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11. 发明申请

US20100230610A1 INTEGRATED DEVICE HAVING AN ARRAY OF PHOTODETECTORS AND AN ARRAY OF SAMPLE SITES 审中-公开
标题翻译：具有照相机阵列和样品库阵列的集成设备
公开(公告)号：US20100230610A1
公开(公告)日：2010-09-16
申请号：US12294469
申请日：2007-03-20
申请人： Pieter Jan Van Der Zaag , Nigel David Young , Hendrik Roelof Stapert
发明人： Pieter Jan Van Der Zaag , Nigel David Young , Hendrik Roelof Stapert
IPC分类号： G01J1/58 , B23P17/04
CPC分类号： G01N21/6454 , G01N21/6428 , G01N21/76 , Y10T29/49826
摘要： An integrated device for detecting emissions from a sample (70) involves forming an array of photo detectors (20) for detecting the emissions and forming an array of sites for receiving the sample such that edges of the sites are defined by edges of the photo detectors. A side wall of a site using a diode can provide a side wall suitable for ink-jet printing samples such as biomolecules with no extra mask steps. This helps enable the sample and the photo detector to be mutually aligned more easily or more cost effectively than conventional devices where the site for receiving the sample is formed separately from the photo detector. The detection can be in any direction, such as lateral or vertical detection. Lateral optical detection with a shielded photodiode means only light emanating from one pixel/spot is detected. A light source (200) to stimulate emissions can be integrated.
摘要翻译：用于检测来自样品（70）的发射的集成装置涉及形成用于检测发射的光电检测器（20）的阵列，并形成用于接收样品的位置阵列，使得位置的边缘由光电检测器的边缘限定。使用二极管的位点的侧壁可以提供适合于喷墨打印样品的侧壁，例如没有额外掩模步骤的生物分子。这有助于样品和光电检测器与传统的接收样品的部位与光电检测器分开形成的装置更容易或更经济地相互对准。检测可以在任何方向，例如横向或垂直检测。使用屏蔽光电二极管的横向光学检测意味着仅检测到从一个像素/点发出的光。可以集成用于刺激排放物的光源（200）。

12. 发明授权

US06323533B1 Semiconductor device with an operating frequency larger than 50 MHz comprising a body composed of a soft ferrite material 失效
标题翻译：工作频率大于50MHz的半导体器件包括由软铁氧体材料构成的主体
公开(公告)号：US06323533B1
公开(公告)日：2001-11-27
申请号：US09556547
申请日：2000-04-24
申请人： Pieter Jan Van Der Zaag , Ronald Dekker , Wilhelmus Mathias Clemens Dolmans
发明人： Pieter Jan Van Der Zaag , Ronald Dekker , Wilhelmus Mathias Clemens Dolmans
IPC分类号： H01L2900
CPC分类号： H01F17/0006 , H01L27/08
摘要： A semiconductor device (1) with an operating frequency above 50 MHz comprises a body (2) composed of a soft ferrite material, which body (2) has a surface (3) to which a semiconductor element (4), a pattern of conductors (5,6) and a passive element in the form of a planar inductor (7) are fastened by means of a layer (8) of adhesive. In order to reduce the manufacturing costs of the semiconductor device without adversely affecting the performance of the semiconductor device performance, a soft ferrite material is applied having a ferromagnetic resonance frequency smaller than the operating frequency of the semiconductor device.
摘要翻译：工作频率高于50MHz的半导体器件（1）包括由软铁氧体材料构成的主体（2），所述主体（2）具有与半导体元件（4）一起的表面（3），导体图案（5,6）和平面电感器（7）形式的无源元件通过粘合剂层（8）固定。为了降低半导体器件的制造成本而不会不利地影响半导体器件性能的性能，施加具有小于半导体器件的工作频率的铁磁共振频率的软铁氧体材料。

13. 发明授权

US08784623B2 Nanopore device and a method for nucleic acid analysis 有权
标题翻译：纳米装置和核酸分析方法
公开(公告)号：US08784623B2
公开(公告)日：2014-07-22
申请号：US13003308
申请日：2009-02-17
申请人： Pieter Jan Van Der Zaag , Anja Van De Stolpe , Elaine McCoo , Eva Van Van Wanrooij
发明人： Pieter Jan Van Der Zaag , Anja Van De Stolpe , Elaine McCoo , Eva Van Van Wanrooij
IPC分类号： G01N27/327
CPC分类号： G01N33/48721
摘要： A nanopore device is described wherein is provided a sample input (110), an input chamber (120), and first and second sample chambers (130, 140) connected to the input chambers (120) via first and second nanopores (135, 145).
摘要翻译：描述了纳米孔装置，其中提供了样品输入（110），输入室（120）以及通过第一和第二纳米孔（135,145）连接到输入室（120）的第一和第二样品室（130,140））。

14. 发明申请

US20130226621A1 IN VITRO DIAGNOSTIC TESTING INCLUDING AUTOMATED BROKERING OF ROYALTY PAYMENTS FOR PROPRIETARY TESTS 审中-公开
标题翻译：在体外诊断测试中，包括自动检测专有费用的专有费用
公开(公告)号：US20130226621A1
公开(公告)日：2013-08-29
申请号：US13881512
申请日：2011-10-24
申请人： Pieter Jan Van Der Zaag , Nevenka Dimitrova , Anja Van De Stolpe , Hendrik Van Houten
发明人： Pieter Jan Van Der Zaag , Nevenka Dimitrova , Anja Van De Stolpe , Hendrik Van Houten
IPC分类号： G06Q20/10 , G06Q50/22
CPC分类号： G06Q20/10 , G06Q10/00 , G06Q50/22 , G16B20/00 , G16H40/20 , G16H40/63
摘要： A method comprises: recording an electronic record of diagnostic events including the performing of in-vitro diagnostic tests; during the recording, identifying the performing of a licensed in-vitro diagnostic test for which license information is stored in a licenses database; and computing license compensation due to a licensor for the performing of the licensed in-vitro diagnostic test based on royalty calculation information stored in the licenses database. The recording, identifying, and computing operations are performed by one or more computers. The method may further include remitting the computed license compensation to the licensor, the remitting also being performed by one or more computers. The licensed in-vitro diagnostic test may comprise a licensed biomarker test, for example one obtained by DNA or RNA sequencing, and the method may further comprise: performing the licensed biomarker test using a genome sequencer, wherein the performing of the licensed biomarker test and the computing of license compensation are both performed at a single medical facility.
摘要翻译：一种方法包括：记录诊断事件的电子记录，包括进行体外诊断测试; 在记录期间，识别许可证体验诊断测试的执行，许可信息被存储在许可证数据库中; 以及根据许可人根据存储在许可证数据库中的版税计算信息执行许可的体外诊断测试来计算许可证补偿。记录，识别和计算操作由一个或多个计算机执行。该方法还可以包括将所计算的许可证补偿递交给许可方，还由一个或多个计算机执行。许可的体外诊断测试可以包括许可的生物标志物测试，例如通过DNA或RNA测序获得的测试，并且该方法还可以包括：使用基因组测序仪进行许可的生物标志物测试，其中执行许可的生物标志物测试和许可证补偿的计算都在单一医疗机构进行。

15. 发明申请

US20140349892A1 APPARATUS FOR THE PROCESSING OF SINGLE MOLECULES 审中-公开
标题翻译：用于单分子加工的装置
公开(公告)号：US20140349892A1
公开(公告)日：2014-11-27
申请号：US14345261
申请日：2012-09-25
申请人： Pieter Jan Van Der Zaag , Reinder Coehoorn , Falco Cornelius Marinus Jacobus Maria Van Delft
发明人： Pieter Jan Van Der Zaag , Reinder Coehoorn , Falco Cornelius Marinus Jacobus Maria Van Delft
IPC分类号： G01N33/487
CPC分类号： G01N33/48721
摘要： The invention relates to an apparatus(100) and a method for the processing of single molecules, particularly for the sensing or sequencing of single-stranded DNA. A bottom layer(110) and an electrically conductive top layer(120) with a first and a second slit(111,121), respectively, are disposed on top of each other such that an aperture(A) is formed by the slits. The slits(111,121) are preferably perpendicular to each other. An electrical circuit(140) may be connected to the top layer(120), allowing to sense single molecules that pass through the aperture(A).
摘要翻译：本发明涉及一种用于处理单分子的装置（100）和方法，特别是单链DNA的感测或测序。具有第一和第二狭缝（111,121）的底层（110）和导电顶层（120）分别设置在彼此的顶部上，使得通过狭缝形成孔（A）。狭缝（111,121）优选地彼此垂直。电路140可以连接到顶层120，以允许感测穿过孔A的单分子。

16. 发明申请

US20110108423A1 NANOPORE DEVICE AND A METHOD FOR NUCLEIC ACID ANALYSIS 有权
标题翻译：纳米装置和核酸分析方法
公开(公告)号：US20110108423A1
公开(公告)日：2011-05-12
申请号：US13003308
申请日：2009-02-17
申请人： Pieter Jan Van Der Zaag , Anja Van De Stolpe , Elaine Mccoo , Eva Van Van Wanrooij
发明人： Pieter Jan Van Der Zaag , Anja Van De Stolpe , Elaine Mccoo , Eva Van Van Wanrooij
IPC分类号： G01N27/447 , H05K13/00 , B82Y5/00
CPC分类号： G01N33/48721
摘要： A nanopore device is described wherein is provided a sample input (110), an input chamber (120), and first and second sample chambers (130, 140) connected to the input chambers (120) via first and second nanopores (135, 145).
摘要翻译：描述了纳米孔装置，其中提供了样品输入（110），输入室（120）以及通过第一和第二纳米孔（135,145）连接到输入室（120）的第一和第二样品室（130,140））。

17. 发明申请

US20090250630A1 PHOTODIODE FOR DETECTION WITHIN MOLECULAR DIAGNOSTICS 失效
标题翻译：用于在分子诊断中检测的光致抗体
公开(公告)号：US20090250630A1
公开(公告)日：2009-10-08
申请号：US12374000
申请日：2007-07-05
申请人： Pieter Jan Van Der Zaag , Ian French , Nigel David Young
发明人： Pieter Jan Van Der Zaag , Ian French , Nigel David Young
IPC分类号： G01N21/64 , G01J1/58 , H01L31/105
CPC分类号： H01L31/1055 , G01N21/6428 , H01L31/103
摘要： A photodiode (200), for instance a PN or a PIN photodiode, is disclosed. The photodiode receives incident radiation having first and second spectral distributions, where the first spectral distribution is spectrally shifted from the second spectral distribution. The photodiode has a first semiconductor layer (211) capable of absorbing incident radiation (231) having a first spectral distribution without generating a photocurrent, while simultaneously transmitting incident radiation having a second spectral distribution to the intrinsic layer (212) for generating a photocurrent (213). The photodiode may be used in connection with detecting the presence of target molecules that has been labeled with labeling agents, such as fluorophores or quantum dots. The labeling agents are characterized by the Stokes shift and, therefore, they emit fluorescent radiation having the second spectral distribution that is spectrally shifted from the illumination radiation having the first spectral distribution.
摘要翻译：公开了一种光电二极管（200），例如PN或PIN光电二极管。光电二极管接收具有第一和第二光谱分布的入射辐射，其中第一光谱分布从第二光谱分布光谱偏移。光电二极管具有能够吸收具有第一光谱分布而不产生光电流的入射辐射（231）的第一半导体层（211），同时将具有第二光谱分布的入射辐射传输到本征层（212）以产生光电流 213）。光电二极管可用于检测已经用标记试剂如荧光团或量子点标记的靶分子的存在。标记试剂的特征在于斯托克斯位移，因此，它们发射具有与具有第一光谱分布的照射辐射光谱偏移的第二光谱分布的荧光辐射。

18. 发明授权

US10373705B2 Providing nucleotide sequence data 有权
公开(公告)号：US10373705B2
公开(公告)日：2019-08-06
申请号：US14124380
申请日：2012-04-17
申请人： Pieter Jan Van Der Zaag , Ronny Amberg , Peter Beyerlein , Wilhelmus Franciscus Johannes Verhaegh , Rene Boettcher
发明人： Pieter Jan Van Der Zaag , Ronny Amberg , Peter Beyerlein , Wilhelmus Franciscus Johannes Verhaegh , Rene Boettcher
IPC分类号： G16B30/00 , C12Q1/6874 , G16B25/00
摘要： A sequencer device generates basic nucleotide sequence data 30 comprising probe data 34 of a capture probe in the sequencer device 10 and a determined sequence of identifiers 32 of a fragment of nucleic acids captured by the probe. The sequencer device outputs enriched nucleotide sequence data 36 that is enriched with data comprising a reference to a sequence 38 that is expected for the fragment of nucleic acids.

19. 发明授权

US09005896B2 Method for amplifying nucleic acids 有权
标题翻译：扩增核酸的方法
公开(公告)号：US09005896B2
公开(公告)日：2015-04-14
申请号：US13818325
申请日：2011-08-31
申请人： Harma Feitsma , Marlieke Overdijk , Anja Van De Stople , Pieter Jan Van Der Zaag
发明人： Harma Feitsma , Marlieke Overdijk , Anja Van De Stople , Pieter Jan Van Der Zaag
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6869 , C12Q1/6837 , C12Q1/6874 , C12Q2565/543 , C12Q2525/301
摘要： The present invention describes methods for amplifying a target nucleic acid wherein target nucleic acids hybridize to capture probe nucleic acids which are immobilized to a support via their 5′ end. The hybridization product is further extended with a polymerase to form a double stranded nucleic acid. To this double stranded nucleic acid, a hairpin nucleic acid is ligated. This ligation product is further amplified and sequenced.
摘要翻译：本发明描述了用于扩增靶核酸的方法，其中靶核酸与捕获通过其5'末端固定在载体上的探针核酸杂交。进一步用聚合酶扩增杂交产物以形成双链核酸。向该双链核酸中连接发夹核酸。该连接产物进一步扩增和测序。

20. 发明申请

US20130210008A1 METHOD FOR AMPLIFYING NUCLEIC ACIDS 有权
标题翻译：放大核酸的方法
公开(公告)号：US20130210008A1
公开(公告)日：2013-08-15
申请号：US13818325
申请日：2011-08-31
申请人： Harma Feitsma , Marlieke Overdijk , Anja Van De Stople , Pieter Jan Van Der Zaag
发明人： Harma Feitsma , Marlieke Overdijk , Anja Van De Stople , Pieter Jan Van Der Zaag
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q1/6837 , C12Q1/6874 , C12Q2565/543 , C12Q2525/301
摘要： The present invention describes methods for amplifying a target nucleic acid wherein target nucleic acids hybridise to capture probe nucleic acids which are immobilized to a support via their 5′ end. The hybridization product is further extended with a polymerase to form a double stranded nucleic acid. To this double stranded nucleic acid, a hairpin nucleic acid is ligated. This ligation product is further amplified and sequenced.
摘要翻译：本发明描述了用于扩增目标核酸的方法，其中靶核酸与通过其5'末端固定在载体上的探针核酸杂交。进一步用聚合酶扩增杂交产物以形成双链核酸。向该双链核酸中连接发夹核酸。该连接产物进一步扩增和测序。

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