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11. 发明授权

US08135548B2 Method, system and computer program product for real-time detection of sensitivity decline in analyte sensors 有权
标题翻译：方法，系统和计算机程序产品，用于实时检测分析物传感器的灵敏度下降
公开(公告)号：US08135548B2
公开(公告)日：2012-03-13
申请号：US11925689
申请日：2007-10-26
申请人： Marc D. Breton , Boris P. Kovatchev , Erwin S. Budiman , Kenneth J. Doniger
发明人： Marc D. Breton , Boris P. Kovatchev , Erwin S. Budiman , Kenneth J. Doniger
IPC分类号： G06F17/18
CPC分类号： H04B17/00 , A61B5/002 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B2560/0223 , G06F19/3418 , G16H40/67
摘要： A computer implemented method for receiving a plurality of analyte sensor related signals, determining a probability of signal attenuation associated with the received plurality of analyte sensor related signals, verifying the presence of signal attenuation when the determined probability exceeds a predetermined threshold level, and generating a first output signal associated with the verification of the presence of signal attenuation is provided. Also provided are systems and kits.
摘要翻译：一种用于接收多个分析物传感器相关信号的计算机实现的方法，确定与所接收的多个分析物传感器相关信号相关联的信号衰减的概率，当确定的概率超过预定阈值水平时验证信号衰减的存在，以及生成提供了与验证信号衰减的存在相关联的第一输出信号。还提供系统和工具包。

12. 发明申请

US20080172205A1 METHOD, SYSTEM AND COMPUTER PROGRAM PRODUCT FOR REAL-TIME DETECTION OF SENSITIVITY DECLINE IN ANALYTE SENSORS 有权
标题翻译：方法，系统和计算机程序产品，用于实时检测分析仪传感器的灵敏度降低
公开(公告)号：US20080172205A1
公开(公告)日：2008-07-17
申请号：US11925689
申请日：2007-10-26
申请人： Marc D. Breton , Boris P. Kovatchev , Erwin S. Budiman , Kenneth J. Doniger
发明人： Marc D. Breton , Boris P. Kovatchev , Erwin S. Budiman , Kenneth J. Doniger
IPC分类号： G06F17/18 , G01N33/50
CPC分类号： H04B17/00 , A61B5/002 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B2560/0223 , G06F19/3418 , G16H40/67
摘要： Method, system and computer program product for providing real time detection of analyte sensor sensitivity decline is continuous glucose monitoring systems are provided.
摘要翻译：提供实时检测分析物传感器灵敏度下降的方法，系统和计算机程序产品是连续的葡萄糖监测系统。

13. 发明申请

US20080154513A1 Systems, Methods and Computer Program Codes for Recognition of Patterns of Hyperglycemia and Hypoglycemia, Increased Glucose Variability, and Ineffective Self-Monitoring in Diabetes 审中-公开
标题翻译：用于识别高血糖和低血糖模式的系统，方法和计算机程序代码，增加葡萄糖变异性和糖尿病无效自我监测
公开(公告)号：US20080154513A1
公开(公告)日：2008-06-26
申请号：US11943226
申请日：2007-11-20
申请人： Boris P. Kovatchev , David Price , Erik Otto , Alan Coulson
发明人： Boris P. Kovatchev , David Price , Erik Otto , Alan Coulson
IPC分类号： G06F17/18 , G01N33/48
CPC分类号： G06F19/3456 , G16H15/00 , G16H50/20
摘要： A method, system, and computer program product related to the maintenance of optimal control of diabetes, and is directed to predicting patterns of hypoglycemia, hyperglycemia, increased glucose variability, and insufficient or excessive testing for the upcoming period of time, based on blood glucose readings collected by a self-monitoring blood glucose device. The method, system, and computer program product pertain directly to the enhancement of existing home blood glucose monitoring devices, by introducing an intelligent data interpretation component capable of predicting and alerting the user to periods of increased risk for hyperglycemia, hypoglycemia, increased glucose variability, and ineffective testing, and to the enhancement of emerging self-monitoring blood glucose devices by the same features. With these predictions the diabetic can take steps to prevent the adverse consequences associated with hyperglycemia, hypoglycemia, and increased glucose variability.
摘要翻译：与维持糖尿病最佳控制相关的方法，系统和计算机程序产品，旨在预测低血糖，高血糖，葡萄糖变异性增加，以及基于血糖的即将到来时间的不足或过量测试通过自我监测血糖仪收集的数据。该方法，系统和计算机程序产品直接关系到现有家用血糖监测装置的增强，引入了智能数据解释组件，能够将用户预测和警告高血糖，低血糖，增加的葡萄糖变异性风险增加的时期，和无效的测试，以及通过相同的特征增强新兴的自我监测血糖仪。通过这些预测，糖尿病患者可以采取措施来预防与高血糖，低血糖和葡萄糖变异性增加相关的不良后果。

14. 发明申请

US20130079613A1 METHOD, SYSTEM, AND COMPUTER PROGRAM PRODUCT FOR IMPROVING THE ACCURACY OF GLUCOSE SENSORS USING INSULIN DELIVERY OBSERVATION IN DIABETES 有权
标题翻译：方法，系统和计算机程序产品，用于提高糖尿病胰岛素输送观察葡萄糖传感器的准确性
公开(公告)号：US20130079613A1
公开(公告)日：2013-03-28
申请号：US13637359
申请日：2011-03-24
申请人： Boris P. Kovatchev , Marc D. Breton , Stephen D. Patek , Colleen H. Karvetski
发明人： Boris P. Kovatchev , Marc D. Breton , Stephen D. Patek , Colleen H. Karvetski
IPC分类号： A61B5/145 , A61M5/142 , A61M1/36 , A61B5/00
CPC分类号： A61B5/14532 , A61B5/1495 , A61B5/4839 , A61B5/7225 , A61B5/725 , A61B2560/0223 , A61M1/36 , A61M5/142
摘要： Method and System for providing a signal from an insulin pump, artificial pancreas, or another insulin delivery device as a source of information for improving the accuracy of a continuous glucose sensor (CGS). The effect of using insulin information to enhance sensor accuracy is most prominent at low blood glucose levels, i.e. in the hypoglycemic range, which is critical for any treatment. A system for providing a filtering/state estimation methodology that may be used to determine a glucose state estimate at time t-τ. The estimation may be extrapolated to some future time t and then the extrapolated value is used to extract the blood glucose component. The blood glucose component of the extrapolation and the output of the CGS are weighted and used to estimate the blood glucose level of a subject.
摘要翻译：用于从胰岛素泵，人造胰腺或另一胰岛素递送装置提供信号的方法和系统作为用于提高连续葡萄糖传感器（CGS）的精度的信息来源。使用胰岛素信息来提高传感器精度的效果在低血糖水平，即在降血糖范围内是最显着的，这在任何治疗中都是至关重要的。一种用于提供可用于在时间t-τ确定葡萄糖状态估计的过滤/状态估计方法的系统。估计可以外推到将来的某个时间t，然后外推值用于提取血糖分量。对外推的血糖成分和CGS的输出进行加权，并用于估计受试者的血糖水平。

15. 发明申请

US20110264378A1 Method, System, and Computer Program Product For Tracking of Blood Glucose Variability in Diabetes 有权
标题翻译：方法，系统和计算机程序产品用于跟踪糖尿病血糖变异性
公开(公告)号：US20110264378A1
公开(公告)日：2011-10-27
申请号：US13131467
申请日：2009-11-24
申请人： Marc D. Breton , Boris P. Kovatchev
发明人： Marc D. Breton , Boris P. Kovatchev
IPC分类号： G06F19/00 , G01N33/48
CPC分类号： G16H40/63 , A61B5/0002 , A61B5/14532 , A61B5/7275 , G06F19/00 , G16H10/20 , G16H50/20
摘要： An embodiment may be in the field of glycemic analysis and control. More specifically, an embodiment or approach may provide a novel method, system, and computer program for the visual and quantitative tracking of blood glucose variability in diabetes from self-monitoring blood glucose (SMBG) data and/or continuous glucose monitoring (CGM) data. More particularly, an embodiment or aspects thereof may use glucose measurements obtained from self-monitoring data and/or CGM data of an individual or a group of individuals to track and analyze blood glucose variability.
摘要翻译：一个实施方案可能在血糖分析和控制领域。更具体地，实施例或方法可以提供用于从自我监测血糖（SMBG）数据和/或连续葡萄糖监测（CGM）数据来视觉和定量跟踪糖尿病血糖变异性的新方法，系统和计算机程序。更具体地，其实施方案或其方面可以使用从个体或一组个体的自我监测数据和/或CGM数据获得的葡萄糖测量值来跟踪和分析血糖变异性。

16. 发明授权

US06804551B2 Method and apparatus for the early diagnosis of subacute, potentially catastrophic illness 有权
标题翻译：用于早期诊断亚急性潜在灾难性疾病的方法和装置
公开(公告)号：US06804551B2
公开(公告)日：2004-10-12
申请号：US09793653
申请日：2001-02-27
申请人： M. Pamela Griffin , J. Randall Moorman , Boris P. Kovatchev
发明人： M. Pamela Griffin , J. Randall Moorman , Boris P. Kovatchev
IPC分类号： A61B50456
CPC分类号： A61B5/02405 , A61B5/02411 , A61B5/0444 , A61B5/0452 , A61B5/412 , A61B5/4362 , A61B5/7275 , G06F19/00 , G16H10/60 , G16H15/00 , G16H50/20 , G16H50/50
摘要： In one aspect of the invention, there is provided a method and apparatus for early detection of subacute, potentially catastrophic illness in a patient. The method comprises: (a) monitoring heart rate variability in the patient; and (b) identifying at least one characteristic abnormality in the heart rate variability that is associated with the illness. This method can be use to diagnose illnesses such as, but not limited to, sepsis, necrotizing enterocolitis, pneumonia and meningitis, as well as noninfectious illnesses. In another aspect of the present invention, there is provided a method and apparatus for early detection of subacute, potentially catastrophic illness in a patient. The method comprises: (a) monitoring the patient's RR intervals; (b) generating a normalized data set of the RR intervals; (c) calculating one or more of (i) moments of the data set selected from the second and higher moments, including the standard deviation (ii) percentile values of the data set, (iii) sample entropy, and (iv) sample asymmetry; and (d) identifying an abnormal heart rate variability associated with the illness based on one or more of the moments, the percentile values, sample entropy, and sample asymmetry analysis.
摘要翻译：在本发明的一个方面，提供了一种用于在患者中早期检测亚急性潜在灾难性疾病的方法和装置。该方法包括：（a）监测患者的心率变异性; 和（b）确定与疾病相关的心率变异性中的至少一种特征异常。该方法可用于诊断疾病，例如但不限于败血症，坏死性小肠结肠炎，肺炎和脑膜炎以及非感染性疾病。在本发明的另一方面，提供了一种用于在患者中早期检测亚急性潜在的灾难性疾病的方法和装置。该方法包括：（a）监测患者的RR间期; （b）生成RR间隔的归一化数据集; （c）计算（i）从第二和更高的时刻选择的数据集的时刻的一个或多个，包括数据集的标准偏差（ii）百分位数值，（iii）样本熵，以及（iv）样本不对称性 ; 和（d）基于一个或多个时刻，百分位数值，样本熵和样本不对称分析来识别与疾病相关的异常心率变异性。

17. 发明申请

US20150190098A1 Method, System and Computer Readable Medium for Adaptive and Advisory Control of Diabetes 审中-公开
标题翻译：方法，系统和计算机可读介质用于糖尿病的自适应和咨询控制
公开(公告)号：US20150190098A1
公开(公告)日：2015-07-09
申请号：US14241383
申请日：2012-08-26
申请人： Stephen D. Patek , Boris P. Kovatchev
发明人： Stephen D. Patek , Boris P. Kovatchev
IPC分类号： A61B5/00 , A61M5/172 , A61B5/11 , A61B5/145 , A61M5/168
CPC分类号： A61B5/7275 , A61B5/002 , A61B5/0022 , A61B5/1118 , A61B5/14532 , A61B5/4812 , A61B5/4839 , A61B5/4848 , A61B5/4857 , A61B5/486 , A61B5/4866 , A61B5/7225 , A61B5/7278 , A61B5/7282 , A61B5/743 , A61B5/7475 , A61B2505/07 , A61B2560/0295 , A61B2560/0475 , A61M5/16886 , A61M5/1723 , G06F19/3468 , G06F19/3481 , G16H50/30 , G16H50/50
摘要： An Adaptive Advisory Control (AA Control) interactive process involving algorithm-based assessment and communication of physiologic and behavioral parameters and patterns assists patients with diabetes with the optimization of their glycemic control. The method and system may uses all available sources of information about the patient; (i) EO Data (e.g. self-monitoring of blood glucose (SMBG) and CMG), (ii) Insulin Data (e.g. insulin pump log files or patient treatment records), and (iii) Patient Self Reporting Data (e.g. self treatment behaviors, meals, and exercise) to: retroactively assess the risk of hypoglycemia, retroactively assess risk-based reduction of insulin delivery, and then report to the patient how a risk-based insulin reduction system would have acted consistently to prevent hypoglycemia.
摘要翻译：自适应咨询控制（AA控制）交互过程涉及基于算法的评估和生理和行为参数和模式的沟通，帮助糖尿病患者优化其血糖控制。该方法和系统可以使用关于患者的所有可用信息来源; （i）EO数据（例如血糖自身监测（SMBG）和CMG），（ii）胰岛素数据（例如胰岛素泵日志文件或患者治疗记录），以及（iii）患者自我报告数据（例如自我治疗行为，膳食和运动）：回溯性地评估低血糖的风险，追溯地评估基于风险的胰岛素递送减少，然后向患者报告如何基于风险的胰岛素减少系统将一致地采取行动来预防低血糖。

18. 发明申请

US20130116649A1 Method and System For The Safety, Analysis and Supervision of Insulin Pump Action and Other Modes of Insulin Delivery in Diabetes 审中-公开
标题翻译：胰岛素泵作用及其他胰岛素输送方式在糖尿病中的安全，分析和监督方法与系统
公开(公告)号：US20130116649A1
公开(公告)日：2013-05-09
申请号：US13634040
申请日：2011-03-11
申请人： Marc D. Breton , Stephen D. Patek , Boris P. Kovatchev , Colleen S. Hughes
发明人： Marc D. Breton , Stephen D. Patek , Boris P. Kovatchev , Colleen S. Hughes
IPC分类号： A61M5/168
CPC分类号： A61M5/1684 , A61M5/16836 , G01N33/74 , G01N2333/62 , G01N2800/042 , G06F19/3468
摘要： An insulin delivery supervisor (IDS) with a safety analysis and supervision function that can reside between the insulin request and the insulin delivery and can intercept any excessive insulin requests before the insulin was delivered. The IDS can be implemented in any system based on insulin pump or pen and will work with either SMBG or CGM modes of blood glucose monitoring.
摘要翻译：具有安全性分析和监督功能的胰岛素递送主管（IDS），其可以位于胰岛素需求和胰岛素递送之间，并且可以在胰岛素递送之前截获任何过量的胰岛素请求。 IDS可以在基于胰岛素泵或笔的任何系统中实现，并且可以使用SMBG或CGM模式的血糖监测。

19. 发明申请

US20120173200A1 Method, System and Computer Program Product for Real-Time Detection of Sensitivity Decline in Analyte Sensors 有权
标题翻译：方法，系统和计算机程序产品，用于实时检测分析物传感器的灵敏度下降
公开(公告)号：US20120173200A1
公开(公告)日：2012-07-05
申请号：US13418305
申请日：2012-03-12
申请人： Marc D. Breton , Boris P. Kovatchev , Erwin S. Budiman , Kenneth J. Doniger
发明人： Marc D. Breton , Boris P. Kovatchev , Erwin S. Budiman , Kenneth J. Doniger
IPC分类号： G06F15/00
CPC分类号： H04B17/00 , A61B5/002 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B2560/0223 , G06F19/3418 , G16H40/67
摘要： Method, system and computer program product for providing real time detection of analyte sensor sensitivity decline is continuous glucose monitoring systems are provided.
摘要翻译：提供实时检测分析物传感器灵敏度下降的方法，系统和计算机程序产品是连续的葡萄糖监测系统。

20. 发明申请

US20110264374A1 Method, Computer Program Product and System for Individual Assessment of Alcohol Sensitivity 审中-公开
标题翻译：方法，计算机程序产品和酒精敏感性个体评估系统
公开(公告)号：US20110264374A1
公开(公告)日：2011-10-27
申请号：US12674348
申请日：2008-08-20
申请人： Bankole A. Johnson , Nassima Ait-Daoud Tiouririne , Marc D. Breton , Boris P. Kovatchev
发明人： Bankole A. Johnson , Nassima Ait-Daoud Tiouririne , Marc D. Breton , Boris P. Kovatchev
IPC分类号： G06F19/00
CPC分类号： G16B5/00
摘要： Methods/computer methods and systems/computer systems for the evaluation of two idiosyncratic indices of alcohol intoxication: the Alcohol Sensitivity Index (ASI), and the brain-specific Cognitive Alcohol Sensitivity Index (CASI). The two indices are based on the new Metabolic and Cognitive Minimal Models of Alcohol Dynamics, and are derived from specific clinical protocols, accompanied by specific data analysis procedures. The two indices may be derived from specific clinical and cognitive assessment protocols, accompanied by specific data analysis procedures based on the new metabolic and cognitive minimal models of alcohol dynamics.
摘要翻译：方法/计算机方法和系统/计算机系统，用于评估酒精中毒的两种特异性指标：酒精敏感指数（ASI）和脑特异性认知酒精敏感性指数（CASI）。这两个指标基于酒精动力学的新型代谢和认知最小模型，并且来自具体的临床方案，并伴有特定的数据分析程序。这两个指标可能来自特定的临床和认知评估方案，并伴随着基于酒精动力学的新代谢和认知最小模型的特定数据分析程序。

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