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11. 发明授权

US07029898B2 DSP-11 dual-specificity phosphatase 失效
公开(公告)号：US07029898B2
公开(公告)日：2006-04-18
申请号：US10655073
申请日：2003-09-04
申请人： Ralf M. Luche , Bo Wei
发明人： Ralf M. Luche , Bo Wei
IPC分类号： C12N9/16 , C12N1/20 , C12N15/00 , C07H21/04 , A61K38/00
CPC分类号： C12N9/16
摘要： Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-11, and polypeptide variants thereof that stimulate dephosphorylation of DSP-11 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-11 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.

12. 发明申请

US20050075489A1 DSP-5 dual-specificity phosphatase 审中-公开
标题翻译： DSP-5双特异性磷酸酶
公开(公告)号：US20050075489A1
公开(公告)日：2005-04-07
申请号：US10644554
申请日：2003-08-19
申请人： Ralf Luche , Bo Wei
发明人： Ralf Luche , Bo Wei
IPC分类号： G01N33/50 , A61K39/395 , A61K45/00 , A61P3/00 , A61P35/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N9/16 , C12N15/09 , C12N15/55 , C12P21/08 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/577 , G01N33/58 , C07K16/18
CPC分类号： C12Y301/03016 , C12N9/16 , C12Y301/03048
摘要： Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-5, and polypeptide variants thereof that stimulate dephosphorylation of DSP-5 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-5 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.
摘要翻译：提供组合物和方法用于治疗与细胞增殖，细胞分化和细胞存活相关的病症。特别地，提供了刺激DSP-5底物去磷酸化的双特异性磷酸酶DSP-5及其多肽变体。多肽可用于例如鉴定抑制DSP-5活性的抗体和其它试剂。多肽和试剂可用于调节细胞增殖，分化和存活。

13. 发明授权

US5838522A Surface treatment of magnetic recording heads 失效
公开(公告)号：US5838522A
公开(公告)日：1998-11-17
申请号：US794672
申请日：1997-02-03
申请人： Kyriakos Komvopoulos , Ian G. Brown , Bo Wei , Simone Anders , Andre Anders , C. Singh Bhatia
发明人： Kyriakos Komvopoulos , Ian G. Brown , Bo Wei , Simone Anders , Andre Anders , C. Singh Bhatia
IPC分类号： C04B41/00 , C04B41/80 , C23C14/32 , C23C14/48 , G11B5/10 , G11B5/187 , G11B5/255 , G11B5/40 , G11B5/60 , G11B33/10
CPC分类号： C04B41/009 , C04B41/0027 , C04B41/0054 , C04B41/80 , C23C14/325 , C23C14/48 , G11B33/10 , G11B5/10 , G11B5/187 , G11B5/255 , G11B5/40 , G11B5/6005
摘要： Surface modification of magnetic recording heads using plasma immersion ion implantation and deposition is disclosed. This method may be carried out using a vacuum arc deposition system with a metallic or carbon cathode. By operating a plasma gun in a long-pulse mode and biasing the substrate holder with short pulses of a high negative voltage, direct ion implantation, recoil implantation, and surface deposition are combined to modify the near-surface regions of the head or substrate in processing times which may be less than 5 min. The modified regions are atomically mixed into the substrate. This surface modification improves the surface smoothness and hardness and enhances the tribological characteristics under conditions of contact-start-stop and continuous sliding. These results are obtained while maintaining original tolerances.

14. 发明授权

US09146683B2 Logical block address mapping 有权
标题翻译：逻辑块地址映射
公开(公告)号：US09146683B2
公开(公告)日：2015-09-29
申请号：US13090695
申请日：2011-04-20
申请人： Bo Wei , Steven TianChye Cheok , YongPeng Chng , CheeSeng Toh
发明人： Bo Wei , Steven TianChye Cheok , YongPeng Chng , CheeSeng Toh
IPC分类号： G06F12/00 , G06F3/06 , G06F12/02
CPC分类号： G06F3/0613 , G06F3/0619 , G06F3/064 , G06F3/0647 , G06F3/0676 , G06F12/0292
摘要： A mapping table is modified to match one or more specified storage conditions of data stored in or expected to be stored in one or more logical block address ranges to physical addresses within a storage drive having performance characteristics that satisfy the specified storage conditions. For example, the performance characteristics may be a reliability of the physical location within the storage drive or a data throughput range of read/write operations. Existing data is moved and/or new data is written to physical addresses on the storage media possessing the performance characteristic(s), according to the mapping table. Further, a standard seeding or a seeding override for the re-mapped logical block addresses can prevent read operations from inadvertently reading incorrect physical addresses corresponding to the re-mapped logical block addresses.
摘要翻译：修改映射表以将存储在或预期存储在一个或多个逻辑块地址范围中的数据的一个或多个指定存储条件与具有满足指定存储条件的性能特性的存储驱动器内的物理地址相匹配。例如，性能特征可以是存储驱动器内的物理位置的可靠性或读/写操作的数据吞吐范围。根据映射表，现有数据被移动和/或新数据被写入具有性能特征的存储介质上的物理地址。此外，用于重新映射的逻辑块地址的标准播种或播种覆盖可以防止读取操作无意中读取与重新映射的逻辑块地址相对应的不正确的物理地址。

15. 发明申请

US20110128815A1 CART FOR ULTRASONIC IMAGING APPARATUS AND ULTRASONIC IMAGING SYSTEM 有权
标题翻译：超声波成像设备和超声波成像系统
公开(公告)号：US20110128815A1
公开(公告)日：2011-06-02
申请号：US12957145
申请日：2010-11-30
申请人： Bo Wei
发明人： Bo Wei
IPC分类号： F16M11/24 , G03B42/06 , B23P11/00
CPC分类号： A61B8/4405 , B62B5/00 , Y10T29/49826 , Y10T29/49959
摘要： A cart for use with an ultrasonic imaging apparatus, comprising: a supporting part, a cart body and a bottom part; said cart body is connected to the supporting part and the bottom part; said supporting part is provided with an interface thereon for supporting and connecting the ultrasonic imaging apparatus; said cart body is an elevator structure provided with a power cable therein for supplying power to the ultrasonic imaging apparatus; the lower portion of the supporting part and the upper portion of the bottom part are both provided with a power socket; said power cable is a coiled cord structure, and its two ends are connected to the two power sockets; a stretchable elastic component having elastic recovery is provided inside the coiled cord structure of the power cable.
摘要翻译：一种与超声波成像装置一起使用的手推车，包括：支撑部件，手推车主体和底部部分; 所述车体与所述支撑部和所述底部连接; 所述支撑部分设置有用于支撑和连接超声波成像装置的界面; 所述车体是在其中设置有用于向超声波成像装置供电的电力电缆的电梯结构; 支撑部分的下部和底部的上部均设有电源插座; 所述电力电缆是线圈结构，其两端连接到两个电源插座; 具有弹性回复的伸缩性弹性部件设置在电力电缆的线圈式电线结构的内部。

16. 发明申请

US20100267037A1 GENOTOXICITY AS A BIOMARKER FOR INFLAMMATION 失效
标题翻译：作为生物标记物的致病因子
公开(公告)号：US20100267037A1
公开(公告)日：2010-10-21
申请号：US12761330
申请日：2010-04-15
申请人： Aya M. Westbrook , Robert H. Schiestl , Bo Wei , Jonathan Braun
发明人： Aya M. Westbrook , Robert H. Schiestl , Bo Wei , Jonathan Braun
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , C12Q1/6883 , C12Q2600/158 , G01N27/447 , G01N33/5014 , G01N33/6875
摘要： The invention provides a method for detection of inflammatory disease in a subject that comprises assaying a test sample of peripheral blood from the subject for a marker of DNA damage. An elevated amount of marker present in the test sample compared to control sample is indicative of inflammatory disease activity, including sub-clinical inflammation. The method can be adapted for quantitatively monitoring the efficacy of treatment of inflammatory disease in a subject. Markers of DNA damage include single- and/or double-stranded breaks in leukocytes, oxidative DNA damage in leukocytes, or a marker of nitric oxide oxidative activity (protein nitrosylation in leukocytes). The inflammatory disease can be inflammatory bowel disease (ulcerative colitis or Crohn's disease). The invention may also be used for detection of other types of inflammatory disease, such as non-immune intestinal inflammatory disease (diverticulitis, pseudomembranous colitis), autoimmune diseases (rheumatoid arthritis, lupus, multiple sclerosis, psoriasis, uveitis, vasculitis), or non-immune lung diseases (asthma, chronic obstructive lung disease, and interstitial pneumonitis). This unexpected discovery of markers of genotoxicity present in circulating leukocytes enables detection of inflammation occurring at a localized site with a relatively simple and minimally invasive assay using peripheral blood.
摘要翻译：本发明提供了一种用于检测受试者的炎性疾病的方法，其包括测定来自受试者的外周血的测试样品用于DNA损伤的标记。与对照样品相比，存在于测试样品中的标记物量增加指示炎症性疾病活动，包括亚临床炎症。该方法可以适应于定量监测受试者中炎性疾病治疗的功效。 DNA损伤的标记包括白细胞中的单链和/或双链断裂，白细胞中的氧化性DNA损伤或一氧化氮氧化活性的标记（白细胞中的蛋白质亚硝基化）。炎性疾病可以是炎性肠病（溃疡性结肠炎或克罗恩病）。本发明还可用于检测其它类型的炎性疾病，例如非免疫性肠炎性炎症（憩室炎，假膜性结肠炎），自身免疫性疾病（类风湿性关节炎，狼疮，多发性硬化，牛皮癣，葡萄膜炎，血管炎）免疫性肺部疾病（哮喘，慢性阻塞性肺病和间质性肺炎）。存在于循环白细胞中的遗传毒性标志物的这种意想不到的发现使得能够使用外周血使用相对简单和微创的测定来检测在局部位点发生的炎症。

17. 发明申请

US20070128199A1 DSP-3 dual-specificity phosphatase 审中-公开
标题翻译： DSP-3双特异性磷酸酶
公开(公告)号：US20070128199A1
公开(公告)日：2007-06-07
申请号：US11488453
申请日：2006-07-17
申请人： Ralf Luche , Bo Wei
发明人： Ralf Luche , Bo Wei
IPC分类号： A61K39/395 , C12Q1/68 , G01N33/53 , C12Q1/34 , C07H21/04 , C12P21/06 , C12N9/16
CPC分类号： G01N33/573 , A61K2039/505 , C12N9/16
摘要： Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-3, and polypeptide variants thereof that stimulate dephosphorylation of DSP-3 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-3 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.
摘要翻译：提供组合物和方法用于治疗与细胞增殖，细胞分化和细胞存活相关的病症。特别地，提供了刺激DSP-3底物去磷酸化的双特异性磷酸酶DSP-3及其多肽变体。多肽可用于例如鉴定抑制DSP-3活性的抗体和其它试剂。多肽和试剂可用于调节细胞增殖，分化和存活。

18. 发明申请

US20060227796A1 Method and apparatus to facilitate real-time packet scheduling in a wireless communications system 有权
标题翻译：用于促进无线通信系统中的实时分组调度的方法和装置
公开(公告)号：US20060227796A1
公开(公告)日：2006-10-12
申请号：US11401246
申请日：2006-04-11
申请人： Bo Wei , Lin Ma , Zhigang Rong , Steven Greer
发明人： Bo Wei , Lin Ma , Zhigang Rong , Steven Greer
IPC分类号： H04L12/56
CPC分类号： H04L47/10 , H04L47/14 , H04L47/2433 , H04L47/283 , H04L47/50 , H04L47/527 , H04L47/56 , H04W72/1242
摘要： A method, apparatus and system for scheduling data packets in a wireless communications system. The invention includes determining a priority for at least one data packet, wherein determining the priority of the data packet is based at least on a plurality of quality of service factors, wherein each of the plurality of QoS factors has a corresponding weighting factor and the determined priority includes minimum-performance guarantees. The invention further includes scheduling transmission of the at least one data packet based at least on the determined priority.
摘要翻译：一种用于在无线通信系统中调度数据分组的方法，装置和系统。本发明包括确定至少一个数据分组的优先级，其中确定数据分组的优先级至少基于多个服务质量因素，其中多个QoS因子中的每一个具有对应的加权因子，并且确定优先级包括最低性能保证。本发明还包括至少基于所确定的优先级来调度所述至少一个数据分组的传输。

19. 发明授权

US07037702B2 DSP-10 dual-specificity phosphatase 失效
公开(公告)号：US07037702B2
公开(公告)日：2006-05-02
申请号：US10346356
申请日：2003-01-15
申请人： Ralf M. Luche , Bo Wei
发明人： Ralf M. Luche , Bo Wei
IPC分类号： C12N9/16 , C12N15/00 , C12N5/00 , C12N1/20 , C07K1/00
CPC分类号： C12Q1/42 , A61K38/00 , C12N9/16 , C12Y301/03016 , C12Y301/03048 , G01N33/573 , G01N2500/04
摘要： Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-10, and polypeptide variants thereof that stimulate dephosphorylation of DSP-10 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-10 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.

20. 发明授权

US06841369B1 DSP-4 dual specificity phosphatase 失效
标题翻译： DSP-4双特异性磷酸酶
公开(公告)号：US06841369B1
公开(公告)日：2005-01-11
申请号：US09544517
申请日：2000-04-06
申请人： Ralf M. Luche , Bo Wei
发明人： Ralf M. Luche , Bo Wei
IPC分类号： C12N9/16 , C12N15/55 , C12Q1/68
CPC分类号： C12Y301/03048 , C12N9/16 , C12Y301/03016
摘要： Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-4, and polypeptide variants thereof that stimulate dephosphorylation of DSP-4 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-4 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.
摘要翻译：提供组合物和方法用于治疗与细胞增殖，细胞分化和细胞存活相关的病症。特别地，提供了刺激DSP-4底物去磷酸化的双重特异性磷酸酶DSP-4及其多肽变体。多肽可用于例如鉴定抑制DSP-4活性的抗体和其它试剂。多肽和试剂可用于调节细胞增殖，分化和存活。

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