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11. 发明授权

US08445494B2 Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine 有权
公开(公告)号：US08445494B2
公开(公告)日：2013-05-21
申请号：US12995771
申请日：2009-06-04
申请人： Jun Qiu , Qi Gao , Shuang Liu , Matthew Isherwood
发明人： Jun Qiu , Qi Gao , Shuang Liu , Matthew Isherwood
IPC分类号： A61K31/501 , C07D401/04 , A61P25/24
CPC分类号： C07F5/04 , C07C215/20 , C07C217/58 , C07C223/02 , C07D217/04 , C07D237/20 , C07D401/04 , C07D413/10 , C07F5/022 , C07F5/025
摘要： The present disclosure generally relates to a crystalline form of 6-[(4S)-2-methyl-4-(naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine. The present disclosure also generally relates to pharmaceutical compositions comprising the crystalline form, as well of methods of using a crystalline form in the treatment of depression and other conditions and methods for obtaining such crystalline form.

12. 发明申请

US20110160220A1 CRYSTALLINE FORM OF 6-[(4S)-2-METHYL-4-(2-NAPHTHYL)-1,2,3,4-TETRAHYDROISOQUINOLIN-7-YL]PYRIDAZIN-3-AMINE 有权
标题翻译： 6 - [（4S）-2-甲基-4-（2-萘基）-1,2,3,4-四氢喹啉-7-YL]吡啶-3-胺的晶体形式
公开(公告)号：US20110160220A1
公开(公告)日：2011-06-30
申请号：US12995771
申请日：2009-06-04
申请人： Jun Qiu , Qi Gao , Shuang Liu , Min Hu , Yuh-Lin Allen Yang , Matthew Isherwood , Rasidul Amin
发明人： Jun Qiu , Qi Gao , Shuang Liu , Min Hu , Yuh-Lin Allen Yang , Matthew Isherwood , Rasidul Amin
IPC分类号： A61K31/501 , C07D401/02 , A61P25/24 , A61P25/22 , A61P29/00 , A61P3/04
CPC分类号： C07F5/04 , C07C215/20 , C07C217/58 , C07C223/02 , C07D217/04 , C07D237/20 , C07D401/04 , C07D413/10 , C07F5/022 , C07F5/025
摘要： The present disclosure generally relates to a crystalline form of 6-[(4S)-2-methyl-4-(naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine. The present disclosure also generally relates to pharmaceutical compositions comprising the crystalline form, as well of methods of using a crystalline form in the treatment of depression and other conditions and methods for obtaining such crystalline form.
摘要翻译：本公开内容通常涉及6 - [（4S）-2-甲基-4-（萘基）-1,2,3,4-四氢异喹啉-7-基]哒嗪-3-胺的结晶形式。本公开还通常涉及包含结晶形式的药物组合物，以及在治疗抑郁症和其它病症中使用结晶形式的方法以及获得这种结晶形式的方法。

13. 发明申请

US20080212849A1 Method and Apparatus For Facial Image Acquisition and Recognition 审中-公开
标题翻译：面部图像获取和识别的方法和装置
公开(公告)号：US20080212849A1
公开(公告)日：2008-09-04
申请号：US10596374
申请日：2004-05-14
申请人： Qi Gao
发明人： Qi Gao
IPC分类号： G06K9/00
CPC分类号： G06K9/00255
摘要： A method and apparatus for facial image acquisition and/or recognition used for person identification. In infrared face image acquisition, near infrared (NIR) images of a face are captured by an imaging unit with the face illuminated by active NIR lights; an NIR optical filter is used in the imaging unit to minimize visible lights in environments while allowing NIR lights to pass through. NIR face images thus acquired provides good image quality for the purpose of face recognition. In face recognition, eyes are localized in NIR face image(s) quickly and accurately by detecting specular highlight reflection in each eye, whereby face is then localized. The invention effectively problems caused by environmental lights, and leads to accurate and fast face recognition under variable lighting conditions. Moreover, the methods use a non-intrusive and user-friendly way of active lighting for face image acquisition and recognition because the NIR lights are in the invisible spectrum.
摘要翻译：一种用于人物识别的面部图像采集和/或识别的方法和装置。在红外面部图像采集中，面部的近红外（NIR）图像由成像单元捕获，其面部由主动近红外光照射; 在成像单元中使用NIR光学滤波器来最小化环境中的可见光，同时允许NIR光通过。因此获得的NIR脸部图像为了面部识别的目的提供了良好的图像质量。在脸部识别中，通过检测每只眼睛中的镜面高光反射，眼睛被快速准确地定位在NIR脸部图像中，由此脸部被局部化。本发明有效地解决了环境光线引起的问题，导致了在不同照明条件下的准确，快速的人脸识别。此外，这些方法使用非侵入性和用户友好的主动照明方式进行面部图像采集和识别，因为NIR灯处于不可见光谱。

14. 发明申请

US20060100209A1 Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione 审中-公开
标题翻译：制备1-（4-苯甲酰基 - 哌嗪-1-基）-2- [4-甲氧基-7-（3-甲基 - [1,2,4]三唑-1-基）-1H-吡咯并[ 3-c]吡啶-3-基] - 乙烷-1,2-二酮
公开(公告)号：US20060100209A1
公开(公告)日：2006-05-11
申请号：US11267441
申请日：2005-11-04
申请人： Chong-Hui Gu , Qi Gao , Shan-Ming Kuang , Chiajen Lai , Jaquan Levons , Feng Qian
发明人： Chong-Hui Gu , Qi Gao , Shan-Ming Kuang , Chiajen Lai , Jaquan Levons , Feng Qian
IPC分类号： A61K31/53
CPC分类号： A61K31/53 , A61K9/14 , A61K9/146 , A61K9/1635 , A61K31/496 , A61K47/32
摘要： The instant invention provides formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione; processes for the production of such formulations; and methods of treating HIV or AIDS with such crystalline materials or such formulations.
摘要翻译：本发明提供1-（4-苯甲酰基 - 哌嗪-1-基）-2- [4-甲氧基-7-（3-甲基 - [1,2,4]三唑-1-基）吡咯并[2,3-c]吡啶-3-基] - 乙烷-1,2-二酮; 制备这种制剂的方法; 以及用这种结晶材料或这种制剂治疗HIV或AIDS的方法。

15. 发明授权

US09052967B2 Detecting resource deadlocks in multi-threaded programs by controlling scheduling in replay 有权
标题翻译：通过控制重播中的调度来检测多线程程序中的资源死锁
公开(公告)号：US09052967B2
公开(公告)日：2015-06-09
申请号：US12848023
申请日：2010-07-30
申请人： Qi Gao , Min Xu
发明人： Qi Gao , Min Xu
IPC分类号： G06F9/52 , G06F11/36
CPC分类号： G06F9/524 , G06F11/3636
摘要： A method and system for determining potential deadlock conditions in a target multi-threaded software application. The target application is first run in a virtual machine and the events within the application are recorded. The recorded events are replayed and analyzed to identify potential lock acquisition conflicts occurring between threads of the application. The potential lock acquisition conflicts are identified by analyzing the order in which resource locks are obtained and pairs of resources that have respective locks obtained in different orders are analyzed. These analyzed pairs are used to define a different order of events in the target application that, when the target application is re-run with the second order of events, may trigger a deadlock condition. The target application is then re-run with the different order of events in an attempt to trigger and then identify potential deadlock situations.
摘要翻译：一种用于确定目标多线程软件应用程序中潜在的死锁状况的方法和系统。目标应用程序首先在虚拟机中运行，并记录应用程序中的事件。记录的事件被重放和分析，以识别在应用程序的线程之间发生的潜在锁定获取冲突。通过分析获得资源锁定的顺序来识别潜在锁获取冲突，并分析具有以不同顺序获得的相应锁的资源对。这些分析的对用于定义目标应用程序中不同的事件顺序，当目标应用程序以二次事件重新运行时，可能会触发死锁条件。然后，目标应用程序以不同的事件顺序重新运行，以尝试触发，然后识别潜在的死锁情况。

16. 发明授权

US07968718B2 Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein 有权
标题翻译：制备三唑取代的亚氮杂双氧乙酸哌嗪衍生物的方法及其中生成的新型盐形式
公开(公告)号：US07968718B2
公开(公告)日：2011-06-28
申请号：US12548809
申请日：2009-08-27
申请人： Nachimuthu Soundararajan , Yuping Qiu , Wenhao Hu , David R. Kronenthal , Pierre Sirard , Jean Lajeunesse , Robert Droghini , Ramakrishnan Chidambaram , Xinhua Qian , Kenneth J. Natalie , Shawn K. Pack , Nathan Reising , Erqing Tang , Michael G. Fakes , Qi Gao , Feng Qian , Blisse J. Vakkalagadda , Chiajen Lai , Shan-Ming Kuang
发明人： Nachimuthu Soundararajan , Yuping Qiu , Wenhao Hu , David R. Kronenthal , Pierre Sirard , Jean Lajeunesse , Robert Droghini , Ramakrishnan Chidambaram , Xinhua Qian , Kenneth J. Natalie , Shawn K. Pack , Nathan Reising , Erqing Tang , Michael G. Fakes , Qi Gao , Feng Qian , Blisse J. Vakkalagadda , Chiajen Lai , Shan-Ming Kuang
IPC分类号： C07D471/02
CPC分类号： C07D471/04 , C07C311/49 , C07D213/26
摘要： A process is provided for preparing triazole substituted azaindoleoxoacetic piperazine derivative. Novel intermediates produced in the above process, and novel N-1 and amorphous forms of a 1,2,3-triazole substituted azaindoloxoacetic piperazine derivatives and processes for producing such novel forms are also provided.
摘要翻译：提供制备三唑取代的氮杂糊精乙酸哌嗪衍生物的方法。还提供了在上述方法中制备的新型中间体和新的N-1和无定形形式的1,2,3-三唑取代的氮杂寡脱氧乙酸哌嗪衍生物及其制备方法。

17. 发明申请

US20100292246A1 FORMULATIONS OF 1-(4-BENZOYL-PIPERAZIN-1-YL)-2-[4-METHOXY-7-(3-METHYL-[1,2,4]TRIAZOL-1-YL)-1H-PYRROLO[2,3-C]PYRIDIN-3-YL]-ETHANE-1,2-DIONE 审中-公开
标题翻译： 1-（4-苯甲酰基 - 哌嗪-1-基）-2- [4-甲氧基-7-（3-甲基 - [1,2,4]三唑-1-基）-1H-吡咯并[2,1- 3-C]吡啶-3-基] - 乙基-1,2-二酮
公开(公告)号：US20100292246A1
公开(公告)日：2010-11-18
申请号：US12847014
申请日：2010-07-30
申请人： Chong-Hui Gu , Qi Gao , Shan-Ming Kuang , Chiajen Lai , Jaquan Kalani Levons , Feng Qian
发明人： Chong-Hui Gu , Qi Gao , Shan-Ming Kuang , Chiajen Lai , Jaquan Kalani Levons , Feng Qian
IPC分类号： A61K31/496 , A61P31/18
CPC分类号： A61K31/53 , A61K9/14 , A61K9/146 , A61K9/1635 , A61K31/496 , A61K47/32
摘要： The instant invention provides formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione; processes for the production of such formulations; and methods of treating HIV or AIDS with such crystalline materials or such formulations.
摘要翻译：本发明提供1-（4-苯甲酰基 - 哌嗪-1-基）-2- [4-甲氧基-7-（3-甲基 - [1,2,4]三唑-1-基）吡咯并[2,3-c]吡啶-3-基] - 乙烷-1,2-二酮; 制备这种制剂的方法; 以及用这种结晶材料或这种制剂治疗HIV或AIDS的方法。

18. 发明申请

US20090227794A1 CRYSTALLINE MATERIALS OF 1-(4-BENZOYL-PIPERAZIN-1-YL)-2-[4-METHOXY-7-(3-METHYL-[1,2,4]TRIAZOL-1-YL)-1H-PYRROLO[2,3-C]PYRIDIN-3-YL]-ETHANE-1,2-DIONE 有权
标题翻译： 1-（4-苯甲酰基 - 哌嗪-1-基）-2- [4-甲氧基-7-（3-甲基 - [1,2,4]三唑-1-基）-1H-吡咯并[2,3-b]吡啶的晶体物质，3-C]吡啶-3-基] - 乙基-1,2-二酮
公开(公告)号：US20090227794A1
公开(公告)日：2009-09-10
申请号：US12468105
申请日：2009-05-19
申请人： John D. Matiskella , Chenkou Wei , Qi Gao , Chong-Hui Gu , Shan-Ming Kuang
发明人： John D. Matiskella , Chenkou Wei , Qi Gao , Chong-Hui Gu , Shan-Ming Kuang
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The instant invention provides crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione; processes for the production of such crystalline materials; pharmaceutical compositions comprising such crystalline materials; and methods of treating HIV or AIDS with such crystalline materials or such pharmaceutical compositions.
摘要翻译：本发明提供1-（4-苯甲酰基 - 哌嗪-1-基）-2- [4-甲氧基-7-（3-甲基 - [1,2,4]三唑-1-基）-1H - 吡咯并[2,3-c]吡啶-3-基] - 乙烷-1,2-二酮; 生产这种结晶材料的方法; 包含这种结晶材料的药物组合物; 以及用这种结晶材料或这种药物组合物治疗HIV或AIDS的方法。

19. 发明申请

US20090041716A1 CRYSTALLINE FORM OF METHYL ((1S)-1-(((2S)-2-(5-(4'-(2-((2S)-1((2S)-2-((METHOXYCARBONYL)AMINO)-3-METHYLBUTANOYL)-2-PYRROLIDINYL)-1H-IMIDAZOL-5-YL)-4-BIPHENYLYL)-1H-IMIDAZOL-2-YL)-1-PYRROLIDINYL)CARBONYL)-2-METHYLPROPYL)CARBAMATE DIHYDROCHLORIDE SALT 有权
标题翻译：（（1S）-1 - （（（2S）-2-（5-（4' - （2 - （（2S）-1（（2S）-2 - （（甲氧基羰基）氨基） -2-甲基吡咯烷-1-基）咪唑并 - 5-YL）-4-二苯基）-1H-咪唑-2-基）-1-吡咯烷基）羰基）-2-甲基丙烯酸）二羧酸二盐酸盐
公开(公告)号：US20090041716A1
公开(公告)日：2009-02-12
申请号：US12175104
申请日：2008-07-17
申请人： Soojin Kim , Qi Gao , Fukang Yang
发明人： Soojin Kim , Qi Gao , Fukang Yang
IPC分类号： A61K38/20 , C07D403/14 , A61K31/4178 , A61K31/7105 , A61P31/12 , A61K38/21 , A61K31/708
CPC分类号： C07D403/04
摘要： The present disclosure generally relates to a crystalline form of methyl ((1S)-1-(((2S)-2-(5-(4′-(2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1 H-imidazol-5-yl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate dihydrochloride salt. The present disclosure also generally relates to a pharmaceutical composition comprising a crystalline form, as well of methods of using a crystalline form in the treatment of Hepatitis C and methods for obtaining such crystalline form.
摘要翻译：本发明一般涉及（（1S）-1 - （（1S）-2-（5-（4' - （2 - （（2S）-1 - （（2S）（（甲氧基羰基）氨基）-3-甲基丁酰基）-2-吡咯烷基）-1H-咪唑-5-基）-4-联苯基）-1H-咪唑-2-基）-1-吡咯烷基）羰基）-2- 甲基丙基）氨基甲酸酯二盐酸盐。本公开还通常涉及包含结晶形式的药物组合物，以及在治疗丙型肝炎中使用结晶形式的方法以及获得这种结晶形式的方法。

20. 发明申请

US20060264406A1 Mono-lysine salts of azole compounds 审中-公开
标题翻译：唑化合物的单赖氨酸盐
公开(公告)号：US20060264406A1
公开(公告)日：2006-11-23
申请号：US11416322
申请日：2006-05-03
申请人： Qi Gao , Chung-Pin Chen , Michael Fakes , Yadagiri Pendri , Susanne Kiau , Blisse Vakkalagadda
发明人： Qi Gao , Chung-Pin Chen , Michael Fakes , Yadagiri Pendri , Susanne Kiau , Blisse Vakkalagadda
IPC分类号： A61K31/675 , C07F9/6509
CPC分类号： C07D405/14 , C07C229/26 , C07D417/06 , C07F9/65583 , C07F9/65586
摘要： Mono-lysine salts of triazole compounds having a secondary or tertiary hydroxy group are provided. More particularly, the new water-soluble triazole antifungal mono-lysine salt compounds, or solvates thereof, are provided having the general formula I: wherein A in formula I represents the non-hydroxy portion of a triazole antifungal compound of the type containing a secondary or tertiary hydroxyl group. R and R1 in formula I can each be a hydrogen atom or an alkyl group having one to six carbon atoms. The novel water-soluble azole compounds are useful for the treatment of fungal infections and can be administered orally, topically and parenterally.
摘要翻译：提供具有仲羟基或叔羟基的三唑化合物的单赖氨酸盐。更具体地，提供了具有通式I的新的水溶性三唑抗真菌单赖氨酸盐化合物或其溶剂合物：其中式I中的A表示含有二级的三唑类抗真菌化合物的非羟基部分或叔羟基。式I中的R 1和R 2各自可以是氢原子或具有1-6个碳原子的烷基。新型水溶性唑类化合物可用于治疗真菌感染，可以口服，局部和肠胃外给药。

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