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11. 发明申请

US20190388700A1 SYSTEM AND METHOD FOR OPTOGENETIC THERAPY 审中-公开
公开(公告)号：US20190388700A1
公开(公告)日：2019-12-26
申请号：US16383438
申请日：2019-04-12
申请人： Circuit Therapeutics, Inc.
发明人： Scott Delp , Karl Deisseroth , Dan Andersen
IPC分类号： A61N5/06 , A61M5/142 , A61B17/34 , A61B17/00 , A61M37/00 , A61M25/01 , A61K41/00 , A61M5/20 , A61N1/36 , A61K48/00 , A61K38/17 , A61K38/16 , A61N1/05
摘要： Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.

12. 发明授权

US10512787B2 System and method for optogenetic therapy 有权
公开(公告)号：US10512787B2
公开(公告)日：2019-12-24
申请号：US14445978
申请日：2014-07-29
申请人： Circuit Therapeutics, Inc.
发明人： Scott Delp , Karl Deisseroth , Dan Andersen
IPC分类号： A61N5/06 , A61N1/05 , A61N1/36 , A61K38/16 , A61K48/00 , A61K41/00 , A61M25/01 , A61M37/00 , A61K38/17 , A61B17/00 , A61B17/34 , A61M5/142 , A61M5/20 , A61N5/067
摘要： Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.

13. 发明申请

US20190160300A1 SYSTEM AND METHOD FOR OPTOGENETIC THERAPY 审中-公开
公开(公告)号：US20190160300A1
公开(公告)日：2019-05-30
申请号：US16215206
申请日：2018-12-10
申请人： Circuit Therapeutics, Inc.
发明人： Scott Delp , Karl Deisseroth , Dan Andersen
IPC分类号： A61N5/06 , A61M25/01 , A61K38/17 , A61M5/20 , A61K38/16 , A61B17/34 , A61B17/00 , A61K41/00 , A61N1/36 , A61M37/00 , A61N1/05 , A61K48/00 , A61M5/142
摘要： Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.

14. 发明申请

US20180361169A1 SYSTEM AND METHOD FOR OPTOGENETIC THERAPY 审中-公开
公开(公告)号：US20180361169A1
公开(公告)日：2018-12-20
申请号：US15912257
申请日：2018-03-05
申请人： Circuit Therapeutics, Inc.
发明人： Scott Delp , Karl Deisseroth , Dan Andersen
IPC分类号： A61N5/06 , A61B17/34 , A61M37/00 , A61K38/16 , A61K38/17 , A61K41/00 , A61K48/00 , A61M5/142 , A61M5/20 , A61M25/01 , A61N1/05 , A61B17/00 , A61N1/36 , A61N5/067
摘要： Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.

15. 发明申请

US20160030765A1 SYSTEM AND METHOD FOR OPTOGENETIC THERAPY 审中-公开
标题翻译：用于OPTOGENETIC治疗的系统和方法
公开(公告)号：US20160030765A1
公开(公告)日：2016-02-04
申请号：US14813106
申请日：2015-07-29
申请人： Circuit Therapeutics, Inc.
发明人： Christopher L. Towne , Michael Kaplitt , Scott Delp , Karl Deisseroth , David Angeley , Greg Stahler , Dan Andersen , David C. Lundmark
IPC分类号： A61N5/06
摘要： One embodiment is directed to a system for controllably managing pain in the afferent nervous system of a patient having a targeted tissue structure that has been genetically modified to have light sensitive protein, comprising a light delivery element configured to direct radiation to at least a portion of a targeted tissue structure; a light source configured to provide light to the light delivery element; and a controller operatively coupled to light source; wherein the targeted tissue structure comprises a sensory neuron of the patient; and wherein the controller is configured to be automatically operated to illuminate the targeted tissue structure with radiation such that a membrane potential of cells comprising the targeted tissue structure is modulated at least in part due to exposure of the light sensitive protein to the radiation.
摘要翻译：一个实施例涉及一种用于可控地管理患有已经被遗传修饰以具有光敏蛋白质的靶组织结构的患者的传入神经系统中的疼痛的系统，该系统包括被配置为将辐射引导至少部分靶组织结构; 光源，被配置为向所述光输送元件提供光; 以及可操作地耦合到光源的控制器; 其中所述靶组织结构包括患者的感觉神经元; 并且其中所述控制器被配置为自动操作以用辐射照射所述目标组织结构，使得包含所述靶组织结构的细胞的膜电位至少部分地由于所述光敏蛋白质暴露于所述辐射而被调制。

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