1/7654 , E04B2001/7691
摘要： A thermal barrier is formed into a hat-shape by folding sections of an extended length of board formed for assembly and insertion as a barrier to thermal radiation into a space between two joists or studs of a floor, wall, roof, or ceiling of a building for completely covering the space while also covering protruding edges of the joists or studs so as to reduce thermal energy transfer through the joists or studs themselves. A thermal barrier assembly is shown with an outer reflective surface and is also shown for assembly into a form having an inner enclosure for enclosing an inner thermal barrier also having a reflective surface for reducing thermal radiation transfer by reflection and protected from dust by virtue of the enclosure.
摘要翻译：通过将形成的用于组装和插入的延伸长度的板的部分折叠成热辐射的屏障，将热障形成折叠成一个地板，墙壁，屋顶或天花板的两个托梁或螺柱之间的空间，形成帽子形状用于完全覆盖空间的同时还覆盖托梁或螺柱的突出边缘，以便减少通过托梁或螺柱本身的热能传递。热屏障组件被示出具有外部反射表面，并且还示出为用于组装成具有用于封闭内部热障壁的形式的形式，其还具有反射表面，用于通过反射减少热辐射传递并且通过反射表面防止灰尘外壳。

20. 发明申请

US20080273435A1 OPTICAL DNA 有权
标题翻译：光学DNA
公开(公告)号：US20080273435A1
公开(公告)日：2008-11-06
申请号：US11689741
申请日：2007-03-22
申请人： Darko Kirovski , Estrada T. Colon , David L. Lewis , Thomas Patrick Powell , Deepak Vijaywargiay
发明人： Darko Kirovski , Estrada T. Colon , David L. Lewis , Thomas Patrick Powell , Deepak Vijaywargiay
IPC分类号： G11B7/085
CPC分类号： H04L9/3247 , G11B20/00086 , G11B20/00123 , H04L2209/30 , H04L2209/603
摘要： The claimed subject matter relates to architectures and/or mechanisms that can facilitate issuing, embedding and verification of an optical DNA (o-DNA) signature. A first mechanism is provided for obtaining a set of manufacturing errors inherent in an optical media instance. These errors can be encoded into the o-DNA that can be cryptographically signed with a private key, then embedded into the source optical media instance. A second mechanism is provided that can decrypt the o-DNA with a public key and compare the authenticated errors to the observed errors to ascertain whether the optical media instance is authentic as opposed to a forgery or counterfeit.
摘要翻译：所要求保护的主题涉及可以促进光学DNA（o-DNA）签名的发布，嵌入和验证的架构和/或机制。提供了一种用于获得光学介质实例中固有的一组制造误差的第一机构。这些错误可以编码到可以使用私钥进行加密签名的o-DNA中，然后嵌入到源光学媒体实例中。提供了可以使用公开密钥来解密o-DNA的第二种机制，并将认证的错误与观察到的错误进行比较，以确定光学媒体实例是否与伪造或伪造相反是真实的。

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