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    • 20. 发明授权
    • Process or making 3-hydroxyaldehydes
    • 制备或制备3-羟基醛
    • US5344993A
    • 1994-09-06
    • US130258
    • 1993-10-01
    • Lynn H. SlaughJuan P. Arhancet
    • Lynn H. SlaughJuan P. Arhancet
    • C07C29/16C07C31/20C07C45/58C07C45/50C07C45/57
    • C07C45/58C07C29/16C07C31/20
    • This invention relates to a process for making 3-hydroxyaldehydes having 4 or more carbon atoms by intimately contacting(a) 1,2-epoxides having 3 or more carbon numbers,(b) ditertiary phosphine-modified cobalt carbonyl catalyst, said phosphine being a hydrocarbylene-bis(monophosphabicyclononane) in which each phosphorus atom is joined to hydrocarbylene and is a member of a bridge linkage without being a bridgehead atom and which hydrocarbylene-bis(monophosphabicyclononane) has 11 to 80 carbon atoms, 5 to 12 carbon atoms thereof together with a phosphorus atom being members of each of the two bicyclic skeletal structures,(c) carbon monoxide, and(d) hydrogen, the molar ratio of carbon monoxide to hydrogen being from about 4:1 to about 1:6, in liquid-phase solution in an inert reaction solvent, at a temperature of from about 30.degree. C. to about 150.degree. C. and a pressure of from about 50 psi to about 10,000 psi. Acids and promoter salts may be added to the reaction mixture to promote the hydroformylation reaction.
    • 本发明涉及一种通过紧密接触(a)具有3个或更多个碳数的1,2-环氧化物制备具有4个或更多个碳原子的3-羟基醛的方法,(b)二膦膦改性的羰基钴催化剂,所述膦是 其中每个磷原子连接到亚烃基并且不是桥头原子的桥连构件的亚烃基 - 双(单磷酰基二环壬烷),并且亚烃基 - 双(单磷杂二环壬烷)具有11至80个碳原子,5至12个碳原子在一起 其中磷原子是两个双环骨架结构中的每一个的成员,(c)一氧化碳和(d)氢,一氧化碳与氢的摩尔比为约4:1至约1:6, 在惰性反应溶剂中,在约30℃至约150℃的温度和约50psi至约10,000psi的压力下进行。 可以向反应混合物中加入酸和促进剂盐以促进加氢甲酰化反应。